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YU40999A - N-hidroksi-2-(alkil,aril ili heteroaril sulfanil,sulfinil ili sulfonil)-3-supstituisani alkil,aril ili heteroarilamidi, kao inhibitori za matrične metaloproteinaze - Google Patents

N-hidroksi-2-(alkil,aril ili heteroaril sulfanil,sulfinil ili sulfonil)-3-supstituisani alkil,aril ili heteroarilamidi, kao inhibitori za matrične metaloproteinaze

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Publication number
YU40999A
YU40999A YU40999A YU40999A YU40999A YU 40999 A YU40999 A YU 40999A YU 40999 A YU40999 A YU 40999A YU 40999 A YU40999 A YU 40999A YU 40999 A YU40999 A YU 40999A
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Yugoslavia
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tnf
aryl
tace
mmps
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YU40999A
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English (en)
Inventor
Mudumbai Aranapakam Venkatesan
George Theodore Grosu
Jamie Marie Davis
Baihua Hu
Mathew James O'dell
Derek Cecil Cole
Jannie Lea Baker
Marcy Pamela Jacobson
Original Assignee
American Cyanamid Company
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Application filed by American Cyanamid Company filed Critical American Cyanamid Company
Publication of YU40999A publication Critical patent/YU40999A/sh

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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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Abstract

Matricne metaloproteinaze (MMP) su grupa enzima koja ucestvuje u patoloskoj razgradnji vezivnog tikiva i osnovnih membrana. Ove endopeptidaze, koje sadrze cink, sastoje se od nekoliko podvrsta enzima, u koje dolaze kolagenaze, stromelizini i zelatinaze. Enzimi za konverziju TNF-α (TACE), proinflamatorni citokin, katalizuju stvaranje TNF-α iz prokursorskog proteina TNF-α vezanog u membrani. Ocekuje se da ce mali molekuli, kao inhibitori MMP i TACE, posedovati potencijal za lecenje niza bolesnih stanja. Sadasnji pronalazak daje ne-peptidne inhibitore matricnih metaloproteinaza (MMP) i enzima za konverziju TNF-α (TACE), niske molarne mase, za lecenje artritisa, metastaza tumora, ulceracije tkiva, abnormalnog zarastanja rana, periodontalnih oboljenja, oboljenja kostiju, dijabetesa (rezistentnost prema insulinu) i HIV infekcije. Jedinjenja ovog pronalaska perdstavlja formula (I) gde su R1, R2, R3 i R4 opisani u tekstu.
YU40999A 1997-02-27 1998-02-17 N-hidroksi-2-(alkil,aril ili heteroaril sulfanil,sulfinil ili sulfonil)-3-supstituisani alkil,aril ili heteroarilamidi, kao inhibitori za matrične metaloproteinaze YU40999A (sh)

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YU41099A YU41099A (sh) 1997-02-27 1998-02-17 N-hidroksi-2-(alkil,aril ili heteroaril sulfanil,sulfinil ili sulfonil)-3-substituisani alkil, aril ili heteroaril- amidi, kao inhibitori za metaloproteinaze

