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AR040928A1 - Compuestos de acidos sulfona-hidroxamicos aromaticos, composiciones farmaceuticas y su uso en la preparacion de medicamentos utiles como inhibidores de proteasas - Google Patents

Compuestos de acidos sulfona-hidroxamicos aromaticos, composiciones farmaceuticas y su uso en la preparacion de medicamentos utiles como inhibidores de proteasas

Info

Publication number
AR040928A1
AR040928A1 ARP020101724A ARP020101724A AR040928A1 AR 040928 A1 AR040928 A1 AR 040928A1 AR P020101724 A ARP020101724 A AR P020101724A AR P020101724 A ARP020101724 A AR P020101724A AR 040928 A1 AR040928 A1 AR 040928A1
Authority
AR
Argentina
Prior art keywords
group
alkyl
optionally substituted
thiocarbonyl
alkoxy
Prior art date
Application number
ARP020101724A
Other languages
English (en)
Inventor
John N Freskos
Yvette M Fobian
Thomas E Barta
Daniel P Becker
Louis J Bedell
Terri L Boehm
Susan L Hockerman
Darren J Kassab
Joseph J Mcdonald
Monica B Norton
Joseph G Rico
John J Talley
Clara I Villamil
Lei Wang
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of AR040928A1 publication Critical patent/AR040928A1/es

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

Compuestos que inhiben la actividad de metaloproteinasa de matriz (también conocidas como "metalproteasa de matriz" o "MMP") y/o la actividad de la agrecanasa. También se describen las composiciones farmacéuticas que los comprenden y el uso de dichos compuestos en la preparación de un medicamento para el tratamiento de un animal, particularmente un animal afectado (o con predisposición a ser afectado) por una condición patológica que se puede tratar inhibiendo la actividad de la metaloproteasa de matriz. Reivindicación 1: Un compuesto o sal del mismo caracterizado porque: el compuesto corresponde en estructura a la fórmula (1): y A1 se selecciona del grupo formado por -H, alquilcarbonilo, alcoxicarbonilo, carbociclilcarbonilo, carbociclilalquilcarbonilo, heterociclilcarbonilo,, heterociclilalquilcarbonilo, carbocicliloxicarbonilo, carbociclilalcoxicarbonilo, aminoalquilcarbonilo, alquil(tiocarbonilo), alcoxi(tiocarbonilo), carbociclil(tiocarbonilo), carbociclilalquil(tiocarbonilo), heterociclil(tiocarbonilo), heterociclilalquil(tiocarbonilo), carbocicliloxi(tiocarbonilo), carbociclilalcoxi(tiocarbonilo), y aminoalquil(tiocarbonilo), donde cualquier miembro de dicho grupo es optativamente sustituido; y A2 y A3, junto con el átomo de carbono al cual ambos están unidos, forman un heterociclilo optativamente sustituido que contiene entre 5 y 8 miembros en el anillo; y E1 se selecciona del grupo formado por -O-, -S(O)2-, S(O)-, -S-, -N(R1)-, -C(O)-N(R1)-, -N(R1)-C(O)-, y -C(R1)(R2)-; y E2 se selecciona del grupo formado por alquilo, cicloalquilo, alquilcicloalquilo, cicloalquilalquilo, y alquilcicloalquilquilalquilo donde cualquier miembro de dicho grupo es optativamente sustituido; y E2 forma un enlace de al menos 2 átomos de carbono entre E1 y E3; E3 se selecciona del grupo formado por -C(O)-, -O-(CO)-, -C(O)-O-, -C(NR3)-, -N(R4)-, -N(R4)-C(NR3)-, C(NR3)-N(R4)-, -C(O)-N(R4)-, -N(R4)-C(O)-, -N(R4)-C(O)-N(R5)-, -S-, -S(O)-, -N(R4)-S(O)2-, -S(O)2-N(R4)-, -C(O)-N(R4)-N(R5)-, -C(O)-, -C(R4)(R6)-C(O)-, -C(R7)(R8)-; y E4 se selecciona del grupo formado por un enlace, alquilo, y alquenilo donde el aquilo o alquenilo es optativamente sustituido; y E5 se selecciona del grupo formado por -OH, alquenilo, alquinilo, alcoxi, alcoxialquilo, carbociclilo, y heterociclilo donde cualquier miembro de dicho grupo es optativamente sustituido; y R1 y R2 se seleccionan independientemente del grupo formado por - H y alquilo donde el alquilo es optativamente sustituido; y R3 se selecciona del grupo formado por -H y -OH; y R4 y R5 se selecciona independientemente del grupo formado por - H, alquilo, carbociclilo, carbociclilalquilo, heterociclilo, y heterociclilalquilo donde cualquier miembro de dicho grupo es optativamente sustituido; y R6 se selecciona del grupo formado por-CN y -OH; y R7 se selecciona del grupo formado por -H, halógeno, -OH, alquilo, alcoxi, y alcoxialquilo donde el alquilo, alcoxi, o alcoxialquilo es optativamente sustituido; y R8 se selecciona del grupo formado por -OH y alcoxi donde el alcoxi es optativamente sustituido; y ni R1 ni R2 forman una estructura de anillo con E2, E3, E4, o E5; y ni R4 ni R5 forman una estructura de anillo con E2, E4, oE5.
ARP020101724A 2001-05-11 2002-05-10 Compuestos de acidos sulfona-hidroxamicos aromaticos, composiciones farmaceuticas y su uso en la preparacion de medicamentos utiles como inhibidores de proteasas AR040928A1 (es)

