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ZA200804587B - Trihydrochloride forms of a dihydropteridinone derivative and processes for preparation - Google Patents

Trihydrochloride forms of a dihydropteridinone derivative and processes for preparation

Info

Publication number
ZA200804587B
ZA200804587B ZA200804587A ZA200804587A ZA200804587B ZA 200804587 B ZA200804587 B ZA 200804587B ZA 200804587 A ZA200804587 A ZA 200804587A ZA 200804587 A ZA200804587 A ZA 200804587A ZA 200804587 B ZA200804587 B ZA 200804587B
Authority
ZA
South Africa
Prior art keywords
processes
preparation
trihydrochloride
forms
dihydropteridinone
Prior art date
Application number
ZA200804587A
Other languages
English (en)
Inventor
Grauert Matthias
Linz Guenter
Schmid Rolf
Sieger Peter
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of ZA200804587B publication Critical patent/ZA200804587B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
ZA200804587A 2006-02-08 2008-05-27 Trihydrochloride forms of a dihydropteridinone derivative and processes for preparation ZA200804587B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06101414 2006-02-08

Publications (1)

Publication Number Publication Date
ZA200804587B true ZA200804587B (en) 2009-04-29

Family

ID=38008126

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200804587A ZA200804587B (en) 2006-02-08 2008-05-27 Trihydrochloride forms of a dihydropteridinone derivative and processes for preparation

Country Status (22)

Country Link
US (3) US7439358B2 (es)
EP (2) EP2543669A3 (es)
JP (1) JP5134552B2 (es)
KR (2) KR101445114B1 (es)
CN (2) CN102093360B (es)
AR (1) AR059349A1 (es)
AU (1) AU2007213752B2 (es)
BR (1) BRPI0707604A8 (es)
CA (1) CA2635834C (es)
EA (2) EA015389B1 (es)
EC (1) ECSP088589A (es)
HK (2) HK1127772A1 (es)
IL (2) IL193217A (es)
NO (1) NO20082610L (es)
NZ (2) NZ606264A (es)
PE (2) PE20071248A1 (es)
SG (2) SG10201404755SA (es)
TW (1) TW200738716A (es)
UA (2) UA101060C2 (es)
UY (1) UY30136A1 (es)
WO (1) WO2007090844A1 (es)
ZA (1) ZA200804587B (es)

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US20130131069A1 (en) 2011-05-13 2013-05-23 Boehringer Ingelheim International Gmbh Method for treatment of solid malignancies including advanced or metastatic solid malignancies
US9370535B2 (en) 2011-05-17 2016-06-21 Boehringer Ingelheim International Gmbh Method for treatment of advanced solid tumors
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CN104003989B (zh) 2014-05-26 2015-11-11 苏州明锐医药科技有限公司 伏拉塞替及其中间体的制备方法
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Also Published As

Publication number Publication date
KR20140082837A (ko) 2014-07-02
UA101060C2 (ru) 2013-02-25
NZ570987A (en) 2011-09-30
EA201100638A1 (ru) 2011-10-31
UY30136A1 (es) 2007-09-28
EP2543669A3 (en) 2013-05-15
KR101462879B1 (ko) 2014-11-18
EA015389B1 (ru) 2011-08-30
CN102093360B (zh) 2014-11-05
EA018663B1 (ru) 2013-09-30
NO20082610L (no) 2008-08-26
HK1158628A1 (en) 2012-07-20
US20070203146A1 (en) 2007-08-30
US8188086B2 (en) 2012-05-29
WO2007090844A1 (en) 2007-08-16
HK1127772A1 (en) 2009-10-09
EP1984367A1 (en) 2008-10-29
PE20071248A1 (es) 2008-01-15
BRPI0707604A2 (pt) 2011-05-10
JP5134552B2 (ja) 2013-01-30
UA95625C2 (ru) 2011-08-25
CN101379064B (zh) 2012-01-25
EA200801769A1 (ru) 2009-02-27
WO2007090844A8 (en) 2007-10-11
US8664222B2 (en) 2014-03-04
CN101379064A (zh) 2009-03-04
IL236736A0 (en) 2015-02-26
SG169397A1 (en) 2011-03-30
ECSP088589A (es) 2008-07-30
AU2007213752A1 (en) 2007-08-16
CN102093360A (zh) 2011-06-15
TW200738716A (en) 2007-10-16
JP2009526017A (ja) 2009-07-16
US20090030004A1 (en) 2009-01-29
KR101445114B1 (ko) 2014-09-29
AR059349A1 (es) 2008-03-26
SG10201404755SA (en) 2014-10-30
US7439358B2 (en) 2008-10-21
PE20110100A1 (es) 2011-02-18
EP2543669A2 (en) 2013-01-09
IL193217A0 (en) 2009-02-11
AU2007213752B2 (en) 2013-01-17
NZ606264A (en) 2014-08-29
CA2635834A1 (en) 2007-08-16
IL193217A (en) 2017-06-29
KR20080093068A (ko) 2008-10-17
US20120214995A1 (en) 2012-08-23
CA2635834C (en) 2014-10-21
BRPI0707604A8 (pt) 2017-12-26

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