ZA200510309B - High titer recombinant influenza viruses for vaccines and gene therapy - Google Patents

High titer recombinant influenza viruses for vaccines and gene therapy Download PDF

Info

Publication number: ZA200510309B
Authority: ZA; South Africa
Prior art keywords: influenza virus; vector; linked; operably linked; promoter operably
Prior art date: 2003-05-28

Application number

ZA200510309A

Other languages

English (en)

Inventor

Yoshihiro Kawaoka

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-05-28

Filing date

2005-12-19

Publication date

2006-08-30

2005-12-19 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

2006-08-30 Publication of ZA200510309B publication Critical patent/ZA200510309B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16141—Use of virus, viral particle or viral elements as a vector
- C12N2760/16143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Virology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pulmonology (AREA)
Mycology (AREA)
Epidemiology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ZA200510309A 2003-05-28 2005-12-19 High titer recombinant influenza viruses for vaccines and gene therapy ZA200510309B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US47379803P	2003-05-28	2003-05-28

Publications (1)

Publication Number	Publication Date
ZA200510309B true ZA200510309B (en)	2006-08-30

Family

ID=33539054

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200510309A ZA200510309B (en)	2003-05-28	2005-12-19	High titer recombinant influenza viruses for vaccines and gene therapy

Country Status (19)

