[go: up one dir, main page]

ZA200601291B - Recombinant lubricin molecules and uses thereof - Google Patents

Recombinant lubricin molecules and uses thereof

Info

Publication number
ZA200601291B
ZA200601291B ZA200601291A ZA200601291A ZA200601291B ZA 200601291 B ZA200601291 B ZA 200601291B ZA 200601291 A ZA200601291 A ZA 200601291A ZA 200601291 A ZA200601291 A ZA 200601291A ZA 200601291 B ZA200601291 B ZA 200601291B
Authority
ZA
South Africa
Prior art keywords
recombinant lubricin
lubricin molecules
molecules
recombinant
lubricin
Prior art date
Application number
ZA200601291A
Other languages
English (en)
Inventor
Carl Ralph Flannery
Bethany Annis Freeman
Christopher John Corcoran
Lisa Anne Racie
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ZA200601291B publication Critical patent/ZA200601291B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA200601291A 2003-08-14 2006-02-13 Recombinant lubricin molecules and uses thereof ZA200601291B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49574103P 2003-08-14 2003-08-14

Publications (1)

Publication Number Publication Date
ZA200601291B true ZA200601291B (en) 2010-08-25

Family

ID=34193342

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200601291A ZA200601291B (en) 2003-08-14 2006-02-13 Recombinant lubricin molecules and uses thereof

Country Status (21)

Country Link
US (6) US7642236B2 (xx)
EP (1) EP1663291B1 (xx)
JP (1) JP2007502122A (xx)
KR (1) KR101078202B1 (xx)
CN (2) CN1867350A (xx)
AU (2) AU2004264970B2 (xx)
BR (1) BRPI0413553A (xx)
CR (1) CR8204A (xx)
DK (1) DK1663291T3 (xx)
EC (1) ECSP066364A (xx)
ES (1) ES2388970T3 (xx)
HK (1) HK1089110A1 (xx)
IL (2) IL173258A (xx)
MX (1) MXPA06001658A (xx)
NO (1) NO20060475L (xx)
NZ (1) NZ545021A (xx)
RU (2) RU2376313C2 (xx)
SG (1) SG145724A1 (xx)
UA (1) UA91818C2 (xx)
WO (1) WO2005016130A2 (xx)
ZA (1) ZA200601291B (xx)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743774B1 (en) 1999-04-23 2004-06-01 Rhode Island Hospital Tribonectins
AU2005267012A1 (en) * 2004-07-23 2006-02-02 Mucosal Therapeutics Llc Compositions and methods for viscosupplementation
US20090068247A1 (en) * 2007-09-12 2009-03-12 Mucosal Therapeutics Biocompatible devices coated with a tribonectin and methods for their production
US20090104148A1 (en) * 2007-09-18 2009-04-23 Jay Gregory D Treatment and prevention of joint disease
US8506944B2 (en) * 2008-05-07 2013-08-13 The Regents Of The University Of California Replenishment and enrichment of ocular surface lubrication
EP2915529B1 (en) * 2008-05-07 2017-06-14 The Regents of The University of California Therapeutic replenishment and enrichment of ocular surface lubrication
WO2010083239A2 (en) 2009-01-13 2010-07-22 Truitt Edward R Iii Therapeutic modulation of vaginal epithelium boundary lubrication
EP2432492B1 (en) * 2009-05-22 2014-12-24 Lubris, Llc Application and uses of prg4 and therapeutic modulation thereof
WO2011091000A2 (en) * 2010-01-19 2011-07-28 Singularis, Inc. Oral care compositions and methods
US8716204B2 (en) 2010-07-27 2014-05-06 Zimmer, Inc. Synthetic synovial fluid compositions and methods for making the same
US20130116186A1 (en) * 2011-10-04 2013-05-09 Rhode Island Hospital, A Lifespan Partner Lubricin injections to maintain cartilage health
US20150361452A1 (en) * 2013-01-25 2015-12-17 Baylor College Of Medicine A Helper-Dependent Adenoviral Gene Therapy Delivery and Expression System
US20150010606A1 (en) * 2013-07-08 2015-01-08 Arthrex, Inc. Intra-articular injection and implant attachment of molecule consisting of lubricin and extracellular superoxide dismutase or hyaluronic acid and extracellular superoxide dismutase
US20160263217A1 (en) * 2013-10-16 2016-09-15 Ensisheim Partners Llc Protein-specific formulations
US9982027B2 (en) 2013-10-22 2018-05-29 Lubris Llc Control of rheological properties of mixed hyaluronate/lubricin solutions
WO2015081121A1 (en) 2013-11-26 2015-06-04 Lubris Llc Compositions and methods for inhibiting intercellular interactions
KR20170123619A (ko) 2015-01-26 2017-11-08 루브리스 엘엘씨 항염증제로서의 prg4의 용도
CN118048321A (zh) * 2016-01-13 2024-05-17 建新公司 用于治疗哺乳动物内骨关节炎和相关关节病症的表达骨保护性基因、包括has2和润滑素的重组aav载体
WO2017132376A1 (en) 2016-01-27 2017-08-03 Just Biotherapeutics, Inc. Hybrid promoter and uses thereof
WO2019246522A1 (en) * 2018-06-21 2019-12-26 Lubris Llc Lubricin for use in wound healing
US20220127318A1 (en) * 2019-01-15 2022-04-28 Cornell University Recombinant lubricins, and compositions and methods for using the same
US20230127949A1 (en) * 2020-02-24 2023-04-27 Novartis Ag Purification of recombinantly produced polypeptides
IT202000022636A1 (it) 2020-09-25 2022-03-25 Ente Ospedaliero Specializzato In Gastroenterologia Istituto Nazionale Di Ricovero E Cura A Caratter “terapia di combinazione di sorafenib e/o regorafenib con la proteina ricombinante umana proteoglicano-4 per il trattamento dell'epatocarcinoma”

