ZA200801791B - Processes and intermediates - Google Patents

Processes and intermediates

Info

Publication number: ZA200801791B
Authority: ZA; South Africa
Prior art keywords: intermediates; processes
Prior art date: 2005-08-19

Application number

ZA200801791A

Other languages

English (en)

Inventor

Gerald J Tanoury

John E Cochran

Chen Minzhang

Original Assignee

Vertex Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-08-19

Filing date

2008-02-25

Publication date

2008-12-31

2008-02-25 Application filed by Vertex Pharma filed Critical Vertex Pharma

2008-12-31 Publication of ZA200801791B publication Critical patent/ZA200801791B/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Virology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Enzymes And Modification Thereof (AREA)

ZA200801791A 2005-08-19 2008-02-25 Processes and intermediates ZA200801791B (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US70996405P	2005-08-19	2005-08-19
US81004206P	2006-06-01	2006-06-01
PCT/US2006/032481 WO2007022459A2 (en)	2005-08-19	2006-08-18	Processes and intermediates

Publications (1)

Publication Number	Publication Date
ZA200801791B true ZA200801791B (en)	2008-12-31

Family

ID=37708299

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200801791A ZA200801791B (en)	2005-08-19	2008-02-25	Processes and intermediates

Country Status (25)

Country	Link
US (3)	US7776887B2 (pl)
EP (4)	EP2364970A1 (pl)
JP (1)	JP5203203B2 (pl)
KR (4)	KR20140069370A (pl)
CN (2)	CN102382170A (pl)
AR (1)	AR058025A1 (pl)
AT (1)	ATE463480T1 (pl)
AU (1)	AU2006279357B2 (pl)
BR (1)	BRPI0615029A2 (pl)
CA (1)	CA2619659A1 (pl)
CY (2)	CY1110214T1 (pl)
DE (1)	DE602006013492D1 (pl)
DK (2)	DK2194043T3 (pl)
ES (2)	ES2449268T3 (pl)
HK (2)	HK1122801A1 (pl)
IL (2)	IL189585A (pl)
NZ (3)	NZ593214A (pl)
PL (3)	PL385229A1 (pl)
PT (2)	PT1934179E (pl)
RU (2)	RU2446171C2 (pl)
SG (1)	SG2014013338A (pl)
SI (2)	SI2194043T1 (pl)
TW (2)	TW201245149A (pl)
WO (1)	WO2007022459A2 (pl)
ZA (1)	ZA200801791B (pl)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1133649C (zh) *	1996-10-18	2004-01-07	沃泰克斯药物股份有限公司	丝氨酸蛋白酶、特别是丙型肝炎病毒ns3蛋白酶的抑制剂
SV2003000617A (es) *	2000-08-31	2003-01-13	Lilly Co Eli	Inhibidores de la proteasa peptidomimetica ref. x-14912m
UY28500A1 (es) *	2003-09-05	2005-04-29	Vertex Pharma	Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc.
EP2402331A1 (en) *	2005-08-02	2012-01-04	Vertex Pharmaceuticals Incorporated	Inhibitors of serine proteases
JP5203203B2 (ja)	2005-08-19	2013-06-05	バーテックスファーマシューティカルズインコーポレイテッド	製造工程および中間体
