US20040092937A1 - Absorbable fastener and applying apparatus - Google Patents
Absorbable fastener and applying apparatus Download PDFInfo
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- US20040092937A1 US20040092937A1 US10/399,486 US39948603A US2004092937A1 US 20040092937 A1 US20040092937 A1 US 20040092937A1 US 39948603 A US39948603 A US 39948603A US 2004092937 A1 US2004092937 A1 US 2004092937A1
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- surgical fastener
- body tissue
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
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- A61B2017/0648—Surgical staples, i.e. penetrating the tissue having one single leg, e.g. tacks threaded, e.g. tacks with a screw thread
Definitions
- the present disclosure relates to a surgical fastener and to an apparatus for applying the surgical fastener as well as to a procedure for fastening objects to body tissue. More particularly, the present disclosure relates to an absorbable surgical fastener and apparatus for applying the absorbable fastener. In addition, the present disclosure relates to procedures for fastening an object to tissue and to procedures that require fastening of tissue together.
- a hernia is a general term referring to a protrusion of tissue through a wall of a cavity in which the tissue is normally contained, also called rupture.
- An inguinal hernia is a condition in which a loop of intestine enters the inguinal canal (i.e., a tubular passage through the lower layers of the abdominal wall).
- a direct inguinal hernia creates a bulge in the groin area, and an indirect hernia descends into the scrotum.
- a hernia In men, a hernia can develop at the point where the spermatic cord passes out of the abdomen into the scrotum.
- An inguinal hernia is a condition in males which occurs in approximately 2% of the male population. Often, an inguinal hernia can be pushed back into the abdominal cavity. However, if the inguinal hernia cannot be forced back through the abdominal wall, the herniated bowel may become trapped in the inguinal ring and/or strangulated. If the flow of blood is restricted (strangulated hernia) or the intestine is blocked (obstructed), emergency surgery is necessary. Without treatment, the strangulated loop of intestine dies as a result of a lack of blood to the loop of intestine.
- the Lichtenstein repair method is a “tension-free hernioplasty” based on two important facts, namely, inguinal hernias are caused by a metabolic disorder, which leads to a progressive destruction of the fibroconnective tissue of the groin, making the tissue unsuitable for use in hernia repair and the fact that traditional tissue repairs are associated with undue tension at the suture line, which leads to more postoperative pain, longer recovery time, and a higher rate of.
- the Lichtenstein repair method includes the following steps. First, a transverse incision is made within a Langer's line, beginning from the pubic tubercle. The external oblique aponeurosis is opened and the spermatic cord with its cremasteric covering, external spermatic vessels, and the genital nerve are freed from the inguinal floor and lifted with a Penrose drain. The spermatic cord is then dissected free from the pubic bone area medial to the pubic tubercle in order to make room for extending the mesh beyond the pubic tubercle.
- the external oblique aponeurosis is dissected from the underlying internal oblique muscle and aponeurosis high enough to make room for a prosthesis.
- the sac is then dissected from the cord beyond its neck and inverted into the properitoneal space without ligation or excision.
- the proximal end is closed, dissected away from the cord structures, and inverted into the preperitoneal space.
- the medial side of the mesh is then shaped to the patient's anatomy.
- the first anchoring suture of the mesh fixes the mesh to the anterior rectus sheath where it inserts into the pubic bone.
- the lower edge of the mesh is sutured to the inguinal ligament using the same suture in a continuous fashion and ends at the lateral border of the internal ring.
- a slit is next made on the lateral end of the mesh, creating 2 tails.
- the upper tail is then passed under the cord and pulled toward the head of the patient, placing the spermatic cord in between the 2 tails.
- the upper tail is then crossed over the lower one and held with a pair of hemostats.
- the tails are later sutured together and tucked under the external oblique aponeurosis.
- the Stoppa method of hernia repair places a single sheet of prosthetic material (i.e., surgical mesh) between the peritoneum and the musculopectineal orifice.
- the surgical mesh is then anchored to Cooper's ligaments using nonabsorbable sutures.
