ZA200307410B - Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent, salts of ranelic acid and their hydrates. - Google Patents

Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent, salts of ranelic acid and their hydrates.

Info

Publication number: ZA200307410B
Authority: ZA; South Africa
Prior art keywords: synthesis; acid; bivalent; hydrates; carboxymethyl
Prior art date: 2002-09-24

Application number

ZA200307410A

Other languages

English (en)

Inventor

Lucile Vaysse-Ludot

Jean-Pierre Lecouve

Pascal Langlois

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-24

Filing date

2003-09-23

Publication date

2004-07-07

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29415190&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200307410(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-09-23 Application filed by Servier Lab filed Critical Servier Lab

2004-07-07 Publication of ZA200307410B publication Critical patent/ZA200307410B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

ZA200307410A 2002-09-24 2003-09-23 Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent, salts of ranelic acid and their hydrates. ZA200307410B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0211764A FR2844796A1 (fr)	2002-09-24	2002-09-24	Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates

Publications (1)

Publication Number	Publication Date
ZA200307410B true ZA200307410B (en)	2004-07-07

Family

ID=29415190

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200307410A ZA200307410B (en)	2002-09-24	2003-09-23	Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent, salts of ranelic acid and their hydrates.

Country Status (39)

Country	Link
US (3)	US7105683B2 (de)
EP (1)	EP1403264B1 (de)
JP (1)	JP4136865B2 (de)
KR (1)	KR100551503B1 (de)
CN (2)	CN1280285C (de)
AP (1)	AP1942A (de)
AR (1)	AR041356A1 (de)
AT (1)	ATE286041T1 (de)
AU (2)	AU2003248279B2 (de)
BR (1)	BR0304194A (de)
CA (1)	CA2442875C (de)
DE (1)	DE60300252T2 (de)
DK (1)	DK1403264T3 (de)
EA (1)	EA007496B1 (de)
EC (1)	ECSP055742A (de)
ES (1)	ES2235144T3 (de)
FR (1)	FR2844796A1 (de)
GE (1)	GEP20074140B (de)
HK (2)	HK1061845A1 (de)
HR (1)	HRP20050360B1 (de)
IL (1)	IL167314A (de)
IS (1)	IS2136B (de)
MA (1)	MA26101A1 (de)
ME (1)	ME00451B (de)
MX (1)	MXPA03008645A (de)
MY (1)	MY131939A (de)
NI (1)	NI200500065A (de)
NO (1)	NO328697B1 (de)
NZ (1)	NZ528400A (de)
OA (1)	OA12933A (de)
PL (1)	PL214414B1 (de)
PT (1)	PT1403264E (de)
RS (1)	RS50929B (de)
SG (1)	SG110070A1 (de)
SI (1)	SI1403264T1 (de)
TN (1)	TNSN05089A1 (de)
UA (1)	UA79991C2 (de)
WO (1)	WO2004029035A1 (de)
ZA (1)	ZA200307410B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2844796A1 (fr) *	2002-09-24	2004-03-26	Servier Lab	Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
FR2844795B1 (fr) *	2002-09-24	2004-10-22	Servier Lab	Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates
PL1745791T3 (pl) *	2003-05-07	2013-11-29	Osteologix As	Leczenie chorób chrząstki/kości za pomocą rozpuszczalnych w wodzie soli strontu
DK2266584T3 (da) *	2003-05-07	2013-01-02	Osteologix As	Sammensætning med strontium og D-vitamin til profylakse og/eller behandling af brusk- og knogletilstande
US20050085531A1 (en) *	2003-10-03	2005-04-21	Hodge Carl N.	Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
KR101165614B1 (ko)	2004-02-26	2012-07-18	오스테올로지스 에이에스	괴사성 골 질환의 예방 또는 치료에 사용하기 위한스트론튬 함유 화합물
EP1768748B2 (de)	2004-06-25	2019-03-13	Mokwalo Pharma S.A.	Zusammensetzungen mit strontium und vitamin d und ihre verwendungen
FR2875807B1 (fr) *	2004-09-30	2006-11-17	Servier Lab	Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
US20070292529A1 (en) *	2006-06-19	2007-12-20	Tabbiner Philip S	Strontium compositions and methods of treating osteoporotic conditions
CN101665483B (zh) *	2008-09-01	2013-01-23	河北医科大学	一种雷尼酸锶中间体化合物ⅱ的合成方法
WO2011110597A1 (de)	2010-03-11	2011-09-15	Azad Pharmaceutical Ingredients Ag	Verfahren zur herstellung von strontiumranelat
CN103319454B (zh) *	2013-06-14	2014-06-18	广东众生药业股份有限公司	一种高纯度雷尼酸四乙酯及其中间体的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR415850A (fr)	1909-07-22	1910-10-05	Gustave Auguste Ferrie	Dispositif de mesure permettant de lire directement la valeur d'une grandeur fonction de deux variables
FR2651497B1 (fr) *	1989-09-01	1991-10-25	Adir	Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
FR2844797B1 (fr) *	2002-09-24	2004-10-22	Servier Lab	Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
FR2844796A1 (fr) *	2002-09-24	2004-03-26	Servier Lab	Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates

2002
- 2002-09-24 FR FR0211764A patent/FR2844796A1/fr active Pending
2003
- 2003-09-17 MY MYPI20033534A patent/MY131939A/en unknown
- 2003-09-22 AP AP2005003259A patent/AP1942A/xx active
- 2003-09-22 DE DE60300252T patent/DE60300252T2/de not_active Expired - Lifetime
- 2003-09-22 JP JP2003330438A patent/JP4136865B2/ja not_active Expired - Fee Related
- 2003-09-22 AT AT03292317T patent/ATE286041T1/de active
- 2003-09-22 DK DK03292317T patent/DK1403264T3/da active
- 2003-09-22 ES ES03292317T patent/ES2235144T3/es not_active Expired - Lifetime
- 2003-09-22 RS YUP-2005/0242A patent/RS50929B/sr unknown
- 2003-09-22 PT PT03292317T patent/PT1403264E/pt unknown
- 2003-09-22 BR BR0304194-8A patent/BR0304194A/pt not_active Application Discontinuation
- 2003-09-22 AU AU2003248279A patent/AU2003248279B2/en not_active Ceased
- 2003-09-22 SI SI200330013T patent/SI1403264T1/xx unknown
- 2003-09-22 UA UAA200503859A patent/UA79991C2/uk unknown
- 2003-09-22 AU AU2003282178A patent/AU2003282178A1/en not_active Abandoned
- 2003-09-22 EP EP03292317A patent/EP1403264B1/de not_active Expired - Lifetime
- 2003-09-22 GE GEAP20038760A patent/GEP20074140B/en unknown
- 2003-09-22 OA OA1200500082A patent/OA12933A/en unknown
- 2003-09-22 WO PCT/FR2003/002776 patent/WO2004029035A1/fr not_active Application Discontinuation
- 2003-09-22 ME MEP-2008-685A patent/ME00451B/me unknown
- 2003-09-23 ZA ZA200307410A patent/ZA200307410B/xx unknown
- 2003-09-23 EA EA200300926A patent/EA007496B1/ru not_active IP Right Cessation
- 2003-09-23 MX MXPA03008645A patent/MXPA03008645A/es active IP Right Grant
- 2003-09-23 KR KR1020030065785A patent/KR100551503B1/ko not_active Expired - Fee Related
- 2003-09-23 PL PL362367A patent/PL214414B1/pl unknown
- 2003-09-23 NO NO20034237A patent/NO328697B1/no not_active IP Right Cessation
- 2003-09-23 NZ NZ528400A patent/NZ528400A/en not_active IP Right Cessation
- 2003-09-23 CA CA002442875A patent/CA2442875C/fr not_active Expired - Fee Related
- 2003-09-23 AR ARP030103454A patent/AR041356A1/es not_active Application Discontinuation
- 2003-09-24 US US10/669,738 patent/US7105683B2/en not_active Expired - Fee Related
- 2003-09-24 CN CNB031348076A patent/CN1280285C/zh not_active Expired - Fee Related
- 2003-09-24 SG SG200305554A patent/SG110070A1/en unknown
- 2003-09-24 CN CNB2006100073351A patent/CN100393707C/zh not_active Expired - Fee Related
- 2003-09-24 MA MA27320A patent/MA26101A1/fr unknown
2004
- 2004-07-05 HK HK04104808A patent/HK1061845A1/xx not_active IP Right Cessation