US8399615B2 (en) *	2005-08-19	2013-03-19	Vertex Pharmaceuticals Incorporated	Processes and intermediates
US7964624B1 (en)	2005-08-26	2011-06-21	Vertex Pharmaceuticals Incorporated	Inhibitors of serine proteases
AR055395A1 (es) *	2005-08-26	2007-08-22	Vertex Pharma	Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
WO2007098270A2 (en)	2006-02-27	2007-08-30	Vertex Pharmaceuticals Incorporated	Co-crystals comprising vx-950 and pharmaceutical compositions comprising the same
JP5313124B2 (ja) *	2006-03-16	2013-10-09	バーテックスファーマシューティカルズインコーポレイテッド	立体的化合物を製造するための方法および中間体
MX2008011868A (es)	2006-03-16	2008-12-15	Vertex Pharma	Inhibidores deuterados de la proteasa de la hepatitis c.
CA2672268A1 (en) *	2006-12-15	2008-06-26	Schering Corporation	Bisulfite purification of an alpha-keto amide
WO2008106058A2 (en) *	2007-02-27	2008-09-04	Vertex Pharmaceuticals Incorporated	Inhibitors of serine proteases
SI2114924T1 (sl) *	2007-02-27	2012-06-29	Vertex Pharma	Ko-kristali in farmacevtski sestavki, ki jih vsebujejo
EP2436682A1 (en) *	2007-08-30	2012-04-04	Vertex Pharmceuticals Incorporated	Co-crystals and pharmaceutical compositions comprising the same
WO2009114633A1 (en) *	2008-03-12	2009-09-17	Virobay, Inc.	Process for the preparation of (3s)-3-amino-n-cyclopropyl-2-hydroxyalkanamide derivatives
WO2009152474A2 (en) *	2008-06-13	2009-12-17	Virobay, Inc.	Process for the preparation of (3s)-3-amino-n-cyclopropyl-2-hydroxyalkanamide derivatives
WO2010008828A2 (en)	2008-06-24	2010-01-21	Codexis, Inc.	Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds
EP2539334A1 (en) *	2010-02-25	2013-01-02	Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg	Process for the preparation of -acyloxy -formamido amides
EP2576508A2 (en) *	2010-06-03	2013-04-10	Vertex Pharmaceuticals Incorporated	Processes and intermediates
CN102167680B (zh) *	2011-03-23	2014-07-02	合亚医药科技（上海）有限公司	八氢环戊基并[c]吡咯羧酸衍生物的制备方法
CN103814001A (zh) *	2011-05-13	2014-05-21	弗特克斯药品有限公司	方法和中间体
WO2012158515A1 (en) *	2011-05-13	2012-11-22	Vertex Phamaceuticals Incorporated	Process for the preparation of protease inhibitors
JP2013010738A (ja) *	2011-05-31	2013-01-17	Sumitomo Chemical Co Ltd	エステル化合物の製造方法
DE112012003510T5 (de)	2011-10-21	2015-03-19	Abbvie Inc.	Verfahren zur Behandlung von HCV umfassend mindestens zwei direkt wirkende antivirale Wirkstoffe, Ribavirin aber nicht Interferon
US8492386B2 (en)	2011-10-21	2013-07-23	Abbvie Inc.	Methods for treating HCV
US8466159B2 (en)	2011-10-21	2013-06-18	Abbvie Inc.	Methods for treating HCV
DK2583680T1 (da)	2011-10-21	2015-01-19	Abbvie Inc	Mono (PSI-7977) eller kombinationsbehandling af DAA til anvendelse ved behandling af HCV
