ZA200601865B - Imidazole derivatives - Google Patents

Imidazole derivatives Download PDF

Info

Publication number: ZA200601865B
Authority: ZA; South Africa
Prior art keywords: methyl; pyridine; imidazol; ylethynyl; compound
Prior art date: 2003-09-04

Application number

ZA200601865A

Other languages

English (en)

Inventor

Buettelmann Bernd

Jaeschke George

Porter Richard Hugh Philip

Ceccarelli Simona Maria

Kolczewski Sabine

Vieira Eric

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-09-04

Filing date

2006-03-03

Publication date

2007-09-26

2006-03-03 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2007-09-26 Publication of ZA200601865B publication Critical patent/ZA200601865B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Ophthalmology & Optometry (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

ZA200601865A 2003-09-04 2006-03-03 Imidazole derivatives ZA200601865B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03019604		2003-09-04

Publications (1)

Publication Number	Publication Date
ZA200601865B true ZA200601865B (en)	2007-09-26

Family

ID=34224067

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200601865A ZA200601865B (en)	2003-09-04	2006-03-03	Imidazole derivatives

Country Status (21)

Country	Link
US (2)	US7452909B2 (de)
EP (1)	EP1831193B1 (de)
JP (1)	JP4490423B2 (de)
KR (2)	KR100893957B1 (de)
CN (1)	CN1875016B (de)
AR (1)	AR045548A1 (de)
AT (1)	ATE427945T1 (de)
AU (1)	AU2004270352B2 (de)
BR (1)	BRPI0414148A (de)
CA (1)	CA2537826C (de)
CO (1)	CO5650235A2 (de)
DE (1)	DE602004020525D1 (de)
ES (1)	ES2321408T3 (de)
IL (1)	IL173911A (de)
MX (1)	MXPA06002453A (de)
NO (1)	NO20061045L (de)
RU (1)	RU2345074C2 (de)
SG (1)	SG146627A1 (de)
TW (1)	TWI290138B (de)
WO (1)	WO2005023795A1 (de)
ZA (1)	ZA200601865B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8204149B2 (en)	2003-12-17	2012-06-19	Qualcomm Incorporated	Spatial spreading in a multi-antenna communication system
US8169889B2 (en)	2004-02-18	2012-05-01	Qualcomm Incorporated	Transmit diversity and spatial spreading for an OFDM-based multi-antenna communication system
US8923785B2 (en)	2004-05-07	2014-12-30	Qualcomm Incorporated	Continuous beamforming for a MIMO-OFDM system
CA2568725C (en) *	2004-06-01	2012-11-27	F. Hoffmann-La Roche Ag	Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as mglu5 receptor antagonists
HRP20080363T3 (hr) *	2004-06-01	2008-09-30	F. Hoffmann - La Roche Ag	Piridin-4-il-etinil-imidazoli i pirazoli kao antagonisti mglu5 receptora
US7978649B2 (en)	2004-07-15	2011-07-12	Qualcomm, Incorporated	Unified MIMO transmission and reception
US8543070B2 (en)	2006-04-24	2013-09-24	Qualcomm Incorporated	Reduced complexity beam-steered MIMO OFDM system
CN101568531B (zh)	2006-12-21	2013-11-13	弗·哈夫曼-拉罗切有限公司	Mglur5受体拮抗剂的多晶型物
WO2009097414A1 (en) *	2008-01-29	2009-08-06	Vanda Pharmaceuticals, Inc.	Use of imidazolylalkyl-pyridines for the treatment of addictive disorders
US8334287B2 (en) *	2009-07-17	2012-12-18	Hoffmann-La Roche Inc.	Imidazoles

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1991000277A1 (en)	1989-06-30	1991-01-10	E.I. Du Pont De Nemours And Company	Substituted imidazoles
CN1170822C (zh) *	1998-12-24	2004-10-13	藤泽药品工业株式会社	咪唑化合物及其药物用途
CA2383524C (en) *	1999-08-31	2010-09-28	Merck & Co., Inc.	Thiazolyl alkynyl compounds and methods of use thereof
EP1458385A4 (de) *	2001-12-19	2005-12-21	Merck & Co Inc	Heteroaryl-substituierte imidazol-modulatoren des metabotropen glutamat-rezeptors-5
TWI292318B (en) *	2003-03-10	2008-01-11	Hoffmann La Roche	Imidazol-4-yl-ethynyl-pyridine derivatives
UA80888C2 (en)	2003-06-05	2007-11-12	Hoffmann La Roche	Imidazole derivatives as glutmate receptor antagonists
WO2004111040A1 (en)	2003-06-12	2004-12-23	F. Hoffmann-La Roche Ag	Heteroaryl-substituted imdazole derivatives as glutamate receptor antagonists
US7091222B2 (en) *	2003-07-03	2006-08-15	Hoffmann-La Roche Inc.	Imidazole derivatives