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Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7115632B1 (en) 1999-05-12 2006-10-03 G. D. Searle & Co. Sulfonyl aryl or heteroaryl hydroxamic acid compounds
US6638952B1 (en) * 1997-03-04 2003-10-28 Pharmacia Corporation Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds
US6696449B2 (en) 1997-03-04 2004-02-24 Pharmacia Corporation Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors
US6794511B2 (en) 1997-03-04 2004-09-21 G. D. Searle Sulfonyl aryl or heteroaryl hydroxamic acid compounds
KR20000075955A (ko) * 1997-03-04 2000-12-26 죤 에이치. 뷰센 방향족 술포닐 알파-히드록시 히드록삼산 화합물
DK1025077T3 (da) * 1997-10-15 2007-05-07 Wyeth Corp Nye aryloxyalkyl-dialkylaminer
US6005102A (en) * 1997-10-15 1999-12-21 American Home Products Corporation Aryloxy-alkyl-dialkylamines
US6750228B1 (en) * 1997-11-14 2004-06-15 Pharmacia Corporation Aromatic sulfone hydroxamic acid metalloprotease inhibitor
US20010039287A1 (en) 1997-11-14 2001-11-08 Thomas E Barta Aromatic sulfone hydroxamic acid metalloprotease inhibitor
CA2306460A1 (en) * 1997-11-14 1999-05-27 G.D. Searle & Co. Aromatic sulfone hydroxamic acid metalloprotease inhibitor
GB9725782D0 (en) 1997-12-05 1998-02-04 Pfizer Ltd Therapeutic agents
EP1054858A1 (en) * 1998-02-19 2000-11-29 American Cyanamid Company N-hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted-alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
DE69915004T2 (de) * 1998-11-05 2004-09-09 Pfizer Products Inc., Groton 5-Oxo-pyrrolidine-2-Carbonsäure-Hydroxamidderivate
US6340691B1 (en) 1999-01-27 2002-01-22 American Cyanamid Company Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors
US6358980B1 (en) * 1999-01-27 2002-03-19 American Cyanamid Company Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
AR035311A1 (es) * 1999-01-27 2004-05-12 Wyeth Corp Derivados de acido hidroxamico que contienen alquinilo, como inhibidores de las metalloproteinasas de matriz y de la tace, composicion farmaceutica y el uso de los mismos para la manufactura de un medicamento
AR035312A1 (es) * 1999-01-27 2004-05-12 Wyeth Corp Compuestos de acido hidroxamico que contienen alquinilo como inhibidores de metaloproteinasa de matriz/tace, composicion farmaceutica que los comprenden y el uso de los mismos para la manufactura de un medicamento
US6753337B2 (en) 1999-01-27 2004-06-22 Wyeth Holdings Corporation Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
US6946473B2 (en) 1999-01-27 2005-09-20 Wyeth Holdings Corporation Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors
US6800646B1 (en) 1999-02-08 2004-10-05 Pharmacia Corporation Sulfamato hydroxamic acid metalloprotease inhibitor
KR20010102000A (ko) * 1999-02-08 2001-11-15 윌리암스 로저 에이 술파마토 히드록삼산 메탈로프로테아제 억제제
SE9901572D0 (sv) 1999-05-03 1999-05-03 Astra Ab New compounds
US6511993B1 (en) 1999-06-03 2003-01-28 Kevin Neil Dack Metalloprotease inhibitors
AU2001233034A1 (en) * 2000-01-27 2001-08-07 American Cyanamid Company Method for preparing alpha-sulfonyl hydroxamic acid derivatives
US6683093B2 (en) 2000-05-12 2004-01-27 Pharmacia Corporation Aromatic sulfone hydroxamic acids and their use as protease inhibitors
AR040928A1 (es) 2001-05-11 2005-04-27 Pharmacia Corp Compuestos de acidos sulfona-hidroxamicos aromaticos, composiciones farmaceuticas y su uso en la preparacion de medicamentos utiles como inhibidores de proteasas
US6683078B2 (en) 2001-07-19 2004-01-27 Pharmacia Corporation Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors
PE20030701A1 (es) 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
EP2324830A1 (en) 2002-03-05 2011-05-25 TransTech Pharma Inc. Process for the preparation of a monocyclic azole derivative that inhibits the interaction of ligands with rage
JP2005537228A (ja) 2002-04-25 2005-12-08 ファルマシア・コーポレーション ピペリジニル−及びピペラジニル−スルホニルメチルヒドロキサム酸並びにプロテアーゼ阻害剤としてのその使用
WO2004000811A1 (en) * 2002-06-25 2003-12-31 Pharmacia Corporation Arylsulfonylhydroxamic acid and amide derivatives and their use as protease inhibitors
TW200418825A (en) 2002-12-16 2004-10-01 Hoffmann La Roche Novel (R)-and (S) enantiomers of thiophene hydroxamic acid derivatives
US7423176B2 (en) 2004-04-13 2008-09-09 Cephalon, Inc. Bicyclic aromatic sulfinyl derivatives
CA2632030A1 (en) 2005-12-15 2007-06-21 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
EP2081905B1 (en) 2006-07-28 2012-09-12 Boehringer Ingelheim International GmbH Sulfonyl compounds which modulate the cb2 receptor
EA200900403A1 (ru) 2006-09-25 2009-10-30 Бёрингер Ингельхайм Интернациональ Гмбх Соединения, которые модулируют рецептор св2
CN101547908A (zh) * 2006-10-05 2009-09-30 詹森药业有限公司 杂环衍生的金属蛋白酶抑制剂
US7879911B2 (en) 2007-02-01 2011-02-01 Johnson Alan T Hydroxamic acid derivatives of phenoxy-acetic acids and analogs useful as therapeutic agents for treating anthrax poisoning
WO2009061652A1 (en) 2007-11-07 2009-05-14 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
WO2010005782A1 (en) 2008-07-10 2010-01-14 Boehringer Ingelheim International Gmbh Sulfone compounds which modulate the cb2 receptor
BRPI0919024A2 (pt) 2008-09-25 2019-09-24 Boehringer Ingelheim Int compostos que seletivamente modulam o receptor cb2
US8299103B2 (en) 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
US8383615B2 (en) 2009-06-16 2013-02-26 Boehringer Ingelheim International Gmbh Azetidine 2-carboxamide derivatives which modulate the CB2 receptor
EP2480544A1 (en) 2009-09-22 2012-08-01 Boehringer Ingelheim International GmbH Compounds which selectively modulate the cb2 receptor
TWI517850B (zh) 2009-09-30 2016-01-21 Ｖｔｖ治療有限責任公司 經取代之咪唑衍生物及其使用方法
WO2011045703A2 (en) * 2009-10-13 2011-04-21 Pfizer Inc. C-linked hydroxamic acid derivatives useful as antibacterial agents
US9315454B2 (en) 2010-01-15 2016-04-19 Boehringer Ingelheim International Gmbh Compounds which modulate the CB2 receptor
EP2542539B1 (en) 2010-03-05 2014-02-26 Boehringer Ingelheim International GmbH Tetrazole compounds which selectively modulate the cb2 receptor
EP2595959B1 (en) 2010-07-22 2015-11-04 Boehringer Ingelheim International GmbH Sulfonyl compounds which modulate the cb2 receptor
SG188545A1 (en) * 2010-09-17 2013-04-30 Univ Tokyo Composition for maintaining function of platelets
WO2014012964A1 (en) * 2012-07-18 2014-01-23 Proyecto De Biomedicina Cima, S.L. New antifibrinolytic compounds
EP2803668A1 (en) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
ES2687040T3 (es) 2014-05-16 2018-10-23 Idorsia Pharmaceuticals Ltd Derivados antibacterianos de quinazolin–4(3H)–ona
CN107188837B (zh) * 2017-06-06 2019-05-28 温州大学 一种α-酰基高烯丙基硫醚类化合物的合成方法
BR112021006407A8 (pt) 2018-10-04 2022-12-06 Inst Nat Sante Rech Med uso de inibidores do egfr para ceratodermas

