WO1996013593A3 - Soluble single chain t cell receptors - Google Patents
Soluble single chain t cell receptors Download PDFInfo
- Publication number
- WO1996013593A3 WO1996013593A3 PCT/US1995/013770 US9513770W WO9613593A3 WO 1996013593 A3 WO1996013593 A3 WO 1996013593A3 US 9513770 W US9513770 W US 9513770W WO 9613593 A3 WO9613593 A3 WO 9613593A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tcr
- single chain
- fusion protein
- soluble
- proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
A fusion protein, comprising a carrier protein connected by a peptide tether to a single chain T cell receptor molecule, consisting of a Vα segment linked to a Vβ segment of the T cell receptor, is disclosed. Also disclosed is a soluble single chain T cell receptor molecule with a conformation that is essentially functionally indistinguishable, based upon reactivity to clonotype-specific antibodies, from that appearing on the surface of T cells. The invention also concerns nucleic acid fragments encoding the fusion protein, expression vectors comprising a nucleic acid fragment encoding the fusion protein, host cells containing such expression vectors, and antibodies to the single chain T cell receptor or to the fusion protein. The invention further pertains to methods of isolating and purifying the fusion proteins, as well as isolating and purifying soluble, single chain T cell receptors. In addition the invention pertains to various uses of soluble TCR fusion protein and isolated single chain TCR. The proteins can be used in molecular assays designed to measure their binding to ligands, including MHC/HLA-peptide antigen complexes or TCR-specific antibodies. Such assays are useful for the detection of agents that block the TCR-ligand interaction. The soluble TCR proteins can also be used to immunize animals, including humans, to produce TCR-specific antibodies. In addition, either in their native or denatured conformation the proteins can be used to vaccinate animals, including humans, in order to suppress the immune response of T cells bearing TCR that share antigenic epitopes with the vaccinating protein.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32931094A | 1994-10-26 | 1994-10-26 | |
| US08/329,310 | 1994-10-26 | ||
| US34789394A | 1994-12-01 | 1994-12-01 | |
| US08/347,893 | 1994-12-01 | ||
| US46813195A | 1995-06-06 | 1995-06-06 | |
| US08/468,131 | 1995-06-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1996013593A2 WO1996013593A2 (en) | 1996-05-09 |
| WO1996013593A3 true WO1996013593A3 (en) | 1996-08-01 |
Family
ID=27406656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1995/013770 WO1996013593A2 (en) | 1994-10-26 | 1995-10-26 | Soluble single chain t cell receptors |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO1996013593A2 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11590167B2 (en) | 2016-12-03 | 2023-02-28 | Juno Therapeutic, Inc. | Methods and compositions for use of therapeutic T cells in combination with kinase inhibitors |
| US11851679B2 (en) | 2017-11-01 | 2023-12-26 | Juno Therapeutics, Inc. | Method of assessing activity of recombinant antigen receptors |
| US12258580B2 (en) | 2017-11-01 | 2025-03-25 | Juno Therapeutics, Inc. | Process for generating therapeutic compositions of engineered cells |
