ZA200904289B - Polymorphs of a Mglur5 receptor antagonist - Google Patents

Polymorphs of a Mglur5 receptor antagonist

Info

Publication number: ZA200904289B
Authority: ZA; South Africa
Prior art keywords: polymorphs; receptor antagonist; mglur5 receptor; mglur5; antagonist
Prior art date: 2006-12-21

Application number

ZA200904289A

Other languages

English (en)

Inventor

Thomas P Cleary

Alexander Glomme

Olaf Grassmann

Shan-Ming Kuang

Roland Meier

Doreen Miller

Regina Moog

Franziska E Rohrer

Jason Yang

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-21

Filing date

2009-06-18

Publication date

2010-04-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39186951&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200904289(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-06-18 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2010-04-28 Publication of ZA200904289B publication Critical patent/ZA200904289B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Diabetes (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

ZA200904289A 2006-12-21 2009-06-18 Polymorphs of a Mglur5 receptor antagonist ZA200904289B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US87639806P	2006-12-21	2006-12-21

Publications (1)

Publication Number	Publication Date
ZA200904289B true ZA200904289B (en)	2010-04-28

Family

ID=39186951

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200904289A ZA200904289B (en)	2006-12-21	2009-06-18	Polymorphs of a Mglur5 receptor antagonist

Country Status (32)

Country	Link
US (2)	US8063076B2 (xx)
EP (1)	EP2125779B1 (xx)
JP (1)	JP5405311B2 (xx)
KR (1)	KR101148580B1 (xx)
CN (1)	CN101568531B (xx)
AR (1)	AR064654A1 (xx)
AU (1)	AU2007336369B2 (xx)
CA (1)	CA2673444C (xx)
CL (1)	CL2007003695A1 (xx)
CO (1)	CO6210731A2 (xx)
CY (1)	CY1117810T1 (xx)
DK (1)	DK2125779T3 (xx)
EC (1)	ECSP099431A (xx)
ES (1)	ES2577391T3 (xx)
HR (1)	HRP20160950T1 (xx)
HU (1)	HUE029324T2 (xx)
IL (1)	IL199181A (xx)
MA (1)	MA31008B1 (xx)
MX (1)	MX2009006694A (xx)
MY (1)	MY148217A (xx)
NO (1)	NO342451B1 (xx)
NZ (1)	NZ577440A (xx)
PE (1)	PE20081484A1 (xx)
PL (1)	PL2125779T3 (xx)
PT (1)	PT2125779T (xx)
RS (1)	RS54853B1 (xx)
RU (1)	RU2460728C2 (xx)
SI (1)	SI2125779T1 (xx)
TW (1)	TWI347320B (xx)
UA (1)	UA96970C2 (xx)
WO (1)	WO2008074697A1 (xx)
ZA (1)	ZA200904289B (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2125779B1 (en)	2006-12-21	2016-04-27	F. Hoffmann-La Roche AG	Polymorphs of a mglur5 receptor antagonist
US20120039999A1 (en) *	2010-08-11	2012-02-16	Ashish Chatterji	Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists
BR112013023813A2 (pt)	2011-03-18	2016-12-13	Novartis Ag	combinações de ativadores do receptor acetilcolina nicotínico alfa 7 e antagonistas de mglur5 para uso em dopamina induzida por discinesia na doença de parkinson
EP2837631A1 (en)	2013-08-14	2015-02-18	Merck & Cie	New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid
GB201317022D0 (en) *	2013-09-25	2013-11-06	Addex Pharmaceuticals Sa	Polymorphs
ES2916873T3 (es)	2014-01-10	2022-07-06	Birdie Biopharmaceuticals Inc	Compuestos y composiciones para inmunoterapia
CN106943597A (zh)	2016-01-07	2017-07-14	博笛生物科技（北京）有限公司	用于治疗肿瘤的抗-egfr组合
CN108794467A (zh)	2017-04-27	2018-11-13	博笛生物科技有限公司	2-氨基-喹啉衍生物
MX2022015407A (es) *	2020-06-05	2023-05-16	Noema Pharma Ag	Metodos de tratamiento del complejo de esclerosis tuberosa.
CN115989024A (zh) *	2020-07-30	2023-04-18	诺埃玛制药公司	治疗三叉神经痛的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3303199A (en)	1963-07-15	1967-02-07	Geigy Chem Corp	Certain imidazolone derivatives and process for making same
US3341548A (en)	1964-04-29	1967-09-12	Hoffmann La Roche	Nitroimidazoles and their preparation
DE2035905A1 (de)	1970-07-20	1972-02-03	Chemische Fabrik Stockhausen & Cie.,4150Krefeld	Imidazolverbindungen und deren Herstellungsverfahren
CA1174673A (en)	1981-02-27	1984-09-18	Walter Hunkeler	Imidazodiazepines
US4508560A (en)	1981-11-11	1985-04-02	Ciba Geigy Corporation	Certain pyridylacetylene compounds, compositions containing same and herbicidal methods of use
US4711962A (en)	1984-10-18	1987-12-08	Stauffer Chemical Company	Process for selective preparation of ratios of isomers formed on N-substitution of asymmetric imidazoles
DE69025473T2 (de)	1989-06-30	1996-10-17	Du Pont	Substituierte imidazole und ihre verwendung als hemmmstoff fur angiotensin ii
TW544448B (en)	1997-07-11	2003-08-01	Novartis Ag	Pyridine derivatives
ATE262331T1 (de)	1997-08-14	2004-04-15	Hoffmann La Roche	Heterocyclische vinylether zur behandlung neurologischer krankheiten
EP1214303A1 (en)	1999-08-31	2002-06-19	Merck & Co., Inc.	Heterocyclic compounds and methods of use thereof
ES2346513T3 (es)	2000-07-24	2010-10-18	Krenitsky Pharmaceuticals, Inc.	5-alquinil pirimidinas sustituidas que tienen actividad neurotrofica.
CN1257894C (zh)	2000-12-04	2006-05-31	弗·哈夫曼-拉罗切有限公司	作为谷氨酸受体拮抗剂的苯基乙烯基或苯基乙炔基衍生物
US6627646B2 (en) *	2001-07-17	2003-09-30	Sepracor Inc.	Norastemizole polymorphs
CA2470612A1 (en)	2001-12-19	2003-07-03	Merck & Co., Inc.	Heteroaryl substituted imidazole modulators of metabotropic glutamate receptor-5
TWI292318B (en)	2003-03-10	2008-01-11	Hoffmann La Roche	Imidazol-4-yl-ethynyl-pyridine derivatives
UA80888C2 (en) *	2003-06-05	2007-11-12	Hoffmann La Roche	Imidazole derivatives as glutmate receptor antagonists
US7091222B2 (en)	2003-07-03	2006-08-15	Hoffmann-La Roche Inc.	Imidazole derivatives
US7452909B2 (en)	2003-09-04	2008-11-18	Hoffman-La Roche Inc.	Imidazole derivatives
EP1756086B1 (en) *	2004-06-01	2008-06-04	F.Hoffmann-La Roche Ag	Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as mglu5 receptor antagonists
EP2125779B1 (en)	2006-12-21	2016-04-27	F. Hoffmann-La Roche AG	Polymorphs of a mglur5 receptor antagonist