2005
- 2005-03-08 IL IL167314A patent/IL167314A/en not_active IP Right Cessation
- 2005-03-18 NI NI200500065A patent/NI200500065A/es unknown
- 2005-03-23 TN TNP2005000089A patent/TNSN05089A1/fr unknown
- 2005-04-19 IS IS7808A patent/IS2136B/xx unknown
- 2005-04-21 HR HRP20050360AA patent/HRP20050360B1/hr not_active IP Right Cessation
- 2005-04-22 EC EC2005005742A patent/ECSP055742A/es unknown
2006
- 2006-02-21 US US11/358,034 patent/US7462714B2/en not_active Expired - Fee Related
- 2006-02-21 US US11/358,496 patent/US7238815B2/en not_active Expired - Fee Related
2007
- 2007-02-01 HK HK07101197A patent/HK1096661A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO2004029035A1 (fr)	2004-04-08
IS7808A (is)	2005-04-19
AP2005003259A0 (en)	2005-03-31
JP4136865B2 (ja)	2008-08-20
PL362367A1 (en)	2004-04-05
US20060142567A1 (en)	2006-06-29
RS50929B (sr)	2010-08-31
AU2003248279B2 (en)	2009-08-06
DE60300252D1 (de)	2005-02-03
MY131939A (en)	2007-09-28
CN1817869A (zh)	2006-08-16
OA12933A (en)	2006-10-13
AP1942A (en)	2009-01-28
SG110070A1 (en)	2005-04-28
HRP20050360A2 (en)	2005-06-30
CA2442875C (fr)	2009-06-02
CN1280285C (zh)	2006-10-18
FR2844796A1 (fr)	2004-03-26
NO328697B1 (no)	2010-04-26
MXPA03008645A (es)	2005-04-19
MA26101A1 (fr)	2004-04-01
EP1403264A1 (de)	2004-03-31
US7238815B2 (en)	2007-07-03
JP2004269495A (ja)	2004-09-30
ATE286041T1 (de)	2005-01-15
IL167314A (en)	2010-04-29
RS20050242A (en)	2007-06-04
US20040059135A1 (en)	2004-03-25
PT1403264E (pt)	2005-04-29
HK1061845A1 (en)	2004-10-08
AU2003282178A1 (en)	2004-04-19
NO20034237D0 (no)	2003-09-23
BR0304194A (pt)	2004-09-08
PL214414B1 (pl)	2013-07-31
EP1403264B1 (de)	2004-12-29
HK1096661A1 (en)	2007-06-08
SI1403264T1 (en)	2005-04-30
UA79991C2 (en)	2007-08-10
IS2136B (is)	2006-08-15
US7462714B2 (en)	2008-12-09
US20060142596A1 (en)	2006-06-29
AR041356A1 (es)	2005-05-11
DK1403264T3 (da)	2005-04-04
ECSP055742A (es)	2005-07-06
AU2003248279A1 (en)	2004-04-08
DE60300252T2 (de)	2005-12-22
ES2235144T3 (es)	2005-07-01
CA2442875A1 (fr)	2004-03-24
TNSN05089A1 (fr)	2007-05-14
NO20034237L (no)	2004-03-25
US7105683B2 (en)	2006-09-12
EA007496B1 (ru)	2006-10-27
CN100393707C (zh)	2008-06-11
KR20040026627A (ko)	2004-03-31
CN1500783A (zh)	2004-06-02
EA200300926A1 (ru)	2004-04-29
GEP20074140B (en)	2007-06-25
ME00451B (me)	2011-10-10
NZ528400A (en)	2004-06-25
KR100551503B1 (ko)	2006-02-13
HRP20050360B1 (hr)	2013-08-31
NI200500065A (es)	2006-01-03

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