YU151691A - 3-aril-4(3h)hinazolinon cck antagonisti - Google Patents
3-aril-4(3h)hinazolinon cck antagonistiInfo
- Publication number
- YU151691A YU151691A YU151691A YU151691A YU151691A YU 151691 A YU151691 A YU 151691A YU 151691 A YU151691 A YU 151691A YU 151691 A YU151691 A YU 151691A YU 151691 A YU151691 A YU 151691A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- hydrogen
- halo
- hinazolinon
- aril
- benzyl
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 150000002431 hydrogen Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- 125000006833 (C1-C5) alkylene group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- -1 methylenedioxy Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Opisano je jedinjenje formule u kome n je 1 ili 2 i m je = ili 1; R je vodonik, C1-C4alkil, benzil, ili fenil; Z je vodonik ili halo; X2,X3,X4 i X5 su vodonik, halo, tri-fluorometil, C1-C6 alkoksi, C1-C5 alkil, C1-C6 alkiltio, i -NR2R3, gde R2 i R3 su nezavisno vodonik, C1-C4 alkil, benzil, ili fenil, ili R2 i R3 uzeti zajedno sa atomom azota za koji su vezani obrazuju 5-ili 6-tročlani prsten; ili Xr i Xr+1, gde r je 2,3, ili 4, uzeti zajedno obrazuju dvovalentnu C -C5 alkilen grupu ili metilendioksi; i Y5 i Y6 su vodonik, C1-C6 alkoksi, halo, i trifluorometil; i farmaceutski prihvatljive soli tog jedinjenja. Takodje su opisani postupci za dobijanje jedinjenja koja su predmet ovog pronalaska biološki aktivnih supstituisanih hinazolinona.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/581,943 US5075313A (en) | 1990-09-13 | 1990-09-13 | 3-aryl-4(3H)quinazolinone CCK antagonists and pharmaceutical formulations thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU151691A true YU151691A (sh) | 1994-01-20 |
Family
ID=24327210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU151691A YU151691A (sh) | 1990-09-13 | 1991-09-11 | 3-aril-4(3h)hinazolinon cck antagonisti |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5075313A (sh) |
| EP (1) | EP0475755B1 (sh) |
| JP (1) | JPH04247080A (sh) |
| KR (1) | KR920006350A (sh) |
| CN (1) | CN1059722A (sh) |
| AU (1) | AU641043B2 (sh) |
| CA (1) | CA2050994A1 (sh) |
| CZ (1) | CZ279774B6 (sh) |
| DE (1) | DE69113379T2 (sh) |
| ES (1) | ES2078455T3 (sh) |
| FI (1) | FI914262L (sh) |
| HU (1) | HUT59128A (sh) |
| IE (1) | IE913217A1 (sh) |
| IL (1) | IL99402A0 (sh) |
| MX (1) | MX9101035A (sh) |
| NO (1) | NO913579L (sh) |
| NZ (1) | NZ239712A (sh) |
| PT (1) | PT98915A (sh) |
| YU (1) | YU151691A (sh) |
| ZA (1) | ZA917149B (sh) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5340801A (en) * | 1991-05-08 | 1994-08-23 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having cholecystokinin and gastrin antagonistic properties |
| US5204354A (en) * | 1992-02-14 | 1993-04-20 | Merck & Co., Inc. | Substituted quinazolinones as neurotensin antagonists useful in the treatment of CNS disorders |
| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| GB0031315D0 (en) * | 2000-12-21 | 2001-02-07 | Glaxo Group Ltd | Indole derivatives |
| US7417039B2 (en) | 2001-01-26 | 2008-08-26 | Schering Corporation | Use of substituted azetidinone compounds for the treatment of sitosterolemia |
| CN100509058C (zh) | 2001-01-26 | 2009-07-08 | 先灵公司 | 过氧化物酶体增殖物激活受体(ppar)活化剂和甾醇吸收抑制剂的组合药以及对于血管适应症的治疗 |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| US7132415B2 (en) | 2001-09-21 | 2006-11-07 | Schering Corporation | Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors |
| CA2504878A1 (en) | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorption inhibitors for the treatment of demyelination |
| JP2006519869A (ja) | 2003-03-07 | 2006-08-31 | シェーリング コーポレイション | 置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用 |
| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| JP5137228B2 (ja) | 2003-03-07 | 2013-02-06 | メルク・シャープ・アンド・ドーム・コーポレーション | 高コレステロール血症の処置のための置換アゼチジノン化合物、置換アゼチジノン処方物およびそれらの使用 |