Country	Link
US (1)	US8475806B2 (zh)
EP (1)	EP1631663B1 (zh)
JP (2)	JP5215561B2 (zh)
KR (1)	KR100908757B1 (zh)
CN (1)	CN1826407B (zh)
AU (1)	AU2004249133B2 (zh)
BR (1)	BRPI0410702B1 (zh)
CA (1)	CA2525953C (zh)
EA (1)	EA012965B1 (zh)
ES (1)	ES2593082T3 (zh)
HK (1)	HK1082769A1 (zh)
HU (1)	HUE030962T2 (zh)
IL (2)	IL171831A (zh)
MX (1)	MX342639B (zh)
NO (1)	NO341506B1 (zh)
NZ (1)	NZ543446A (zh)
UA (1)	UA92132C2 (zh)
WO (1)	WO2004112831A2 (zh)
ZA (1)	ZA200510309B (zh)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8715940B2 (en)	1999-04-06	2014-05-06	Wisconsin Alumni Research Foundation	Method of making recombinant influenza virus
ES2217967B1 (es) *	2003-03-31	2006-01-01	Consejo Sup. Investig. Cientificas	Procedimiento de produccion de particulas virales vacias (vlps) del virus inductor de la bursitis infecciosa (ibdv), composiciones necesarias para su puesta a punto y su uso en la elaboracion de vacunas frente al ibdv.
EA012965B1 (ru)	2003-05-28	2010-02-26	Висконсин Эламни Рисёч Фаундэйшн	Композиция для получения реассортантного рекомбинантного вируса гриппа, способ получения указанного вируса и реассортантный рекомбинантный вирус гриппа
ES2307345B1 (es) *	2004-01-21	2009-11-13	Consejo Sup. Investig. Cientificas	Capsidas vacias quimericas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), su procedimiento de obtencion y aplicaciones.
ES2307346B1 (es) *	2004-01-21	2009-11-13	Consejo Sup. Investig. Cientificas	Capsidas vacias (vlps(-vp4)) del virus causante de la enfermedad de la bursitis infecciosa (ibdv), su procedimiento de obtencion y aplicaciones.
EP1814990A2 (en)	2004-11-19	2007-08-08	Wisconsin Alumni Research Foundation	Recombinant influenza vectors with tandem transcription units
US7572620B2 (en)	2005-01-11	2009-08-11	Wisconsin Alumni Research Foundation	H3 equine influenza A virus
US7790434B2 (en)	2005-06-21	2010-09-07	Medimmune, Llc	Methods and compositions for expressing negative-sense viral RNA in canine cells
BRPI0612268A2 (pt) *	2005-06-21	2009-01-27	Medimmune Vaccines Inc	Ácido nucleico isolado, vetor de expressço, mÉtodos para produzir um rna genâmico da influenza, para produzir um vÍrus da influenza recombinante, para gerar um vÍrus de rna segmentado de filamento negativo recombinante nas cÉlulas caninas cultivadas e para gerar partÍculas virais da influenza infecciosa em cÉlulas caninas cultivadas, cÉlula, e, vÍrus
ES2310062B1 (es) *	2005-07-15	2009-11-13	Bionostra, S.L.	Particulas pseudovirales vacias quimericas derivadas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), procedimiento de obtencion y aplicaciones.
US7871626B2 (en)	2005-08-04	2011-01-18	St. Jude Children's Research Hospital	Modified influenza virus for monitoring and improving vaccine efficiency
DK1951296T4 (da)	2005-11-01	2014-09-01	Novartis Vaccines & Diagnostic	Celleafledte viral vacciner med lave niveauer af restcelle-DNA
KR101484305B1 (ko) *	2006-03-10	2015-01-19	위스콘신 얼럼나이 리서어치 화운데이션	Ｈ3 말 인플루엔자 ａ 바이러스
JP2007259758A (ja) *	2006-03-28	2007-10-11	Wisconsin Alumni Research Foundation	Ｈ３型ウマａ型インフルエンザウイルス
EP2010557B1 (en) *	2006-03-31	2014-02-26	Wisconsin Alumni Research Foundation	High titer recombinant influenza viruses for vaccines
AU2013204811B2 (en) *	2006-04-19	2015-01-22	Medimmune, Llc	Methods and compositions for expressing negative-sense viral rna in canine cells
RU2457250C2 (ru)	2006-04-19	2012-07-27	Медиммуне, Ллк	Способы и композиции для экспрессии антисмысловой вирусной рнк в клетках собаки
US20090017444A1 (en) *	2006-06-09	2009-01-15	Wisconsin Alumni Research Foundation	Screening method for modulators of viral transcription or replication
JP2009543554A (ja)	2006-07-14	2009-12-10	サノフィパスツールバイオロジクスカンパニー	ベクターウイルスタンパク質への外来免疫決定基の直接トランスポゾン媒介挿入による組換え型ウイルスワクチンの構築
US20100239605A1 (en) *	2006-09-29	2010-09-23	Sanofi Pasteur Biologics Co.	Recombinant Rhinovirus Vectors
EP2146575A4 (en) *	2007-04-12	2010-11-24	Alnylam Pharmaceuticals Inc	INFLUENZA POLYNUCLEOTIDES, EXPRESSION CONSTRUCTS, COMPOSITIONS AND METHOD FOR THEIR USE
WO2008156778A2 (en)	2007-06-18	2008-12-24	Tokiko Watanabe	Influenza m2 protein mutant viruses as live influenza attenuated vaccines
ES2813347T3 (es)	2009-10-26	2021-03-23	Wisconsin Alumni Res Found	Virus recombinantes de la influenza de alto título con replicación mejorada en células Vero
US10130697B2 (en)	2010-03-23	2018-11-20	Wisconsin Alumni Research Foundation (Warf)	Vaccines comprising mutant attenuated influenza viruses
US20120015346A1 (en) *	2010-07-08	2012-01-19	New York Medical College	Influenza virus detection and diagnosis
CA3103774A1 (en) *	2011-06-24	2012-12-27	Flugen, Inc.	Influenza virus mutants and uses therefor
JP6054883B2 (ja) *	2012-03-02	2016-12-27	ノバルティスアーゲー	インフルエンザウイルスの再集合
JP2013099339A (ja) *	2013-01-04	2013-05-23	Wisconsin Alumni Research Foundation	Ｈ３型ウマａ型インフルエンザウイルス
JP2016524915A (ja) *	2013-07-15	2016-08-22	ウィスコンシンアルムニリサーチファンデイション	Ｍｄｃｋ、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス
KR101493613B1 (ko) *	2013-10-25	2015-02-13	위스콘신 얼럼나이 리서어치 화운데이션	Ｈ3 말 인플루엔자 ａ 바이러스
EP3119883A4 (en)	2014-03-17	2018-01-10	Flugen, Inc.	Influenza virus vectors and uses therefor
