ZA200406856B - Selective dipeptide inhibitors of kallikrein. - Google Patents

Selective dipeptide inhibitors of kallikrein. Download PDF

Info

Publication number: ZA200406856B
Authority: ZA; South Africa
Prior art keywords: lower alkyl; piperidine; carboxamidine; phenylpropanoylamino; amino
Prior art date: 2002-03-08

Application number

ZA200406856A

Other languages

English (en)

Inventor

David Michael Evans

Original Assignee

Ferring Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-08

Filing date

2004-08-27

Publication date

2005-11-30

2004-08-27 Application filed by Ferring Bv filed Critical Ferring Bv

2005-11-30 Publication of ZA200406856B publication Critical patent/ZA200406856B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Hematology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA200406856A 2002-03-08 2004-08-27 Selective dipeptide inhibitors of kallikrein. ZA200406856B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0205527.5A GB0205527D0 (en)	2002-03-08	2002-03-08	Inhibitors

Publications (1)

Publication Number	Publication Date
ZA200406856B true ZA200406856B (en)	2005-11-30

Family

ID=9932619

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200406856A ZA200406856B (en)	2002-03-08	2004-08-27	Selective dipeptide inhibitors of kallikrein.

Country Status (27)

Country	Link
US (1)	US7649000B2 (es)
EP (1)	EP1483284B1 (es)
JP (1)	JP4330450B2 (es)
KR (1)	KR100974633B1 (es)
CN (1)	CN1274713C (es)
AR (1)	AR039868A1 (es)
AT (1)	ATE333463T1 (es)
AU (1)	AU2003208471B2 (es)
CA (1)	CA2478099C (es)
DE (1)	DE60306904T2 (es)
DK (1)	DK1483284T3 (es)
EG (1)	EG25482A (es)
ES (1)	ES2264523T3 (es)
GB (1)	GB0205527D0 (es)
HK (1)	HK1072265A1 (es)
IL (2)	IL163710A0 (es)
MX (1)	MXPA04008523A (es)
MY (1)	MY130830A (es)
NO (1)	NO332678B1 (es)
NZ (1)	NZ534891A (es)
PL (1)	PL209670B1 (es)
PT (1)	PT1483284E (es)
RU (1)	RU2301225C2 (es)
TW (1)	TWI283685B (es)
UY (1)	UY27699A1 (es)
WO (1)	WO2003076458A2 (es)
ZA (1)	ZA200406856B (es)

Families Citing this family (40)

