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KR920006350A - 3-아릴-4(3h)퀴나졸리논 cck 길항물질 및 그의 약학 조성물 - Google Patents

3-아릴-4(3h)퀴나졸리논 cck 길항물질 및 그의 약학 조성물 Download PDF

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Publication number
KR920006350A
KR920006350A KR1019910015830A KR910015830A KR920006350A KR 920006350 A KR920006350 A KR 920006350A KR 1019910015830 A KR1019910015830 A KR 1019910015830A KR 910015830 A KR910015830 A KR 910015830A KR 920006350 A KR920006350 A KR 920006350A
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South Korea
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compound
hydrogen
alkyl
alkoxy
halo
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KR1019910015830A
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레이 맥코완 제퍼슨
제프 트래셔 케네쓰
조셉 유 멜빈
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리로이 휘테커
일라이 릴리 앤드 캄파니
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Publication of KR920006350A publication Critical patent/KR920006350A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

3-아릴-4(3H)퀴나졸리논 CCK 길항물질 및 그의 약학 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (29)

  1. 하기 일반식(Ⅰ)의 화합물 및 그의 약학적으로 허용되는 염;
    상기 식에서 n은 1 또는 2이고; m은 0 또는 1이며, R은 수소, C1-C4알킬, 벤질 또는 페닐이고; Z는 수소, 또는 할로이며, X2, X3, X4및 X5는 독립적으로 수소, 할로, 트리플루오로 메틸, C1-C6알콕시, C1-C6알킬, C1-C6알킬티오 및 -NR2R3(여기서, R2및 R3는 독립적으로 수소, C1-C4알킬, 벤질 또는 페닐이거나, 또는 R2및 R3는 그들이 결합된 질소원자와 함께 5-또는 6-원 고리를 형성한다)로 이루어진 그룹중에서 선택되거나, 또는 XrXr+1(여기서, r은 2, 3또는 4이다)은 함께 2가의 C3-C5알킬렌 그룹 또는 메틸렌디옥시를 형성하고, Y5및 Y6는 독립적으로 수소, C1-C6알킬, C1-C6알콕시, 할로 및 트리풀루오로메틸로 이루어진 그룹 중에서 선택된다.
  2. 제1항에 있어서, Z가 수소인 화합물.
  3. 제2항에 있어서, m이 0이고 n이 2인 화합물.
  4. 제3항에 있어서, Y5가 수소, C1-C6알킬, C1-C6알콕시 또는 할로이고, Y6가 수소인 화합물.
  5. 제4항에 있어서, Y5가 할로, 메톡시 또는 메틸인 화합물.
  6. 제4항에 있어서, X2, X3, X4및 X5중 적어도 2개가 수소인 화합물.
  7. 제6항에 있어서, X3가 C1-C6알킬인 화합물.
  8. 제6항에 있어서, X3가 C1-C6알콕시인 화합물.
  9. 제1항에 있어서, m이 0이고 n이 2인 화합물.
  10. 제1항에 있어서, Y5가 수소, C1-C6알킬, C1-C6알콕시 또는 할로 이고, Y6가 수소인 화합물.
  11. 제1항에 있어서, X2,X3,X4및 X5중 적어도 2개가 수소인 화합물.
  12. 제1항에 있어서, X2, X4및 X5가 수소이고, X3가 C1-C6알킬인 화합물.
  13. 제1항에 있어서, X2, X4및 X5가 수소이고, X3가 C1-C6알콕시인 화합물.
  14. 제6항에 있어서, X2, X4및 X5가 수소인 화합물.
  15. 제14항에 있어서, X3가 이소프로폭시인 화합물.
  16. 제15항에 있어서, Y5가 수소인 화합물.
  17. 제15항에 있어서 Y5가 클로로인 화합물.
  18. 제15항에 있어서 Y5가 플루오로인 화합물.
  19. 제15항에 있어서 Y5가 브로모인 화합물.
  20. 제1항에 있어서 Z가 할로인 화합물.
  21. 제20항에 있어서 Z가 클로로인 화합물.
  22. 제21항에 있어서, m이 0이고 n이 2인 화합물.
  23. 제22항에 있어서, Y5가 클로로 또는 브로모인 화합물.
  24. 제23항에 있어서, X3가 C1-C6알콕시이고, X2, X4및 X5가 수소인 화합물.
  25. 제1항에 있어서, m이 1이고, R이 메틸, 벤질 및 페닐로 이루어진 그룹 중에서 선택되는 화합물.
  26. 제25항에 있어서, n이 1인 화합물.
  27. 제26항에 있어서, Y5가 수소 또는 브로모이고, Y6가 수소인 화합물.
  28. 제27항에 있어서, X3가 C1-C6알킬 또는 C1-C6알콕시이고, X2, X4및 X5가 수소인 화합물.
  29. 활성성분으로서 제1항 내지 제28항중 어느 한 항에 따르는 화합물을 약학적으로 허용되는 담체, 부형제 또는 희석제 하나 이상과 함께 포함하는, CCK 및 가스트린 길항 활성을 갖는 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910015830A 1990-09-13 1991-09-11 3-아릴-4(3h)퀴나졸리논 cck 길항물질 및 그의 약학 조성물 KR920006350A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/581,943 1990-09-13
US07/581,943 US5075313A (en) 1990-09-13 1990-09-13 3-aryl-4(3H)quinazolinone CCK antagonists and pharmaceutical formulations thereof

