ZA200209630B - Coated articles. - Google Patents

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Info

Publication number: ZA200209630B
Authority: ZA; South Africa
Prior art keywords: radical; alkyl; substituted; formula; alkylene
Prior art date: 2000-05-30

Application number

ZA200209630A

Other languages

English (en)

Inventor

Peter Chabrecek

Dieter Lohmann

Joerg Leukel

Lynn Cook Winterton

Yongxing Qiu

John Martin Lally

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-30

Filing date

2002-11-27

Publication date

2003-10-20

2002-11-27 Application filed by Novartis Ag filed Critical Novartis Ag

2003-10-20 Publication of ZA200209630B publication Critical patent/ZA200209630B/en

Links

-1 poly(N,N- dimethylacrylamide) Polymers 0.000 claims description 128
229910052739 hydrogen Inorganic materials 0.000 claims description 101
239000001257 hydrogen Substances 0.000 claims description 95
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 67
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 58
239000013590 bulk material Substances 0.000 claims description 57
238000000576 coating method Methods 0.000 claims description 44
229920000831 ionic polymer Polymers 0.000 claims description 44
239000011248 coating agent Substances 0.000 claims description 39
239000000463 material Substances 0.000 claims description 36
229910052799 carbon Inorganic materials 0.000 claims description 35
239000002131 composite material Substances 0.000 claims description 32
125000001424 substituent group Chemical group 0.000 claims description 29
239000000178 monomer Substances 0.000 claims description 27
238000000034 method Methods 0.000 claims description 25
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 24
229920001577 copolymer Polymers 0.000 claims description 23
229920000083 poly(allylamine) Polymers 0.000 claims description 22
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 21
150000002431 hydrogen Chemical class 0.000 claims description 20
229920006318 anionic polymer Polymers 0.000 claims description 19
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 19
229920002125 Sokalan® Polymers 0.000 claims description 18
229920006317 cationic polymer Polymers 0.000 claims description 18
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 18
150000001875 compounds Chemical class 0.000 claims description 16
229920000642 polymer Polymers 0.000 claims description 16
238000006243 chemical reaction Methods 0.000 claims description 14
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims description 14
230000002209 hydrophobic effect Effects 0.000 claims description 12
239000004584 polyacrylic acid Substances 0.000 claims description 12
238000006116 polymerization reaction Methods 0.000 claims description 12
230000015572 biosynthetic process Effects 0.000 claims description 11
150000001720 carbohydrates Chemical class 0.000 claims description 11
125000004433 nitrogen atom Chemical group N* 0.000 claims description 11
229920002873 Polyethylenimine Polymers 0.000 claims description 10
239000003999 initiator Substances 0.000 claims description 10
239000003607 modifier Substances 0.000 claims description 10
229920001542 oligosaccharide Polymers 0.000 claims description 9
150000002482 oligosaccharides Chemical class 0.000 claims description 9
HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 8
HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 8
HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 8
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 8
230000005660 hydrophilic surface Effects 0.000 claims description 8
238000004519 manufacturing process Methods 0.000 claims description 8
229920001296 polysiloxane Polymers 0.000 claims description 8
230000008569 process Effects 0.000 claims description 8
125000002947 alkylene group Chemical group 0.000 claims description 7
150000001450 anions Chemical class 0.000 claims description 7
229920001519 homopolymer Polymers 0.000 claims description 7
239000003505 polymerization initiator Substances 0.000 claims description 7
229920000570 polyether Polymers 0.000 claims description 6
238000010526 radical polymerization reaction Methods 0.000 claims description 6
229920002554 vinyl polymer Polymers 0.000 claims description 6
229910052727 yttrium Inorganic materials 0.000 claims description 6
108010038807 Oligopeptides Proteins 0.000 claims description 5
102000015636 Oligopeptides Human genes 0.000 claims description 5
229910006069 SO3H Inorganic materials 0.000 claims description 5
239000002253 acid Substances 0.000 claims description 5
125000001931 aliphatic group Chemical group 0.000 claims description 5
125000005010 perfluoroalkyl group Chemical group 0.000 claims description 5
229920000058 polyacrylate Polymers 0.000 claims description 5
230000005855 radiation Effects 0.000 claims description 5
229920002845 Poly(methacrylic acid) Polymers 0.000 claims description 4
229920000388 Polyphosphate Polymers 0.000 claims description 4
210000004087 cornea Anatomy 0.000 claims description 4
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 4
229920002401 polyacrylamide Polymers 0.000 claims description 4
230000000379 polymerizing effect Effects 0.000 claims description 4
229920000193 polymethacrylate Polymers 0.000 claims description 4
239000001205 polyphosphate Substances 0.000 claims description 4
235000011176 polyphosphates Nutrition 0.000 claims description 4
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims description 4
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 4
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Natural products OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 3
CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims description 3
KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 claims description 3
239000004721 Polyphenylene oxide Substances 0.000 claims description 3
230000009471 action Effects 0.000 claims description 3
235000014113 dietary fatty acids Nutrition 0.000 claims description 3
239000000194 fatty acid Substances 0.000 claims description 3
229930195729 fatty acid Natural products 0.000 claims description 3
150000004665 fatty acids Chemical class 0.000 claims description 3
125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 claims description 3
229920002939 poly(N,N-dimethylacrylamides) Polymers 0.000 claims description 3
229920000172 poly(styrenesulfonic acid) Polymers 0.000 claims description 3
229920002689 polyvinyl acetate Polymers 0.000 claims description 3
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 3
229920002126 Acrylic acid copolymer Polymers 0.000 claims description 2
PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims description 2
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims description 2
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 2
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 2
PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims description 2
239000001530 fumaric acid Substances 0.000 claims description 2
229960002591 hydroxyproline Drugs 0.000 claims description 2
125000002883 imidazolyl group Chemical group 0.000 claims description 2
125000001041 indolyl group Chemical group 0.000 claims description 2
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 2
239000011976 maleic acid Substances 0.000 claims description 2
229920000620 organic polymer Polymers 0.000 claims description 2
229920000233 poly(alkylene oxides) Polymers 0.000 claims description 2
239000011118 polyvinyl acetate Substances 0.000 claims description 2
FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 claims description 2
241000405961 Scomberomorus regalis Species 0.000 claims 1
229960002598 fumaric acid Drugs 0.000 claims 1
235000011087 fumaric acid Nutrition 0.000 claims 1
229940098895 maleic acid Drugs 0.000 claims 1
150000003254 radicals Chemical class 0.000 description 149
239000000243 solution Substances 0.000 description 93
XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 28
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 26
125000000129 anionic group Chemical group 0.000 description 22
150000003839 salts Chemical class 0.000 description 22
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 18
HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 18
229910052786 argon Inorganic materials 0.000 description 14
239000000203 mixture Substances 0.000 description 14
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 12
125000002091 cationic group Chemical group 0.000 description 12
229940088644 n,n-dimethylacrylamide Drugs 0.000 description 12
YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 description 12
229920001222 biopolymer Polymers 0.000 description 10
229910021642 ultra pure water Inorganic materials 0.000 description 10
239000012498 ultrapure water Substances 0.000 description 10
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
125000004956 cyclohexylene group Chemical group 0.000 description 9
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 9
125000000524 functional group Chemical group 0.000 description 9
229920000867 polyelectrolyte Polymers 0.000 description 9
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 8
125000003277 amino group Chemical group 0.000 description 8
238000004630 atomic force microscopy Methods 0.000 description 8
238000001035 drying Methods 0.000 description 8
125000001261 isocyanato group Chemical group *N=C=O 0.000 description 8
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 8
239000002904 solvent Substances 0.000 description 7
238000005507 spraying Methods 0.000 description 7
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
150000002734 metacrylic acid derivatives Chemical class 0.000 description 6
238000004483 ATR-FTIR spectroscopy Methods 0.000 description 5
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 5
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229920006362 Teflon® Polymers 0.000 description 5
150000001252 acrylic acid derivatives Chemical class 0.000 description 5
239000007864 aqueous solution Substances 0.000 description 5
235000014633 carbohydrates Nutrition 0.000 description 5
238000007598 dipping method Methods 0.000 description 5
125000005842 heteroatom Chemical group 0.000 description 5
238000005259 measurement Methods 0.000 description 5
FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 5
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 5
VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
235000000346 sugar Nutrition 0.000 description 5
238000003786 synthesis reaction Methods 0.000 description 5
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
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239000005058 Isophorone diisocyanate Substances 0.000 description 4
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 4
229920002518 Polyallylamine hydrochloride Polymers 0.000 description 4
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 4
XXROGKLTLUQVRX-UHFFFAOYSA-N allyl alcohol Chemical compound OCC=C XXROGKLTLUQVRX-UHFFFAOYSA-N 0.000 description 4
NIMLQBUJDJZYEJ-UHFFFAOYSA-N isophorone diisocyanate Chemical compound CC1(C)CC(N=C=O)CC(C)(CN=C=O)C1 NIMLQBUJDJZYEJ-UHFFFAOYSA-N 0.000 description 4
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KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 3
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YSYRISKCBOPJRG-UHFFFAOYSA-N 4,5-difluoro-2,2-bis(trifluoromethyl)-1,3-dioxole Chemical compound FC1=C(F)OC(C(F)(F)F)(C(F)(F)F)O1 YSYRISKCBOPJRG-UHFFFAOYSA-N 0.000 description 3
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239000005977 Ethylene Substances 0.000 description 3
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241001085205 Prenanthella exigua Species 0.000 description 3
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150000001735 carboxylic acids Chemical class 0.000 description 3
125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 3
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125000000623 heterocyclic group Chemical group 0.000 description 3
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150000002632 lipids Chemical class 0.000 description 3
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BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 3
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JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 description 2
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OCIBBXPLUVYKCH-QXVNYKTNSA-N alpha-maltohexaose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)O[C@H](O[C@@H]2[C@H](O[C@H](O[C@@H]3[C@H](O[C@H](O[C@@H]4[C@H](O[C@H](O[C@@H]5[C@H](O[C@H](O)[C@H](O)[C@H]5O)CO)[C@H](O)[C@H]4O)CO)[C@H](O)[C@H]3O)CO)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O OCIBBXPLUVYKCH-QXVNYKTNSA-N 0.000 description 2
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MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 2
125000004432 carbon atom Chemical group C* 0.000 description 2
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125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
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235000013681 dietary sucrose Nutrition 0.000 description 1
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BLZSRIYYOIZLJL-UHFFFAOYSA-N ethenyl pentanoate Chemical compound CCCCC(=O)OC=C BLZSRIYYOIZLJL-UHFFFAOYSA-N 0.000 description 1
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
229940117927 ethylene oxide Drugs 0.000 description 1
238000000605 extraction Methods 0.000 description 1
229920002313 fluoropolymer Polymers 0.000 description 1
229930182830 galactose Natural products 0.000 description 1
229960003082 galactose Drugs 0.000 description 1
239000000499 gel Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
229910021397 glassy carbon Inorganic materials 0.000 description 1
235000012209 glucono delta-lactone Nutrition 0.000 description 1
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239000008103 glucose Substances 0.000 description 1
229960001031 glucose Drugs 0.000 description 1
238000010559 graft polymerization reaction Methods 0.000 description 1
239000008187 granular material Substances 0.000 description 1
239000010439 graphite Substances 0.000 description 1
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235000019382 gum benzoic Nutrition 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 description 1
210000003709 heart valve Anatomy 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
229920000669 heparin Polymers 0.000 description 1
230000036571 hydration Effects 0.000 description 1
238000006703 hydration reaction Methods 0.000 description 1
150000002432 hydroperoxides Chemical class 0.000 description 1
229920001477 hydrophilic polymer Polymers 0.000 description 1
125000004356 hydroxy functional group Chemical group O* 0.000 description 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
239000007943 implant Substances 0.000 description 1
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239000011261 inert gas Substances 0.000 description 1
230000000977 initiatory effect Effects 0.000 description 1
230000010354 integration Effects 0.000 description 1
210000004153 islets of langerhan Anatomy 0.000 description 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
229940099563 lactobionic acid Drugs 0.000 description 1
239000008101 lactose Substances 0.000 description 1
TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 description 1
239000007788 liquid Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
229940041290 mannose Drugs 0.000 description 1
229910044991 metal oxide Inorganic materials 0.000 description 1
150000004706 metal oxides Chemical class 0.000 description 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
230000003278 mimic effect Effects 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
210000003097 mucus Anatomy 0.000 description 1
229950006780 n-acetylglucosamine Drugs 0.000 description 1
125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
KKFHAJHLJHVUDM-UHFFFAOYSA-N n-vinylcarbazole Chemical compound C1=CC=C2N(C=C)C3=CC=CC=C3C2=C1 KKFHAJHLJHVUDM-UHFFFAOYSA-N 0.000 description 1
125000004957 naphthylene group Chemical group 0.000 description 1
230000009871 nonspecific binding Effects 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
239000002245 particle Substances 0.000 description 1
150000002978 peroxides Chemical class 0.000 description 1
JRKICGRDRMAZLK-UHFFFAOYSA-L persulfate group Chemical group S(=O)(=O)([O-])OOS(=O)(=O)[O-] JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
229920000765 poly(2-oxazolines) Polymers 0.000 description 1
229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
229920002239 polyacrylonitrile Polymers 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
108010064470 polyaspartate Proteins 0.000 description 1
229920002857 polybutadiene Polymers 0.000 description 1
238000006068 polycondensation reaction Methods 0.000 description 1
229920000647 polyepoxide Polymers 0.000 description 1
229920000728 polyester Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920002643 polyglutamic acid Polymers 0.000 description 1
229920001721 polyimide Polymers 0.000 description 1
229920001195 polyisoprene Polymers 0.000 description 1
229920000098 polyolefin Polymers 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
229920001343 polytetrafluoroethylene Polymers 0.000 description 1
239000004810 polytetrafluoroethylene Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
150000003141 primary amines Chemical class 0.000 description 1
238000007639 printing Methods 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
HJWLCRVIBGQPNF-UHFFFAOYSA-N prop-2-enylbenzene Chemical compound C=CCC1=CC=CC=C1 HJWLCRVIBGQPNF-UHFFFAOYSA-N 0.000 description 1
QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
125000001453 quaternary ammonium group Chemical group 0.000 description 1
101150031250 retm gene Proteins 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
229910052702 rhenium Inorganic materials 0.000 description 1
150000003335 secondary amines Chemical class 0.000 description 1
229910052604 silicate mineral Inorganic materials 0.000 description 1
229910052710 silicon Inorganic materials 0.000 description 1
239000010703 silicon Substances 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
MNCGMVDMOKPCSQ-UHFFFAOYSA-M sodium;2-phenylethenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C=CC1=CC=CC=C1 MNCGMVDMOKPCSQ-UHFFFAOYSA-M 0.000 description 1
BWYYYTVSBPRQCN-UHFFFAOYSA-M sodium;ethenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C=C BWYYYTVSBPRQCN-UHFFFAOYSA-M 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
241000894007 species Species 0.000 description 1
238000004528 spin coating Methods 0.000 description 1
239000007921 spray Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
125000000547 substituted alkyl group Chemical group 0.000 description 1
229960004793 sucrose Drugs 0.000 description 1
150000005846 sugar alcohols Chemical class 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
238000006557 surface reaction Methods 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
238000010345 tape casting Methods 0.000 description 1
150000003512 tertiary amines Chemical group 0.000 description 1
125000001302 tertiary amino group Chemical group 0.000 description 1
238000012360 testing method Methods 0.000 description 1
125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
238000012719 thermal polymerization Methods 0.000 description 1
YRHRIQCWCFGUEQ-UHFFFAOYSA-N thioxanthen-9-one Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3SC2=C1 YRHRIQCWCFGUEQ-UHFFFAOYSA-N 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
230000000007 visual effect Effects 0.000 description 1
238000009736 wetting Methods 0.000 description 1
230000029663 wound healing Effects 0.000 description 1
229910052724 xenon Inorganic materials 0.000 description 1
FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
229920001221 xylan Polymers 0.000 description 1
150000004823 xylans Chemical class 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
- C08J7/12—Chemical modification
- C08J7/16—Chemical modification with polymerisable compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/21—Circular sheet or circular blank
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31855—Of addition polymer from unsaturated monomers
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31855—Of addition polymer from unsaturated monomers
- Y10T428/31909—Next to second addition polymer from unsaturated monomers
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31855—Of addition polymer from unsaturated monomers
- Y10T428/31909—Next to second addition polymer from unsaturated monomers
- Y10T428/31928—Ester, halide or nitrile of addition polymer
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31855—Of addition polymer from unsaturated monomers
- Y10T428/31935—Ester, halide or nitrile of addition polymer

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
Physics & Mathematics (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Dermatology (AREA)
Oral & Maxillofacial Surgery (AREA)
Transplantation (AREA)
Epidemiology (AREA)
General Physics & Mathematics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Optics & Photonics (AREA)
Veterinary Medicine (AREA)
Materials For Medical Uses (AREA)
Paints Or Removers (AREA)
Eyeglasses (AREA)
Treatments Of Macromolecular Shaped Articles (AREA)
Compositions Of Macromolecular Compounds (AREA)
Laminated Bodies (AREA)
General Preparation And Processing Of Foods (AREA)
Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA200209630A 2000-05-30 2002-11-27 Coated articles. ZA200209630B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP00111526		2000-05-30

Publications (1)

Publication Number	Publication Date
ZA200209630B true ZA200209630B (en)	2003-10-20

Family

ID=32523988

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200209630A ZA200209630B (en)	2000-05-30	2002-11-27	Coated articles.

Country Status (12)

Country	Link
EP (1)	EP1299753B1 (zh)
JP (1)	JP4776863B2 (zh)
CN (1)	CN1432136A (zh)
AR (1)	AR030282A1 (zh)
AT (1)	ATE266873T1 (zh)
AU (1)	AU2001267488A1 (zh)
BR (1)	BR0111395A (zh)
CA (1)	CA2408938A1 (zh)
DE (1)	DE60103278T2 (zh)
MX (1)	MXPA02011857A (zh)
WO (1)	WO2001092924A1 (zh)
ZA (1)	ZA200209630B (zh)

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TW200407367A (en) *	2001-11-13	2004-05-16	Novartis Ag	Method for modifying the surface of biomedical articles
US7402318B2 (en) *	2001-11-14	2008-07-22	Novartis Ag	Medical devices having antimicrobial coatings thereon
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JP2003277691A (ja) *	2002-03-26	2003-10-02	Nippon Paint Co Ltd	水中摩擦低減塗膜及び水中摩擦低減方法
US7101947B2 (en)	2002-06-14	2006-09-05	Florida State University Research Foundation, Inc.	Polyelectrolyte complex films for analytical and membrane separation of chiral compounds
US6926965B2 (en)	2002-09-11	2005-08-09	Novartis Ag	LbL-coated medical device and method for making the same
US6896926B2 (en) *	2002-09-11	2005-05-24	Novartis Ag	Method for applying an LbL coating onto a medical device
US8172395B2 (en) *	2002-12-03	2012-05-08	Novartis Ag	Medical devices having antimicrobial coatings thereon
US8309117B2 (en) *	2002-12-19	2012-11-13	Novartis, Ag	Method for making medical devices having antimicrobial coatings thereon
WO2004058318A1 (en) *	2002-12-23	2004-07-15	Bausch & Lomb Incorporated	Surface treatment utilizing microwave radiation
US20060251795A1 (en)	2005-05-05	2006-11-09	Boris Kobrin	Controlled vapor deposition of biocompatible coatings for medical devices
US20070197681A1 (en) *	2006-02-22	2007-08-23	Advanced Medical Optics	Lens surface enhancement
US8044112B2 (en)	2006-03-30	2011-10-25	Novartis Ag	Method for applying a coating onto a silicone hydrogel lens
US8795782B2 (en)	2006-08-18	2014-08-05	Commonwealth Scientific And Industrial Research Organisation	Polymeric coatings and methods for forming them
AU2007284002B2 (en)	2006-08-18	2013-12-19	Commonwealth Scientific And Industrial Research Organisation	Polymeric coatings and methods for forming them
CA2667781C (en)	2006-10-30	2015-12-01	Novartis Ag	Method for applying a coating onto a silicone hydrogel lens
JP5473605B2 (ja)	2006-12-21	2014-04-16	ノバルティスアーゲー	生物医学的物品のコーティング方法
CN101971057B (zh)	2008-03-18	2013-03-27	诺瓦提斯公司	眼用透镜涂覆方法
US9046644B2 (en)	2010-02-16	2015-06-02	Toray Industries, Inc.	Low water content soft lens for eye, and method for producing the same
KR102266815B1 (ko) *	2010-07-30	2021-06-18	알콘 인코포레이티드	수분이 풍부한 표면을 갖는 실리콘 히드로겔 렌즈
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US9005700B2 (en)	2011-10-12	2015-04-14	Novartis Ag	Method for making UV-absorbing ophthalmic lenses
MX2014007207A (es) *	2011-12-14	2015-04-14	Semprus Biosciences Corp	Proceso de alta intensidad ionica para modificacion de lente de contacto.
JP2013235034A (ja) *	2012-05-02	2013-11-21	Menicon Co Ltd	表面処理樹脂成形体の製造方法及び表面処理樹脂成形体
US9395468B2 (en)	2012-08-27	2016-07-19	Ocular Dynamics, Llc	Contact lens with a hydrophilic layer
SG11201504763UA (en)	2012-12-17	2015-07-30	Novartis Ag	Method for making improved uv-absorbing ophthalmic lenses
EP3570093B1 (en)	2013-11-15	2021-09-15	Tangible Science, Inc.	Contact lens with a hydrophilic layer
US10525170B2 (en)	2014-12-09	2020-01-07	Tangible Science, Llc	Medical device coating with a biocompatible layer
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2001
- 2001-05-28 WO PCT/EP2001/006082 patent/WO2001092924A1/en active IP Right Grant
- 2001-05-28 DE DE60103278T patent/DE60103278T2/de not_active Expired - Lifetime
- 2001-05-28 AT AT01945203T patent/ATE266873T1/de not_active IP Right Cessation
- 2001-05-28 EP EP01945203A patent/EP1299753B1/en not_active Expired - Lifetime
- 2001-05-28 JP JP2002501079A patent/JP4776863B2/ja not_active Expired - Lifetime
- 2001-05-28 MX MXPA02011857A patent/MXPA02011857A/es not_active Application Discontinuation
- 2001-05-28 AR ARP010102539 patent/AR030282A1/es unknown
- 2001-05-28 AU AU2001267488A patent/AU2001267488A1/en not_active Abandoned
- 2001-05-28 CN CN01810445A patent/CN1432136A/zh active Pending
- 2001-05-28 BR BR0111395-0A patent/BR0111395A/pt not_active Application Discontinuation
- 2001-05-28 CA CA002408938A patent/CA2408938A1/en not_active Abandoned
2002
- 2002-11-27 ZA ZA200209630A patent/ZA200209630B/en unknown

Also Published As

Publication number	Publication date
JP2003534860A (ja)	2003-11-25
DE60103278D1 (de)	2004-06-17
AU2001267488A1 (en)	2001-12-11
AR030282A1 (es)	2003-08-20
CN1432136A (zh)	2003-07-23
CA2408938A1 (en)	2001-12-06
JP4776863B2 (ja)	2011-09-21
WO2001092924A1 (en)	2001-12-06
BR0111395A (pt)	2003-06-03
DE60103278T2 (de)	2004-09-23
ATE266873T1 (de)	2004-05-15
MXPA02011857A (es)	2003-04-10
EP1299753A1 (en)	2003-04-09
EP1299753B1 (en)	2004-05-12

Publication	Publication Date	Title
US6589665B2 (en)	2003-07-08	Coated articles
EP1299753B1 (en)	2004-05-12	Coated articles
US7040756B2 (en)	2006-05-09	Process for surface modifying substrates and modified substrates resulting therefrom
US6465056B1 (en)	2002-10-15	Process for coating a material surface
US6586038B1 (en)	2003-07-01	Process for the modification of a material surface
EP1451615B1 (en)	2007-11-14	Method for modifying the surface of biomedical articles
EP1095711B1 (en)	2004-01-28	Process for coating a material surface
CA2327743C (en)	2008-06-10	Organic articles
US6521352B1 (en)	2003-02-18	Process for the modification of a material surface
US6835410B2 (en)	2004-12-28	Bottle-brush type coatings with entangled hydrophilic polymer
EP1351780B1 (en)	2004-10-13	Process for coating a material surface
EP1095966B1 (en)	2006-01-11	Process for the modification of a material surface
EP1095965B1 (en)	2005-02-09	Process for the modification of a material surface
EP1263804B1 (en)	2004-02-18	Reactive polymers