HK1158628A1 - Process for preparing dihydropteridinone derivatives - Google Patents

Process for preparing dihydropteridinone derivatives

Info

Publication number: HK1158628A1
Authority: HK; Hong Kong
Prior art keywords: preparing; dihydropteridinone derivatives; dihydropteridinone; derivatives; preparing dihydropteridinone
Prior art date: 2006-02-08

Application number

HK11112923.4A

Other languages

English (en)

Chinese (zh)

Inventor

馬賽厄斯‧格勞爾特

岡特‧林茨

羅爾夫‧施米德

彼得‧西格

Original Assignee

貝林格爾．英格海姆國際有限公司

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-02-08

Filing date

2009-07-28

Publication date

2012-07-20

2009-07-28 Application filed by 貝林格爾．英格海姆國際有限公司 filed Critical 貝林格爾．英格海姆國際有限公司

2012-07-20 Publication of HK1158628A1 publication Critical patent/HK1158628A1/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Biomedical Technology (AREA)
Virology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Psychiatry (AREA)
Molecular Biology (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Hydrogenated Pyridines (AREA)

HK11112923.4A 2006-02-08 2009-07-28 Process for preparing dihydropteridinone derivatives HK1158628A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP06101414		2006-02-08

Publications (1)

Publication Number	Publication Date
HK1158628A1 true HK1158628A1 (en)	2012-07-20

Family

ID=38008126

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
HK11112923.4A HK1158628A1 (en)	2006-02-08	2009-07-28	Process for preparing dihydropteridinone derivatives
HK09106923.0A HK1127772A1 (en)	2006-02-08	2009-07-28	Trihydrochloride forms of a dihydropteridinone derivative and processes for preparation

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
HK09106923.0A HK1127772A1 (en)	2006-02-08	2009-07-28	Trihydrochloride forms of a dihydropteridinone derivative and processes for preparation

Country Status (22)

Country	Link
US (3)	US7439358B2 (xx)
EP (2)	EP1984367A1 (xx)
JP (1)	JP5134552B2 (xx)
KR (2)	KR101462879B1 (xx)
CN (2)	CN102093360B (xx)
AR (1)	AR059349A1 (xx)
AU (1)	AU2007213752B2 (xx)
BR (1)	BRPI0707604A8 (xx)
CA (1)	CA2635834C (xx)
EA (2)	EA018663B1 (xx)
EC (1)	ECSP088589A (xx)
HK (2)	HK1158628A1 (xx)
IL (2)	IL193217A (xx)
NO (1)	NO20082610L (xx)
NZ (2)	NZ570987A (xx)
PE (2)	PE20071248A1 (xx)
SG (2)	SG169397A1 (xx)
TW (1)	TW200738716A (xx)
UA (2)	UA101060C2 (xx)
UY (1)	UY30136A1 (xx)
WO (1)	WO2007090844A1 (xx)
ZA (1)	ZA200804587B (xx)

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EP1632493A1 (de) *	2004-08-25	2006-03-08	Boehringer Ingelheim Pharma GmbH & Co.KG	Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE102004058337A1 (de) *	2004-12-02	2006-06-14	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
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US8546566B2 (en)	2010-10-12	2013-10-01	Boehringer Ingelheim International Gmbh	Process for manufacturing dihydropteridinones and intermediates thereof
US9358233B2 (en)	2010-11-29	2016-06-07	Boehringer Ingelheim International Gmbh	Method for treating acute myeloid leukemia
US20130131069A1 (en)	2011-05-13	2013-05-23	Boehringer Ingelheim International Gmbh	Method for treatment of solid malignancies including advanced or metastatic solid malignancies
US9370535B2 (en)	2011-05-17	2016-06-21	Boehringer Ingelheim International Gmbh	Method for treatment of advanced solid tumors
US20140154304A1 (en)	2012-11-30	2014-06-05	Boehringer Ingelheim International Gmbh	Combination therapy with volasertib
EA201600133A1 (ru) *	2013-07-26	2016-07-29	Бёрингер Ингельхайм Интернациональ Гмбх	Воласертиб в комбинации с децитабином для лечения острого миелоидного лейкоза и миелодиспластического синдрома
WO2015011236A1 (en)	2013-07-26	2015-01-29	Boehringer Ingelheim International Gmbh	Treatment of myelodysplastic syndrome
CN104003989B (zh)	2014-05-26	2015-11-11	苏州明锐医药科技有限公司	伏拉塞替及其中间体的制备方法
US9867831B2 (en)	2014-10-01	2018-01-16	Boehringer Ingelheim International Gmbh	Combination treatment of acute myeloid leukemia and myelodysplastic syndrome
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US7728134B2 (en) *	2004-08-14	2010-06-01	Boehringer Ingelheim International Gmbh	Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
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CN109503584A (zh)	2006-05-04	2019-03-22	勃林格殷格翰国际有限公司	多晶型
EP3098223A1 (en)	2007-08-03	2016-11-30	Boehringer Ingelheim International GmbH	Crystalline form of a dihydropteridione derivative
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US8546566B2 (en)	2010-10-12	2013-10-01	Boehringer Ingelheim International Gmbh	Process for manufacturing dihydropteridinones and intermediates thereof
US9358233B2 (en)	2010-11-29	2016-06-07	Boehringer Ingelheim International Gmbh	Method for treating acute myeloid leukemia
US20130131069A1 (en)	2011-05-13	2013-05-23	Boehringer Ingelheim International Gmbh	Method for treatment of solid malignancies including advanced or metastatic solid malignancies
US9370535B2 (en)	2011-05-17	2016-06-21	Boehringer Ingelheim International Gmbh	Method for treatment of advanced solid tumors