WO2013072328A1 (en)	2011-11-14	2013-05-23	Sanofi	Use of telaprevir and related compounds in atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases
CN103183632A (zh) *	2011-12-29	2013-07-03	山东方明药业集团股份有限公司	一种3-氮杂双环辛烷盐酸盐的提纯方法
ITMI20120192A1 (it) *	2012-02-13	2013-08-14	Dipharma Francis Srl	Procedimento per la preparazione di un inibitore delle proteasi virali e suoi intermedi
ITMI20120359A1 (it)	2012-03-07	2013-09-08	Dipharma Francis Srl	Procedimento per la preparazione di intermedi utili nella preparazione di un inibitore delle proteasi virali
ITMI20121668A1 (it) *	2012-10-05	2014-04-06	Dipharma Francis Srl	Sintesi di un intermedio di un composto antivirale
WO2013136265A1 (en)	2012-03-13	2013-09-19	Dipharma Francis S.R.L.	Synthesis of an intermediate of an antiviral compound
ITMI20120391A1 (it) *	2012-03-13	2013-09-14	Dipharma Francis Srl	Procedimento per la sintesi di un intermedio ciclopropilammidico utile nella preparazione di un inibitore delle proteasi virali
WO2013135870A1 (en)	2012-03-16	2013-09-19	Sandoz Ag	Process for the synthesis of telaprevir, or pharmaceutically acceptable salts or solvates as well as intermediate products thereof
ITMI20120608A1 (it)	2012-04-13	2013-10-14	Dipharma Francis Srl	Procedimento per la preparazione di un inibitore delle proteasi virali in forma amorfa
ITMI20120800A1 (it) *	2012-05-10	2013-11-11	Dipharma Francis Srl	Procedimento per la preparazione di un intermedio utile nella preparazione di un inibitore delle proteasi virali
CN103450066B (zh) *	2012-05-30	2017-03-15	博瑞生物医药（苏州）股份有限公司	特拉匹韦中间体的制备方法
WO2013178682A2 (en)	2012-05-30	2013-12-05	Chemo Ibérica, S.A.	Multicomponent process for the preparation of bicyclic compounds
ITMI20120990A1 (it) *	2012-06-07	2013-12-08	Dipharma Francis Srl	Sintesi di un inibitore delle proteasi virali
WO2013189980A1 (en)	2012-06-20	2013-12-27	Sandoz Ag	SYNTHESIS OF TELAPREVIR AND BOCEPREVIR, OR PHARMACEUTICALLY ACCEPTABLE SALTS OR SOLVATES AS WELL AS INTERMEDIATE PRODUCTS THEREOF INCLUDING ß-AMINO ACIDS PREPARED VIA MUKAIYAMA ALDOL ADDITION
WO2013189978A1 (en)	2012-06-20	2013-12-27	Sandoz Ag	PROCESS FOR PREPARING ß-AMINO ACID DERIVATIVES AND USE OF SAID PROCESS FOR PREPARING TELAPREVIR
WO2014019179A1 (zh) *	2012-08-01	2014-02-06	上海迪赛诺药业有限公司	特拉匹韦及其中间体的制备方法
WO2014033667A1 (en)	2012-08-30	2014-03-06	Ranbaxy Laboratories Limited	Process for the preparation of telaprevir
CN102875648B (zh) *	2012-09-26	2014-02-19	深圳翰宇药业股份有限公司	一种制备特拉匹韦的方法
