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ZA844299B - Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine immunomodulators - Google Patents

Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine immunomodulators

Info

Publication number
ZA844299B
ZA844299B ZA844299A ZA844299A ZA844299B ZA 844299 B ZA844299 B ZA 844299B ZA 844299 A ZA844299 A ZA 844299A ZA 844299 A ZA844299 A ZA 844299A ZA 844299 B ZA844299 B ZA 844299B
Authority
ZA
South Africa
Prior art keywords
imidazo
pyridine
immunomodulators
pyrrolo
imidazole
Prior art date
Application number
ZA844299A
Other languages
English (en)
Inventor
Thomas A Davidson
Robert J Murray
Original Assignee
Pennwalt Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pennwalt Corp filed Critical Pennwalt Corp
Publication of ZA844299B publication Critical patent/ZA844299B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Detergent Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
ZA844299A 1983-07-29 1984-06-07 Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine immunomodulators ZA844299B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/518,514 US4507481A (en) 1983-07-29 1983-07-29 Pyrrolo[1,2-a]imidazoles and imidazo[1,2-a]pyridines

Publications (1)

Publication Number Publication Date
ZA844299B true ZA844299B (en) 1985-01-30

Family

ID=24064258

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA844299A ZA844299B (en) 1983-07-29 1984-06-07 Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine immunomodulators

Country Status (15)

Country Link
US (1) US4507481A (fi)
EP (1) EP0150255B1 (fi)
JP (1) JPS6042384A (fi)
KR (1) KR910002837B1 (fi)
AT (1) ATE59042T1 (fi)
AU (1) AU562722B2 (fi)
CA (1) CA1250295A (fi)
DE (1) DE3483745D1 (fi)
DK (1) DK367084A (fi)
FI (1) FI78090C (fi)
IL (1) IL71943A (fi)
NO (1) NO161741C (fi)
NZ (1) NZ208266A (fi)
PH (1) PH19437A (fi)
ZA (1) ZA844299B (fi)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728645A (en) * 1982-12-21 1988-03-01 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives and other substituted bicyclic derivatives, useful as aromatase inhibitors
US4551535A (en) * 1983-07-29 1985-11-05 Pennwalt Corporation Process for preparing novel 7-thioester derivatives of 3H pyrrolo [1,2-a]-imidazole and 8-thioester derivatives of imidazo [1,2-a] pyridine
US4670445A (en) * 1984-03-05 1987-06-02 Eli Lilly And Company Inotropic agents
US4719218A (en) * 1985-12-12 1988-01-12 Smithkline Beckman Corporation Pyrrolo[1,2-a]imidazole and pyrrolo[1,2-a]pyridine derivatives and their use as 5-lipoxygenase pathway inhibitor
US4751310A (en) * 1985-12-12 1988-06-14 Smithkline Beckman Corporation Inhibition of the 5-lipoxygenase pathway
US5134150A (en) * 1985-12-12 1992-07-28 Smithkline Beecham Corporation Inhibition of the 5-lipoxygenase pathway
US5002941A (en) * 1985-12-12 1991-03-26 Smithkline Beecham Corporation Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
US5145858A (en) * 1985-12-12 1992-09-08 Smithkline Beecham Corp. Pyrrolo [1,2-a] imidazole and imidazo [1,2a] pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
US4794114A (en) * 1986-08-19 1988-12-27 Smithkline Beckman Corporation Inhibition of interleukin-1 production by monocytes and/or macrophages
AU622330B2 (en) * 1989-06-23 1992-04-02 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
KR930703321A (ko) * 1990-12-13 1993-11-29 스튜어트 알. 슈터 신규한 사이토킨 억제성 소염 의약
AU686115B2 (en) * 1992-11-02 1998-02-05 Fujisawa Pharmaceutical Co., Ltd. Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation
US5574042A (en) * 1992-11-02 1996-11-12 Fujisawa Pharmaceutical Co., Ltd Imidazo [1,2-a] pyridines and their pharmaceutical use
CA2134009C (en) * 1993-11-11 2005-03-08 Oleg Werbitzky Bicyclic amidines, process for their preparation, and their use as catalyst
AU2682695A (en) * 1994-06-20 1996-01-15 Takeda Chemical Industries Ltd. Condensed imidazole compounds, their production and use
WO2016183266A1 (en) 2015-05-13 2016-11-17 Enanta Pharmaceuticals, Inc. Ehpatitis b antiviral agents
US10179131B2 (en) 2015-07-13 2019-01-15 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10301255B2 (en) 2015-07-22 2019-05-28 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10280175B2 (en) 2016-02-02 2019-05-07 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
EP3426245B1 (en) 2016-03-07 2022-12-14 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
MX2018015315A (es) 2016-06-10 2019-04-25 Enanta Pharm Inc Agentes antivirales contra la hepatitis b.
KR102556744B1 (ko) 2017-08-28 2023-07-18 이난타 파마슈티칼스, 인코포레이티드 B형 간염 항바이러스제
US10723733B2 (en) 2017-12-06 2020-07-28 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2019113173A1 (en) 2017-12-06 2019-06-13 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
WO2019143902A2 (en) 2018-01-22 2019-07-25 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2019191166A1 (en) 2018-03-29 2019-10-03 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
CA3113235A1 (en) 2018-09-21 2020-03-26 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
WO2020106816A1 (en) 2018-11-21 2020-05-28 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
WO2020247444A1 (en) 2019-06-03 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
WO2020247575A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
US11760755B2 (en) 2019-06-04 2023-09-19 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2021007488A1 (en) 2019-07-11 2021-01-14 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2021055425A2 (en) 2019-09-17 2021-03-25 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
WO2021188414A1 (en) 2020-03-16 2021-09-23 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2984665A (en) * 1958-05-14 1961-05-16 Rohm & Haas Condensed heterocyclic compounds
US4126685A (en) * 1975-01-31 1978-11-21 Imperial Chemical Industries Limited 6-Aryl-pyrrolo[1,2,9]imidazole derivatives which possess anti-hypertensive activity
US4096264A (en) * 1975-12-09 1978-06-20 Merck & Co., Inc. Certain substituted imidazo [1,2-a] pyridines
EP0068378B1 (en) * 1981-06-26 1986-03-05 Schering Corporation Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0150255B1 (en) 1990-12-12
EP0150255A2 (en) 1985-08-07
FI843001A (fi) 1985-01-30
US4507481A (en) 1985-03-26
ATE59042T1 (de) 1990-12-15
PH19437A (en) 1986-04-15
DE3483745D1 (de) 1991-01-24
FI843001A0 (fi) 1984-07-27
IL71943A0 (en) 1984-09-30
NO161741C (no) 1989-09-20
NO843053L (no) 1985-01-30
NZ208266A (en) 1987-03-31
AU562722B2 (en) 1987-06-18
JPS6042384A (ja) 1985-03-06
CA1250295A (en) 1989-02-21
IL71943A (en) 1987-07-31
AU2885284A (en) 1985-01-31
EP0150255A3 (en) 1988-01-07
KR850001210A (ko) 1985-03-16
FI78090B (fi) 1989-02-28
NO161741B (no) 1989-06-12
KR910002837B1 (ko) 1991-05-06
DK367084A (da) 1985-01-30
FI78090C (fi) 1989-06-12
DK367084D0 (da) 1984-07-27

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