ATE487720T1 - 5,6,7,8-tetrahydropteridin-derivate als hsp90- hemmer - Google Patents

5,6,7,8-tetrahydropteridin-derivate als hsp90- hemmer

Info

Publication number: ATE487720T1
Authority: AT; Austria
Prior art keywords: hsp90 inhibitors; medicaments; treatment; tetrahydropteridine; derivatives
Prior art date: 2007-02-01

Application number

AT08701973T

Other languages

English (en)

Inventor

Thorsten Nowak

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-02-01

Filing date

2008-01-31

Publication date

2010-11-15

2008-01-31 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2010-11-15 Application granted granted Critical

2010-11-15 Publication of ATE487720T1 publication Critical patent/ATE487720T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Oncology (AREA)
Hematology (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Obesity (AREA)
Ophthalmology & Optometry (AREA)
Communicable Diseases (AREA)
Vascular Medicine (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Transplantation (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT08701973T 2007-02-01 2008-01-31 5,6,7,8-tetrahydropteridin-derivate als hsp90- hemmer ATE487720T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US88771607P	2007-02-01	2007-02-01
US95065407P	2007-07-19	2007-07-19
PCT/GB2008/000303 WO2008093075A2 (en)	2007-02-01	2008-01-31	5,6,7,8-tetrahydropteridine derivatives as hsp90 inhibitors

Publications (1)

Publication Number	Publication Date
ATE487720T1 true ATE487720T1 (de)	2010-11-15

Family

ID=39365852

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08701973T ATE487720T1 (de)	2007-02-01	2008-01-31	5,6,7,8-tetrahydropteridin-derivate als hsp90- hemmer

Country Status (13)

Country	Link
US (1)	US7799781B2 (de)
EP (1)	EP2109612B1 (de)
JP (1)	JP2010517989A (de)
KR (1)	KR20090104920A (de)
CN (1)	CN101652365A (de)
AT (1)	ATE487720T1 (de)
AU (1)	AU2008211729A1 (de)
BR (1)	BRPI0807868A2 (de)
CA (1)	CA2675677A1 (de)
DE (1)	DE602008003404D1 (de)
MX (1)	MX2009008084A (de)
RU (1)	RU2009132605A (de)
WO (1)	WO2008093075A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102008061214A1 (de) *	2008-12-09	2010-06-10	Merck Patent Gmbh	Chinazolinamidderivate
CA2753304C (en)	2009-02-25	2014-07-15	Daiichi Sankyo Company, Limited	Tricyclic pyrazolopyrimidine derivatives as hsp inhibitors
AR077405A1 (es)	2009-07-10	2011-08-24	Sanofi Aventis	Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr)	2009-09-03	2011-11-25	Sanofi Aventis	Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
WO2011036566A1 (en) *	2009-09-25	2011-03-31	Vertex Pharmaceuticals Incorporated	Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
JPWO2012026433A1 (ja)	2010-08-23	2013-10-28	第一三共株式会社	三環性ピラゾロピリミジン誘導体のフリー体結晶
CN103052642A (zh)	2010-08-23	2013-04-17	第一三共株式会社	三环吡唑并嘧啶衍生物的晶体
WO2012087943A2 (en) *	2010-12-20	2012-06-28	The Regents Of The University Of Michigan	Inhibitors of the epidermal growth factor receptor-heat shock protein 90 binding interaction
EP2776444A4 (de)	2011-11-10	2015-07-22	Osi Pharmaceuticals Llc	Dihydropteridinone
WO2014144715A1 (en)	2013-03-15	2014-09-18	Memorial Sloan-Kettering Cancer Center	Hsp90-targeted cardiac imaging and therapy
CA2961499A1 (en)	2014-09-17	2016-03-24	Memorial Sloan Kettering Cancer Center	Hsp90-targeted inflammation and infection imaging and therapy
KR20190017030A (ko)	2016-06-13	2019-02-19	글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드	Dnmt1의 억제제로서의 치환된 피리딘