WO2014053533A1 (en)	2012-10-05	2014-04-10	Sanofi	Use of substituted 3-heteroaroylamino-propionic acid derivatives as pharmaceuticals for prevention/treatment of atrial fibrillation
ITMI20122036A1 (it) *	2012-11-29	2014-05-30	Dipharma Francis Srl	Sintesi di un intermedio di un composto antivirale
WO2014096374A1 (en)	2012-12-21	2014-06-26	Sandoz Ag	Process for the synthesis of pyrrolidines and pyrroles
EP2935245A1 (en) *	2012-12-21	2015-10-28	Sandoz AG	Novel forms of telaprevir
CN103936651B (zh) *	2013-01-18	2016-06-22	上海医药工业研究院	抗丙肝药物Boceprevir的中间体Ⅲ及其制备方法和应用
ITMI20130706A1 (it)	2013-04-30	2014-10-31	Dipharma Francis Srl	Procedimento per la preparazione di un inibitore delle proteasi virali e suoi intermedi
CN103288671B (zh) *	2013-06-20	2014-10-29	上海步越化工科技有限公司	一种(3s)-3-氨基-n-环丙基-2-羟基己酰胺盐酸盐的合成方法
WO2014203224A1 (en)	2013-06-21	2014-12-24	Ranbaxy Laboratories Limited	Process for the preparation of telaprevir and its intermediates
WO2014203208A1 (en)	2013-06-21	2014-12-24	Ranbaxy Laboratories Limited	Process for the preparation of telaprevir and intermediates thereof
CN104292146B (zh) *	2013-06-24	2017-04-26	上海医药工业研究院	特拉匹韦中间体及其制备方法
CN103342656B (zh) *	2013-07-04	2015-04-08	苏州永健生物医药有限公司	特拉匹韦中间体的合成方法
CN103435532B (zh) *	2013-09-02	2015-07-08	苏州永健生物医药有限公司	波普瑞韦中间体的合成方法
WO2015036522A1 (en) *	2013-09-13	2015-03-19	Sandoz Ag	Process for the preparation and isolation of (s)-3-amino-n-cyclopropyl-2,2-dialkoxyhexanamide and (s)-tert-butyl(1-(cyclopropylamino)-2,2-dialkoxy-1-oxohexan-3-yl)carbamate and use thereof for the preparation of telaprevir
JP2016539931A (ja)	2013-10-23	2016-12-22	株式会社カネカ	テトラペプチド化合物及びその製造方法
CN103664739B (zh) *	2013-12-10	2016-04-27	湖南科源生物制品有限公司	一种特拉匹韦中间体的制备方法
US10118890B2 (en)	2014-10-10	2018-11-06	The Research Foundation For The State University Of New York	Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
CN105646329A (zh) *	2014-11-28	2016-06-08	重庆圣华曦药业股份有限公司	一种制备特拉匹韦中间体的方法
CN105111129A (zh) *	2015-08-24	2015-12-02	上海合全药业股份有限公司	(1S,3aR,6aS)-八氢环戊烯并[C]吡咯-1-羧酸叔丁酯草酸盐的制备方法
CN105601556B (zh) *	2015-12-02	2018-11-13	镇江市高等专科学校	特拉匹韦双环吡咯烷中间体的制备方法
US11192914B2 (en)	2016-04-28	2021-12-07	Emory University	Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
CN113167802B (zh)	2018-12-04	2025-02-07	百时美施贵宝公司	通过多同位素体反应监测使用样品内校准曲线的分析方法
BR112022025037A2 (pt)	2020-06-10	2023-02-14	Aligos Therapeutics Inc	Compostos antivirais para tratar infecções por coronavírus, picornavírus e norovírus
WO2023283256A1 (en)	2021-07-09	2023-01-12	Aligos Therapeutics, Inc.	Anti-viral compounds
US12065428B2 (en)	2021-09-17	2024-08-20	Aligos Therapeutics, Inc.	Anti-viral compounds