2007
- 2007-12-11 EP EP07857408.4A patent/EP2125779B1/en active Active
- 2007-12-11 MY MYPI20092393A patent/MY148217A/en unknown
- 2007-12-11 MX MX2009006694A patent/MX2009006694A/es active IP Right Grant
- 2007-12-11 WO PCT/EP2007/063721 patent/WO2008074697A1/en active Application Filing
- 2007-12-11 UA UAA200907474A patent/UA96970C2/ru unknown
- 2007-12-11 AU AU2007336369A patent/AU2007336369B2/en active Active
- 2007-12-11 JP JP2009541986A patent/JP5405311B2/ja active Active
- 2007-12-11 ES ES07857408.4T patent/ES2577391T3/es active Active
- 2007-12-11 KR KR1020097012810A patent/KR101148580B1/ko active Active
- 2007-12-11 CN CN2007800475969A patent/CN101568531B/zh active Active
- 2007-12-11 CA CA2673444A patent/CA2673444C/en active Active
- 2007-12-11 NZ NZ577440A patent/NZ577440A/en unknown
- 2007-12-11 HU HUE07857408A patent/HUE029324T2/en unknown
- 2007-12-11 RU RU2009123135/04A patent/RU2460728C2/ru active
- 2007-12-11 SI SI200731792A patent/SI2125779T1/sl unknown
- 2007-12-11 DK DK07857408.4T patent/DK2125779T3/en active
- 2007-12-11 PT PT78574084T patent/PT2125779T/pt unknown
- 2007-12-11 RS RS20160461A patent/RS54853B1/sr unknown
- 2007-12-11 PL PL07857408.4T patent/PL2125779T3/pl unknown
- 2007-12-14 PE PE2007001802A patent/PE20081484A1/es not_active Application Discontinuation
- 2007-12-17 US US11/957,515 patent/US8063076B2/en active Active
- 2007-12-19 TW TW096148786A patent/TWI347320B/zh active
- 2007-12-19 CL CL200703695A patent/CL2007003695A1/es unknown
- 2007-12-21 AR ARP070105822A patent/AR064654A1/es not_active Application Discontinuation
2009
- 2009-06-04 IL IL199181A patent/IL199181A/en active IP Right Grant
- 2009-06-05 CO CO09058653A patent/CO6210731A2/es not_active Application Discontinuation
- 2009-06-15 EC EC2009009431A patent/ECSP099431A/es unknown
- 2009-06-17 MA MA32012A patent/MA31008B1/fr unknown
- 2009-06-18 ZA ZA200904289A patent/ZA200904289B/xx unknown
- 2009-06-19 NO NO20092357A patent/NO342451B1/no unknown
2011
- 2011-10-14 US US13/273,266 patent/US8329912B2/en active Active
2016
- 2016-07-19 CY CY20161100705T patent/CY1117810T1/el unknown
- 2016-07-26 HR HRP20160950TT patent/HRP20160950T1/hr unknown

