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UY38436A - Nuevas 6,7-dihidro-4h-pirazolo[1,5-a] pirazinindol-2-carboxamidas activas contra el virus de la hepatitis b (vhb) - Google Patents

Nuevas 6,7-dihidro-4h-pirazolo[1,5-a] pirazinindol-2-carboxamidas activas contra el virus de la hepatitis b (vhb)

Info

Publication number
UY38436A
UY38436A UY0001038436A UY38436A UY38436A UY 38436 A UY38436 A UY 38436A UY 0001038436 A UY0001038436 A UY 0001038436A UY 38436 A UY38436 A UY 38436A UY 38436 A UY38436 A UY 38436A
Authority
UY
Uruguay
Prior art keywords
hbv
virus
hepatitis
new
pyrazinindol
Prior art date
Application number
UY0001038436A
Other languages
English (en)
Inventor
Susanne Bonsmann
Alastair Donald
Andreas Urban
Jasper Springer
Anita Wegert
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of UY38436A publication Critical patent/UY38436A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere, en general, a nuevos agentes antivíricos. Específicamente, la presente invención se refiere a compuestos que pueden inhibir la proteína o proteínas codificada(s) por el virus de la hepatitis B (VHB) o interferir con la función del ciclo de replicación del VHB, a composiciones que comprenden estos compuestos, a métodos para inhibir la replicación del virus VHB, a métodos para tratar o prevenir la infección por VHB y a procesos o intermedios para fabricar los compuestos.
UY0001038436A 2018-11-02 2019-10-31 Nuevas 6,7-dihidro-4h-pirazolo[1,5-a] pirazinindol-2-carboxamidas activas contra el virus de la hepatitis b (vhb) UY38436A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18000876 2018-11-02

Publications (1)

Publication Number Publication Date
UY38436A true UY38436A (es) 2020-05-29

Family

ID=64362286

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001038436A UY38436A (es) 2018-11-02 2019-10-31 Nuevas 6,7-dihidro-4h-pirazolo[1,5-a] pirazinindol-2-carboxamidas activas contra el virus de la hepatitis b (vhb)

Country Status (20)

Country Link
US (1) US20220363686A1 (es)
EP (1) EP3873909A1 (es)
JP (1) JP2022512871A (es)
KR (1) KR20210099562A (es)
CN (1) CN113056467A (es)
AR (1) AR116947A1 (es)
AU (1) AU2019370994A1 (es)
BR (1) BR112021008361A2 (es)
CA (1) CA3118380A1 (es)
CL (1) CL2021001117A1 (es)
CU (1) CU20210038A7 (es)
EA (1) EA202191216A1 (es)
EC (1) ECSP21031085A (es)
IL (1) IL282480A (es)
MX (1) MX2021004986A (es)
PH (1) PH12021550979A1 (es)
SG (1) SG11202104130SA (es)
TW (1) TW202031661A (es)
UY (1) UY38436A (es)
WO (1) WO2020089453A1 (es)

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UY38437A (es) * 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv)
JP2022530522A (ja) * 2019-04-30 2022-06-29 アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト Ｂ型肝炎ウイルス（ｈｂｖ）に対し活性な新規のインドール－２－カルボキサミド
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US20230331732A1 (en) * 2020-09-10 2023-10-19 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
CN116396204B (zh) * 2023-03-29 2024-09-24 无锡科华生物科技有限公司 一种4,6,7-三氟-1h-吲哚-2-羧酸的制备方法

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Also Published As

Publication number Publication date
IL282480A (en) 2021-06-30
CN113056467A (zh) 2021-06-29
PH12021550979A1 (en) 2021-11-22
SG11202104130SA (en) 2021-05-28
CL2021001117A1 (es) 2021-11-05
AR116947A1 (es) 2021-06-30
BR112021008361A2 (pt) 2021-08-03
US20220363686A1 (en) 2022-11-17
ECSP21031085A (es) 2021-05-31
TW202031661A (zh) 2020-09-01
AU2019370994A1 (en) 2021-05-27
EA202191216A1 (ru) 2021-08-03
CU20210038A7 (es) 2021-12-08
JP2022512871A (ja) 2022-02-07
MX2021004986A (es) 2021-06-15
EP3873909A1 (en) 2021-09-08
KR20210099562A (ko) 2021-08-12
WO2020089453A1 (en) 2020-05-07
CA3118380A1 (en) 2020-05-07

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Effective date: 20240610