- the Stoppa hernia repair method is further described in the attached article in Appendix A, the entire contents of which are hereby incorporated by reference.
- TAPP TransAbdominal PrePeritoneal Laparoscopic Hernia repair method
- a pneumoperitoneum is created in the abdomen and an intra-abdominal pressure is maintained.
- the repair is then initiated.
- a laparoscope then inserted and is pointed toward the afflicted inguinal canal.
- the peritoneal defect or hernia is identified.
- a peritoneal incision is made, which incision is extended from the lateral aspect of the inguinal region to the lateral umbilical ligament.
- the Cooper's ligament is then exposed as well as the inferior epigastric vessels and the spermatic Cord.
- the indirect inguinal hernia sac is then dissected carefully from the spermatic cord.
- a surgical mesh is then inserted into the intra-abdominal cavity and deployed over the inguinal region. There are three methods to place and secure the mesh over the inguinal region.
- the mesh is then secured in place with a surgical stapler. It is first stapled on to Cooper's ligament followed by placing several staples perpendicular to the ligament followed by a row more lateral and parallel to Cooper's Ligament.
- the graft is also anchored around the inferior epigastric vessels and lateral to them. If the mesh is wrapped around the spermatic cord, both limbs of the mesh are stapled closed. The peritoneum is then closed using additional staples and homeostasis is checked.
- TEP Total ExtraPeritoneal Laparoscopic Hernia repair method. This method is identical to the TAPP repair method, however, it entirely takes place in the preperitoneal space.
- the TEP method includes the following steps. Unlike the TAPP repair method, no pneumoperitoneum is created in the TEP repair method. Instead, a small incision is made below the umbilicus (midline) and the midline exposed. An incision is made slightly lateral to the midline aponevrosis and the anterior and posterior rectus muscle sheaths are exposed. The anatomy must first be clearly identified. Cooper's ligament should be first visualized as well as the inferior epigastric vessels.
- the indirect hernia sac should be bluntly pulled away from the spermatic cord and the inguinal canal.
- the hernia sac should then be dissected as medially as possible to allow a surgical mesh to cover the entire inguinal region.
- the mesh is then inserted and stapled into place as in the TAPP repair method. With the repair completed the small incisions can be closed.
- TEP Total ExtraPeritoneal
- TAPP TransAbdominal PrePeritoneal
- Each of the above disclosed procedures utilizes titanium staples to retain the mesh in place. These staples become permanent residents in the body cavity.
- a disadvantage of permanent metal staples is the possibility of the formation of excessive scar tissue (adhesions) which can in turn cause further patient complications and hinder future surgical procedures.
- these permanent staples may be associated with increased long-term discomfort to the patient as a result of the hernia repair procedure.
- the tether provides the advantage of holding the mesh in place loosely thus minimizing the tension in the surrounding tissue and reducing fastener pull-out occurrences.
- the presently disclosed surgical fastener apparatus and method serve the function of previously used staples to secure objects to body tissue as performed in previous methods, for example, mesh being fixed to specific anatomic landmarks surrounding the hernia repair, or attaching mesh to tissue, or attaching tissue to tissue or attaching tissue to ligaments.
- the presently disclosed absorbable fastener apparatus and method have the uniquely advantageous feature that the absorbable fasteners are utilized to attach the mesh to the tissue for a sufficient time to allow tissue in-growth to occur on the mesh material. In this manner, the absorbable fasteners help prevent early mesh migration and then after sufficient tissue in-growth are absorbed in the body.
- a surgical fastener apparatus for securing a surgical mesh material to body tissue, in which the apparatus includes a pair of anchors each having retaining means formed on an outer surface thereof and a suture tether interconnecting said pair of anchors to one another.
- the fastener apparatus is preferably made from a bioabsorbable material and is dimensioned such that the apparatus will only be partially absorbed over a period of 2 to 3 weeks after implantation and will be completely absorbed into the body at any time thereafter.