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU177986B (en) *	1979-02-23	1982-02-28	Egyt Gyogyszervegyeszeti Gyar	Process for preparing 1-acyl-1,2- or -1,4-dihydro-pyrido/3,4-e/-as-triazine derivatives
JP2000154139A (ja)	1998-09-16	2000-06-06	Kyowa Hakko Kogyo Co Ltd	縮環ピラジン誘導体
IL142893A0 (en) *	1998-11-12	2002-04-21	Neurocrine Biosciences Inc	Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same
US6531475B1 (en) *	1998-11-12	2003-03-11	Neurocrine Biosciences, Inc.	CRF receptor antagonists and methods relating thereto
CA2426952C (en)	2000-11-02	2012-06-26	Sloan-Kettering Institute For Cancer Research	Small molecule compositions for binding to hsp90
US6806272B2 (en) *	2001-09-04	2004-10-19	Boehringer Ingelheim Pharma Kg	Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
JP4397691B2 (ja)	2001-10-30	2010-01-13	コンフォーマ・セラピューティクス・コーポレイション	Ｈｓｐ９０阻害活性を有するプリン類似体
WO2005021552A1 (en)	2003-08-29	2005-03-10	Vernalis (Cambridge) Ltd	Pyrimidothiophene compounds
US7138401B2 (en) *	2003-09-18	2006-11-21	Conforma Therapeutics Corporation	2-aminopurine analogs having HSP90-inhibiting activity
DE102004058337A1 (de)	2004-12-02	2006-06-14	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
EP1828186A1 (de)	2004-12-13	2007-09-05	Sunesis Pharmaceuticals, Inc.	Pyridopyrimidinone, dihydropyrimidopyrimidinone und pteridinone, die sich als raf-kinase-inhibitoren eignen
WO2006084030A2 (en)	2005-02-01	2006-08-10	Sloan-Kettering Institute For Cancer Research	Small-molecule hsp90 inhibitors
CN101180297A (zh)	2005-03-30	2008-05-14	康福玛医药公司	作为hsp90-抑制剂的炔基吡咯并嘧啶及相关类似物
JP2008540395A (ja)	2005-05-03	2008-11-20	ファイザー・インク	アミドレソルシノール化合物
DE102005022977A1 (de)	2005-05-19	2006-12-07	Merck Patent Gmbh	Phenylchinazolinderivate
WO2007035963A2 (en)	2005-09-23	2007-03-29	Conforma Therapeutics Corporation	Anti-tumor methods using multi drug resistance independent synthetic hsp90 inhibitors
WO2007092496A2 (en)	2006-02-07	2007-08-16	Conforma Therapeutics Corporation	7,9-dihydro-purin-8-one and related analogs as hsp90-inhibitors
US7439358B2 (en)	2006-02-08	2008-10-21	Boehringer Ingelheim International Gmbh	Specific salt, anhydrous and crystalline form of a dihydropteridione derivative

2008
- 2008-01-31 CN CN200880010915A patent/CN101652365A/zh active Pending
- 2008-01-31 JP JP2009547752A patent/JP2010517989A/ja active Pending
- 2008-01-31 BR BRPI0807868-8A patent/BRPI0807868A2/pt not_active Application Discontinuation
- 2008-01-31 WO PCT/GB2008/000303 patent/WO2008093075A2/en active Application Filing
- 2008-01-31 AT AT08701973T patent/ATE487720T1/de not_active IP Right Cessation
- 2008-01-31 DE DE602008003404T patent/DE602008003404D1/de active Active
- 2008-01-31 RU RU2009132605/04A patent/RU2009132605A/ru not_active Application Discontinuation
- 2008-01-31 US US12/023,202 patent/US7799781B2/en not_active Expired - Fee Related
- 2008-01-31 EP EP08701973A patent/EP2109612B1/de not_active Not-in-force
- 2008-01-31 CA CA002675677A patent/CA2675677A1/en not_active Abandoned
- 2008-01-31 AU AU2008211729A patent/AU2008211729A1/en not_active Abandoned
- 2008-01-31 KR KR1020097018333A patent/KR20090104920A/ko not_active Application Discontinuation
- 2008-01-31 MX MX2009008084A patent/MX2009008084A/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP2109612B1 (de)	2010-11-10
DE602008003404D1 (de)	2010-12-23
MX2009008084A (es)	2009-10-12
AU2008211729A1 (en)	2008-08-07
US20080194572A1 (en)	2008-08-14
CA2675677A1 (en)	2008-08-07
JP2010517989A (ja)	2010-05-27
WO2008093075A3 (en)	2008-10-02
WO2008093075A2 (en)	2008-08-07
EP2109612A2 (de)	2009-10-21
RU2009132605A (ru)	2011-03-10
US7799781B2 (en)	2010-09-21
KR20090104920A (ko)	2009-10-06
BRPI0807868A2 (pt)	2013-10-15
CN101652365A (zh)	2010-02-17

