ZA200706392B - Intermediate and process for preparing of beta-anomer enriched 21-deoxy-21, 21 - difluoro-D-ribofuranosyl nucleosides - Google Patents

Intermediate and process for preparing of beta-anomer enriched 21-deoxy-21, 21 - difluoro-D-ribofuranosyl nucleosides

Info

Publication number: ZA200706392B
Authority: ZA; South Africa
Prior art keywords: deoxy; difluoro; beta; preparing; anomer enriched
Prior art date: 2005-03-04

Application number

ZA200706392A

Other languages

English (en)

Inventor

Maikap Golak Chandra

Bhatt Deependra

Panda Bijan Kumar

Original Assignee

Dabur Pharma Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-03-04

Filing date

2007-08-01

Publication date

2008-09-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35457749&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200706392(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-08-01 Application filed by Dabur Pharma Ltd filed Critical Dabur Pharma Ltd

2008-09-25 Publication of ZA200706392B publication Critical patent/ZA200706392B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

ZA200706392A 2005-03-04 2007-08-01 Intermediate and process for preparing of beta-anomer enriched 21-deoxy-21, 21 - difluoro-D-ribofuranosyl nucleosides ZA200706392B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IN472DE2005		2005-03-04

Publications (1)

Publication Number	Publication Date
ZA200706392B true ZA200706392B (en)	2008-09-25

Family

ID=35457749

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200706392A ZA200706392B (en)	2005-03-04	2007-08-01	Intermediate and process for preparing of beta-anomer enriched 21-deoxy-21, 21 - difluoro-D-ribofuranosyl nucleosides

Country Status (24)

Country	Link
US (2)	US7235647B2 (es)
EP (1)	EP1853616B1 (es)
JP (1)	JP2008531680A (es)
KR (1)	KR20070112774A (es)
CN (1)	CN101203524B (es)
AP (1)	AP2219A (es)
AR (1)	AR052860A1 (es)
AT (1)	ATE458743T1 (es)
AU (1)	AU2005328519B2 (es)
BR (1)	BRPI0520050A2 (es)
CA (1)	CA2598895A1 (es)
CL (1)	CL2005003456A1 (es)
DE (1)	DE602005019626D1 (es)
EA (1)	EA011558B1 (es)
ES (1)	ES2341663T3 (es)
GE (1)	GEP20094822B (es)
IL (1)	IL184957A (es)
MX (1)	MX2007010316A (es)
MY (1)	MY141378A (es)
NZ (1)	NZ560735A (es)
TW (1)	TWI333493B (es)
UA (1)	UA88940C2 (es)
WO (1)	WO2006092808A1 (es)
ZA (1)	ZA200706392B (es)

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WO2008026222A2 (en) *	2006-08-28	2008-03-06	Shilpa Medicare Ltd	Process and intermediates of 2,2' difluoronucleosides
KR100846143B1 (ko)	2007-02-28	2008-07-14	(주) 유일팜테크	2'-데옥시-2',2'-디플루오로시티딘의 전구체 및 그의제조방법
CN102093451A (zh) *	2009-12-12	2011-06-15	上海华理生物医药有限公司	一种制备吉西他滨中间体的方法
CN102153601A (zh) *	2011-02-26	2011-08-17	湖南欧亚生物有限公司	一种高选择性的制备盐酸吉西他滨以及其中间体的方法
CN102603838B (zh) *	2012-02-14	2015-02-18	江苏八巨药业有限公司	一种制备吉西他滨盐酸盐的方法
CN103232508A (zh) *	2012-05-22	2013-08-07	湖北一半天制药有限公司	工业化盐酸吉西他滨的合成方法
EP3564207B1 (en) *	2016-12-28	2021-09-15	Kaneka Corporation	Method for producing alcohol compound
BR112019022470A2 (pt)	2017-04-26	2020-05-12	I. Kalman Thomas	Composto, composição, e, método para tratamento de um indivíduo com câncer.
CN107200757B (zh) *	2017-06-29	2020-06-02	上海泓博智源医药股份有限公司	一种桥环氟代酯及其制备方法和应用
CN110511258A (zh) *	2018-05-21	2019-11-29	中国科学院上海药物研究所	一种胞嘧啶核苷的制备方法
CN109796506A (zh) *	2019-01-28	2019-05-24	江苏八巨药业有限公司	一种吉西他滨关键中间体的制备方法
CN111909229B (zh) *	2020-08-12	2023-05-05	福建瑞博奥科技有限公司	一种β-烟酰胺核糖氯化物的制备方法