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3211676A1 (de)	1982-03-30	1983-10-06	Hoechst Ag	Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung
US5468858A (en) *	1993-10-28	1995-11-21	The Board Of Regents Of Oklahoma State University Physical Sciences	N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
JPH0967344A (ja) *	1995-09-05	1997-03-11	Koei Chem Co Ltd	光学活性ｎ−ベンジルオキシカルボニルピペコリン酸の製造方法
WO1997043310A1 (en)	1996-05-10	1997-11-20	Schering Corporation	Synthetic inhibitors of hepatitis c virus ns3 protease
JP3863230B2 (ja)	1996-08-16	2006-12-27	株式会社カネカ	β−アミノ−α−ヒドロキシ酸誘導体の製造方法
CN1133649C (zh)	1996-10-18	2004-01-07	沃泰克斯药物股份有限公司	丝氨酸蛋白酶、特别是丙型肝炎病毒ns3蛋白酶的抑制剂
GB9623908D0 (en)	1996-11-18	1997-01-08	Hoffmann La Roche	Amino acid derivatives
GB9707659D0 (en)	1997-04-16	1997-06-04	Peptide Therapeutics Ltd	Hepatitis C NS3 Protease inhibitors
NZ503263A (en)	1997-08-11	2002-10-25	Boehringer Ingelheim Ca Ltd	Hepatitis C NS3 protease inhibitor peptides and peptide analogues
US6767991B1 (en)	1997-08-11	2004-07-27	Boehringer Ingelheim (Canada) Ltd.	Hepatitis C inhibitor peptides
NZ503262A (en)	1997-08-11	2002-10-25	Boehringer Ingelheim Ca Ltd	Hepatitis C NS3 protease inhibitor peptides and peptide analogues
IT1299134B1 (it)	1998-02-02	2000-02-29	Angeletti P Ist Richerche Bio	Procedimento per la produzione di peptidi con proprieta' inibitrici della proteasi ns3 del virus hcv, peptidi cosi' ottenibili e peptidi
EP1066247B1 (en)	1998-03-31	2006-11-22	Vertex Pharmaceuticals Incorporated	Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
GB9812523D0 (en)	1998-06-10	1998-08-05	Angeletti P Ist Richerche Bio	Peptide inhibitors of hepatitis c virus ns3 protease
US6323180B1 (en)	1998-08-10	2001-11-27	Boehringer Ingelheim (Canada) Ltd	Hepatitis C inhibitor tri-peptides
DE19836514A1 (de)	1998-08-12	2000-02-17	Univ Stuttgart	Modifikation von Engineeringpolymeren mit N-basischen Gruppe und mit Ionenaustauschergruppen in der Seitenkette
GB9825946D0 (en)	1998-11-26	1999-01-20	Angeletti P Ist Richerche Bio	Pharmaceutical compounds for the inhibition of hepatitis C virus NS3 protease
GB2363605B (en)	1999-03-12	2004-02-04	Ajinomoto Kk	Process for the preparation of alpha-aminoketone derivatives
UA74546C2 (en)	1999-04-06	2006-01-16	Boehringer Ingelheim Ca Ltd	Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
US6608027B1 (en)	1999-04-06	2003-08-19	Boehringer Ingelheim (Canada) Ltd	Macrocyclic peptides active against the hepatitis C virus
US7122627B2 (en)	1999-07-26	2006-10-17	Bristol-Myers Squibb Company	Lactam inhibitors of Hepatitis C virus NS3 protease
WO2001007407A1 (en)	1999-07-26	2001-02-01	Bristol-Myers Squibb Pharma Company	Lactam inhibitors of hepatitis c virus ns3 protease
JP2003525294A (ja)	2000-02-29	2003-08-26	ブリストル−マイヤーズスクイブファーマカンパニー	Ｃ型肝炎ウイルスｎｓ３プロテアーゼの阻害剤
AU2001243515A1 (en) *	2000-03-08	2001-09-17	Rhode Island Hospital, A Lifespan Partner	Combination drug therapy
WO2001074768A2 (en)	2000-04-03	2001-10-11	Vertex Pharmaceuticals Incorporated	Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
