WO2016080942A1 - Method for obtaining a pasty form of sorbent based on hydrogel o methylsilicic acid - Google Patents
Method for obtaining a pasty form of sorbent based on hydrogel o methylsilicic acid Download PDFInfo
- Publication number
- WO2016080942A1 WO2016080942A1 PCT/UA2016/000003 UA2016000003W WO2016080942A1 WO 2016080942 A1 WO2016080942 A1 WO 2016080942A1 UA 2016000003 W UA2016000003 W UA 2016000003W WO 2016080942 A1 WO2016080942 A1 WO 2016080942A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hydrogel
- methylsilicic acid
- sorbent
- obtaining
- methylsilicic
- Prior art date
Links
- FXSGDOZPBLGOIN-UHFFFAOYSA-N trihydroxy(methoxy)silane Chemical compound CO[Si](O)(O)O FXSGDOZPBLGOIN-UHFFFAOYSA-N 0.000 title claims abstract description 20
- 239000002594 sorbent Substances 0.000 title claims abstract description 19
- 238000000034 method Methods 0.000 title claims abstract description 18
- 239000000017 hydrogel Substances 0.000 title claims abstract description 17
- 235000011837 pasties Nutrition 0.000 title claims abstract description 11
- 239000002245 particle Substances 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000002904 solvent Substances 0.000 claims abstract description 7
- 235000020374 simple syrup Nutrition 0.000 claims abstract description 5
- 238000000227 grinding Methods 0.000 claims abstract description 4
- 239000003053 toxin Substances 0.000 abstract description 3
- 238000001179 sorption measurement Methods 0.000 description 17
- 239000000047 product Substances 0.000 description 16
- 230000000694 effects Effects 0.000 description 14
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 239000000499 gel Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 6
- 229940027941 immunoglobulin g Drugs 0.000 description 5
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 4
- IQFVPQOLBLOTPF-HKXUKFGYSA-L congo red Chemical compound [Na+].[Na+].C1=CC=CC2=C(N)C(/N=N/C3=CC=C(C=C3)C3=CC=C(C=C3)/N=N/C3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)N)=CC(S([O-])(=O)=O)=C21 IQFVPQOLBLOTPF-HKXUKFGYSA-L 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 235000019441 ethanol Nutrition 0.000 description 4
- 229960000907 methylthioninium chloride Drugs 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 3
- 239000007900 aqueous suspension Substances 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 3
- 239000008108 microcrystalline cellulose Substances 0.000 description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 235000012239 silicon dioxide Nutrition 0.000 description 3
- 231100000699 Bacterial toxin Toxicity 0.000 description 2
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 239000003463 adsorbent Substances 0.000 description 2
- 239000000688 bacterial toxin Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 230000035987 intoxication Effects 0.000 description 2
- 231100000566 intoxication Toxicity 0.000 description 2
- 150000002605 large molecules Chemical class 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 229940126601 medicinal product Drugs 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 206010021135 Hypovitaminosis Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 206010025476 Malabsorption Diseases 0.000 description 1
- 208000004155 Malabsorption Syndromes Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 239000002817 coal dust Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- ZZRGHKUNLAYDTC-UHFFFAOYSA-N ethoxy(methyl)silane Chemical compound CCO[SiH2]C ZZRGHKUNLAYDTC-UHFFFAOYSA-N 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Substances [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- STZCRXQWRGQSJD-GEEYTBSJSA-M methyl orange Chemical compound [Na+].C1=CC(N(C)C)=CC=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 STZCRXQWRGQSJD-GEEYTBSJSA-M 0.000 description 1
- 229940012189 methyl orange Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- -1 polymethylsiloxane Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000012088 reference solution Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/24—Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
- B01J20/28004—Sorbent size or size distribution, e.g. particle size
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
- B01J20/28057—Surface area, e.g. B.E.T specific surface area
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
- B01J20/28078—Pore diameter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/3021—Milling, crushing or grinding
Definitions
- the invention relates to a medical industry and refers to a method of obtaining organosilicon adsorbent in the form of paste, which can be used in medicine as enterosorbent to eliminate organic and toxic metabolites, in particularly having high molecular weight.
- Activated charcoal has been widely used as sorbent. (VIDAL Guideline. Medicinal products in Russia. - M.: OVPEE - Astra Pharm Service, 2000. - P.E-8). It is convenient to use, as it is produced in the form of tablets and powder and is used in chemical, food, pharmaceutical industry, as well as medicine.
- activated charcoal has significant deficiencies: small sorption activity and low selectivity of the sorption action, e.g., to cholesterol, bilirubin, urea, uric acid, which are usually removed from the body by excretory organs.
