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YU71395A - Acilovani analozi insulina - Google Patents

Acilovani analozi insulina

Info

Publication number
YU71395A
YU71395A YU71395A YU71395A YU71395A YU 71395 A YU71395 A YU 71395A YU 71395 A YU71395 A YU 71395A YU 71395 A YU71395 A YU 71395A YU 71395 A YU71395 A YU 71395A
Authority
YU
Yugoslavia
Prior art keywords
xaa
cys
seq
leu
val
Prior art date
Application number
YU71395A
Other languages
English (en)
Inventor
Baker
Hanquier
Original Assignee
Eli Lilly Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly Company filed Critical Eli Lilly Company
Publication of YU71395A publication Critical patent/YU71395A/sh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Ovaj pronalazak odnosi se na acilovane insulinske analoge sa produženim trajanjem delovanja. Ti analozi insulina ili njihove farmaceutski- prihvatljive soli imaju formulu SEQ ID NO:1 Xaa He Val Glu Gin Cys Cys Thr Ser He Cys Ser 1 5 10 Leu Tyr Gin Leu Glu Asn Tyr Cys Asn 15 20 i SEQ ID NO:2 Xaa Val Asn Gin His Leu Cys Gly Ser His Leu Val 1 5 10 Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Prh 15 20 Phe Tyr Thr Xaa Xaa Thr 25 30 i međusobno su pravilno unakrsno vezani, gde Xaa na poziciji 28 SEQ ID NO:2 predstavlja acilovan Lys, a na poziciji 29 SEQ ID NO:2, Xaa predstavlja Pro. Acilujuća grupa je C6 - C17 masna kiselina. Pronalazak dalje obezbeđuje farmaceutsku smešu koja sadrži efikasnu količinu acilovanog insulinskog analoga iz ovog pronalaska u kombinaciji sa jednim ili više farmaceutski prihvatljivih ekscipijenata i postupak za dobijanje te smeše.
YU71395A 1994-11-17 1995-11-14 Acilovani analozi insulina YU71395A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/342,931 US5693609A (en) 1994-11-17 1994-11-17 Acylated insulin analogs

Publications (1)

Publication Number Publication Date
YU71395A true YU71395A (sh) 1998-07-10

Family

ID=23343907

Family Applications (1)

Application Number Title Priority Date Filing Date
YU71395A YU71395A (sh) 1994-11-17 1995-11-14 Acilovani analozi insulina

Country Status (25)

Country Link
US (2) US5693609A (sh)
EP (1) EP0712861B1 (sh)
JP (1) JPH10511644A (sh)
KR (1) KR970706842A (sh)
AR (1) AR002700A1 (sh)
AT (1) ATE237635T1 (sh)
AU (1) AU711282B2 (sh)
BR (1) BR9509653A (sh)
CA (1) CA2205060A1 (sh)
CO (1) CO4520284A1 (sh)
CZ (1) CZ145797A3 (sh)
DE (1) DE69530353T2 (sh)
ES (1) ES2194890T3 (sh)
FI (1) FI972031L (sh)
HU (1) HUT77030A (sh)
IL (1) IL115973A (sh)
NO (1) NO972169L (sh)
NZ (1) NZ297257A (sh)
PL (1) PL320644A1 (sh)
RU (1) RU2160118C2 (sh)
TR (1) TR199501420A2 (sh)
TW (1) TW434259B (sh)
WO (1) WO1996015804A1 (sh)
YU (1) YU71395A (sh)
ZA (1) ZA959679B (sh)

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TW434259B (en) 2001-05-16
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CA2205060A1 (en) 1996-05-30
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