2007
- 2007-01-30 US US11/668,681 patent/US7439358B2/en active Active
- 2007-02-06 PE PE2007000127A patent/PE20071248A1/es not_active Application Discontinuation
- 2007-02-06 PE PE2010000509A patent/PE20110100A1/es not_active Application Discontinuation
- 2007-02-07 EP EP07704397A patent/EP1984367A1/en not_active Ceased
- 2007-02-07 BR BRPI0707604A patent/BRPI0707604A8/pt not_active IP Right Cessation
- 2007-02-07 AR ARP070100503A patent/AR059349A1/es active Pending
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2008
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Also Published As

Publication number	Publication date
EA015389B1 (ru)	2011-08-30
NO20082610L (no)	2008-08-26
NZ606264A (en)	2014-08-29
TW200738716A (en)	2007-10-16
WO2007090844A1 (en)	2007-08-16
WO2007090844A8 (en)	2007-10-11
US8664222B2 (en)	2014-03-04
US20120214995A1 (en)	2012-08-23
EA200801769A1 (ru)	2009-02-27
EP2543669A3 (en)	2013-05-15
AR059349A1 (es)	2008-03-26
CA2635834A1 (en)	2007-08-16
US8188086B2 (en)	2012-05-29
EA201100638A1 (ru)	2011-10-31
CN101379064B (zh)	2012-01-25
JP5134552B2 (ja)	2013-01-30
EP1984367A1 (en)	2008-10-29
PE20071248A1 (es)	2008-01-15
UA101060C2 (ru)	2013-02-25
UY30136A1 (es)	2007-09-28
AU2007213752B2 (en)	2013-01-17
EA018663B1 (ru)	2013-09-30
IL193217A0 (en)	2009-02-11
US7439358B2 (en)	2008-10-21
NZ570987A (en)	2011-09-30
CN102093360A (zh)	2011-06-15
UA95625C2 (ru)	2011-08-25
BRPI0707604A2 (pt)	2011-05-10
US20070203146A1 (en)	2007-08-30
ZA200804587B (en)	2009-04-29
EP2543669A2 (en)	2013-01-09
KR20140082837A (ko)	2014-07-02
IL193217A (en)	2017-06-29
CN102093360B (zh)	2014-11-05
SG169397A1 (en)	2011-03-30
KR20080093068A (ko)	2008-10-17
ECSP088589A (es)	2008-07-30
BRPI0707604A8 (pt)	2017-12-26
CA2635834C (en)	2014-10-21
CN101379064A (zh)	2009-03-04
KR101445114B1 (ko)	2014-09-29
KR101462879B1 (ko)	2014-11-18
PE20110100A1 (es)	2011-02-18
HK1127772A1 (en)	2009-10-09
SG10201404755SA (en)	2014-10-30
IL236736A0 (en)	2015-02-26
JP2009526017A (ja)	2009-07-16
AU2007213752A1 (en)	2007-08-16
US20090030004A1 (en)	2009-01-29

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2019-09-13	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20190207