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Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL341379A1 (en) * 1997-11-14 2001-04-09 Searle & Co Aromatic sulphone substituted hydroxamic acid as inhibitor of metalloprotease
GB9901147D0 (en) * 1999-01-19 1999-03-10 Merck Sharp & Dohme Therapeutic agents
US6683093B2 (en) * 2000-05-12 2004-01-27 Pharmacia Corporation Aromatic sulfone hydroxamic acids and their use as protease inhibitors
US20040024024A1 (en) * 2001-05-11 2004-02-05 Freskos John N. Aromatic sulfone hydroxamates and their use as protease inhibitors
US20050209278A1 (en) * 2002-04-25 2005-09-22 Mcdonald Joseph J Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors
MXPA04010555A (es) 2002-04-25 2005-02-17 Pharmacia Corp Acidos piperidinil- y piperazinil-sulfonilmetil hidroxamicos y su uso como inhibidores de proteasa.
AU2003277878A1 (en) * 2002-06-25 2004-01-06 Pharmacia Corporation Arylsulfonylhydroxamic acid and amide derivatives and their use as protease inhibitors
ES2537514T3 (es) 2003-04-04 2015-06-09 Incyte Corporation Composiciones, métodos y kits relacionados con la escisión de HER-2
WO2004098582A2 (en) * 2003-05-07 2004-11-18 The University Court Of The University Of Aberdeen Ketones and reduced ketones as therapeutic agents for the treatment of bone conditions
CN1901971A (zh) * 2003-12-15 2007-01-24 日本烟草产业株式会社 环丙烷化合物及其药物应用
WO2005061448A1 (en) * 2003-12-24 2005-07-07 Monash University Compositions and methods for treating vascular conditions
US20050250789A1 (en) * 2004-04-20 2005-11-10 Burns David M Hydroxamic acid derivatives as metalloprotease inhibitors
US7709516B2 (en) * 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
SG177221A1 (en) 2006-12-15 2012-01-30 Abbott Lab Novel oxadiazole compounds
SG11201501036RA (en) 2012-08-23 2015-03-30 Alios Biopharma Inc Compounds for the treatment of paramoxyvirus viral infections
MX2016016507A (es) 2014-06-12 2017-04-27 Cedars Sinai Medical Center Composiciones y metodos para tratar canceres.
CN104292180A (zh) * 2014-10-12 2015-01-21 湖南华腾制药有限公司 一种恶二唑衍生物的制备方法
EP3676260B1 (en) * 2017-08-31 2024-10-30 Ahammune Biosciences Private Limited Thiophene compounds, process for synthesis and use thereof for the treatment of autoimmune disorders
KR102533605B1 (ko) * 2018-01-10 2023-05-17 주식회사 라이조테크 신규한 페닐설포닐 옥사졸 유도체 및 이의 용도
JP2024528329A (ja) * 2021-07-28 2024-07-26 ユニバーシティ オブ クワズル－ナタル メタロ－β－ラクタマーゼ阻害剤
CN117800921B (zh) * 2024-02-28 2024-06-11 南京市鸿舜医药科技有限公司 一种咪唑烷二酮类hdac抑制剂、制备方法及应用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595700A (en) 1984-12-21 1986-06-17 G. D. Searle & Co. Thiol based collagenase inhibitors
US4882434A (en) 1986-10-29 1989-11-21 Takeda Chemical Industries, Ltd. Gamma-lactonecarboxylic acid derivatives and their use as antibacterial agents or intermediates
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
JP3122161B2 (ja) 1991-05-16 2001-01-09 武田薬品工業株式会社 γ−ラクトン免疫抑制剤
EP0634998B1 (en) 1992-04-07 1997-03-19 British Biotech Pharmaceuticals Limited Hydroxamic acid based collagenase and cytokine inhibitors