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Publication number	Priority date	Publication date	Assignee	Title
JP4775259B2 (ja)	2004-03-31	2011-09-21	味の素株式会社	アニリン誘導体
EP2195010A4 (en) *	2007-08-21	2012-03-14	Genzyme Corp	TREATMENT WITH INHIBITORS OF KALLIKREINE
GB0918924D0 (en) *	2009-10-28	2009-12-16	Vantia Ltd	Azaindole derivatives
US9290485B2 (en)	2010-08-04	2016-03-22	Novartis Ag	N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides
GB2494851A (en)	2011-07-07	2013-03-27	Kalvista Pharmaceuticals Ltd	Plasma kallikrein inhibitors
EP2807156A1 (en)	2012-01-27	2014-12-03	Novartis AG	Aminopyridine derivatives as plasma kallikrein inhibitors
EP2807157A1 (en)	2012-01-27	2014-12-03	Novartis AG	5-membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
GB201212081D0 (en)	2012-07-06	2012-08-22	Kalvista Pharmaceuticals Ltd	New polymorph
PH12015501492B1 (en)	2013-01-08	2015-09-28	Kalvista Pharmaceuticals Ltd	Benzylamine derivatives
GB201300304D0 (en)	2013-01-08	2013-02-20	Kalvista Pharmaceuticals Ltd	Benzylamine derivatives
GB2510407A (en)	2013-02-04	2014-08-06	Kalvista Pharmaceuticals Ltd	Aqueous suspensions of kallikrein inhibitors for parenteral administration
SI3305778T1 (sl)	2013-05-23	2022-04-29	Kalvista Pharmaceuticals Limited	Zaviralci plazemskega kalikreina
TWI636047B (zh)	2013-08-14	2018-09-21	英商卡爾維斯塔製藥有限公司	雜環衍生物
GB2517908A (en)	2013-08-14	2015-03-11	Kalvista Pharmaceuticals Ltd	Bicyclic inhibitors
ES2674088T3 (es)	2013-08-14	2018-06-27	Kalvista Pharmaceuticals Limited	Inhibidores de la calicreína plasmática
CA2927554C (en) *	2013-10-28	2022-11-29	Bicycle Therapeutics Limited	Novel polypeptides
CN108892661B (zh)	2014-02-07	2023-03-14	艾克赛特赫拉制药有限责任公司	治疗化合物和组合物
GB201421083D0 (en)	2014-11-27	2015-01-14	Kalvista Pharmaceuticals Ltd	Enzyme inhibitors
GB201421088D0 (en)	2014-11-27	2015-01-14	Kalvista Pharmaceuticals Ltd	New enzyme inhibitors
GB201421085D0 (en)	2014-11-27	2015-01-14	Kalvista Pharmaceuticals Ltd	New enzyme inhibitors
US11180484B2 (en)	2016-05-31	2021-11-23	Kalvista Pharmaceuticals Limited	Pyrazole derivatives as plasma kallikrein inhibitors
GB201609603D0 (en)	2016-06-01	2016-07-13	Kalvista Pharmaceuticals Ltd	Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
GB201609607D0 (en)	2016-06-01	2016-07-13	Kalvista Pharmaceuticals Ltd	Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
GB201719881D0 (en)	2017-11-29	2018-01-10	Kalvista Pharmaceuticals Ltd	Solid forms of plasma kallikrein inhibitor and salts thereof
IL312036A (en)	2017-11-29	2024-06-01	Kalvista Pharmaceuticals Ltd	Dosage forms comprising a plasma kallikrein inhibitor
CA3117549A1 (en)	2018-10-30	2020-05-07	eXIthera Pharmaceuticals Inc.	Therapeutic compounds and compositions
GB201910125D0 (en)	2019-07-15	2019-08-28	Kalvista Pharmaceuticals Ltd	Treatments of angioedema
GB201910116D0 (en)	2019-07-15	2019-08-28	Kalvista Pharmaceuticals Ltd	Treatments of hereditary angioedema
EP4010333A1 (en)	2019-08-09	2022-06-15	Kalvista Pharmaceuticals Limited	Plasma kallikrein inhibitors
GB201918994D0 (en)	2019-12-20	2020-02-05	Kalvista Pharmaceuticals Ltd	Treatments of diabetic macular edema and impaired visual acuity
GB2591730A (en)	2019-12-09	2021-08-11	Kalvista Pharmaceuticals Ltd	New polymorphs
WO2021198534A1 (en)	2020-04-04	2021-10-07	Oxurion NV	Plasma kallikrein inhibitors for use in the treatment of coronaviral disease
TW202228686A (zh)	2020-10-15	2022-08-01	英商卡爾維斯塔製藥有限公司	血管性水腫之治療
WO2022084693A1 (en)	2020-10-23	2022-04-28	Kalvista Pharmaceuticals Limited	Treatments of angioedema
EP4291186A1 (en)	2021-02-09	2023-12-20	Kalvista Pharmaceuticals Limited	Treatments of hereditary angioedema
WO2023002219A1 (en)	2021-07-23	2023-01-26	Kalvista Pharmaceuticals Limited	Treatments of hereditary angioedema
WO2023144030A1 (en)	2022-01-31	2023-08-03	Oxurion NV	Plasma kallikrein inhibitor therapy for anti-vegf sensitization
WO2023148016A1 (en)	2022-02-04	2023-08-10	Oxurion NV	Biomarker for plasma kallikrein inhibitor therapy response
PL4288036T3 (pl)	2022-04-27	2024-11-25	Kalvista Pharmaceuticals Limited	Preparaty inhibitora kalikreiny osoczowej
WO2024180100A1 (en)	2023-02-27	2024-09-06	Kalvista Pharmaceuticals Limited	New solid form of a plasma kallikrein inhibitor