US10053671B2 (en)	2014-06-20	2018-08-21	Wisconsin Alumni Research Foundation (Warf)	Mutations that confer genetic stability to additional genes in influenza viruses
US10633422B2 (en)	2015-06-01	2020-04-28	Wisconsin Alumni Research Foundation (Warf)	Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
WO2016201127A1 (en)	2015-06-09	2016-12-15	Sanofi Pasteur, Inc.	Methods of optimizing nucleotide sequences encoding engineered influenza proteins
US9890363B2 (en)	2015-07-06	2018-02-13	Wisconsin Alumni Research Foundation (Warf)	Influenza virus replication for vaccine development
US10912864B2 (en)	2015-07-24	2021-02-09	Musculoskeletal Transplant Foundation	Acellular soft tissue-derived matrices and methods for preparing same
JP6560056B2 (ja) *	2015-08-07	2019-08-14	ウィスコンシンアルムニリサーチファンデイション	Ｈ３型ウマａ型インフルエンザウイルス
RU2660562C2 (ru) *	2016-03-30	2018-07-06	Общество с ограниченной ответственностью "ФАРМИНТЕРПРАЙСЕЗ БИОТЕХ"	Аттенуированный гриппозный вектор и мукозальная универсальная гриппозная вакцина на его основе
EP3417056A1 (en)	2016-02-19	2018-12-26	Wisconsin Alumni Research Foundation (WARF)	Improved influenza b virus replication for vaccine development
JP2017038622A (ja) *	2016-11-21	2017-02-23	ウィスコンシンアルムニリサーチファンデイション	Ｈ３型ウマａ型インフルエンザウイルス
EP3700562A1 (en)	2017-10-25	2020-09-02	Wisconsin Alumni Research Foundation (WARF)	Recombinant influenza viruses with stabilized ha for replication in eggs
WO2019086463A1 (en)	2017-10-30	2019-05-09	Baxalta GmbH	Environmentally compatible detergents for inactivation of lipid-enveloped viruses
US11389523B2 (en)	2018-08-20	2022-07-19	Wisconsin Alumni Research Foundation (Warf)	Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (HA) protein
JP2022527235A (ja)	2019-01-23	2022-06-01	義裕河岡	インフルエンザウイルスにおける付加的遺伝子に遺伝的安定性を付与する突然変異
CN113874496A (zh)	2019-02-08	2021-12-31	威斯康星校友研究基金会(Warf)	人源化细胞系
CN114929269A (zh) *	2019-05-01	2022-08-19	威斯康星校友研究基金会(Warf)	用于疫苗开发的改进的流感病毒复制
JP7627911B2 (ja)	2019-08-27	2025-02-07	ウィスコンシンアルムニリサーチファンデイション	卵内複製のための安定化されたｈａを持つ組換えインフルエンザウイルス
CN118497151B (zh) *	2024-07-11	2024-10-01	昆明理工大学	表达trail的重组溶瘤流感病毒及应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4071618A (en)	1974-09-03	1978-01-31	Research Foundation For Microbial Diseases Of Osaka University	Process for preparing virus disease live vaccines
JPS57136528A (en)	1981-02-09	1982-08-23	Hayashibara Biochem Lab Inc	Preparation of viral vaccine
US5166057A (en)	1989-08-28	1992-11-24	The Mount Sinai School Of Medicine Of The City University Of New York	Recombinant negative strand rna virus expression-systems
US5840520A (en)	1989-08-28	1998-11-24	Aviron	Recombinant negative strand RNA virus expression systems
US5854037A (en)	1989-08-28	1998-12-29	The Mount Sinai School Of Medicine Of The City University Of New York	Recombinant negative strand RNA virus expression systems and vaccines
DK0702085T4 (da)	1994-07-18	2010-04-06	Conzelmann Karl Klaus Prof Dr	Rekombinant infektiøs ikke-segmenteret negativ-strenget RNA-virus
WO1996010400A1 (en)	1994-09-30	1996-04-11	The Uab Research Foundation	Gene therapy vectors and vaccines based on non-segmented negatives stranded rna viruses
US5716821A (en)	1994-09-30	1998-02-10	Uab Research Foundation	Prevention and treatment of respiratory tract disease
ATE451451T1 (de)	1996-07-15	2009-12-15	Us Gov Health & Human Serv	Herstellung von attenuierten respiratorischen syncytialvirus-impfstoffen aus klonierten nukleotidsequenzen
CN1250725C (zh)	1997-05-23	2006-04-12	美国政府健康及人类服务部	从克隆的核苷酸序列制备减毒副流感病毒疫苗的方法
KR100281676B1 (ko)	1997-11-29	2001-04-02	신동권	신규한독감생백신바이러스
US6146642A (en)	1998-09-14	2000-11-14	Mount Sinai School Of Medicine, Of The City University Of New York	Recombinant new castle disease virus RNA expression systems and vaccines
US8715940B2 (en)	1999-04-06	2014-05-06	Wisconsin Alumni Research Foundation	Method of making recombinant influenza virus
DE122008000061I1 (de) *	1999-04-06	2009-02-12	Wisconsin Alumni Res Found	Rekombinante influenzaviren zur vakzinherstellung und gentherapie
WO2001079273A2 (en)	2000-04-14	2001-10-25	Wisconsin Alumni Research Foundation	Viruses comprising mutated ion channel protein
DK1317559T3 (da) *	2000-04-28	2009-03-23	St Jude Childrens Res Hospital	DNA-transfektionssystem til frembringelse af smitsom negativstrenget RNA-virus
EP1201760A1 (en) *	2000-10-30	2002-05-02	ARTEMIS Pharmaceuticals GmbH	Influenza virus vector for human dendritic cells
WO2003068923A2 (en)	2002-02-13	2003-08-21	Wisconsin Alumni Research Foundation	Signal for packaging of influenza virus vectors
AU2004232992A1 (en)	2003-04-23	2004-11-04	Wisconsin Alumni Research Foundation	Recombinant influenza viruses holding a mutation in a transmembrane protein gene
EA012965B1 (ru)	2003-05-28	2010-02-26	Висконсин Эламни Рисёч Фаундэйшн	Композиция для получения реассортантного рекомбинантного вируса гриппа, способ получения указанного вируса и реассортантный рекомбинантный вирус гриппа
CN1829799A (zh)	2003-05-28	2006-09-06	威斯康星旧生研究基金会	含polii启动子和核酶的重组流感载体
EP1814990A2 (en)	2004-11-19	2007-08-08	Wisconsin Alumni Research Foundation	Recombinant influenza vectors with tandem transcription units
EP2010557B1 (en) *	2006-03-31	2014-02-26	Wisconsin Alumni Research Foundation	High titer recombinant influenza viruses for vaccines

2004
- 2004-05-27 EA EA200501890A patent/EA012965B1/ru not_active IP Right Cessation
- 2004-05-27 BR BRPI0410702-0A patent/BRPI0410702B1/pt not_active IP Right Cessation
- 2004-05-27 NZ NZ543446A patent/NZ543446A/en not_active IP Right Cessation
- 2004-05-27 EP EP04776133.3A patent/EP1631663B1/en not_active Expired - Lifetime
- 2004-05-27 MX MX2012009249A patent/MX342639B/es unknown
- 2004-05-27 UA UAA200512619A patent/UA92132C2/ru unknown
- 2004-05-27 KR KR1020057022564A patent/KR100908757B1/ko not_active Expired - Lifetime
- 2004-05-27 ES ES04776133.3T patent/ES2593082T3/es not_active Expired - Lifetime
- 2004-05-27 WO PCT/US2004/016680 patent/WO2004112831A2/en active Application Filing
- 2004-05-27 CN CN2004800212599A patent/CN1826407B/zh not_active Expired - Lifetime
- 2004-05-27 AU AU2004249133A patent/AU2004249133B2/en not_active Expired
- 2004-05-27 US US10/855,875 patent/US8475806B2/en not_active Expired - Lifetime
- 2004-05-27 JP JP2006533439A patent/JP5215561B2/ja not_active Expired - Fee Related
- 2004-05-27 HU HUE04776133A patent/HUE030962T2/en unknown
- 2004-05-27 CA CA2525953A patent/CA2525953C/en not_active Expired - Lifetime
2005
- 2005-11-08 IL IL171831A patent/IL171831A/en active IP Right Grant
- 2005-12-19 ZA ZA200510309A patent/ZA200510309B/en unknown
- 2005-12-20 NO NO20056074A patent/NO341506B1/no unknown
2006
- 2006-04-28 HK HK06105116.2A patent/HK1082769A1/zh not_active IP Right Cessation
2012
- 2012-12-14 JP JP2012273898A patent/JP5695020B2/ja not_active Expired - Lifetime
2015
- 2015-05-03 IL IL238584A patent/IL238584B/en active IP Right Grant