US5376664A (en) 1992-07-27 1994-12-27 The Du Pont Merck Pharmaceutical Company Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents
US5455258A (en) 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
GB9307956D0 (en) 1993-04-17 1993-06-02 Walls Alan J Hydroxamic acid derivatives
GB9320660D0 (en) 1993-10-07 1993-11-24 British Bio Technology Inhibition of cytokine production
GB9323165D0 (en) 1993-11-10 1994-01-05 Chiros Ltd Compounds
WO1995029892A1 (en) 1994-04-28 1995-11-09 The Du Pont Merck Pharmaceutical Company Hydroxamic acid and amino acid derivatives and their use as anti-arthritic agents
GB9416897D0 (en) 1994-08-20 1994-10-12 British Biotech Pharm Metalloproteinase inhibitors
AU695796B2 (en) 1994-10-05 1998-08-20 Darwin Discovery Limited Peptidyl compounds and their therapeutic use as inhibitors of metalloproteases
IL134816A (en) 1995-12-08 2003-02-12 Agouron Pharma Substituted diarylether sulfonic acids and their preparation
DK0780386T3 (da) 1995-12-20 2003-02-03 Hoffmann La Roche Matrixmetalloproteaseinhibitorer
JP4358908B2 (ja) 1996-01-02 2009-11-04 アヴェンティス ファーマシューティカルズ インコーポレイテッド 置換（アリール、ヘテロアリール、アリールメチル又はヘテロアリールメチル）ヒドロキサム酸化合物
KR20000022532A (ko) 1996-06-27 2000-04-25 오노 야꾸힝 고교 가부시키가이샤 아릴(설파이드, 설폭시드 및 설폰)유도체 및 이를 활성 성분으로 함유하는 약물
IL128079A0 (en) 1996-07-22 1999-11-30 Monsanto Co Thiol sulfone metalloprotease inhibitors
PL335401A1 (en) 1997-02-27 2000-04-25 American Cyanamid Co N-hydroxy-2-(alkyl, aryl or heteroaryl sulphanyl, sulphinyn of sulphonyl)-3-substituted alkyl, aryl or heteroaryl amides as inhibotors of intercellular substance metaloproteinases
US6300514B1 (en) 1997-06-25 2001-10-09 Ono Pharmaceutical Co., Ltd. Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient
HRP980443A2 (en) 1997-08-18 1999-10-31 Carl P. Decicco Novel inhibitors of aggrecanase and matrix metalloproteinases for the treatment of arthritis
US20010039287A1 (en) * 1997-11-14 2001-11-08 Thomas E Barta Aromatic sulfone hydroxamic acid metalloprotease inhibitor
PL341379A1 (en) 1997-11-14 2001-04-09 Searle & Co Aromatic sulphone substituted hydroxamic acid as inhibitor of metalloprotease
US6750228B1 (en) * 1997-11-14 2004-06-15 Pharmacia Corporation Aromatic sulfone hydroxamic acid metalloprotease inhibitor
IL127496A0 (en) 1997-12-19 1999-10-28 Pfizer Prod Inc The use of MMP inhibitors for the treatment of ocular angiogenesis
JP2002503717A (ja) 1998-02-19 2002-02-05 アメリカン・サイアナミド・カンパニー マトリクス金属プロテイナーゼ阻害薬としてのｎ−ヒドロキシ−２−（アルキル、アリールまたはヘテロアリールスルファニル、スルフィニルまたはスルホニル）−３−置換−アルキル、アリールまたはヘテロアリールアミド
CA2362230A1 (en) 1999-02-08 2000-08-10 G.D. Searle & Co. Sulfamato hydroxamic acid metalloprotease inhibitor
EP1165500A1 (en) 1999-04-02 2002-01-02 Du Pont Pharmaceuticals Company Amide derivatives as inhibitors of matrix metalloproteinases,tnf-alpha,and aggrecanase
EP1081137A1 (en) 1999-08-12 2001-03-07 Pfizer Products Inc. Selective inhibitors of aggrecanase in osteoarthritis treatment
US6683093B2 (en) 2000-05-12 2004-01-27 Pharmacia Corporation Aromatic sulfone hydroxamic acids and their use as protease inhibitors

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