SK14192002A3 (sk)	2000-04-05	2003-03-04	Schering Corporation	Makrocyklické zlúčeniny, farmaceutický prostriedok s ich obsahom a ich použitie
BR0110104A (pt)	2000-04-19	2003-01-07	Schering Corp	Inibidores de ns-3 serina rotease macrocìclica do vìrus da hepatite c compreendendo porções de alquil e aril alanina p2
AR034127A1 (es)	2000-07-21	2004-02-04	Schering Corp	Imidazolidinonas como inhibidores de ns3-serina proteasa del virus de hepatitis c, composicion farmaceutica, un metodo para su preparacion, y el uso de las mismas para la manufactura de un medicamento
US7244721B2 (en) *	2000-07-21	2007-07-17	Schering Corporation	Peptides as NS3-serine protease inhibitors of hepatitis C virus
AR029851A1 (es)	2000-07-21	2003-07-16	Dendreon Corp	Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c
EP1303487A4 (en)	2000-07-21	2005-11-23	Schering Corp	NOVEL PEPTIDES AS INHIBITORS OF THE NS3 SERINE PROTEASE OF HEPATITIS C VIRUS
MXPA03000627A (es)	2000-07-21	2004-07-30	Schering Corp	Nuevos peptidos como inhibidores de proteasa serina-ns3 del virus de la hepatitis c.
SV2003000617A (es)	2000-08-31	2003-01-13	Lilly Co Eli	Inhibidores de la proteasa peptidomimetica ref. x-14912m
US6846806B2 (en)	2000-10-23	2005-01-25	Bristol-Myers Squibb Company	Peptide inhibitors of Hepatitis C virus NS3 protein
MXPA03004299A (es)	2000-11-20	2004-02-12	Bristol Myers Squibb Co	Inhibidores de tripeptido de hepatitis c.
AU2002230763A1 (en)	2000-12-13	2008-01-03	Bristol-Myers Squibb Pharma Company	Inhibitors of hepatitis c virus ns3 protease
US6653295B2 (en)	2000-12-13	2003-11-25	Bristol-Myers Squibb Company	Inhibitors of hepatitis C virus NS3 protease
AU2002230764A1 (en)	2000-12-13	2002-06-24	Bristol-Myers Squibb Pharma Company	Imidazolidinones and their related derivatives as hepatitis c virus ns3 protease inhibitors
GB0107924D0 (en)	2001-03-29	2001-05-23	Angeletti P Ist Richerche Bio	Inhibitor of hepatitis C virus NS3 protease
US6909000B2 (en)	2001-07-11	2005-06-21	Vertex Pharmaceuticals Incorporated	Bridged bicyclic serine protease inhibitors
AU2002348414B2 (en) *	2001-10-24	2009-10-01	Vertex Pharmaceuticals Incorporated	Inhibitors of serine protease, particularly hepatitis C virus NS3-NS4A protease, incorporating a fused ring system
US20040180815A1 (en)	2003-03-07	2004-09-16	Suanne Nakajima	Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors
JP2007524576A (ja)	2003-02-07	2007-08-30	エナンタファーマシューティカルズインコーポレイテッド	大環状のｃ型肝炎セリンプロテアーゼ阻害剤
EP1613620A1 (en)	2003-04-11	2006-01-11	Vertex Pharmaceuticals Incorporated	Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
PE20050953A1 (es) *	2003-09-26	2005-11-19	Schering Corp	Compuestos macrociclicos como inhibidores de la serina proteasa ns3 del virus de la hepatitis c
AR048413A1 (es) *	2004-02-27	2006-04-26	Schering Corp	Compuestos prolina 3,4- (ciclopentil) - fusionados , como inhibidores de serina proteasa ns3 del virus de la hepatitis c
JP5203203B2 (ja)	2005-08-19	2013-06-05	バーテックスファーマシューティカルズインコーポレイテッド	製造工程および中間体
WO2008137126A2 (en)	2007-05-04	2008-11-13	Vertex Pharmaceuticals Incorporated	Combination therapy for the treatment of hcv infection