| MXPA05009501A (es) | 2003-03-07 | 2005-10-18 | Schering Corp | Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia. |
| BRPI0412684A (pt) | 2003-07-17 | 2006-10-03 | Plexxinko Inc | compostos ppar-ativos |
| US7348338B2 (en) * | 2003-07-17 | 2008-03-25 | Plexxikon, Inc. | PPAR active compounds |
| GB0319126D0 (en) * | 2003-08-14 | 2003-09-17 | Smithkline Beecham Corp | Chemical compounds |
| AU2005311826A1 (en) * | 2004-11-30 | 2006-06-08 | Plexxikon, Inc. | Indole derivatives for use as PPAR active compounds |
| AU2005311925A1 (en) * | 2004-11-30 | 2006-06-08 | Plexxikon, Inc. | Indole derivatives for use as PPAR PPAR active compounds |
| BRPI0615948A2 (pt) * | 2005-09-07 | 2011-05-31 | Plexxikon Inc | composto ativo de ppar, sua composição, seu kit e seu uso |
| JP2009509932A (ja) * | 2005-09-07 | 2009-03-12 | プレキシコン，インコーポレーテッド | Ｐｐａｒ活性化合物 |
| CA2628441A1 (en) * | 2005-11-04 | 2007-05-18 | Hydra Biosciences, Inc. | Compounds for modulating trpv3 function |
| PE20090159A1 (es) * | 2007-03-08 | 2009-02-21 | Plexxikon Inc | COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs |
| JP2023512664A (ja) | 2020-01-29 | 2023-03-28 | カマリ ファーマ リミテッド | 皮膚障害の治療に使用するための化合物及び組成物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ192392A (en) * | 1978-12-19 | 1983-02-15 | M Ishikawa | 3-(substituted (phenyl or pyridyl)) -3,4-dihydroquinazolin-4-ones |
| WO1989010355A1 (en) * | 1988-04-05 | 1989-11-02 | Abbott Laboratories | Derivatives of tryptophan as cck antagonists |
-
1990
- 1990-09-13 US US07/581,943 patent/US5075313A/en not_active Expired - Fee Related
-
1991
- 1991-09-04 IL IL99402A patent/IL99402A0/xx unknown
- 1991-09-09 CA CA002050994A patent/CA2050994A1/en not_active Abandoned
- 1991-09-09 NZ NZ239712A patent/NZ239712A/xx unknown
- 1991-09-09 ZA ZA917149A patent/ZA917149B/xx unknown
- 1991-09-09 JP JP3227902A patent/JPH04247080A/ja active Pending
- 1991-09-10 FI FI914262A patent/FI914262L/fi unknown
- 1991-09-10 PT PT98915A patent/PT98915A/pt not_active Application Discontinuation
- 1991-09-10 HU HU912921A patent/HUT59128A/hu unknown
- 1991-09-11 AU AU83829/91A patent/AU641043B2/en not_active Ceased
- 1991-09-11 CZ CS912799A patent/CZ279774B6/cs unknown
- 1991-09-11 KR KR1019910015830A patent/KR920006350A/ko not_active Application Discontinuation
- 1991-09-11 MX MX9101035A patent/MX9101035A/es unknown
- 1991-09-11 YU YU151691A patent/YU151691A/sh unknown
- 1991-09-11 NO NO91913579A patent/NO913579L/no unknown
- 1991-09-12 DE DE69113379T patent/DE69113379T2/de not_active Expired - Fee Related
- 1991-09-12 ES ES91308324T patent/ES2078455T3/es not_active Expired - Lifetime
- 1991-09-12 CN CN91108887A patent/CN1059722A/zh active Pending
- 1991-09-12 IE IE321791A patent/IE913217A1/en unknown
- 1991-09-12 EP EP91308324A patent/EP0475755B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69113379D1 (de) | 1995-11-02 |
| AU641043B2 (en) | 1993-09-09 |
| CN1059722A (zh) | 1992-03-25 |
| HUT59128A (en) | 1992-04-28 |
| CZ279774B6 (cs) | 1995-06-14 |
| CS279991A3 (en) | 1992-04-15 |
| US5075313A (en) | 1991-12-24 |
| FI914262A0 (fi) | 1991-09-10 |
| EP0475755B1 (en) | 1995-09-27 |
| NO913579L (no) | 1992-03-16 |
| PT98915A (pt) | 1992-08-31 |
| IE913217A1 (en) | 1992-02-25 |
| IL99402A0 (en) | 1992-08-18 |
| DE69113379T2 (de) | 1996-03-21 |
| ZA917149B (en) | 1992-05-27 |
| KR920006350A (ko) | 1992-04-27 |
| NZ239712A (en) | 1993-06-25 |
| FI914262L (fi) | 1992-03-14 |
| JPH04247080A (ja) | 1992-09-03 |
| EP0475755A1 (en) | 1992-03-18 |
| ES2078455T3 (es) | 1995-12-16 |
| CA2050994A1 (en) | 1992-03-14 |
| AU8382991A (en) | 1992-03-19 |
| NO913579D0 (no) | 1991-09-11 |
| MX9101035A (es) | 1992-05-04 |
| HU912921D0 (en) | 1992-01-28 |
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