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2734862A (en) * 1956-02-14 Synthetic casein fiber elastic grease
US2487377A (en) * 1948-04-17 1949-11-08 Socony Vacuum Oil Co Inc Lubricant
US2878184A (en) * 1953-12-29 1959-03-17 Rockwell Mfg Co Hydrocarbon resistant glycerol base lubricant
AR207237A1 (es) * 1974-02-25 1976-09-22 Thomas A Procedimiento para obtener extractos biologicos estables liofilizados solubles constituidos por complejos proteicos termorresistentes
EP0050644B1 (en) * 1980-04-25 1985-09-18 A/S Orthana Kemisk Fabrik Sterilized, preserved, stable mucine-containing solutions and sterilization method
US5403592A (en) * 1987-08-25 1995-04-04 Macnaught Pty Limited Lubricant composition for rheumatism
GB8803697D0 (en) * 1988-02-17 1988-03-16 Deltanine Research Ltd Clinical developments using amniotic membrane cells
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5260417A (en) * 1989-04-03 1993-11-09 Genetics Institute, Inc. Megakaryocyte growth promoting activity protein
US5326558A (en) * 1989-08-08 1994-07-05 Genetics Institute, Inc. Megakaryocytopoietic factor
US6433142B1 (en) 1989-08-08 2002-08-13 Genetics Institute, Llc Megakaryocyte stimulating factors
CA2060223C (en) * 1991-02-12 1999-07-20 Clarence C. Lee Injectable medical lubricating fluid composition and method of use
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
CN1107891A (zh) 1994-03-04 1995-09-06 上海贝特生物技术有限公司 人促巨核细胞生成素及其分离纯化和基因克隆方法及应用
US5709020A (en) * 1994-07-19 1998-01-20 University Of Kentucky Research Foundation Method for reducing the generation of wear particulates from an implant
US5515590A (en) * 1994-07-19 1996-05-14 University Of Kentucky Research Foundation Method for reducing the generation of wear particulates from an implant
US5510122A (en) * 1994-09-28 1996-04-23 The Research Foundation Of State University Of New York Preparation and use of whole saliva
US7001881B1 (en) * 1999-04-23 2006-02-21 Rhode Island Hospital Tribonectins
US6743774B1 (en) * 1999-04-23 2004-06-01 Rhode Island Hospital Tribonectins
US6960562B2 (en) * 1999-04-23 2005-11-01 Rhode Island Hospital, A Lifespan Partner Tribonectin polypeptides and uses thereof
WO2001007068A1 (en) 1999-07-23 2001-02-01 Case Western Reserve University Novel methods and reagents for the treatment of osteoarthritis
WO2002062847A2 (en) 2000-12-29 2002-08-15 Glaxo Group Limited Superficial zone protein and methods of making and using same
EP1440981A3 (en) 2003-01-21 2005-11-23 Research Association for Biotechnology Full-length human cdna