- the surgical fastener apparatus includes a conical body portion having a pointed distal tip and an enlarged proximal head.
- the conical body portion being provided with a helical thread commencing at or near the distal tip and terminating preferably at a distance spaced from the enlarged proximal head.
- a hernial repair method utilizing the fasteners in accordance with the present disclosure is provided in which a surgical mesh is secured in place over the hernia repair site by imbedding the surgical fasteners in to body tissue through the surgical mesh.
- FIG. 1 is an enlarged perspective view of one embodiment of an absorbable surgical fastener apparatus constructed in accordance with the present disclosure
- FIG. 2 is a side view of a barb portion of the absorbable surgical fastener apparatus of FIG. 1;
- FIG. 3 is an enlarged perspective view of an alternative embodiment of an absorbable surgical fastener in accordance with the present disclosure
- FIG. 4 is an end view of the surgical fastener of FIG. 3;
- FIG. 5 is an enlarged perspective view of an absorbable surgical fastener apparatus including a pair of fasteners as shown in FIG. 3;
- FIG. 6 is a cross-sectional view of the absorbable fastener shown in FIG. 5, taken along the longitudinal axis;
- FIG. 7 is an illustration of a sequential step in one embodiment of attaching an object to body tissue using the presently disclosed absorbable surgical fasteners
- FIG. 8 is a further sequential step according to the method embodiment of FIG. 7;
- FIG. 9 is a still further sequential step of the method of FIG. 7;
- FIG. 10 is another sequential step of the method of FIG. 7.
- FIG. 11 is another illustration of a step of the method embodiment of FIG. 7.
- an absorbable surgical fastener apparatus for connecting objects to body tissue such as absorbable fastener 10 includes dual fastener anchors 12 and 14 secured to one another by a suture tether 16 extending therebetween.
- Each anchor 12 and 14 has a substantially cylindrical body portion 18 having a conically tapered distal end 20 and a substantially planar proximal end surface 22 .
- Anchors 12 and 14 are preferably provided with conically shaped distal ends 20 for easier penetration of anchors 12 and 14 into hard tissues, such as, for example, Cooper's ligament. While a generally conical distal end has been disclosed, it is envisioned that other shaped ends (e.g., pyramid, and the like) can be provided.
- Each anchor 12 and 14 is provided with a pair of opposed flattened side surfaces 22 extending longitudinally along the length thereof.
- Anchors 12 and 14 are provided with barbs 12 a , 12 b , 12 c , and 14 a , 14 b , 14 c respectively to inhibit fastener pull-out occurrences in either hard or soft tissue.
- Each barb is semi-circular having a planar proximal surface 24 which is orthogonal to a central longitudinal axis “A” of each anchor 12 and 14 , and a tapered lower surface 26 .
- barbs 12 a - 12 c and 14 a - 14 c share a common central axis “B”, however, it is envisioned that each respective barb can have a different center as compared to other barbs on the anchor.
- central axis “B” is spaced a distance “X” from longitudinal axis “A”.
- the center of barbs 12 a - 12 c and 14 a - 14 c can be positioned to reveal a greater amount of planar proximal surface 24 in order to provide an anchor with predetermined anchoring and securing characteristics for body tissue without compromising the strength of body portion 18 of each anchor 12 and 14 .
- distance “X” between central axis “B” and longitudinal axis “A” is increased thereby forming a bard with a larger planar proximal surface 24 .
- a fastener having a larger projecting barb is desired in order to better anchor the fastener into the soft tissue of the patient.
- each barb 12 a - 12 c and 14 a - 14 c is orthogonal to longitudinal axis “A” of each anchor 12 and 14 respectively, it is envisioned that each barb can be angled relative to longitudinal axis “A” such that barbs 12 a , 12 b and 12 c form a partial thread around body portion 18 of each anchor 12 and 14 . In this manner, as each anchor 12 and 14 is pressed into body tissue, each anchor 12 and 14 will rotate into the body tissue.
- FIGS. 1 and 2 illustrate barbs formed partially around the circumference of anchors 12 and 14
- multiple barb configurations can be utilized and are within the scope of the present disclosure.
- single barb, circumferential barb i.e., barbs encircling the entire anchor
- sharp barbs dull barbs
- multiple barbs and various geometrically shaped barbs may be utilized.
- each anchor 12 and 14 can be provided with a notch or detent (not shown) formed in the proximal end thereof. In this manner, when a series of absorbable fasteners 10 are joined together, the tapered distal ends 18 are received in the detents to thereby maintain the absorbable fasteners 10 and anchors 12 and 14 longitudinally aligned with one another.
- Absorbable fasteners 10 are preferably made of medical grade absorbable materials, for example, Polyglycolic Acid (PGA) and Polylactic Acid (PLA).
- PGA Polyglycolic Acid
- PLA Polylactic Acid
- a critical feature of the presently disclosed absorbable fastener is that the absorbable fastener provide sufficient strength to retain a mesh material in place for a desired period of time. For example, in the case of applying a hernia repair mesh material, it is recommended that absorbable fasteners 10 remain in place retaining the mesh material for approximately 2-3 weeks and be absorbed into the body tissue anytime after that.
- absorbable fasteners 10 are approximately 3 mm long, from the tip of distal end 18 to proximal end 20 , by approximately 1.5 mm in diameter. Other suitably configured and dimensioned fasteners may also be utilized depending on the particular application. It is also preferred that absorbable fasteners 10 are configured and dimensioned to avoid penetrating too far into the tissue.
- An example of a similar fastener structure and an instrument for applying such fasteners are disclosed in U.S. Pat. No. 5,997,552 (hereinafter “the '552 patent”), issued to Person et al. and entitled Meniscle Fastener Applying Device, the entire contents of which are hereby incorporated by reference.
- the barbs of fastener 10 have a center “B” which is spaced a distance “X” from the longitudinal axis “A” of the anchor as opposed to the body of the anchor being cut away to reveal a barb in the '552 patent.
- a barb having a larger height is achieved without altering the dimensions of the body portion, which larger height more firmly secures the anchor of fastener 10 into body tissue as compared to the fastener disclosed in the '552 patent.
- the applicator according to the present disclosure is preferably adapted to fire 20 to 30 fasteners per instrument for use in either open and/or laparoscopic procedures. It is envisioned that the applicator instrument be either entirely disposable after use or be provided with a replaceable cartridge of fasteners which can be coupled to the end of a reusable applicator and replaced within a given procedure while the handle of such an applicator would still be disposable but would be reusable within a single procedure. While an alternate applier may be used, the fastener applier disclosed in the '552 reference can be used to apply the surgical fasteners disclosed herein.
- the general procedure of applying a mesh material during a hernia repair procedure is to first create an access to the location of the hernia (i.e., incision and dissection) thereby exposing the hernia; then place a prosthetic mesh over the hernia defect; next fasten the mesh to the surrounding tissue by firing a plurality of absorbable fasteners 10 through the mesh and into tissue to thereby secure the mesh into place; and finally close the access wound.
- fastener 200 includes a substantially conical body portion 202 depending from a circular head portion 204 .
- Conical body portion 202 includes a helical thread 206 commencing at a pointed distal tip 208 of body portion 202 and terminating at a distance spaced from head portion 204 .
- the helical thread 206 advances from distal tip . 206 toward head portion 204 , the radial projection of the helical thread 206 from the body portion 202 increases.
- helical thread 206 is disclosed as commencing at the distal tip 208 , it is envisioned that the helical thread 206 can commence at a distance spaced from the distal tip 208 .
- head portion 204 can be provided with a recess or notch (not shown) formed in the center of the proximal surface thereof. The recess being configured to receive the distal tip 208 of an adjacent fastener 200 therein. In this manner, a series of fasteners 200 can be aligned in a tip-to-tail fashion with one another and share a common axis.
- fastener 200 is pressed into body tissue “T”, through surgical mesh “M”, until the entire body portion 202 of fastener 200 has passed through mesh “M” and has been buried in tissue “T”. Head portion 204 ensures that fastener 200 does not completely pass through mesh “M” thereby ensuring that mesh “M” is in contact with tissue “T”.
- Fastener 200 includes an arcuate tooth 210 projecting radially outwardly from the proximal end of helical thread 206 and oriented such that the curve of the arcuate tooth 210 is oriented to inhibit a rotation of fastener 200 which would remove fastener 200 from body tissue “T”.
- surgical fastener apparatus 300 Similar to fastener 200 , surgical fastener apparatus 300 includes a pair of substantially conical anchors 302 each having a helical thread 304 commencing at a distal tip 306 of each anchor 302 and terminating at a proximal end surface 308 of each anchor 302 .
- the radial projection of the helical thread 304 on anchor 302 increases as the helical thread 304 advances from the distal tip 306 to the proximal end of the anchor 302 .
- helical thread 304 is disclosed as commencing the distal tip 306 , it is envisioned that the helical thread 304 can commence at a distance spaced from the distal tip 306 just as well.
- Anchors 302 are connected to one another by a suture tether 310 extending therebetween.
- the orientation of helical thread 304 on each anchor 302 is in the same direction. In this manner, as anchors 302 are being imbedded into body tissue and commence rotating in the direction of helical thread 304 , suture tether 310 on each anchor 302 will rotate in the same direction and not become tightened.
- each helical thread is provided with an arcuate tooth 312 , which arcuate tooth 312 is oriented such that after anchors 302 have been completely imbedded into the body tissue the tooth 312 will dig into the body tissue if the anchor is rotated in a direction which would remove the anchor from the body tissue.
- surgical fastener apparatus 300 can be provided with a detent or recess 314 (see FIG. 6) formed in the proximal end surface thereof. In this manner, a series of fasteners 300 can be aligned in tip-to-tail fashion with one another in a fastener applier so that fasteners 300 share a common axis.
- helical thread 304 is made up of a distal surface 316 and a proximal surface 318 joined together to form a sharp edge 320 .
- suture tether 310 is fixedly retained within anchors 302 , however, it is envisioned that suture tether 310 can be rotatably mounted to proximal surface 308 .
- Fasteners 200 and 300 are also preferably made of medical grade absorbable materials, for example, Polyglycolic Acid (PGA) and Polylactic Acid (PLA).
- PGA Polyglycolic Acid
- PLA Polylactic Acid
- a critical feature of the presently disclosed absorbable fastener is that the absorbable fastener provide sufficient strength to retain a mesh material in place for a desired period of time. For example, in the case of applying a hernia repair mesh material, it is recommended that absorbable fasteners 200 or 300 remain in place retaining the mesh material for approximately 2-3 weeks and be absorbed into the body. tissue anytime after that.
- absorbable fastener 200 and that each anchor of fastener apparatus 300 are approximately 3 mm long, from the tip of distal end to the proximal end, and wherein the proximal end is approximately 1.5 mm in diameter. It is preferred that fastener 200 and fastener apparatus 300 are configured and dimensioned to avoid penetrating too far into the body tissue.
- Fasteners 200 and 300 can be imbedded into body tissue by either pressing the fastener in to the tissue and allowing the thread on the fastener to automatically twist the fastener into the tissue, by providing a twisting applier which turns the fastener and thus the helical threads draw the fastener into the body tissue or by a combination of pressing and twisting.
- a Lichtenstein repair method will now be described as performed using any of the absorbable surgical fasteners in accordance with the present disclosure.
- a 5 cm to 6 cm transverse incision is made within a Langer's line, beginning from the pubic tubercle.
- the external oblique aponeurosis is opened.
- the spermatic cord with its cremasteric covering, external spermatic vessels, and the genital nerve are freed from the inguinal floor and lifted with a Penrose drain.
- the spermatic cord is dissected free from the pubic bone area for approximately 2 cm medial to the pubic tubercle in order to make room for extending a prosthetic mesh beyond the pubic tubercle.
- the external oblique aponeurosis is dissected from the underlying internal oblique muscle and aponeurosis high enough to make room for a prosthesis that is 6 cm to 7 cm in height.
- the sac is then dissected from the cord beyond its neck and inverted into the properitoneal space without ligation or excision.
- a medial side of the mesh is shaped to the patient's anatomy.
- a first absorbable fastener 10 , 200 or 300 is applied to the mesh to fix the mesh to the anterior rectus sheath where it inserts into the pubic bone.
- the absorbable fastener is placed approximately 2 cm medial to the pubic tubercle in order to be sure that the area is covered by the mesh.
- Additional absorbable fasteners 10 , 200 or 300 are placed therearound and end at the lateral border of the internal ring.
- the lower edge of the mesh is then anchored to the inguinal ligament using the same fasteners 10 , 200 or 300 around the surgical mesh and ending at the lateral border of the internal ring.
- the absorbable fastener is secured into place by firing the fastener into the body tissue such that a first anchor of the surgical fastener penetrates through the surgical mesh and into the body tissue and such that a second anchor of the surgical fastener is implanted directly into the body tissue.
- the suture tether of the fastener apparatus extends partially across the surgical mesh and partially across body tissue.
- an absorbable fastener in accordance with the present disclosure can be secured into place such that both anchors are imbedded into the body tissue and pass through the surgical mesh. If fastener 200 is used in the method, fasteners 200 are anchored into the body tissue solely through the mesh.
- a slit is then made on the lateral end of the mesh, as seen in FIG. 9, creating 2 tails—2 ⁇ 3 above and 1 ⁇ 3 below.
- the upper tail is then passed under the cord and pulled toward the head of the patient, placing the spermatic cord in between the 2 tails.
- the upper tail is then crossed over the lower one and held with a pair of hemostat, as seen in FIG. 10.
- the tails are later sutured together and tucked under the external oblique aponeurosis, leaving 5 cm to 6 cm of mesh lateral to the internal ring.
- a Total ExtraPeritoneal Laparoscopic Hernia repair using fasteners 10 or 300 in accordance with the present disclosure, will now be described.
- a skin incision is created and the fascia is incised.
- a balloon type distractor is then placed therein and distended in order to create an operative extraperitoneal space.
- Umbilical trocars and secondary trocars are then inserted into the extraperitoneal space and the space explored.
- the medial and lateral structures are then dissected and the spermatic chord identified.
- a surgical mesh is then cut to the desired size and shape such that a slit is provided in order to wrap the mesh on either side of the spermatic chord.
- the mesh is then laterally fixed in place using surgical fasteners 10 , 200 or 300 in order to anchor the mesh to the tranversus arch and the iliopubic tract. This step is repeated for the opposite side.
- the mesh is then medially fixed in place using additional fasteners 10 , 200 or 300 to the transversus arch and to Cooper's ligament or in the alternative, fix the mesh to the medial iliopubic tract. Finally, the incision is closed.
- fasteners 10 , 200 or 300 can be used in a TAPP repair method to replace suturing of the mesh both laterally and medially.
- fasteners 10 , 200 or 300 are used to secure the mesh in to place by penetrating the mesh and being anchored into the body tissue.
- fasteners having a similar structure can be used in surgical procedures for fastening items to bone or cartilage.
- the surgical fasteners can be made from surgical grade stainless steel, titanium or any other surgical grade material having sufficient strength to penetrate bone.
