UY23762A1 - Procedimiento de preparacion de lipopeptidos procedentes de actinoplanes sp. con efecto farmacologigo y sus usos - Google Patents
Procedimiento de preparacion de lipopeptidos procedentes de actinoplanes sp. con efecto farmacologigo y sus usosInfo
- Publication number
- UY23762A1 UY23762A1 UY23762A UY23762A UY23762A1 UY 23762 A1 UY23762 A1 UY 23762A1 UY 23762 A UY23762 A UY 23762A UY 23762 A UY23762 A UY 23762A UY 23762 A1 UY23762 A1 UY 23762A1
- Authority
- UY
- Uruguay
- Prior art keywords
- lipopeptides
- tnfalpha
- molecule
- culture medium
- human
- Prior art date
Links
- 108010028921 Lipopeptides Proteins 0.000 title abstract 6
- 241000187712 Actinoplanes sp. Species 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- 230000000144 pharmacologic effect Effects 0.000 title 1
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 abstract 5
- 102000057041 human TNF Human genes 0.000 abstract 5
- 239000001963 growth medium Substances 0.000 abstract 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 3
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract 3
- 241000192125 Firmicutes Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 108010033276 Peptide Fragments Proteins 0.000 abstract 1
- 102000007079 Peptide Fragments Human genes 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 208000034189 Sclerosis Diseases 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037976 chronic inflammation Diseases 0.000 abstract 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/827—Actinoplanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Procedimiento para la preparación de uno o varios lipopéptidos, caracterizado porque son sintetizados por fermentación en un medio de cultivo que contiene Actinoplanes sp., hasta que se acumulen en dicho medio de cultivo uno o varios lipopéptidos y se purifican uno o varios lipopéptidos a partir de dicho medio de cultivo. Se refiere también al procedimiento para el aislamiento de los lipopéptidos a partir del medio de cultivo y su purificación, su utilización como sustancias activas farmacológicamente, especialmente contra bacterias gram - positivas, así como a actinoplanes sp. dsm 7.358 para la preparación de los lipopéptidos antes mencionados. Una molécula de TNFalfa humano modificada capaz de incitar anticuerpos neutralizantes hacia el TNFalfa humano del tipo sin cultivar, luego de la administración de dicha molécula de TNFalfa modificada a un huésped humano, donde por lo menos un fragmento de péptido de la molécula de TNFalfa humano ha sido sustituido por un peptido como minimo que, según se sabe, contiene un epitopo de celulas T inmuno-dominante o una forma truncada de dicha molécula que contiene un epitopo inmuno-dominante, y una o ambas regiones flanqueadoras de la molécula de TNFalfa humano que comprende por lo menos un epitopo de células B de TNFalfa, donde la sustitución introduce un cambio sustancial en la secuencia de aminoácidos de la lámina beta frontal, en uno cualquiera de los bucles conestores y/o en uno cualquiera de los filamentos B', I o D de la lámina beta posterior. Las moléculas de TNFalfa humano modificadas o el ADN que las codifica pueden formularse como vacunas contra el TNFalfa, opcionalmente con adyuvantes farmacéuticamente aceptables, para la prevención o el tratamiento de enfermedades inflamatorias crónicas, tales como artritis, enfermedades inflamatorias, cáncer, esclerosis, diabetes, psoriasis, osteoporosis o asma.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4319007 | 1993-06-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY23762A1 true UY23762A1 (es) | 1994-05-03 |
Family
ID=6489896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY23762A UY23762A1 (es) | 1993-06-08 | 1994-04-25 | Procedimiento de preparacion de lipopeptidos procedentes de actinoplanes sp. con efecto farmacologigo y sus usos |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6194383B1 (es) |
| EP (2) | EP0864584B1 (es) |
| JP (1) | JP2660161B2 (es) |
| KR (2) | KR0174264B1 (es) |
| AT (2) | ATE174604T1 (es) |
| AU (1) | AU672691B2 (es) |
| CA (1) | CA2125376C (es) |
| CY (1) | CY2190B1 (es) |
| CZ (1) | CZ285322B6 (es) |
| DE (2) | DE59409616D1 (es) |
| DK (2) | DK0629636T3 (es) |
| ES (2) | ES2127312T3 (es) |
| FI (1) | FI942660L (es) |
| GR (2) | GR3029591T3 (es) |
| HK (1) | HK1012009A1 (es) |
| HU (1) | HU217177B (es) |
| IL (2) | IL109917A (es) |
| MA (1) | MA23216A1 (es) |
| NO (1) | NO942110L (es) |
| NZ (1) | NZ260682A (es) |
| OA (1) | OA10066A (es) |
| PL (2) | PL179581B1 (es) |
| PT (1) | PT864584E (es) |
| RU (1) | RU2117672C1 (es) |
| SK (1) | SK281830B6 (es) |
| TW (1) | TW455591B (es) |
| UY (1) | UY23762A1 (es) |
| ZA (1) | ZA943983B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4411025A1 (de) * | 1994-03-30 | 1995-10-05 | Hoechst Ag | Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| DE19807972A1 (de) | 1998-02-25 | 1999-08-26 | Hoechst Marion Roussel De Gmbh | Lipopeptidantibiotika-Calciumsalze, Verfahren zu ihrer Herstellung und Verwendung |
| KR100291406B1 (ko) * | 1999-05-13 | 2001-05-15 | 이길정 | 직거 염색기용 기어박스 |
| KR100423751B1 (ko) * | 1999-05-18 | 2004-03-22 | 심선희 | 지그염색기의 직물이송속도 유지장치 |
| KR100331966B1 (ko) * | 1999-10-23 | 2002-04-10 | 윤기룡 | 염색된 직물의 직물권취장치 |
| US6696412B1 (en) * | 2000-01-20 | 2004-02-24 | Cubist Pharmaceuticals, Inc. | High purity lipopeptides, Lipopeptide micelles and processes for preparing same |
| US6750199B2 (en) | 2000-07-17 | 2004-06-15 | Micrologix Biotech Inc. | Antimicrobial sulfonamide derivatives of lipopeptide antibiotics |
| US6737403B2 (en) | 2000-07-17 | 2004-05-18 | Micrologix Biotech Inc. | Derivatives of laspartomycin and preparation and use thereof |
| US6511962B1 (en) | 2000-07-17 | 2003-01-28 | Micrologix Biotech Inc. | Derivatives of laspartomycin and preparation and use thereof |
| US20060014674A1 (en) | 2000-12-18 | 2006-01-19 | Dennis Keith | Methods for preparing purified lipopeptides |
| AU2003202878B2 (en) | 2002-01-03 | 2008-07-31 | Migenix Inc. | Dab9 derivatives of lipopeptide antibiotics and methods of making and using the same |
| US6887900B2 (en) * | 2002-03-04 | 2005-05-03 | Divergence, Inc. | Nematicidal compositions and methods |
| US20040157803A1 (en) * | 2002-03-04 | 2004-08-12 | Williams Deryck J. | Nematicidal fatty acid and fatty acid ester related compounds |
| CN1839150A (zh) * | 2003-07-17 | 2006-09-27 | 麦根克斯有限公司 | 脂肽抗菌衍生物组合物及其应用方法 |
| US7368629B2 (en) * | 2004-02-04 | 2008-05-06 | Divergence, Inc. | Nucleic acids encoding anthelmintic agents and plants made therefrom |
| DE102004060750A1 (de) | 2004-12-15 | 2006-07-13 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Deacylierung von Lipopeptiden |
| GB0821540D0 (en) * | 2008-11-25 | 2008-12-31 | Merlion Pharmaceuticals Pte Ltd | Lipopeptide compounds and their use |
| AR079127A1 (es) | 2009-11-23 | 2011-12-28 | Cubist Pharm Inc | Composiciones de daptomicina y metodos relacionados |
| KR101151878B1 (ko) | 2010-06-08 | 2012-05-31 | 미원상사주식회사 | 지방산 트리펩타이드염 및 이를 함유하는 항균 조성물 |
| WO2013012101A1 (ko) * | 2011-07-15 | 2013-01-24 | 미원상사주식회사 | 지방산 트리펩타이드염 및 이를 함유하는 항균 조성물 |
| FR2980802B1 (fr) * | 2011-10-03 | 2014-12-26 | Univ Lille 1 Sciences Et Technologies Ustl | Procede de production de biosurfactants et dispositif de mise en œuvre |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4000397A (en) | 1975-03-21 | 1976-12-28 | Spectra-Physics, Inc. | Signal processor method and apparatus |
| US4001397A (en) * | 1975-08-11 | 1977-01-04 | Pfizer Inc. | Antibiotic compound 41,012 |
| DE4411025A1 (de) * | 1994-03-30 | 1995-10-05 | Hoechst Ag | Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
-
1993
- 1993-12-17 TW TW082110700A patent/TW455591B/zh not_active IP Right Cessation
-
1994
- 1994-04-25 UY UY23762A patent/UY23762A1/es not_active IP Right Cessation
- 1994-05-06 HU HU9401465A patent/HU217177B/hu not_active IP Right Cessation
- 1994-06-01 EP EP98110484A patent/EP0864584B1/de not_active Expired - Lifetime
- 1994-06-01 DK DK94108443T patent/DK0629636T3/da active
- 1994-06-01 AT AT94108443T patent/ATE174604T1/de not_active IP Right Cessation
- 1994-06-01 ES ES94108443T patent/ES2127312T3/es not_active Expired - Lifetime
- 1994-06-01 AT AT98110484T patent/ATE198209T1/de not_active IP Right Cessation
- 1994-06-01 DE DE59409616T patent/DE59409616D1/de not_active Expired - Lifetime
- 1994-06-01 DE DE59407475T patent/DE59407475D1/de not_active Expired - Lifetime
- 1994-06-01 EP EP94108443A patent/EP0629636B1/de not_active Expired - Lifetime
- 1994-06-01 PT PT98110484T patent/PT864584E/pt unknown
- 1994-06-01 DK DK98110484T patent/DK0864584T3/da active
- 1994-06-01 ES ES98110484T patent/ES2153224T3/es not_active Expired - Lifetime
- 1994-06-03 NZ NZ260682A patent/NZ260682A/en unknown
- 1994-06-06 PL PL94303716A patent/PL179581B1/pl unknown
- 1994-06-06 PL PL94334634A patent/PL180230B1/pl unknown
- 1994-06-06 FI FI942660A patent/FI942660L/fi unknown
- 1994-06-06 AU AU64620/94A patent/AU672691B2/en not_active Ceased
- 1994-06-06 SK SK685-94A patent/SK281830B6/sk unknown
- 1994-06-06 CZ CZ941381A patent/CZ285322B6/cs not_active IP Right Cessation
- 1994-06-06 MA MA23529A patent/MA23216A1/fr unknown
- 1994-06-07 ZA ZA943983A patent/ZA943983B/xx unknown
- 1994-06-07 JP JP6125062A patent/JP2660161B2/ja not_active Expired - Fee Related
- 1994-06-07 CA CA002125376A patent/CA2125376C/en not_active Expired - Lifetime
- 1994-06-07 IL IL10991794A patent/IL109917A/en not_active IP Right Cessation
- 1994-06-07 RU RU94022485/04A patent/RU2117672C1/ru not_active IP Right Cessation
- 1994-06-07 NO NO942110A patent/NO942110L/no not_active Application Discontinuation
- 1994-06-08 KR KR1019940012795A patent/KR0174264B1/ko not_active Expired - Fee Related
- 1994-06-08 OA OA60522A patent/OA10066A/fr unknown
-
1997
- 1997-03-05 US US08/811,843 patent/US6194383B1/en not_active Expired - Lifetime
-
1998
- 1998-07-11 KR KR1019980028496A patent/KR100319563B1/ko not_active Expired - Fee Related
- 1998-07-21 IL IL12545098A patent/IL125450A0/xx unknown
- 1998-12-10 HK HK98113032A patent/HK1012009A1/xx not_active IP Right Cessation
-
1999
- 1999-03-05 GR GR990400678T patent/GR3029591T3/el unknown
-
2000
- 2000-06-16 CY CY0000024A patent/CY2190B1/xx unknown
-
2001
- 2001-01-10 GR GR20010400022T patent/GR3035204T3/el not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| VENC | Patent expired |
Effective date: 20140817 |