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50121218A (sh) * 1974-03-01 1975-09-23
DE2424742C3 (de) * 1974-05-21 1982-04-22 Schering Ag, 1000 Berlin Und 4619 Bergkamen Thiophenderivate Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US3994997A (en) * 1975-05-09 1976-11-30 Gulf Oil Corporation O,O-diethyl-O-carboxamidophosphate esters
GB1520812A (en) * 1975-10-02 1978-08-09 Lafon Labor Benzhydrylsulphinyl derivatives
GB1574822A (en) * 1976-03-23 1980-09-10 Lafon Labor Acetohydroxamic acid derivatives and pharmaceutical compositions thereof
FR2528041A1 (fr) * 1982-06-04 1983-12-09 Lafon Labor Acides halogenobenzhydrylsulfinylacetohydroxamiques, procede de preparation et utilisation en therapeutique
FR2561646B1 (fr) * 1984-03-23 1987-10-09 Lafon Labor Derives d'acide (a-(alkylaminomethyl)-benzyl)-thioacetique, procede de preparation et utilisation en therapeutique
IL92915A0 (en) * 1989-01-05 1990-09-17 Ciba Geigy Ag Certain pyrrolylphenyl-substituted hydroxamic acid derivatives
AU3899193A (en) * 1992-04-07 1993-11-08 British Bio-Technology Limited Hydroxamic acid based collagenase and cytokine inhibitors
US5455258A (en) * 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
FR2708201B1 (fr) * 1993-06-30 1995-10-20 Lafon Labor Utilisation de dérivés d'acétamide pour la fabrication de médicaments.
GB9416897D0 (en) * 1994-08-20 1994-10-12 British Biotech Pharm Metalloproteinase inhibitors
ES2184861T3 (es) * 1995-05-10 2003-04-16 Darwin Discovery Ltd Compuestos peptidicos inhibidores de la liberacion de la metaloproteinasa y del tnf y su utilizacion terapeutica.
US5665777A (en) * 1995-11-14 1997-09-09 Abbott Laboratories Biphenyl hydroxamate inhibitors of matrix metalloproteinases
WO1997024117A1 (en) * 1996-01-02 1997-07-10 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted (aryl, heteroaryl, arylmethyl or heteroarylmethyl) hydroxamic acid compounds

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GEP20022627B (en) 2002-02-25
ATE263554T1 (de) 2004-04-15
EP0973512A1 (en) 2000-01-26
NZ337298A (en) 2002-11-26
ES2217540T3 (es) 2004-11-01
BR9807802A (pt) 2000-03-21
HUP0001463A2 (hu) 2000-08-28
SK115899A3 (en) 2000-05-16
PT973512E (pt) 2004-07-30
CY2477B1 (en) 2005-06-03
NO994125D0 (no) 1999-08-26
EA001742B1 (ru) 2001-08-27
NO994124D0 (no) 1999-08-26
DK0970046T3 (da) 2004-04-13
WO1998037877A1 (en) 1998-09-03
EE04295B1 (et) 2004-06-15
DE69823019D1 (de) 2004-05-13
CN1210263C (zh) 2005-07-13
KR20000075809A (ko) 2000-12-26
GEP20022626B (en) 2002-02-25
WO1998038163A1 (en) 1998-09-03
DE69820424D1 (en) 2004-01-22
NO994124L (no) 1999-10-26
JP2001519777A (ja) 2001-10-23
AU748998B2 (en) 2002-06-13
NO314258B1 (no) 2003-02-24
ZA981625B (en) 1999-08-26
ZA981628B (en) 2000-02-28
ES2212274T3 (es) 2004-07-16
EA003836B1 (ru) 2003-10-30
DE69823019T2 (de) 2005-03-31
DK0973512T3 (da) 2004-07-12
EA199900768A1 (ru) 2000-08-28
CN1252790A (zh) 2000-05-10
IL131257A0 (en) 2001-01-28
CA2282655A1 (en) 1998-09-03
AU6436898A (en) 1998-09-18
EA199900769A1 (ru) 2000-04-24
TR199901901T2 (xx) 1999-12-21
PL335401A1 (en) 2000-04-25

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