| US12263190B2 (en) | 2019-11-07 | 2025-04-01 | Juno Therapeutics, Inc. | Methods and combinations for treatment and T cell modulation |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0977886A4 (en) * | 1997-03-07 | 2002-10-23 | Sunol Molecular Corp | Fusion proteins comprising bacteriophage coat protein and a single-chain t cell receptor |
| US20030109680A1 (en) | 2001-11-21 | 2003-06-12 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
| US20060235209A9 (en) | 1997-03-10 | 2006-10-19 | Jin-An Jiao | Use of anti-tissue factor antibodies for treating thromboses |
| US5986065A (en) | 1997-03-10 | 1999-11-16 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
| US7749498B2 (en) | 1997-03-10 | 2010-07-06 | Genentech, Inc. | Antibodies for inhibiting blood coagulation and methods of use thereof |
| WO1999018129A1 (en) * | 1997-10-02 | 1999-04-15 | Sunol Molecular Corporation | Soluble single-chain t-cell receptor proteins |
| JP4271850B2 (en) | 1998-01-23 | 2009-06-03 | イミュネックス・コーポレーション | IL-18 receptor |
| CN1464790A (en) * | 2000-06-05 | 2003-12-31 | 苏诺尔分子公司 | T cell receptor fusions and conjugates and methods of use thereof |
| DK1546188T3 (en) | 2001-06-05 | 2008-10-27 | Altor Bioscience Corp | P53-binding T cell receptor molecules and uses thereof |
| EP2102236B1 (en) | 2007-01-12 | 2014-08-06 | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services | GP100-specific T cell receptors and related materials and methods of use |
| CA2945816A1 (en) | 2014-04-15 | 2015-10-22 | University Of Virginia Patent Foundation | Isolated t cell receptors and methods of use therefor |
| AU2016363696B2 (en) * | 2015-12-02 | 2021-05-20 | Innovative Targeting Solutions Inc. | Single variable domain T-cell receptors |
| AU2017261380A1 (en) | 2016-05-06 | 2018-11-22 | Editas Medicine, Inc. | Genetically engineered cells and methods of making the same |
| CA3028002A1 (en) | 2016-06-27 | 2018-01-04 | Juno Therapeutics, Inc. | Method of identifying peptide epitopes, molecules that bind such epitopes and related uses |
| MA45491A (en) | 2016-06-27 | 2019-05-01 | Juno Therapeutics Inc | CMH-E RESTRICTED EPITOPES, BINDING MOLECULES AND RELATED METHODS AND USES |
| AU2017338827B2 (en) | 2016-10-03 | 2023-08-31 | Juno Therapeutics, Inc. | HPV-specific binding molecules |
| MX2019004181A (en) | 2016-10-13 | 2019-10-30 | Juno Therapeutics Inc | IMMUNOTHERAPY METHODS AND COMPOSITIONS INVOLVING MODULATORS OF THE METABOLIC TRYPTOPHAN PATH. |
| WO2018093591A1 (en) | 2016-11-03 | 2018-05-24 | Juno Therapeutics, Inc. | Combination therapy of a cell based therapy and a microglia inhibitor |
| CN110139669A (en) | 2016-11-03 | 2019-08-16 | 朱诺治疗学股份有限公司 | The combination treatment of T cell therapy and BTK inhibitor |
| EP4279136A3 (en) | 2016-12-03 | 2024-03-20 | Juno Therapeutics, Inc. | Methods for determining car-t cells dosing |
| US20190358262A1 (en) | 2016-12-03 | 2019-11-28 | Juno Therapeutics, Inc. | Methods for modulation of car-t cells |
| EP3548611A1 (en) | 2016-12-05 | 2019-10-09 | Juno Therapeutics, Inc. | Production of engineered cells for adoptive cell therapy |
| AU2018207305A1 (en) | 2017-01-10 | 2019-07-25 | Juno Therapeutics, Inc. | Epigenetic analysis of cell therapy and related methods |
| EP3571221A2 (en) | 2017-01-20 | 2019-11-27 | Juno Therapeutics GmbH | Cell surface conjugates and related cell compositions and methods |
| EP3582782B1 (en) | 2017-02-17 | 2023-06-07 | Fred Hutchinson Cancer Center | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
| CA3053539A1 (en) | 2017-02-27 | 2018-08-30 | Juno Therapeutics, Inc. | Compositions, articles of manufacture and methods related to dosing in cell therapy |
| EA201992155A1 (en) | 2017-03-14 | 2020-03-16 | Джуно Терапьютикс, Инк. | METHODS OF CRYOGENIC STORAGE |
| CA3056261A1 (en) | 2017-04-07 | 2018-10-11 | Juno Therapeutics, Inc. | Engineered cells expressing prostate-specific membrane antigen (psma) or a modified form thereof and related methods |
| CN110709700A (en) | 2017-04-14 | 2020-01-17 | 朱诺治疗学股份有限公司 | Methods for Assessing Cell Surface Glycosylation |
| AU2018263887A1 (en) | 2017-05-01 | 2019-11-21 | Juno Therapeutics, Inc. | Combination of a cell therapy and an immunomodulatory compound |
| KR20200054160A (en) | 2017-06-02 | 2020-05-19 | 주노 쎄러퓨티크스 인코퍼레이티드 | Preparation and method of articles for treatment with adoptive cell therapy |
| JP7379164B2 (en) | 2017-06-02 | 2023-11-14 | ジュノー セラピューティクス インコーポレイテッド | Articles of manufacture and methods related to toxicity associated with cell therapy |
| MX2019015155A (en) | 2017-06-29 | 2020-08-03 | Juno Therapeutics Inc | MOUSE MODEL TO ASSESS TOXICITIES ASSOCIATED WITH IMMUNOTHERAPIES. |
| ES3009018T3 (en) | 2017-07-29 | 2025-03-25 | Juno Therapeutics Inc | Reagents for expanding cells expressing recombinant receptors |
| EP4516896A2 (en) | 2017-08-09 | 2025-03-05 | Juno Therapeutics, Inc. | Methods and compositions for preparing genetically engineered cells |
| MX2020001490A (en) | 2017-08-09 | 2020-08-06 | Juno Therapeutics Inc | METHODS FOR PRODUCING GENETICALLY MODIFIED CELL COMPOSITIONS AND RELATED COMPOSITIONS. |
| MA50057A (en) | 2017-09-01 | 2020-07-08 | Juno Therapeutics Inc | GENE EXPRESSION AND ASSESSMENT OF A RISK OF DEVELOPING TOXICITY FOLLOWING CELL THERAPY |
| US20200292526A1 (en) | 2017-09-07 | 2020-09-17 | Juno Therapeutics, Inc. | Methods of identifying cellular attributes related to outcomes associated with cell therapy |
| KR20200104284A (en) | 2017-10-03 | 2020-09-03 | 주노 쎄러퓨티크스 인코퍼레이티드 | HPV-specific binding molecule |
| WO2019089848A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
| CN111615556A (en) | 2017-11-01 | 2020-09-01 | 朱诺治疗学股份有限公司 | Methods of producing T cell compositions |
| BR112020008478A2 (en) | 2017-11-01 | 2020-10-20 | Editas Medicine, Inc. | methods, compositions and components for editing crispr-cas9 of tgfbr2 in t cells for immunota-rapy |
| US12031975B2 (en) | 2017-11-01 | 2024-07-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
| MA50564A (en) | 2017-11-06 | 2020-09-16 | Hutchinson Fred Cancer Res | COMBINATION OF CELL THERAPY AND A GAMMA SECRETASE INHIBITOR |
| CN111556893A (en) | 2017-11-06 | 2020-08-18 | 爱迪塔斯医药股份有限公司 | Methods, compositions, and components for CRISPR-CAS9 editing of CBLB in immunotherapy T cells |
| GB201719169D0 (en) | 2017-11-20 | 2018-01-03 | Univ College Cardiff Consultants Ltd | Novel T-cell receptor and ligand |
| WO2019109053A1 (en) | 2017-12-01 | 2019-06-06 | Juno Therapeutics, Inc. | Methods for dosing and for modulation of genetically engineered cells |
| CA3084445A1 (en) | 2017-12-08 | 2019-06-13 | Juno Therapeutics, Inc. | Process for producing a composition of engineered t cells |
| EP3720480A2 (en) | 2017-12-08 | 2020-10-14 | Juno Therapeutics, Inc. | Phenotypic markers for cell therapy and related methods |
| SG11202005228YA (en) | 2017-12-08 | 2020-07-29 | Juno Therapeutics Inc | Serum-free media formulation for culturing cells and methods of use thereof |
| WO2019152743A1 (en) | 2018-01-31 | 2019-08-08 | Celgene Corporation | Combination therapy using adoptive cell therapy and checkpoint inhibitor |
| CA3095027A1 (en) | 2018-04-05 | 2019-10-10 | Juno Therapeutics, Inc. | T cell receptors and engineered cells expressing same |
| US20210017249A1 (en) | 2018-04-05 | 2021-01-21 | Juno Therapeutics, Inc. | Methods of producing cells expressing a recombinant receptor and related compositions |
| WO2019195491A1 (en) | 2018-04-05 | 2019-10-10 | Juno Therapeutics, Inc. | T cells expressing a recombinant receptor, related polynucleotides and methods |
| EA202190469A1 (en) | 2018-08-09 | 2021-06-28 | Джуно Терапьютикс, Инк. | METHODS FOR ASSESSMENT OF INTEGRATED NUCLEIC ACIDS |
| CA3108657A1 (en) | 2018-08-09 | 2020-02-13 | Juno Therapeutics, Inc. | Processes for generating engineered cells and compositions thereof |
| WO2020056047A1 (en) | 2018-09-11 | 2020-03-19 | Juno Therapeutics, Inc. | Methods for mass spectrometry analysis of engineered cell compositions |
| JP7582940B2 (en) | 2018-10-31 | 2024-11-13 | ジュノ セラピューティクス ゲーエムベーハー | Methods and devices for cell selection and stimulation |
| MX2021005021A (en) | 2018-11-06 | 2021-08-11 | Juno Therapeutics Inc | Process for producing genetically engineered t cells. |
| SG11202104411VA (en) | 2018-11-08 | 2021-05-28 | Juno Therapeutics Inc | Methods and combinations for treatment and t cell modulation |
| EP4427810A3 (en) | 2018-11-30 | 2024-12-04 | Juno Therapeutics, Inc. | Methods for treatment using adoptive cell therapy |
| EP4393547A3 (en) | 2018-11-30 | 2024-09-18 | Juno Therapeutics, Inc. | Methods for dosing and treatment of b cell malignancies in adoptive cell therapy |
| WO2020223535A1 (en) | 2019-05-01 | 2020-11-05 | Juno Therapeutics, Inc. | Cells expressing a recombinant receptor from a modified tgfbr2 locus, related polynucleotides and methods |
| EP3980530A1 (en) | 2019-06-07 | 2022-04-13 | Juno Therapeutics, Inc. | Automated t cell culture |
| KR20220034782A (en) | 2019-06-12 | 2022-03-18 | 주노 쎄러퓨티크스 인코퍼레이티드 | Combination therapy of cell-mediated cytotoxicity therapy and pro-survival BLC2 family protein inhibitors |
| EP4017527A1 (en) | 2019-08-22 | 2022-06-29 | Juno Therapeutics, Inc. | Combination therapy of a t cell therapy and an enhancer of zeste homolog 2 (ezh2) inhibitor and related methods |
| JP2023500318A (en) | 2019-10-30 | 2023-01-05 | ジュノ セラピューティクス ゲーエムベーハー | Cell selection and/or cell stimulation devices and methods of use |
| US20230053787A1 (en) | 2019-12-06 | 2023-02-23 | Juno Therapeutics, Inc. | Methods related to toxicity and response associated with cell therapy for treating b cell malignancies |
| US20230090117A1 (en) | 2020-01-28 | 2023-03-23 | Juno Therapeutics, Inc. | Methods for t cell transduction |
| EP4125943A1 (en) | 2020-03-27 | 2023-02-08 | Mendus B.V. | In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
| JP2023519346A (en) | 2020-03-27 | 2023-05-10 | メンドゥス・ベスローテン・フェンノートシャップ | Ex vivo (EX VIVO) use of leukemia-derived modified cells to enhance the efficacy of adoptive cell therapy |
| KR20230022868A (en) | 2020-05-13 | 2023-02-16 | 주노 쎄러퓨티크스 인코퍼레이티드 | Method for producing donor-batch cells expressing a recombinant acceptor |
| WO2021231657A1 (en) | 2020-05-13 | 2021-11-18 | Juno Therapeutics, Inc. | Methods of identifying features associated with clinical response and uses thereof |
| JP2023531531A (en) | 2020-06-26 | 2023-07-24 | ジュノ セラピューティクス ゲーエムベーハー | Engineered T Cells Conditionally Expressing Recombinant Receptors, Related Polynucleotides, and Methods |
| WO2022060904A1 (en) | 2020-09-16 | 2022-03-24 | Obsidian Therapeutics, Inc. | Compositions and methods for expression of t-cell receptors with small molecule-regulated cd40l in t cells |
| US20240325539A1 (en) | 2020-10-20 | 2024-10-03 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods and compositions for treating epstein barr virus-associated cancer |
| US12024559B2 (en) | 2020-10-23 | 2024-07-02 | Asher Biotherapeutics, Inc. | Fusions with CD8 antigen binding molecules for modulating immune cell function |
| EP4240405A1 (en) | 2020-11-05 | 2023-09-13 | Mendus B.V. | Use of tumor-independent antigens in immunotherapies |
| WO2022133030A1 (en) | 2020-12-16 | 2022-06-23 | Juno Therapeutics, Inc. | Combination therapy of a cell therapy and a bcl2 inhibitor |
| WO2022187406A1 (en) | 2021-03-03 | 2022-09-09 | Juno Therapeutics, Inc. | Combination of a t cell therapy and a dgk inhibitor |
| CN117321417A (en) | 2021-03-22 | 2023-12-29 | 朱诺治疗学股份有限公司 | Method for determining the efficacy of therapeutic cell compositions |
| JP2024514245A (en) | 2021-03-29 | 2024-03-29 | ジュノー セラピューティクス インコーポレイテッド | Methods for dosing and treatment using a combination of checkpoint inhibitor therapy and CAR T cell therapy |
| EP4334341A2 (en) | 2021-05-06 | 2024-03-13 | Juno Therapeutics GmbH | Methods for stimulating and transducing t cells |
| WO2023288203A2 (en) | 2021-07-12 | 2023-01-19 | Ludwig Institute For Cancer Research Ltd | T cell receptors specific for tumor-associated antigens and methods of use thereof |
| KR20240137075A (en) | 2022-01-28 | 2024-09-19 | 주노 쎄러퓨티크스 인코퍼레이티드 | Method for preparing a cell composition |
| WO2023213969A1 (en) | 2022-05-05 | 2023-11-09 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
| US20240002800A1 (en) | 2022-05-16 | 2024-01-04 | Mendus B.V. | Use of leukemia-derived cells for enhancing natural killer (nk) cell therapy |
| WO2023230548A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Method for predicting response to a t cell therapy |
| WO2024006960A1 (en) | 2022-06-29 | 2024-01-04 | Juno Therapeutics, Inc. | Lipid nanoparticles for delivery of nucleic acids |
| WO2024054944A1 (en) | 2022-09-08 | 2024-03-14 | Juno Therapeutics, Inc. | Combination of a t cell therapy and continuous or intermittent dgk inhibitor dosing |
| WO2024100604A1 (en) | 2022-11-09 | 2024-05-16 | Juno Therapeutics Gmbh | Methods for manufacturing engineered immune cells |
| WO2024124132A1 (en) | 2022-12-09 | 2024-06-13 | Juno Therapeutics, Inc. | Machine learning methods for predicting cell phenotype using holographic imaging |
| WO2024161021A1 (en) | 2023-02-03 | 2024-08-08 | Juno Therapeutics Gmbh | Methods for non-viral manufacturing of engineered immune cells |
| WO2024220588A1 (en) | 2023-04-18 | 2024-10-24 | Juno Therapeutics, Inc. | Cytotoxicity assay for assessing potency of therapeutic cell compositions |
| WO2024243365A2 (en) | 2023-05-23 | 2024-11-28 | Juno Therapeutics, Inc. | Activation markers of t cells and method for assessing t cell activation |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991018019A1 (en) * | 1990-05-15 | 1991-11-28 | E.R. Squibb & Sons, Inc. | Soluble single chain t cell receptors |
| WO1992001715A1 (en) * | 1990-07-19 | 1992-02-06 | The Board Of Trustees Of The Leland Stanford Junior University | Soluble cell-surface dimeric proteins |
| WO1993022332A2 (en) * | 1992-04-24 | 1993-11-11 | Board Of Regents, The University Of Texas System | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
-
1995
- 1995-10-26 WO PCT/US1995/013770 patent/WO1996013593A2/en active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991018019A1 (en) * | 1990-05-15 | 1991-11-28 | E.R. Squibb & Sons, Inc. | Soluble single chain t cell receptors |
| WO1992001715A1 (en) * | 1990-07-19 | 1992-02-06 | The Board Of Trustees Of The Leland Stanford Junior University | Soluble cell-surface dimeric proteins |
| WO1993022332A2 (en) * | 1992-04-24 | 1993-11-11 | Board Of Regents, The University Of Texas System | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
Non-Patent Citations (8)
| Title |
|---|
| C. WONG ET AL.: "Single chain T cell receptor as a tumor specific vaccine.", THE FASEB JOURNAL, vol. 9, no. 3, 9 March 1995 (1995-03-09), BETHESDA, MD, USA, pages A514, XP002002800 * |
| D. LAKE ET AL.: "Construction and serological characterization of a recombinant human single chain T cell receptor.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 201, no. 3, 30 June 1994 (1994-06-30), DULUTH, MN, USA, pages 1502 - 1509, XP002002799 * |
| J. NEWCOMB ET AL.: "Demonstration of soluble T cell receptor function using proliferation-based assays. In: THE 9TH INTERNATIONAL CONGRESS OF IMMUNOLOGY. San Francisco, July 23-29, 1995. Abstract book.", 1995, SAN FRANCISCO, CA, USA, XP002002801 * |
| J. NOVOTNY ET AL.: "A soluble single chain T cell receptor fragment endowed with antigen-combining properties.", THE FASEB JOURNAL, vol. 6, no. 1, 1 January 1992 (1992-01-01), BETHESDA, MD, USA, pages A351, XP002002795 * |
| J. NOVOTNY ET AL.: "A soluble, single-chain T cell receptor fragment endowed with antigen-combining properties.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 88, no. 19, 1 October 1991 (1991-10-01), WASHINGTON, DC, USA, pages 8646 - 8650, XP002002796 * |
| M. JESSON ET AL.: "Immunogenicity of recombinant, soluble T cell receptors in syngeneic mice. In: THE 9TH INTERNATIONAL CONGRESS OF IMMUNOLOGY. San Francisco, July 23-29, 1995. Abstract book.", 1995, SAN FRANCISCO, CA, USA, XP002002802 * |
| P. FINK ET AL.: "Correlations between T-cell specificity and the structure of the antigen receptor.", NATURE, vol. 321, 15 May 1986 (1986-05-15), LONDON, GB, pages 219 - 226, XP002002798 * |
| W. SOO HOO ET AL.: "Characterization of a single-chain T-cell receptor expressed in Escherichia coli.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 89, no. 10, 15 May 1992 (1992-05-15), WASHINGTON, DC, USA, pages 4759 - 4763, XP002002797 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11590167B2 (en) | 2016-12-03 | 2023-02-28 | Juno Therapeutic, Inc. | Methods and compositions for use of therapeutic T cells in combination with kinase inhibitors |
| US11851679B2 (en) | 2017-11-01 | 2023-12-26 | Juno Therapeutics, Inc. | Method of assessing activity of recombinant antigen receptors |
| US12258580B2 (en) | 2017-11-01 | 2025-03-25 | Juno Therapeutics, Inc. | Process for generating therapeutic compositions of engineered cells |
| US12263190B2 (en) | 2019-11-07 | 2025-04-01 | Juno Therapeutics, Inc. | Methods and combinations for treatment and T cell modulation |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996013593A2 (en) | 1996-05-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO1996013593A3 (en) | Soluble single chain t cell receptors | |
| Mestecky et al. | Studies on human secretory immunoglobulin A: II. Subunit structure | |
| Yonemasu et al. | C1q: rapid purification method for preparation of monospecific antisera and for biochemical studies | |
| Ljungberg et al. | The interaction between different domains of staphylococcal protein A and human polyclonal IgG, IgA, IgM and F (ab') 2: separation of affinity from specificity | |
| NO934801D0 (en) | CTL4A receptor, fusion proteins containing it and its use | |
| Jemmerson et al. | Topographic antigenic determinants on cytochrome c. Immunoadsorbent separation of the rabbit antibody populations directed against horse cytochrome. | |
| Sharon et al. | Possible association between IL-2 receptors and class I HLA molecules on T cells. | |
| FI940270A0 (en) | Methods for Regulating the Immune Response Using CTLA4 Binding Molecules and IL4 Binding Molecules | |
| Butler | Antibody-antigen and antibody-hapten reactions | |
| Smith et al. | The preparation and characterization of anti-peptide heteroantisera recognizing subregions of the intracytoplasmic domain of class I H-2 antigens | |
| Tragardh et al. | Chemical, physical-chemical, and immunological properties of papain-solubilized human transplantation antigens | |
| Ball Jr et al. | Immunochemical studies of (Na++ K+)-ATPase using site-specific, synthetic peptide directed antibodies | |
| WO1996021028A3 (en) | Soluble heterodimeric t cell receptors and their antibodies | |
| Turner et al. | Pepsin digestion of human G-myeloma proteins of different subclasses. II. Immunochemical investigations of the products of peptic digestion | |
| Grey et al. | The subunit structure of mouse IgA | |
| Cunningham et al. | Structure of murine histocompatibility antigens | |
| Givol et al. | Isolation and fragmentation of antibodies to polytyrosyl gelatin | |
| Montgomery | Molecular aspects of equine antibodies | |
| Eilat et al. | Secretion of a soluble, chimeric gamma delta T-cell receptor-immunoglobulin heterodimer. | |
| Wedderburn et al. | Single-step immunosorbent preparation of F-protein from mouse liver with conservation of the allo-antigenic site, and determination of concentration in liver and serum | |
| Lögdberg et al. | Binding of mammalian β2-microglobulin by glycoproteins in fish serum | |
| Patil et al. | Detection of mycobacterial antigens in leprosy serum immune complex | |
| Chersi et al. | Generation of rabbit antipeptide antibodies to HLA-class II antigens by the use of synthetic peptides | |
| Zeng et al. | A novel approach to experimentally estimating the number of reactive epitopes on multivalent antigens | |
| Szelke | 1. IMMUNOGENS AND THE IMMUNE RESPONSE 1.1 Immunogens What are the main criteria that determine immunogenicity? Molecular size. ¹-3 Many chemicals (eg small peptides, steroids, drugs) of molecular weight less than about 1000 daltons are non-immunogenic, although |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AK | Designated states |
Kind code of ref document: A2 Designated state(s): CA JP MX |
|
| AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE |
|
| DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
| 122 | Ep: pct application non-entry in european phase |