- the tablet form is convenient, but does not allow the intake of the required amount of sorbent per single administration: achievement of a therapeutic effect requires doses of 5-15 g, which corresponds to 25-75 tablets, which is naturally difficult for the patient to take at a time.
- activated charcoal in powder form is also difficult because it is dewetting or insoluble in water.
- Activated charcoal is contraindicated in ulcerative lesions of the gastrointestinal tract, stomach bleeding, for children.
- MCC microcrystalline cellulose
- Deficiencies unpleasant taste, gastrointestinal discomfort (constipation).
- Silicon dioxide powder has certain sorptive abilities .
- Polysorb inorganic multifunctional enterosorbent based on a highly dispersed silicon dioxide.
- the powder is used to prepare a suspension for oral administration.
- the use of drugs or food supplements in powder form is usually associated with great inconvenience compared with their use in a tablet form.
- RU,2234931 discloses an enterosorbent containing silicon dioxide in a tablet form.
- this enterosorbent contains lignin hydrolyzed and microcrystalline cellulose, which also have adsorption properties, as well as excipients used to obtain tablets, such as pectin, starch, and magnesium or calcium stearate.
- enterosorbent as a product of nonlinear condensation of methylsilicic acid (the chemical name - polymethylsiloxane polyhydrate), known under the trademark name- "Enterosgel” produced in a gel form.
- Various raw materials can be used as a source for gel synthesis.
- WO2011/075095 a method of obtaining methylsilicic acid hydrogel from methylethoxy silane (MTES) and aqueous ethanol with a volume portion of ethyl alcohol of 60 to 96.5%, which is treated with a hydro lyzing blend of hydrochloric acid and purified water.
- MTES methylethoxy silane
- aqueous ethanol with a volume portion of ethyl alcohol of 60 to 96.5%
- RU 2111979 discloses a method of obtaining an enterosorbent based on methylsilicic acid hydrogel as an adsorbent of medium molecular weight metabolites.
- Medium molecular weight metabolites are substances with a molecular weight of about 500-5000 Da; usually these are protein decomposition products that play an important role in intoxication phenomena.
- methylsilicic acid compounds According to the author's experiments, the ability of methylsilicic acid compounds to have affinity for substances of a particular mass depends on the physical state and particle size of the sorbent, as well as the solvent itself.
- WO 2008/036056 discloses a method of obtaining a sorbent based on methylsilicic acid hydrogel, where the sorbent with the general formula
- ⁇ (CH 3 SiOi.5)-nH 2 0 ⁇ can be produced as paste by varying n ratio, but the concrete Examples for obtaining such form are not described.
- the main object of the invention is obtaining a pasty form of the sorbent based on hydrogel of methylsilicic acid having a pronounced sorption properties in relation to high molecular weight substances.
- This object is achieved by the method wherein the synthesized hydrogel of methylsilicic acid is subjected to an additional mechanical processing, preferably in a rotor-type homogenizer, in a solvent for grinding of particles contained in the product to the desired size, preferably to the size of 10-200 ⁇ .
- water or sugar syrup may be used as the solvent.
- Target product output 36.7 70-85 %
- Adsorption activity (A) of the product, ⁇ /g was calculated by the formula:
- Adsorption activity for high molecular weight substances - immunoglobulin G (more than 100 000 Da) and bacterial toxin (more than 10 000 Da) was measured similarly).
- the pasty sorbent shows more marked activity in relation to high molecular weight compound, exceeding that of the gel in 1.5-1.83 times.
- Average particle size and adsorption activity was determined under the microscope.
- Particle size was 200 ⁇ , adsorption activity by methylene blue - 3.2 ⁇ /g, immunoglobulin G - 330.1 mg/g.
- Average particle size and adsorption activity was determined under the microscope.
- Particle size was 10 ⁇ , adsorption activity by methylene blue - 3.6 ⁇ /g, immunoglobulin G - 333.2 mg/g.
- Particle size was 10 ⁇ , adsorption activity by methylene blue - 3.0 ⁇ /g, immunoglobulin G - 330.1 mg/g.
- Average particle size and adsorption activity was determined under the microscope.
- Particle size was 10 ⁇ , adsorption activity by methylene blue - 2.7 ⁇ /g, immunoglobulin G - 318.1 mg/g.
- the pasty form of the sorbent based on methylsilicic acid hydrogel and obtained by the claimed method additionally has pronounced sorption properties in relation to high molecular weight substances.
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UAA201412487A UA112474C2 (uk) | 2014-11-20 | 2014-11-20 | Спосіб одержання пастоподібного сорбенту на основі гідрогелю метилкремнієвої кислоти |
| UAA201412487 | 2014-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2016080942A1 true WO2016080942A1 (en) | 2016-05-26 |
Family
ID=55358089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/UA2016/000003 WO2016080942A1 (en) | 2014-11-20 | 2016-01-12 | Method for obtaining a pasty form of sorbent based on hydrogel o methylsilicic acid |
Country Status (3)
| Country | Link |
|---|---|
| RU (1) | RU2014151576A (uk) |
| UA (1) | UA112474C2 (uk) |
| WO (1) | WO2016080942A1 (uk) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2111979C1 (ru) | 1994-03-11 | 1998-05-27 | Юрий Николаевич Шевченко | Гидрогели метилкремневой кислоты как адсорбенты среднемолекулярных метаболитов и способ их получения |
| RU2234931C2 (ru) | 2002-07-29 | 2004-08-27 | Пермская государственная фармацевтическая академия | Композиционный энтеросорбент и способ его приготовления |
| WO2008036056A1 (fr) | 2006-09-20 | 2008-03-27 | Zakryte Aktsionerne Tovarystvo 'ekologoohoronna Firma 'kreoma-Farm' | Procédé de fabrication d'un sorbant à base d'un hydrogel d'acide méthylsilicilique |
| WO2011075095A1 (ru) | 2009-12-16 | 2011-06-23 | Kabachnyi Gennadii Ivanovych | Способ получения гидрогеля метилкремниевой кислоты |
| US20130129659A1 (en) * | 2011-11-23 | 2013-05-23 | Vadim Kozlovskyi | Composite enterosorbent |
-
2014
- 2014-11-20 UA UAA201412487A patent/UA112474C2/uk unknown
- 2014-12-19 RU RU2014151576A patent/RU2014151576A/ru not_active Application Discontinuation
-
2016
- 2016-01-12 WO PCT/UA2016/000003 patent/WO2016080942A1/en active Application Filing
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2111979C1 (ru) | 1994-03-11 | 1998-05-27 | Юрий Николаевич Шевченко | Гидрогели метилкремневой кислоты как адсорбенты среднемолекулярных метаболитов и способ их получения |
| RU2234931C2 (ru) | 2002-07-29 | 2004-08-27 | Пермская государственная фармацевтическая академия | Композиционный энтеросорбент и способ его приготовления |
| WO2008036056A1 (fr) | 2006-09-20 | 2008-03-27 | Zakryte Aktsionerne Tovarystvo 'ekologoohoronna Firma 'kreoma-Farm' | Procédé de fabrication d'un sorbant à base d'un hydrogel d'acide méthylsilicilique |
| EP2075276A1 (en) * | 2006-09-20 | 2009-07-01 | Zakryte Aktsionerne Tovarystvo "Ekologoohoronna" Firma "Kreoma-Farm" | Method for producing a sorbent based on a methyl- silicic acid hydrogel |
| WO2011075095A1 (ru) | 2009-12-16 | 2011-06-23 | Kabachnyi Gennadii Ivanovych | Способ получения гидрогеля метилкремниевой кислоты |
| US20130129659A1 (en) * | 2011-11-23 | 2013-05-23 | Vadim Kozlovskyi | Composite enterosorbent |
Non-Patent Citations (3)
| Title |
|---|
| "Marketing Authorization of the Ministry of Health of the Russian Federation P 97.128.5", STATE REGISTRY OF MEDICINAL PRODUCTS, 2000, pages 102 |
| "VIDAL Guideline. Medicinal products in Russia", M.: OVPEE - ASTRA PHARM SERVICE, 2000 |
| YASHINA ET AL: "Sol-Gel Technology of the Mesoporous Methylsilicic Acid Hydrogel: Medicine Aspects of Globular Porous Organosilicon Materials Application", PROCEEDINGS OF THE NATO ADVANCED RESEARCH WORKSHOP ON SOL-GEL APPROACHES TO MATERIALS FOR POLLUTION CONTROL, WATER PURIFICATION AND SOIL REMEDIATION, KYIV, UKRAINE, 25 - 27 OCTOBER 2007,, 2008, pages 481 - 488, XP009169386, ISBN: 978-1-4020-8522-2 * |
Also Published As
| Publication number | Publication date |
|---|---|
| UA112474C2 (uk) | 2016-09-12 |
| RU2014151576A (ru) | 2016-07-10 |
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