2006
- 2006-08-18 JP JP2008527189A patent/JP5203203B2/ja not_active Expired - Fee Related
- 2006-08-18 SG SG2014013338A patent/SG2014013338A/en unknown
- 2006-08-18 DK DK10155058.0T patent/DK2194043T3/da active
- 2006-08-18 CN CN2011102403592A patent/CN102382170A/zh active Pending
- 2006-08-18 RU RU2008110479/04A patent/RU2446171C2/ru not_active IP Right Cessation
- 2006-08-18 KR KR1020147013418A patent/KR20140069370A/ko not_active Ceased
- 2006-08-18 CA CA002619659A patent/CA2619659A1/en not_active Abandoned
- 2006-08-18 TW TW101126397A patent/TW201245149A/zh unknown
- 2006-08-18 EP EP11150041A patent/EP2364970A1/en not_active Withdrawn
- 2006-08-18 ES ES10155058.0T patent/ES2449268T3/es active Active
- 2006-08-18 AT AT06813568T patent/ATE463480T1/de active
- 2006-08-18 CN CN2006800384541A patent/CN101291909B/zh not_active Expired - Fee Related
- 2006-08-18 SI SI200631745T patent/SI2194043T1/sl unknown
- 2006-08-18 ES ES06813568T patent/ES2344156T3/es active Active
- 2006-08-18 KR KR1020137024964A patent/KR20130110236A/ko not_active Ceased
- 2006-08-18 NZ NZ593214A patent/NZ593214A/xx not_active IP Right Cessation
- 2006-08-18 NZ NZ566049A patent/NZ566049A/en not_active IP Right Cessation
- 2006-08-18 PT PT06813568T patent/PT1934179E/pt unknown
- 2006-08-18 PL PL385229A patent/PL385229A1/pl not_active Application Discontinuation
- 2006-08-18 PL PL10155058T patent/PL2194043T3/pl unknown
- 2006-08-18 PL PL06813568T patent/PL1934179T4/pl unknown
- 2006-08-18 EP EP10155058.0A patent/EP2194043B1/en not_active Not-in-force
- 2006-08-18 BR BRPI0615029-2A patent/BRPI0615029A2/pt not_active IP Right Cessation
- 2006-08-18 DE DE602006013492T patent/DE602006013492D1/de active Active
- 2006-08-18 EP EP06813568A patent/EP1934179B1/en not_active Not-in-force
- 2006-08-18 AU AU2006279357A patent/AU2006279357B2/en not_active Ceased
- 2006-08-18 DK DK06813568.0T patent/DK1934179T3/da active
- 2006-08-18 WO PCT/US2006/032481 patent/WO2007022459A2/en active Application Filing
- 2006-08-18 KR KR1020137005426A patent/KR20130038947A/ko not_active Ceased
- 2006-08-18 TW TW095130511A patent/TWI391376B/zh not_active IP Right Cessation
- 2006-08-18 AR ARP060103610A patent/AR058025A1/es unknown
- 2006-08-18 US US11/506,550 patent/US7776887B2/en not_active Expired - Fee Related
- 2006-08-18 NZ NZ604087A patent/NZ604087A/en not_active IP Right Cessation
- 2006-08-18 SI SI200630710T patent/SI1934179T1/sl unknown
- 2006-08-18 EP EP11150039A patent/EP2357170A1/en not_active Withdrawn
- 2006-08-18 PT PT101550580T patent/PT2194043E/pt unknown
2008
- 2008-02-18 IL IL189585A patent/IL189585A/en not_active IP Right Cessation
- 2008-02-25 ZA ZA200801791A patent/ZA200801791B/xx unknown
- 2008-03-18 KR KR1020087006558A patent/KR101474405B1/ko not_active Expired - Fee Related
- 2008-12-23 HK HK08113896.0A patent/HK1122801A1/xx not_active IP Right Cessation
2010
- 2010-03-15 US US12/661,319 patent/US8637457B2/en not_active Expired - Fee Related
- 2010-07-05 CY CY20101100613T patent/CY1110214T1/el unknown
- 2010-12-09 HK HK10111510.6A patent/HK1145022A1/xx not_active IP Right Cessation
2011
- 2011-11-29 RU RU2011148615/04A patent/RU2011148615A/ru not_active Application Discontinuation
2013
- 2013-10-07 IL IL228770A patent/IL228770A0/en unknown
- 2013-12-17 US US14/109,631 patent/US20140107318A1/en not_active Abandoned
2014
- 2014-02-25 CY CY20141100149T patent/CY1114916T1/el unknown

Also Published As

Publication number	Publication date
AU2006279357B2 (en)	2012-05-31
IL228770A0 (en)	2013-12-31
EP1934179A2 (en)	2008-06-25
DE602006013492D1 (de)	2010-05-20
SI1934179T1 (sl)	2010-08-31
CN101291909B (zh)	2012-09-05
ES2449268T3 (es)	2014-03-19
EP2194043B1 (en)	2013-12-25
PL1934179T3 (pl)	2010-09-30
EP2364970A1 (en)	2011-09-14
EP2194043A3 (en)	2010-11-24
RU2008110479A (ru)	2009-09-27
IL189585A0 (en)	2008-08-07
PT2194043E (pt)	2014-03-04
KR20130110236A (ko)	2013-10-08
AU2006279357A1 (en)	2007-02-22
CN101291909A (zh)	2008-10-22
KR20130038947A (ko)	2013-04-18
RU2446171C2 (ru)	2012-03-27
US20140107318A1 (en)	2014-04-17
ES2344156T3 (es)	2010-08-19
NZ593214A (en)	2013-02-22
EP1934179B1 (en)	2010-04-07
US8637457B2 (en)	2014-01-28
JP2009504780A (ja)	2009-02-05
DK2194043T3 (da)	2014-01-20
AR058025A1 (es)	2008-01-23
IL189585A (en)	2013-10-31
TW200800889A (en)	2008-01-01
RU2011148615A (ru)	2013-06-10
SG2014013338A (en)	2014-06-27
HK1122801A1 (en)	2009-05-29
NZ604087A (en)	2014-07-25
PL2194043T3 (pl)	2014-07-31
HK1145022A1 (en)	2011-03-25
US20100174077A1 (en)	2010-07-08
CN102382170A (zh)	2012-03-21
TWI391376B (zh)	2013-04-01
WO2007022459A3 (en)	2008-02-28
DK1934179T3 (da)	2010-08-09
WO2007022459A2 (en)	2007-02-22
KR20080047396A (ko)	2008-05-28
CY1114916T1 (el)	2016-12-14
PL1934179T4 (pl)	2014-03-31
EP2357170A1 (en)	2011-08-17
CA2619659A1 (en)	2007-02-22
SI2194043T1 (sl)	2014-04-30
US20070087973A1 (en)	2007-04-19
TW201245149A (en)	2012-11-16
PT1934179E (pt)	2010-07-12
KR20140069370A (ko)	2014-06-09
PL385229A1 (pl)	2008-09-29
NZ566049A (en)	2011-07-29
KR101474405B1 (ko)	2014-12-23
JP5203203B2 (ja)	2013-06-05
BRPI0615029A2 (pt)	2009-06-16
ATE463480T1 (de)	2010-04-15
EP2194043A2 (en)	2010-06-09
US7776887B2 (en)	2010-08-17
CY1110214T1 (el)	2015-01-14

Publication	Publication Date	Title
HK1122801A1 (en)	2009-05-29	Processes and intermediates
IL218487A0 (en)	2012-04-30	Processes and intermediates
GB0414120D0 (en)	2004-07-28	Novel processes and intermediates
GB0511807D0 (en)	2005-07-20	Process and compound
GB2422232B (en)	2009-01-07	Course and sail-plan predictor
GB2433536B (en)	2009-05-06	Metal Section
GB0400329D0 (en)	2004-02-11	Novel processes
GB0400382D0 (en)	2004-02-11	Novel processes
HU0500519D0 (en)	2005-08-29	New process and intermediate
GB0502843D0 (en)	2005-03-16	Jig-was and jig-will
AU3393P (en)	2007-09-05	Breakwell xTriticosecale
AU3621P (en)	2008-09-23	Scacover Scaevola aemula
AU3292P (en)	2007-04-30	DP303 Dianella prunina
AU3401P (en)	2007-10-12	Archise Arctotis fastuosa
GB0522259D0 (en)	2005-12-07	e-s-spi-l-d-film-cinema-back-engineering armageddon-system and project
GB0517240D0 (en)	2005-09-28	Chronorotron mk1-system and project
GB0517239D0 (en)	2005-09-28	Geogrotren-mk1-system and project
GB0400405D0 (en)	2004-02-11	Novel processes
GB0518875D0 (en)	2005-10-26	Methods and means
GB0507291D0 (en)	2005-05-18	Practice aid
AU2005157V (en)	2005-10-05	PVHL1 Hakea laurina
AU309752S (en)	2006-09-12	Airer
AU302343S (en)	2005-07-07	Lockclip
AU305159S (en)	2006-01-30	Ballpen
AU305160S (en)	2006-01-30	Ballpen