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US4814438A (en) *	1986-12-24	1989-03-21	Eli Lilly And Company	Immunoglobulin conjugates of 2',2'-difluronucleosides
US4994558A (en) *	1986-12-24	1991-02-19	Eli Lilly And Company	Immunoglobulin conjugates
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US5401861A (en) *	1992-06-22	1995-03-28	Eli Lilly And Company	Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
US5426183A (en) *	1992-06-22	1995-06-20	Eli Lilly And Company	Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5256798A (en) *	1992-06-22	1993-10-26	Eli Lilly And Company	Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
US5821357A (en) *	1992-06-22	1998-10-13	Eli Lilly And Company	Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides
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UA41261C2 (uk) *	1992-06-22	2001-09-17	Елі Ліллі Енд Компані	Спосіб одержання збагачених бета-аномером нуклеозидів
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US5521294A (en) *	1995-01-18	1996-05-28	Eli Lilly And Company	2,2-difluoro-3-carbamoyl ribose sulfonate compounds and process for the preparation of beta nucleosides
US5559222A (en) *	1995-02-03	1996-09-24	Eli Lilly And Company	Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose
FR2808797A1 (fr) *	2000-05-09	2001-11-16	Hoechst Marion Roussel Inc	Nouveaux derives de l'uridine, leur procede de preparation et leur application comme medicaments
CN101010329B (zh) *	2004-12-30	2011-06-08	韩美控股株式会社	2’-脱氧-2’,2'-二氟胞苷的制备方法
EA011558B1 (ru) *	2005-03-04	2009-04-28	Дабур Фарма Лимитед	ПРОМЕЖУТОЧНОЕ СОЕДИНЕНИЕ И СПОСОБ ПОЛУЧЕНИЯ ОБОГАЩЕННЫХ β-АНОМЕРОМ 2-ДЕЗОКСИ-2,2-ДИФТОР-D-РИБОФУРАНОЗИЛНУКЛЕОЗИДОВ

2005
- 2005-09-23 EA EA200701889A patent/EA011558B1/ru not_active IP Right Cessation
- 2005-09-23 BR BRPI0520050-4A patent/BRPI0520050A2/pt not_active IP Right Cessation
- 2005-09-23 GE GEAP200510300A patent/GEP20094822B/en unknown
- 2005-09-23 ES ES05794951T patent/ES2341663T3/es active Active
- 2005-09-23 KR KR1020077018233A patent/KR20070112774A/ko not_active Application Discontinuation
- 2005-09-23 AU AU2005328519A patent/AU2005328519B2/en not_active Ceased
- 2005-09-23 UA UAA200709045A patent/UA88940C2/ru unknown
- 2005-09-23 CN CN200580049120XA patent/CN101203524B/zh not_active Expired - Fee Related
- 2005-09-23 EP EP05794951A patent/EP1853616B1/en active Active
- 2005-09-23 AP AP2007004098A patent/AP2219A/xx active
- 2005-09-23 NZ NZ560735A patent/NZ560735A/en not_active IP Right Cessation
- 2005-09-23 AT AT05794951T patent/ATE458743T1/de not_active IP Right Cessation
- 2005-09-23 WO PCT/IN2005/000322 patent/WO2006092808A1/en active Application Filing
- 2005-09-23 JP JP2007557679A patent/JP2008531680A/ja active Pending
- 2005-09-23 MX MX2007010316A patent/MX2007010316A/es active IP Right Grant
- 2005-09-23 DE DE602005019626T patent/DE602005019626D1/de active Active
- 2005-09-23 CA CA002598895A patent/CA2598895A1/en not_active Abandoned
- 2005-12-28 MY MYPI20056213A patent/MY141378A/en unknown
- 2005-12-28 CL CL200503456A patent/CL2005003456A1/es unknown
- 2005-12-29 AR ARP050105638A patent/AR052860A1/es not_active Application Discontinuation
2006
- 2006-01-13 US US11/332,830 patent/US7235647B2/en not_active Expired - Fee Related
- 2006-02-15 TW TW095105122A patent/TWI333493B/zh active
2007
- 2007-02-26 US US11/678,927 patent/US20070208170A1/en not_active Abandoned
- 2007-07-31 IL IL184957A patent/IL184957A/en not_active IP Right Cessation
- 2007-08-01 ZA ZA200706392A patent/ZA200706392B/xx unknown

Also Published As

Publication number	Publication date
EA200701889A1 (ru)	2008-02-28
JP2008531680A (ja)	2008-08-14
UA88940C2 (ru)	2009-12-10
DE602005019626D1 (de)	2010-04-08
CN101203524B (zh)	2011-06-15
AP2219A (en)	2011-03-22
EP1853616B1 (en)	2010-02-24
US20070208170A1 (en)	2007-09-06
CA2598895A1 (en)	2006-09-08
AU2005328519A1 (en)	2006-09-08
CL2005003456A1 (es)	2008-05-02
US20060217547A1 (en)	2006-09-28
AP2007004098A0 (en)	2007-08-31
MY141378A (en)	2010-04-30
GEP20094822B (en)	2009-11-10
US7235647B2 (en)	2007-06-26
KR20070112774A (ko)	2007-11-27
EP1853616A1 (en)	2007-11-14
AR052860A1 (es)	2007-04-04
AU2005328519B2 (en)	2012-03-01
BRPI0520050A2 (pt)	2009-11-17
MX2007010316A (es)	2008-02-19
NZ560735A (en)	2009-07-31
IL184957A0 (en)	2007-12-03
ATE458743T1 (de)	2010-03-15
TW200643027A (en)	2006-12-16
IL184957A (en)	2011-06-30
CN101203524A (zh)	2008-06-18
ES2341663T3 (es)	2010-06-24
EA011558B1 (ru)	2009-04-28
TWI333493B (en)	2010-11-21
WO2006092808A1 (en)	2006-09-08

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