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ZA200307677B - Modified interferon alpha with reduced immunogenicity. - Google Patents

Modified interferon alpha with reduced immunogenicity. Download PDF

Info

Publication number
ZA200307677B
ZA200307677B ZA200307677A ZA200307677A ZA200307677B ZA 200307677 B ZA200307677 B ZA 200307677B ZA 200307677 A ZA200307677 A ZA 200307677A ZA 200307677 A ZA200307677 A ZA 200307677A ZA 200307677 B ZA200307677 B ZA 200307677B
Authority
ZA
South Africa
Prior art keywords
molecule
amino acid
modified
peptide
sequence
Prior art date
Application number
ZA200307677A
Other languages
English (en)
Inventor
Francis J Carr
Tim Jones
John Watkins
Graham Carter
Matthew Baker
Marian Hanalon
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA200307677B publication Critical patent/ZA200307677B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • C07K14/56IFN-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA200307677A 2001-03-02 2003-10-01 Modified interferon alpha with reduced immunogenicity. ZA200307677B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01105088 2001-03-02

Publications (1)

Publication Number Publication Date
ZA200307677B true ZA200307677B (en) 2004-07-13

Family

ID=8176646

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200307677A ZA200307677B (en) 2001-03-02 2003-10-01 Modified interferon alpha with reduced immunogenicity.

Country Status (13)

Country Link
US (1) US20060062761A1 (pt)
EP (1) EP1379555A2 (pt)
JP (1) JP2004535173A (pt)
KR (1) KR20030081479A (pt)
CN (1) CN1529714A (pt)
BR (1) BR0207704A (pt)
CA (1) CA2439690A1 (pt)
HU (1) HUP0303309A2 (pt)
MX (1) MXPA03007838A (pt)
PL (1) PL363181A1 (pt)
RU (1) RU2003129056A (pt)
WO (1) WO2002085941A2 (pt)
ZA (1) ZA200307677B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2498319A1 (en) 2002-09-09 2004-03-18 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
CA2500626A1 (en) * 2002-10-01 2004-04-15 Xencor, Inc. Interferon variants with improved properties
AU2004213565A1 (en) * 2003-02-18 2004-09-02 Merck Patent Gmbh Fusion proteins of interferon alpha muteins with improved properties
US20080260820A1 (en) * 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
US20090010966A1 (en) * 2007-06-21 2009-01-08 Angelica Therapeutics, Inc. Modified diphtheria toxins
US8470314B2 (en) * 2008-02-29 2013-06-25 Angelica Therapeutics, Inc. Modified toxins
US20110224407A1 (en) * 2008-09-09 2011-09-15 University Of Medicine And Dentistry Of New Jersey Type I Interferon Antagonists
WO2014150600A2 (en) 2013-03-15 2014-09-25 Angelica Therapeutics, Inc. Modified toxins
CN105255840A (zh) * 2015-10-16 2016-01-20 西安医学院 通过去除显性表位b8r重组痘苗病毒的方法及其病毒
CN105200017A (zh) * 2015-10-16 2015-12-30 西安医学院 一种去除a47l降低痘苗病毒免疫优势的方法及病毒
WO2018200635A1 (en) 2017-04-28 2018-11-01 The Regents Of The University Of Colorado, A Body Corporate Methods of treating rheumatoid arthritis using rna-guided genome editing of hla gene
AR117715A1 (es) * 2019-12-17 2021-08-25 Univ Nacional Del Litoral Unl Interferón hiperglicosilado con inmunogenicidad reducida
WO2022240916A1 (en) 2021-05-10 2022-11-17 The Regents Of The University Of Colorado, A Body Corporate Engineered hla alleles for treating autoimmunity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997033998A1 (en) * 1996-03-14 1997-09-18 The Immune Response Corporation Targeted delivery of genes encoding interferon

Also Published As

Publication number Publication date
BR0207704A (pt) 2004-07-06
KR20030081479A (ko) 2003-10-17
WO2002085941A2 (en) 2002-10-31
US20060062761A1 (en) 2006-03-23
HUP0303309A2 (hu) 2003-12-29
PL363181A1 (en) 2004-11-15
RU2003129056A (ru) 2005-04-20
CA2439690A1 (en) 2002-10-31
EP1379555A2 (en) 2004-01-14
MXPA03007838A (es) 2003-12-08
JP2004535173A (ja) 2004-11-25
CN1529714A (zh) 2004-09-15
WO2002085941A3 (en) 2003-10-30

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