Also Published As

Publication number	Publication date
WO2004112831A2 (en)	2004-12-29
NZ543446A (en)	2008-06-30
HUE030962T2 (en)	2017-06-28
EP1631663B1 (en)	2016-08-24
JP2007518395A (ja)	2007-07-12
JP5695020B2 (ja)	2015-04-01
MX342639B (es)	2016-10-07
BRPI0410702A (pt)	2006-06-13
UA92132C2 (ru)	2010-10-11
KR100908757B1 (ko)	2009-07-22
EA012965B1 (ru)	2010-02-26
IL238584A0 (en)	2015-06-30
CA2525953A1 (en)	2004-12-29
IL171831A (en)	2015-05-31
NO20056074L (no)	2006-03-22
US20050003349A1 (en)	2005-01-06
IL238584B (en)	2020-06-30
EA200501890A1 (ru)	2006-06-30
HK1082769A1 (zh)	2006-06-16
AU2004249133B2 (en)	2009-05-28
EP1631663A2 (en)	2006-03-08
JP5215561B2 (ja)	2013-06-19
KR20060016095A (ko)	2006-02-21
CN1826407A (zh)	2006-08-30
BRPI0410702B1 (pt)	2022-04-12
CA2525953C (en)	2023-10-10
ES2593082T3 (es)	2016-12-05
US8475806B2 (en)	2013-07-02
JP2013059346A (ja)	2013-04-04
AU2004249133A1 (en)	2004-12-29
NO341506B1 (no)	2017-11-27
CN1826407B (zh)	2013-09-11
WO2004112831A3 (en)	2005-03-24

Publication	Publication Date	Title
US8475806B2 (en)	2013-07-02	High titer recombinant influenza viruses for vaccines and gene therapy
US9926535B2 (en)	2018-03-27	High titer recombinant influenza viruses for vaccines
US10808229B2 (en)	2020-10-20	High titer recombinant influenza viruses with enhanced replication in vero cells
AU2014202470B2 (en)	2016-08-04	High titer recombinant influenza viruses for vaccines
AU2012204138B2 (en)	2014-02-06	High titer recombinant influenza viruses for vaccines
AU2014290203B2 (en)	2020-12-24	High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs
US11390649B2 (en)	2022-07-19	Influenza virus replication for vaccine development
KAWAOKA	0	Patent 2525953 Summary
MXPA05012712A (en)	2006-10-17	High titer recombinant influenza viruses for vaccines and gene therapy