Also Published As

Publication number Publication date
AU2004264970A1 (en) 2005-02-24
BRPI0413553A (pt) 2006-10-17
US8420793B2 (en) 2013-04-16
NO20060475L (no) 2006-03-13
US20150343019A1 (en) 2015-12-03
EP1663291A4 (en) 2009-08-05
WO2005016130A3 (en) 2006-02-02
AU2010201537B2 (en) 2012-02-23
KR20060072124A (ko) 2006-06-27
EP1663291A2 (en) 2006-06-07
US8987205B2 (en) 2015-03-24
DK1663291T3 (da) 2012-07-02
US20100080848A1 (en) 2010-04-01
US7642236B2 (en) 2010-01-05
CN1867350A (zh) 2006-11-22
US20100074935A1 (en) 2010-03-25
IL199528A0 (en) 2011-08-01
HK1089110A1 (en) 2006-11-24
SG145724A1 (en) 2008-09-29
ES2388970T3 (es) 2012-10-22
AU2010201537A1 (en) 2010-05-06
AU2004264970B2 (en) 2010-02-11
EP1663291B1 (en) 2012-06-06
RU2009130434A (ru) 2011-02-20
MXPA06001658A (es) 2006-04-28
IL173258A0 (en) 2006-06-11
NZ545021A (en) 2009-03-31
US20130196930A1 (en) 2013-08-01
CR8204A (es) 2007-10-01
US20110189731A1 (en) 2011-08-04
ECSP066364A (es) 2006-08-30
IL199528A (en) 2013-03-24
US20070191268A1 (en) 2007-08-16
JP2007502122A (ja) 2007-02-08
IL173258A (en) 2010-12-30
RU2006107925A (ru) 2006-07-27
US7897571B2 (en) 2011-03-01
KR101078202B1 (ko) 2011-11-01
WO2005016130A2 (en) 2005-02-24
US7893029B2 (en) 2011-02-22
RU2376313C2 (ru) 2009-12-20
CN102924584A (zh) 2013-02-13
UA91818C2 (ru) 2010-09-10

Similar Documents

Publication Publication Date Title
ZA200601291B (en) Recombinant lubricin molecules and uses thereof
HK1084883A1 (en) 2-cyanopyrrolopyrimidines and pharmaceutical uses thereof
EP1636334A4 (en) RECOMBINANT ANTI-CD30 ANTIBODIES AND USES THEREOF
SI1673460T1 (sl) Rekombinantna cepiva in njihova uporaba
EP1539941A4 (en) ADZYMES AND THEIR USES
IL174479A0 (en) Hemiasterlin derivatives and uses thereof
EP1652855A4 (en) POLYPEPTIDES ACTING ON PREDISPOSITIONS TO BRAIN PATHOLOGIES AND THE USE OF SAID POLYPEPTIDES
HK1088837A1 (en) Clk-peptide and slk-peptide
EP1736541A4 (en) NEW GALECTIN 9 MODIFICATION PROTEIN AND ITS USE
EP1753468A4 (en) CARBORANYLPORPHYRINS AND USES THEREOF
IL165112A0 (en) Variant integrinpolypeptides and thereof
GB0624182D0 (en) Isoelectric particles and uses thereof
EP1767634A4 (en) NEW GALECTIN 8 MODIFICATION PROTEIN AND USE THEREOF
GB0324457D0 (en) Modified peptides and their uses
AU2003272423A8 (en) Centrosome proteins and uses thereof
AU2003231827A8 (en) Pseudo-tissues and uses thereof
EP1778082A4 (en) CARBORANYLPORPHYRINS AND USES THEREOF
HK1134030A1 (en) Survivin-derived peptides and use thereof
EP1487547A4 (en) MEDIUM FOR PHYSICAL INTERACTION AND ITS RELATED USES
GB0317376D0 (en) Immunogenic protein and uses thereof
EP1699809A4 (en) PEPTIDE FROM AMNIOTIC LIQUID AND USES THEREOF
AU2003228397A8 (en) Hausp-p53 interaction and uses thereof
AU2003219732A8 (en) Oligomeric molecules and uses thereof
AU2003216442A8 (en) Enkurin and uses thereof
IL160376A (en) Arp peptide and uses thereof