Also Published As

Publication number	Publication date
RU2009123135A (ru)	2011-01-27
TWI347320B (en)	2011-08-21
PE20081484A1 (es)	2008-10-18
CA2673444C (en)	2015-01-20
PT2125779T (pt)	2016-07-19
JP2010513378A (ja)	2010-04-30
MA31008B1 (fr)	2009-12-01
CN101568531A (zh)	2009-10-28
ES2577391T3 (es)	2016-07-14
UA96970C2 (xx)	2011-12-26
CA2673444A1 (en)	2008-06-26
IL199181A (en)	2016-02-29
HRP20160950T1 (hr)	2016-10-07
SI2125779T1 (sl)	2016-07-29
MY148217A (en)	2013-03-29
ECSP099431A (es)	2009-07-31
CY1117810T1 (el)	2017-05-17
HUE029324T2 (en)	2017-02-28
US20080312288A1 (en)	2008-12-18
AR064654A1 (es)	2009-04-15
DK2125779T3 (en)	2016-07-04
AU2007336369A1 (en)	2008-06-26
RU2460728C2 (ru)	2012-09-10
US20120035222A1 (en)	2012-02-09
MX2009006694A (es)	2009-06-30
BRPI0720954A2 (pt)	2014-03-18
CL2007003695A1 (es)	2008-07-04
RS54853B1 (sr)	2016-10-31
EP2125779B1 (en)	2016-04-27
TW200833679A (en)	2008-08-16
US8329912B2 (en)	2012-12-11
AU2007336369B2 (en)	2013-01-17
US8063076B2 (en)	2011-11-22
KR101148580B1 (ko)	2012-05-24
KR20090081026A (ko)	2009-07-27
NO20092357L (no)	2009-07-15
EP2125779A1 (en)	2009-12-02
CO6210731A2 (es)	2010-10-20
NO342451B1 (no)	2018-05-22
WO2008074697A1 (en)	2008-06-26
NZ577440A (en)	2011-12-22
PL2125779T3 (pl)	2016-11-30
JP5405311B2 (ja)	2014-02-05
CN101568531B (zh)	2013-11-13

Publication	Publication Date	Title
HRP20160950T1 (hr)	2016-10-07	Polimorfi antagonista mglur5 receptora
HK1245264A1 (zh)	2018-08-24	多晶型
EP2034832A4 (en)	2010-12-08	IL-8 RECEPTOR ANTAGONIST
HRP20151108T1 (xx)	2015-11-20	Antagonisti nogo-receptora
IL196587A0 (en)	2009-11-18	2-phenyl-indoles as prostaglandin d2 receptor antagonists
IL194811A0 (en)	2009-08-03	Il-8 receptor antagonists
ZA201006830B (en)	2011-05-25	Heterocyclic compounds as adenosine receptor antagonist
IL194700A0 (en)	2009-08-03	Il-8 receptor antagonists
EP2099300A4 (en)	2011-12-07	IL-8 RECEPTOR ANTAGONISTS
ZA200903271B (en)	2010-04-28	Solid dispersion of a neurokinin antagonist
EP2191830A4 (en)	2011-11-23	SOLID PREPARATION COMPRISING A NPYY5 RECEPTOR ANTAGONIST
IL195807A0 (en)	2009-09-01	Cgrp receptor antagonists
EP2153736A4 (en)	2011-08-24	NEW LEUKOTRIEN RECEPTOR ANTAGONIST
ZA200808766B (en)	2010-01-27	Nitrated heterocyclic compounds as endothelin receptor antagonist
HK1206363A1 (zh)	2016-01-08	μ-阿片受體肽的有益鹽
IL205949A0 (en)	2010-11-30	3-carboxypropyl-aminotetralin derivatives and related compounds as mu opioid receptor antagonists
EP2057144A4 (en)	2010-06-02	NEW POLYMORPHIC FROM RIMONABANT
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ZA200810564B (en)	2009-11-25	2-phenyl-indoles as prostaglandin D2 receptor antagonists
ZA200903609B (en)	2010-07-28	Motilide polymorphs
GB0525029D0 (en)	2006-01-18	Receptor Antagonist
GB0701632D0 (en)	2007-03-07	MET receptor antagonists
GB0623853D0 (en)	2007-01-10	Receptor
GB0623399D0 (en)	2007-01-03	Receptor
GB0608516D0 (en)	2006-06-07	Receptor