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GB9019558D0 (en) *	1990-09-07	1990-10-24	Szelke Michael	Enzyme inhibitors
AU2882792A (en) *	1991-10-23	1993-05-21	Procter & Gamble Company, The	Tripeptide derivative anti-inflammatory agents
SE9301911D0 (sv) *	1993-06-03	1993-06-03	Ab Astra	New peptide derivatives
GB9318637D0 (en) *	1993-09-08	1993-10-27	Ferring Res Ltd	Enzyme inhibitors

2002
- 2002-03-08 GB GBGB0205527.5A patent/GB0205527D0/en not_active Ceased
2003
- 2003-02-26 TW TW092104061A patent/TWI283685B/zh not_active IP Right Cessation
- 2003-03-03 EG EG2003030209A patent/EG25482A/xx active
- 2003-03-04 RU RU2004126610/04A patent/RU2301225C2/ru not_active IP Right Cessation
- 2003-03-04 WO PCT/GB2003/000908 patent/WO2003076458A2/en active IP Right Grant
- 2003-03-04 AU AU2003208471A patent/AU2003208471B2/en not_active Ceased
- 2003-03-04 EP EP03706759A patent/EP1483284B1/en not_active Expired - Lifetime
- 2003-03-04 ES ES03706759T patent/ES2264523T3/es not_active Expired - Lifetime
- 2003-03-04 AT AT03706759T patent/ATE333463T1/de active
- 2003-03-04 MX MXPA04008523A patent/MXPA04008523A/es active IP Right Grant
- 2003-03-04 JP JP2003574673A patent/JP4330450B2/ja not_active Expired - Fee Related
- 2003-03-04 DE DE60306904T patent/DE60306904T2/de not_active Expired - Lifetime
- 2003-03-04 US US10/506,535 patent/US7649000B2/en active Active
- 2003-03-04 PL PL372977A patent/PL209670B1/pl unknown
- 2003-03-04 CA CA2478099A patent/CA2478099C/en not_active Expired - Lifetime
- 2003-03-04 IL IL16371003A patent/IL163710A0/xx unknown
- 2003-03-04 CN CNB038054019A patent/CN1274713C/zh not_active Expired - Fee Related
- 2003-03-04 NZ NZ534891A patent/NZ534891A/xx not_active IP Right Cessation
- 2003-03-04 PT PT03706759T patent/PT1483284E/pt unknown
- 2003-03-04 DK DK03706759T patent/DK1483284T3/da active
- 2003-03-04 KR KR1020047013816A patent/KR100974633B1/ko not_active Expired - Fee Related
- 2003-03-06 UY UY27699A patent/UY27699A1/es not_active Application Discontinuation
- 2003-03-06 AR ARP030100772A patent/AR039868A1/es active IP Right Grant
- 2003-03-07 MY MYPI20030803A patent/MY130830A/en unknown
2004
- 2004-08-24 IL IL163710A patent/IL163710A/en active IP Right Grant
- 2004-08-27 ZA ZA200406856A patent/ZA200406856B/en unknown
- 2004-09-03 NO NO20043695A patent/NO332678B1/no not_active IP Right Cessation
2005
- 2005-05-24 HK HK05104336A patent/HK1072265A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
US7649000B2 (en)	2010-01-19
DE60306904D1 (de)	2006-08-31
KR20040089705A (ko)	2004-10-21
CA2478099C (en)	2011-10-04
RU2301225C2 (ru)	2007-06-20
JP4330450B2 (ja)	2009-09-16
HK1072265A1 (en)	2005-08-19
NZ534891A (en)	2006-03-31
JP2005533750A (ja)	2005-11-10
RU2004126610A (ru)	2005-05-27
GB0205527D0 (en)	2002-04-24
CN1274713C (zh)	2006-09-13
MXPA04008523A (es)	2004-12-06
US20060052313A1 (en)	2006-03-09
UY27699A1 (es)	2003-10-31
DK1483284T3 (da)	2006-10-16
DE60306904T2 (de)	2007-02-08
ES2264523T3 (es)	2007-01-01
AU2003208471B2 (en)	2006-09-28
EP1483284B1 (en)	2006-07-19
ATE333463T1 (de)	2006-08-15
WO2003076458A3 (en)	2003-11-06
CA2478099A1 (en)	2003-09-18
EP1483284A2 (en)	2004-12-08
IL163710A (en)	2010-12-30
EG25482A (en)	2012-01-15
PT1483284E (pt)	2006-11-30
TWI283685B (en)	2007-07-11
IL163710A0 (en)	2005-12-18
TW200403255A (en)	2004-03-01
MY130830A (en)	2007-07-31
WO2003076458A2 (en)	2003-09-18
NO20043695L (no)	2004-10-07
PL372977A1 (en)	2005-08-08
AR039868A1 (es)	2005-03-09
KR100974633B1 (ko)	2010-08-06
PL209670B1 (pl)	2011-10-31
NO332678B1 (no)	2012-12-03
AU2003208471A1 (en)	2003-09-22
CN1639186A (zh)	2005-07-13