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- Health & Medical Sciences (AREA)
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- Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
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Priority Applications (7)
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US12/052,077 US8034076B2 (en) | 2000-10-23 | 2008-03-20 | Absorbable fastener and applying apparatus |
US12/052,071 US8114101B2 (en) | 2000-10-23 | 2008-03-20 | Absorbable fastener and applying apparatus |
US13/231,093 US8597311B2 (en) | 2000-10-23 | 2011-09-13 | Absorbable fastener and applying apparatus |
US13/294,442 US20120059397A1 (en) | 2000-10-23 | 2011-11-11 | Absorbable fastener and applying apparatus |
US13/312,031 US8728102B2 (en) | 2000-10-23 | 2011-12-06 | Absorbable fastener and applying apparatus |
US13/345,786 US20120109157A1 (en) | 2000-10-23 | 2012-01-09 | Absorbable fastener and applying apparatus |
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PCT/US2001/050165 WO2002034140A2 (en) | 2000-10-23 | 2001-10-23 | Absorbable fastener and applying apparatus |
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US12/052,071 Expired - Fee Related US8114101B2 (en) | 2000-10-23 | 2008-03-20 | Absorbable fastener and applying apparatus |
US13/231,093 Expired - Fee Related US8597311B2 (en) | 2000-10-23 | 2011-09-13 | Absorbable fastener and applying apparatus |
US13/294,442 Abandoned US20120059397A1 (en) | 2000-10-23 | 2011-11-11 | Absorbable fastener and applying apparatus |
US13/312,031 Expired - Fee Related US8728102B2 (en) | 2000-10-23 | 2011-12-06 | Absorbable fastener and applying apparatus |
US13/345,786 Abandoned US20120109157A1 (en) | 2000-10-23 | 2012-01-09 | Absorbable fastener and applying apparatus |
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US12/052,077 Expired - Fee Related US8034076B2 (en) | 2000-10-23 | 2008-03-20 | Absorbable fastener and applying apparatus |
US12/052,071 Expired - Fee Related US8114101B2 (en) | 2000-10-23 | 2008-03-20 | Absorbable fastener and applying apparatus |
US13/231,093 Expired - Fee Related US8597311B2 (en) | 2000-10-23 | 2011-09-13 | Absorbable fastener and applying apparatus |
US13/294,442 Abandoned US20120059397A1 (en) | 2000-10-23 | 2011-11-11 | Absorbable fastener and applying apparatus |
US13/312,031 Expired - Fee Related US8728102B2 (en) | 2000-10-23 | 2011-12-06 | Absorbable fastener and applying apparatus |
US13/345,786 Abandoned US20120109157A1 (en) | 2000-10-23 | 2012-01-09 | Absorbable fastener and applying apparatus |
Country Status (7)
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US (7) | US20040092937A1 (xx) |
EP (2) | EP2298183B1 (xx) |
JP (2) | JP4092196B2 (xx) |
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US8114101B2 (en) | 2012-02-14 |
JP4748813B2 (ja) | 2011-08-17 |
US20120078275A1 (en) | 2012-03-29 |
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EP1328196A2 (en) | 2003-07-23 |
JP4092196B2 (ja) | 2008-05-28 |
CA2426474A1 (en) | 2002-05-02 |
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WO2002034140A2 (en) | 2002-05-02 |
US20080167668A1 (en) | 2008-07-10 |
US20120004674A1 (en) | 2012-01-05 |
CA2692564C (en) | 2013-08-27 |
WO2002034140A3 (en) | 2002-08-08 |
US20120109157A1 (en) | 2012-05-03 |
EP2298183B1 (en) | 2013-03-27 |
JP2004530450A (ja) | 2004-10-07 |
ES2365129T3 (es) | 2011-09-22 |
AU2002232798B2 (en) | 2006-01-05 |
US20120059397A1 (en) | 2012-03-08 |
CA2692564A1 (en) | 2002-05-02 |
US20080167667A1 (en) | 2008-07-10 |
CA2426474C (en) | 2010-05-04 |
JP2008136876A (ja) | 2008-06-19 |
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AS | Assignment |
Owner name: TYCO HEALTHCARE GROUP LP, CONNECTICUT Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:CRISCUOLO, CHRISTOPHER J.;HEINRICH, RUSSELL S.;AZARBARZIN, KOUROSH;REEL/FRAME:014298/0753;SIGNING DATES FROM 20021021 TO 20021025 |
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STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |