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YU58902A - Oralne formulacije opijatnog agonista otporne na mehaničke, termičke i/ili hemijske promene fizičkih osobina doznog oblika - Google Patents

Oralne formulacije opijatnog agonista otporne na mehaničke, termičke i/ili hemijske promene fizičkih osobina doznog oblika

Info

Publication number
YU58902A
YU58902A YU58902A YUP58902A YU58902A YU 58902 A YU58902 A YU 58902A YU 58902 A YU58902 A YU 58902A YU P58902 A YUP58902 A YU P58902A YU 58902 A YU58902 A YU 58902A
Authority
YU
Yugoslavia
Prior art keywords
dosage form
antagonist
tamper
opioid agonist
released
Prior art date
Application number
YU58902A
Other languages
English (en)
Inventor
Benjamin Oshlack
Curtis Wright
Original Assignee
Euro-Celtique S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22663996&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU58902(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euro-Celtique S.A. filed Critical Euro-Celtique S.A.
Publication of YU58902A publication Critical patent/YU58902A/sh
Publication of RS50407B publication Critical patent/RS50407B/sr

Links

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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

Opisan je oralni oblik za doziranje koji sadrži (i) opijatni agonist u obliku iz koga može da se oslobadja, i (ii) izolovani antagonist, koji se ne oslobadja bitno ukoliko se oblik za doziranje ordinira nedirnut, tako da je odnos količine antagonista oslobodjenog iz pomenutog oblika za doziranje nakon tamperovanja, tj. mehaničkog, termičkog ili hemijskog manipulisanja, prema količini pomenutog antagonista oslobodjenog iz pomenutog nedirnutog oblika za doziranje oko 4:1 ili više, na osnovu rastvaranja in vitro pomenutog oblika za doziranje tokom 1 h u 900 ml simuliranog želudačnog fluida, koristeći aparaturu USP Type II (paddle) apparatus, pri 75 o/min, na 37В°C, pri čemu su pomenuti agonist i antagonist medjusobno dispergovani, a nisu izolovani jedan od drugog u dva različita sloja.[Disclosed is an oral dosage form comprising (i) an opioid agonist in releasable form and (ii) a sequestered opioid antagonist which is substantially not released when the dosage form is administered intact, such that the ratio of the amount of antagonist released from said dosage form after tampering to the amount of said antagonist released from said intact dosage form is about 4:1 or greater, based on the in-vitro dissolution at 1 hour of said dosage form in 900 ml of Simulated Gastric Fluid using a USP Type II (paddle) apparatus at 75 rpm at 37 degrees C wherein said agonist and antagonist are interdispersed and are not isolated from each other in two distinct layers.
YUP-589/02A 2000-02-08 2001-02-08 Oralne formulacije opijatnog agonista otporne na mehaničke,termičke i/ili hemijske promene fizičkih osobina doznog oblika RS50407B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18136900P 2000-02-08 2000-02-08

Publications (2)

Publication Number Publication Date
YU58902A true YU58902A (sh) 2005-11-28
RS50407B RS50407B (sr) 2009-12-31

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