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BR0207704A - Alfa interferon modificado com imunogenicidade reduzida - Google Patents

Alfa interferon modificado com imunogenicidade reduzida

Info

Publication number
BR0207704A
BR0207704A BR0207704-3A BR0207704A BR0207704A BR 0207704 A BR0207704 A BR 0207704A BR 0207704 A BR0207704 A BR 0207704A BR 0207704 A BR0207704 A BR 0207704A
Authority
BR
Brazil
Prior art keywords
alpha interferon
reduced immunogenicity
polypeptides
modified
modified alpha
Prior art date
Application number
BR0207704-3A
Other languages
English (en)
Inventor
Francis J Carr
Graham Carter
Tim Jones
Matthew Baker
John Watkins
Marian Hanlon
Original Assignee
Merck Patent Ges Mit Beschaenk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Ges Mit Beschaenk filed Critical Merck Patent Ges Mit Beschaenk
Publication of BR0207704A publication Critical patent/BR0207704A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"ALFA INTERFERON MODIFICADO COM IMUNOGENICIDADE REDUZIDA". A presente invenção refere-se a polipeptídeos a serem administrados especialmente a seres humanos e em particular para uso terapêutico. Os polipeptídeos são polipeptídeos modificados em que a modificação resulta em uma propensão reduzida para que o polipeptídeo estimule uma resposta imune quando de administração ao ser humano. A invenção refere-se, em particular, à modificação de alfa interferon humano e especificamente alfa interferon 2 humano (INF<244>2) para resultar em proteínas que são substancialmente não imunogênicas ou menos imunogênicas do que qualquer contra-parte não-modificada quando usadas in vivo.
BR0207704-3A 2001-03-02 2002-03-01 Alfa interferon modificado com imunogenicidade reduzida BR0207704A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01105088 2001-03-02
PCT/EP2002/002218 WO2002085941A2 (en) 2001-03-02 2002-03-01 Modified interferon alpha with reduced immunogenicity

Publications (1)

Publication Number Publication Date
BR0207704A true BR0207704A (pt) 2004-07-06

Family

ID=8176646

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0207704-3A BR0207704A (pt) 2001-03-02 2002-03-01 Alfa interferon modificado com imunogenicidade reduzida

Country Status (13)

Country Link
US (1) US20060062761A1 (pt)
EP (1) EP1379555A2 (pt)
JP (1) JP2004535173A (pt)
KR (1) KR20030081479A (pt)
CN (1) CN1529714A (pt)
BR (1) BR0207704A (pt)
CA (1) CA2439690A1 (pt)
HU (1) HUP0303309A2 (pt)
MX (1) MXPA03007838A (pt)
PL (1) PL363181A1 (pt)
RU (1) RU2003129056A (pt)
WO (1) WO2002085941A2 (pt)
ZA (1) ZA200307677B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2343518T3 (es) 2002-09-09 2010-08-03 Hanall Biopharma Co., Ltd. Polipeptidos interferon alfa modificados resistentes a proteasas.
CA2500626A1 (en) * 2002-10-01 2004-04-15 Xencor, Inc. Interferon variants with improved properties
PL376673A1 (pl) * 2003-02-18 2006-01-09 Merck Patent Gmbh Białka fuzyjne mutein interferonu alfa o ulepszonych właściwościach
US20080260820A1 (en) * 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
CA2691539C (en) * 2007-06-21 2014-08-26 Angelica Therapeutics, Inc. Modified toxins
EP2268297A4 (en) * 2008-02-29 2011-11-16 Angelica Therapeutics Inc MODIFIED TOXINS
WO2010030671A1 (en) * 2008-09-09 2010-03-18 University Of Medicine And Dentistry Of New Jersey Type i interferon antagonists
EP2968450A4 (en) 2013-03-15 2016-10-26 Angelica Therapeutics Inc MODIFIED TOXINS
CN105200017A (zh) * 2015-10-16 2015-12-30 西安医学院 一种去除a47l降低痘苗病毒免疫优势的方法及病毒
CN105255840A (zh) * 2015-10-16 2016-01-20 西安医学院 通过去除显性表位b8r重组痘苗病毒的方法及其病毒
JP7457302B2 (ja) 2017-04-28 2024-03-28 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・コロラド・ア・ボディ・コーポレイト Ｈｌａ遺伝子のｒｎａガイドゲノム編集を使用して関節リウマチを処置する方法
AR117715A1 (es) * 2019-12-17 2021-08-25 Univ Nacional Del Litoral Unl Interferón hiperglicosilado con inmunogenicidad reducida
KR20240023035A (ko) 2021-05-10 2024-02-20 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코퍼레이트 자가면역 치료를 위한 hla 조작 방법 및 조성물

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000506865A (ja) * 1996-03-14 2000-06-06 ジ イミューン リスポンス コーポレイション インターフェロンをコードする遺伝子の標的を定めた送達

Also Published As

Publication number Publication date
JP2004535173A (ja) 2004-11-25
US20060062761A1 (en) 2006-03-23
HUP0303309A2 (hu) 2003-12-29
MXPA03007838A (es) 2003-12-08
WO2002085941A3 (en) 2003-10-30
ZA200307677B (en) 2004-07-13
WO2002085941A2 (en) 2002-10-31
EP1379555A2 (en) 2004-01-14
CN1529714A (zh) 2004-09-15
KR20030081479A (ko) 2003-10-17
RU2003129056A (ru) 2005-04-20
PL363181A1 (en) 2004-11-15
CA2439690A1 (en) 2002-10-31

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5O, 6O E 7O ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2029 DE 24/11/2009.