Publication	Publication Date	Title
ATE487720T1 (de)	2010-11-15	5,6,7,8-tetrahydropteridin-derivate als hsp90- hemmer
MX2010014057A (es)	2011-03-21	Compuestos de piridina.
MX2009008953A (es)	2009-12-18	Compuestos como inhibidores de angiogenesis.
MX2009009843A (es)	2009-09-24	Compuestos espiro sustituidos como inhibidores de la angiogenesis.
MY150958A (en)	2014-03-31	Compounds for the treatment of multi-drug resistant bacterial infections
EA200901133A1 (ru)	2010-04-30	Производные дианилинопиримидина как ингибиторы киназы wee1, фармацевтическая композиция и применение
TW200800998A (en)	2008-01-01	Phenylalanine derivatives
ATE452129T1 (de)	2010-01-15	N-phenyl-2-pyrimidine-amine derivatives
UA111588C2 (uk)	2016-05-25	Композиція інгібітора jak для місцевого застосування
EA201070167A1 (ru)	2013-07-30	Замещенные производные индазола, активные как ингибиторы киназы
ATE514699T1 (de)	2011-07-15	Substituierte pyrrolopyrazolderivate als kinaseinhibitoren
TW200745043A (en)	2007-12-16	Substituted pyrazoline compounds, their preparation and use as medicaments
ATE520668T1 (de)	2011-09-15	Sigmarezeptor-inhibitoren
AU2009282962A8 (en)	2011-11-10	Compounds as kinase inhibitors
DE602005021770D1 (de)	2010-07-22	Indol-1-yl-essigsäurederivate
TW200731975A (en)	2007-09-01	Novel combinations of medicaments for the treatment of respiratory diseases
TW200738699A (en)	2007-10-16	4-Substituted pyrazoline compounds, their preparation and use as medicaments
EA201001196A1 (ru)	2011-02-28	Соединения 4-пиридинона и их применение для лечения рака
MX340985B (es)	2016-08-01	Compuestos de n-heteroarilo.
MX2008001211A (es)	2008-03-24	Derivados de bencilpiperazina y su uso medico.
EA201492097A1 (ru)	2015-04-30	5-амино[1,4]тиазины в качестве ингибиторов бета-секретазы 1
CL2009001267A1 (es)	2010-12-31	Compuestos derivados de triciclos nitrogenados, con actividad antibacteriana; procedimiento de preparacion; composicion farmceutica que los comprende; para el tratamiento de la tuberculosis.
ATE522500T1 (de)	2011-09-15	Amidderivate als ionenkanalliganden sowie pharmazeutische zusammensetzungen und verwendungsverfahren dafür
MX2009010374A (es)	2010-03-04	Derivados de tetrahidro-naftalenamina sustituidos con heterociclilo, su preparacion y su uso como medicamentos.
PH12015501945B1 (en)	2016-01-11	Formulations of organic compounds

Legal Events

Date	Code	Title	Description
2011-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties