ZA200102587B - Substituted 1,3-diaryl-2-pyridine-2-yl-3-(pyridine-2-ylamino)-propanol derivatives, methods for their production, pharmaceutical compositions containing the same and their use. - Google Patents

Substituted 1,3-diaryl-2-pyridine-2-yl-3-(pyridine-2-ylamino)-propanol derivatives, methods for their production, pharmaceutical compositions containing the same and their use. Download PDF

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Publication number: ZA200102587B
Authority: ZA; South Africa
Prior art keywords: alkyl; cycloalkyl; alkylene; phenyl; coo
Prior art date: 1998-10-02

Application number

ZA200102587A

Other languages

English (en)

Inventor

Reinhard Kirsch

Alfons Enhsen

Heiner Glombik

Werner Kramer

Eugen Falk

Original Assignee

Aventis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-02

Filing date

2001-03-29

Publication date

2001-11-05

2001-03-29 Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh

2001-11-05 Publication of ZA200102587B publication Critical patent/ZA200102587B/en

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-1 CONHg Chemical group 0.000 claims description 23
125000001544 thienyl group Chemical group 0.000 claims description 20
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YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
YSMODUONRAFBET-WHFBIAKZSA-N threo-5-hydroxy-L-lysine Chemical compound NC[C@@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-WHFBIAKZSA-N 0.000 description 1
TUQOTMZNTHZOKS-UHFFFAOYSA-N tributylphosphine Chemical compound CCCCP(CCCC)CCCC TUQOTMZNTHZOKS-UHFFFAOYSA-N 0.000 description 1
OHSJPLSEQNCRLW-UHFFFAOYSA-N triphenylmethyl radical Chemical compound C1=CC=CC=C1[C](C=1C=CC=CC=1)C1=CC=CC=C1 OHSJPLSEQNCRLW-UHFFFAOYSA-N 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
239000004474 valine Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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Chemical & Material Sciences (AREA)
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Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

ZA200102587A 1998-10-02 2001-03-29 Substituted 1,3-diaryl-2-pyridine-2-yl-3-(pyridine-2-ylamino)-propanol derivatives, methods for their production, pharmaceutical compositions containing the same and their use. ZA200102587B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19845406A DE19845406C2 (de)	1998-10-02	1998-10-02	Substituierte 1,3-Diaryl-2-pyridin-2-yl-3-(pyridin-2-ylamino)- propanolderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung

Publications (1)

Publication Number	Publication Date
ZA200102587B true ZA200102587B (en)	2001-11-05

Family

ID=7883187

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200102587A ZA200102587B (en)	1998-10-02	2001-03-29	Substituted 1,3-diaryl-2-pyridine-2-yl-3-(pyridine-2-ylamino)-propanol derivatives, methods for their production, pharmaceutical compositions containing the same and their use.

Country Status (22)

Country	Link
US (1)	US6596728B1 (pt)
EP (1)	EP1117642B1 (pt)
JP (1)	JP4544746B2 (pt)
KR (1)	KR100609255B1 (pt)
CN (1)	CN1173951C (pt)
AR (1)	AR021845A1 (pt)
AT (1)	ATE267809T1 (pt)
AU (1)	AU757689B2 (pt)
BR (1)	BR9915027B1 (pt)
CA (1)	CA2345985C (pt)
CZ (1)	CZ299569B6 (pt)
DE (2)	DE19845406C2 (pt)
DK (1)	DK1117642T3 (pt)
ES (1)	ES2219066T3 (pt)
HU (1)	HU226688B1 (pt)
ID (1)	ID29249A (pt)
PL (1)	PL205034B1 (pt)
PT (1)	PT1117642E (pt)
RU (1)	RU2224748C2 (pt)
TR (1)	TR200100896T2 (pt)
WO (1)	WO2000020393A1 (pt)
ZA (1)	ZA200102587B (pt)

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* Cited by examiner, † Cited by third party
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HRP20030501A2 (en)	2000-12-21	2005-04-30	Aventis Pharma Deutschland Gmbh	Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use
DE10064402A1 (de) *	2000-12-21	2002-06-27	Aventis Pharma Gmbh	Diphenylazetidinonderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
EP1420826A2 (de) *	2001-08-22	2004-05-26	Aventis Pharma Deutschland GmbH	Kombinationspräparate von arylsubstituierten propanolaminderivaten mit weiteren wirkstoffen und deren verwendung
US7161008B2 (en) *	2002-05-03	2007-01-09	Sanofi - Aventis Deutschland GmbH	Optically active β-aminoketones, optically active 1,3-amino alcohols and processes for preparing them
DE10219987A1 (de) *	2002-05-03	2004-04-08	Aventis Pharma Deutschland Gmbh	Optisch aktive β-Aminoketone, optisch aktive 1,3-Aminoalkohole und Verfahren zu deren Herstellung
GB0307918D0 (en)	2003-04-05	2003-05-14	Astrazeneca Ab	Therapeutic use
JP4800216B2 (ja) *	2003-10-24	2011-10-26	エグゼリクシス，インコーポレイテッド	ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法
EP3593802A3 (en)	2010-05-26	2020-03-25	Satiogen Pharmaceuticals, Inc.	Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
CN107375291A (zh)	2011-10-28	2017-11-24	鲁美纳医药公司	用于治疗高胆血症和胆汁淤积性肝病的胆汁酸再循环抑制剂
KR102051030B1 (ko)	2011-10-28	2019-12-02	루메나 파마수티컬즈, 인코포레이티드	소아 담즙울체성 간 질환 치료용 담즙산 재순환 억제제
CA2907214A1 (en)	2013-03-15	2014-09-18	Lumena Pharmaceuticals, Inc.	Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease
MX2015013193A (es)	2013-03-15	2016-04-15	Lumena Pharmaceuticals Inc	Inhibidores del reciclaje de acidos biliares para el tratamiento de colangitis esclerosante primaria y enfermedad inflamatoria intestinal.
JP6361168B2 (ja) *	2013-06-17	2018-07-25	Jsr株式会社	液晶配向剤、液晶配向膜、液晶表示素子、液晶表示素子の製造方法、重合体及び化合物
HRP20240801T1 (hr)	2019-02-12	2024-09-27	Mirum Pharmaceuticals, Inc.	Postupci za povećanje rasta kod pedijatrijskih pojedinaca koji imaju kolestatsku bolest jetre

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0000816A1 (en) *	1977-08-06	1979-02-21	Beecham Group Plc	Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them
SU1194273A3 (ru) *	1981-02-09	1985-11-23	Пфайзер Инк (Фирма)	Способ получени пирбутерола или его аналогов
GB9203347D0 (en) *	1992-02-17	1992-04-01	Wellcome Found	Hypolipidaemic compounds
EP0557879B1 (de) *	1992-02-22	1997-01-08	Hoechst Aktiengesellschaft	4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19845402B4 (de) *	1998-10-02	2005-04-07	Aventis Pharma Deutschland Gmbh	Mit Heterocyclen substituierte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
ES2223091T3 (es) *	1997-04-04	2005-02-16	Aventis Pharma Deutschland Gmbh	Derivados de propanolamina hipolipidemicos.
DE19845405C2 (de) *	1998-10-02	2000-07-13	Aventis Pharma Gmbh	Arylsubstituierte Propanolaminderivate und deren Verwendung

1998
- 1998-10-02 DE DE19845406A patent/DE19845406C2/de not_active Expired - Fee Related
1999
- 1999-09-18 JP JP2000574510A patent/JP4544746B2/ja not_active Expired - Fee Related
- 1999-09-18 CN CNB99811636XA patent/CN1173951C/zh not_active Expired - Fee Related
- 1999-09-18 ES ES99948791T patent/ES2219066T3/es not_active Expired - Lifetime
- 1999-09-18 DK DK99948791T patent/DK1117642T3/da active
- 1999-09-18 WO PCT/EP1999/006933 patent/WO2000020393A1/de active IP Right Grant
- 1999-09-18 KR KR1020017004096A patent/KR100609255B1/ko not_active Expired - Fee Related
- 1999-09-18 CZ CZ20011152A patent/CZ299569B6/cs not_active IP Right Cessation
- 1999-09-18 BR BRPI9915027-1A patent/BR9915027B1/pt not_active IP Right Cessation
- 1999-09-18 AU AU61926/99A patent/AU757689B2/en not_active Ceased
- 1999-09-18 RU RU2001111841/04A patent/RU2224748C2/ru not_active IP Right Cessation
- 1999-09-18 TR TR2001/00896T patent/TR200100896T2/xx unknown
- 1999-09-18 AT AT99948791T patent/ATE267809T1/de active
- 1999-09-18 PT PT99948791T patent/PT1117642E/pt unknown
- 1999-09-18 HU HU0103533A patent/HU226688B1/hu not_active IP Right Cessation
- 1999-09-18 PL PL347096A patent/PL205034B1/pl unknown
- 1999-09-18 EP EP99948791A patent/EP1117642B1/de not_active Expired - Lifetime
- 1999-09-18 DE DE59909606T patent/DE59909606D1/de not_active Expired - Lifetime
- 1999-09-18 ID IDW20010736A patent/ID29249A/id unknown
- 1999-09-18 CA CA2345985A patent/CA2345985C/en not_active Expired - Fee Related
- 1999-09-30 AR ARP990104960A patent/AR021845A1/es active IP Right Grant
- 1999-10-01 US US09/410,083 patent/US6596728B1/en not_active Expired - Lifetime
2001
- 2001-03-29 ZA ZA200102587A patent/ZA200102587B/en unknown

Also Published As

Publication number	Publication date
EP1117642A1 (de)	2001-07-25
US6596728B1 (en)	2003-07-22
CZ20011152A3 (cs)	2001-07-11
DE19845406C2 (de)	2001-10-18
CZ299569B6 (cs)	2008-09-03
HUP0103533A3 (en)	2003-01-28
CN1391558A (zh)	2003-01-15
KR100609255B1 (ko)	2006-08-04
JP2002526530A (ja)	2002-08-20
CA2345985C (en)	2010-06-29
PL205034B1 (pl)	2010-03-31
PL347096A1 (en)	2002-03-25
BR9915027A (pt)	2001-07-17
JP4544746B2 (ja)	2010-09-15
AR021845A1 (es)	2002-08-07
WO2000020393A1 (de)	2000-04-13
RU2224748C2 (ru)	2004-02-27
CN1173951C (zh)	2004-11-03
EP1117642B1 (de)	2004-05-26
ES2219066T3 (es)	2004-11-16
HK1051533A1 (en)	2003-08-08
DK1117642T3 (da)	2004-08-09
KR20010075496A (ko)	2001-08-09
BR9915027B1 (pt)	2010-09-08
AU757689B2 (en)	2003-03-06
ID29249A (id)	2001-08-16
PT1117642E (pt)	2004-09-30
TR200100896T2 (tr)	2001-09-21
CA2345985A1 (en)	2000-04-13
DE19845406A1 (de)	2000-04-13
DE59909606D1 (de)	2004-07-01
ATE267809T1 (de)	2004-06-15
HU226688B1 (hu)	2009-06-29
HUP0103533A2 (hu)	2002-02-28
AU6192699A (en)	2000-04-26

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