Publications (1)

Publication Number Publication Date
KR920006350A true KR920006350A (ko) 1992-04-27

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KR1019910015830A KR920006350A (ko) 1990-09-13 1991-09-11 3-아릴-4(3h)퀴나졸리논 cck 길항물질 및 그의 약학 조성물

Country Status (20)

Country Link
US (1) US5075313A (ko)
EP (1) EP0475755B1 (ko)
JP (1) JPH04247080A (ko)
KR (1) KR920006350A (ko)
CN (1) CN1059722A (ko)
AU (1) AU641043B2 (ko)
CA (1) CA2050994A1 (ko)
CZ (1) CZ279774B6 (ko)
DE (1) DE69113379T2 (ko)
ES (1) ES2078455T3 (ko)
FI (1) FI914262L (ko)
HU (1) HUT59128A (ko)
IE (1) IE913217A1 (ko)
IL (1) IL99402A0 (ko)
MX (1) MX9101035A (ko)
NO (1) NO913579L (ko)
NZ (1) NZ239712A (ko)
PT (1) PT98915A (ko)
YU (1) YU151691A (ko)
ZA (1) ZA917149B (ko)

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US5204354A (en) * 1992-02-14 1993-04-20 Merck & Co., Inc. Substituted quinazolinones as neurotensin antagonists useful in the treatment of CNS disorders
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
GB0031315D0 (en) * 2000-12-21 2001-02-07 Glaxo Group Ltd Indole derivatives
US7417039B2 (en) 2001-01-26 2008-08-26 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
CN100509058C (zh) 2001-01-26 2009-07-08 先灵公司 过氧化物酶体增殖物激活受体(ppar)活化剂和甾醇吸收抑制剂的组合药以及对于血管适应症的治疗
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US7132415B2 (en) 2001-09-21 2006-11-07 Schering Corporation Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors
CA2504878A1 (en) 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorption inhibitors for the treatment of demyelination
JP2006519869A (ja) 2003-03-07 2006-08-31 シェーリング　コーポレイション 置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用
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JP5137228B2 (ja) 2003-03-07 2013-02-06 メルク・シャープ・アンド・ドーム・コーポレーション 高コレステロール血症の処置のための置換アゼチジノン化合物、置換アゼチジノン処方物およびそれらの使用
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BRPI0615948A2 (pt) * 2005-09-07 2011-05-31 Plexxikon Inc composto ativo de ppar, sua composição, seu kit e seu uso
JP2009509932A (ja) * 2005-09-07 2009-03-12 プレキシコン，インコーポレーテッド Ｐｐａｒ活性化合物
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PE20090159A1 (es) * 2007-03-08 2009-02-21 Plexxikon Inc COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
JP2023512664A (ja) 2020-01-29 2023-03-28 カマリ ファーマ リミテッド 皮膚障害の治療に使用するための化合物及び組成物

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Also Published As

Publication number Publication date
DE69113379D1 (de) 1995-11-02
AU641043B2 (en) 1993-09-09
CN1059722A (zh) 1992-03-25
HUT59128A (en) 1992-04-28
YU151691A (sh) 1994-01-20
CZ279774B6 (cs) 1995-06-14
CS279991A3 (en) 1992-04-15
US5075313A (en) 1991-12-24
FI914262A0 (fi) 1991-09-10
EP0475755B1 (en) 1995-09-27
NO913579L (no) 1992-03-16
PT98915A (pt) 1992-08-31
IE913217A1 (en) 1992-02-25
IL99402A0 (en) 1992-08-18
DE69113379T2 (de) 1996-03-21
ZA917149B (en) 1992-05-27
NZ239712A (en) 1993-06-25
FI914262L (fi) 1992-03-14
JPH04247080A (ja) 1992-09-03
EP0475755A1 (en) 1992-03-18
ES2078455T3 (es) 1995-12-16
CA2050994A1 (en) 1992-03-14
AU8382991A (en) 1992-03-19
NO913579D0 (no) 1991-09-11
MX9101035A (es) 1992-05-04
HU912921D0 (en) 1992-01-28

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