2004
- 2004-08-26 US US10/926,670 patent/US7452909B2/en not_active Expired - Fee Related
- 2004-08-27 AU AU2004270352A patent/AU2004270352B2/en not_active Ceased
- 2004-08-27 ES ES04764532T patent/ES2321408T3/es not_active Expired - Lifetime
- 2004-08-27 JP JP2006525079A patent/JP4490423B2/ja not_active Expired - Fee Related
- 2004-08-27 MX MXPA06002453A patent/MXPA06002453A/es active IP Right Grant
- 2004-08-27 BR BRPI0414148-2A patent/BRPI0414148A/pt not_active IP Right Cessation
- 2004-08-27 KR KR1020077026004A patent/KR100893957B1/ko not_active Expired - Fee Related
- 2004-08-27 CN CN2004800321399A patent/CN1875016B/zh not_active Expired - Fee Related
- 2004-08-27 CA CA2537826A patent/CA2537826C/en not_active Expired - Fee Related
- 2004-08-27 RU RU2006110537/04A patent/RU2345074C2/ru not_active IP Right Cessation
- 2004-08-27 WO PCT/EP2004/009558 patent/WO2005023795A1/en active Application Filing
- 2004-08-27 EP EP04764532A patent/EP1831193B1/de not_active Expired - Lifetime
- 2004-08-27 KR KR1020067004489A patent/KR100811898B1/ko not_active Expired - Fee Related
- 2004-08-27 DE DE602004020525T patent/DE602004020525D1/de not_active Expired - Lifetime
- 2004-08-27 AT AT04764532T patent/ATE427945T1/de active
- 2004-08-27 SG SG200806715-9A patent/SG146627A1/en unknown
- 2004-09-01 TW TW093126399A patent/TWI290138B/zh not_active IP Right Cessation
- 2004-09-01 AR ARP040103128A patent/AR045548A1/es unknown
2006
- 2006-02-23 IL IL173911A patent/IL173911A/en not_active IP Right Cessation
- 2006-02-27 CO CO06019310A patent/CO5650235A2/es not_active Application Discontinuation
- 2006-03-03 ZA ZA200601865A patent/ZA200601865B/en unknown
- 2006-03-03 NO NO20061045A patent/NO20061045L/no not_active Application Discontinuation
2008
- 2008-09-17 US US12/211,849 patent/US7964620B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR100811898B1 (ko)	2008-03-10
TWI290138B (en)	2007-11-21
CO5650235A2 (es)	2006-06-30
IL173911A (en)	2012-07-31
US7452909B2 (en)	2008-11-18
RU2345074C2 (ru)	2009-01-27
RU2006110537A (ru)	2007-10-10
JP4490423B2 (ja)	2010-06-23
AU2004270352A1 (en)	2005-03-17
IL173911A0 (en)	2006-07-05
KR20060037460A (ko)	2006-05-03
ES2321408T3 (es)	2009-06-05
EP1831193A1 (de)	2007-09-12
US20050054686A1 (en)	2005-03-10
DE602004020525D1 (en)	2009-05-20
CA2537826C (en)	2012-04-17
MXPA06002453A (es)	2006-06-20
KR100893957B1 (ko)	2009-04-20
ATE427945T1 (de)	2009-04-15
WO2005023795A1 (en)	2005-03-17
KR20070113325A (ko)	2007-11-28
EP1831193B1 (de)	2009-04-08
TW200517382A (en)	2005-06-01
BRPI0414148A (pt)	2006-10-31
SG146627A1 (en)	2008-10-30
CN1875016B (zh)	2011-06-01
JP2007504188A (ja)	2007-03-01
CA2537826A1 (en)	2005-03-17
CN1875016A (zh)	2006-12-06
US20090018171A1 (en)	2009-01-15
AU2004270352B2 (en)	2011-02-24
NO20061045L (no)	2006-03-31
US7964620B2 (en)	2011-06-21
AR045548A1 (es)	2005-11-02

Publication	Publication Date	Title
US7964620B2 (en)	2011-06-21	Imidazole derivatives
US7973165B2 (en)	2011-07-05	Imidazole derivatives
JP4404896B2 (ja)	2010-01-27	イミダゾール−４−イル−エチニル−ピリジン誘導体
IL179524A (en)	2012-04-30	Pyridin- 4 - yl - ethynyl - imidazoles, process for their preparation, medicaments comprising them and use thereof in the manufacture of medicaments for the treatment and prevention of mglu5 receptor mediated disorders
CA2527587C (en)	2010-09-28	Heteroaryl-substituted imidazole derivatives as glutamate receptor antagonists
CA2531210C (en)	2012-05-29	Imidazole derivatives and their use in the treatment of mglur5 receptor mediated disorders
HK1207639B (en)	2017-07-28	Ethynyl derivatives as modulators of mglur5 receptor activity