Publication	Publication Date	Title
ZA200406856B (en)	2005-11-30	Selective dipeptide inhibitors of kallikrein.
EP0772590B1 (en)	2002-10-09	Thrombin inhibitors
NO169543B (no)	1992-03-30	Analogifremgangsmaate ved fremstilling av terapeutisk aktive peptidaseinhibitorer
CA2217682A1 (en)	1996-10-17	Thrombin inhibitors
EP0542525A2 (en)	1993-05-19	Antithrombotic agents
WO1993025574A1 (en)	1993-12-23	Inhibitors of angiotensin i chymase(s) including human heart chymase
HU204847B (en)	1992-02-28	Process for producing new peptidase inhibitors
PL188411B1 (pl)	2005-01-31	Nowe inhibitory trombiny i ich zastosowanie
EP1244621A1 (en)	2002-10-02	Nitrile derivatives as cathepsin k inhibitors
WO1992016549A1 (de)	1992-10-01	Para-substituierte phenylalanin-derivate
CA2449292A1 (en)	2002-11-21	Dipeptide derivatives
CA2170896A1 (en)	1995-03-16	Kininogen inhibitors
WO1999037668A1 (de)	1999-07-29	Thrombininhibitoren
CA2342985C (en)	2009-09-15	Hydroxamate-containing cysteine and serine protease inhibitors
US5798377A (en)	1998-08-25	Thrombin inhibitors
EP0858262B1 (en)	2002-12-04	Thrombin inhibitors
US5888971A (en)	1999-03-30	Macrocyclic peptides useful in the treatment of thrombin related disorders
EP1049673A1 (de)	2000-11-08	Heterocyclische amidine als kallikrein protease inhibitoren
CZ200392A3 (cs)	2003-05-14	Aminoisochinolinové deriváty
DE69606552T2 (de)	2000-09-14	Acylierte enolderivate von alpha-ketoestern und alpha-ketoamiden
KR840002357B1 (ko)	1984-12-21	S-(아실아미도아실)메르캅토아실 프롤린류의 제조방법
CZ20002463A3 (cs)	2000-10-11	Nové inhibitory trombinu
CA2163011A1 (en)	1994-12-22	New peptides derivatives