UA73789C2 - 1,3-dioxolans with antitussive activity - Google Patents

1,3-dioxolans with antitussive activity Download PDF

Info

Publication number: UA73789C2
Authority: UA; Ukraine
Prior art keywords: phenylpiperazin; diol; propane; cyclohexylidene; formula
Prior art date: 2000-07-28

Application number

UA2003021767A

Other languages

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-28

Filing date

2001-07-18

Publication date

2005-09-15

2001-07-18 Application filed filed Critical

2005-09-15 Publication of UA73789C2 publication Critical patent/UA73789C2/uk

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Pulmonology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Glass Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

UA2003021767A 2000-07-28 2001-07-18 1,3-dioxolans with antitussive activity UA73789C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2000MI001734A IT1318650B1 (it)	2000-07-28	2000-07-28	1,3-diossolani ad attivita' antitosse.
PCT/EP2001/008304 WO2002010149A1 (en)	2000-07-28	2001-07-18	1,3-dioxolanes with antitussive activity

Publications (1)

Publication Number	Publication Date
UA73789C2 true UA73789C2 (en)	2005-09-15

Family

ID=11445591

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA2003021767A UA73789C2 (en)	2000-07-28	2001-07-18	1,3-dioxolans with antitussive activity

Country Status (27)

Country	Link
US (1)	US6835734B2 (et)
EP (1)	EP1307441B1 (et)
JP (1)	JP5107497B2 (et)
KR (1)	KR100781403B1 (et)
CN (1)	CN1204135C (et)
AT (1)	ATE266018T1 (et)
AU (1)	AU2001287638A1 (et)
BR (1)	BR0112765A (et)
CZ (1)	CZ301087B6 (et)
DE (1)	DE60103164T2 (et)
DK (1)	DK1307441T3 (et)
EE (1)	EE05178B1 (et)
ES (1)	ES2219562T3 (et)
HK (1)	HK1058797A1 (et)
HU (1)	HUP0301497A3 (et)
IL (2)	IL153515A0 (et)
IT (1)	IT1318650B1 (et)
MX (1)	MXPA02012920A (et)
PL (1)	PL206307B1 (et)
PT (1)	PT1307441E (et)
RS (1)	RS50861B (et)
RU (1)	RU2276149C2 (et)
SI (1)	SI21040A (et)
SK (1)	SK286794B6 (et)
TR (1)	TR200401315T4 (et)
UA (1)	UA73789C2 (et)
WO (1)	WO2002010149A1 (et)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1318651B1 (it) *	2000-07-28	2003-08-27	Dompe Spa	Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.
TWI496776B (zh) *	2007-11-15	2015-08-21	Astrazeneca Ab	製備(3aR,4S,6R,6aS)-6-胺基-2,2-二甲基四氫-3aH-環戊并[d][1,3]二氧雜環戊烯-4-醇之純非對映異構性之二苯甲醯-L-酒石酸鹽之方法
EP2070915A1 (en) *	2007-12-03	2009-06-17	A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.p.A.	New process for the synthesis of moguisteine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4049660A (en) *	1971-06-18	1977-09-20	Delalande S.A.	N-substituted derivatives of 4 (N-piperazinylmethyl) spiro dibenzocycloheptadi- (or tri-) ene-5, 2-dioxolane (1,3) their method of preparation and their application in therapeutics
IT1203721B (it) *	1983-12-29	1989-02-23	Dompe Farmaceutici Spa	Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono
NL8801622A (nl) *	1988-06-25	1990-01-16	Stamicarbon	Bereiding van enantiomeren van dropropizine.
IT1226570B (it) *	1988-08-01	1991-01-24	Bidachem Spa	Procedimento di preparazione della levo- e destro-dropropizina
IT1254452B (it) *	1992-02-14	1995-09-25	Dompe Farmaceutici Spa	N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli
IT1254993B (it) *	1992-06-24	1995-10-11		Procedimento per la preparazione degli enantiomeri della dropropizina
IL111730A (en) *	1993-11-29	1998-12-06	Fujisawa Pharmaceutical Co	Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
IT1318651B1 (it) *	2000-07-28	2003-08-27	Dompe Spa	Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.

2000
- 2000-07-28 IT IT2000MI001734A patent/IT1318650B1/it active
2001
- 2001-07-18 US US10/333,979 patent/US6835734B2/en not_active Expired - Fee Related
- 2001-07-18 SI SI200120036A patent/SI21040A/sl not_active IP Right Cessation
- 2001-07-18 PL PL361172A patent/PL206307B1/pl not_active IP Right Cessation
- 2001-07-18 UA UA2003021767A patent/UA73789C2/uk unknown
- 2001-07-18 EP EP01967203A patent/EP1307441B1/en not_active Expired - Lifetime
- 2001-07-18 TR TR2004/01315T patent/TR200401315T4/xx unknown
- 2001-07-18 MX MXPA02012920A patent/MXPA02012920A/es active IP Right Grant
- 2001-07-18 DK DK01967203T patent/DK1307441T3/da active
- 2001-07-18 WO PCT/EP2001/008304 patent/WO2002010149A1/en active IP Right Grant
- 2001-07-18 AU AU2001287638A patent/AU2001287638A1/en not_active Abandoned
- 2001-07-18 DE DE60103164T patent/DE60103164T2/de not_active Expired - Lifetime
- 2001-07-18 JP JP2002515880A patent/JP5107497B2/ja not_active Expired - Fee Related
- 2001-07-18 IL IL15351501A patent/IL153515A0/xx active IP Right Grant
- 2001-07-18 BR BR0112765-9A patent/BR0112765A/pt not_active Application Discontinuation
- 2001-07-18 EE EEP200300036A patent/EE05178B1/et not_active IP Right Cessation
- 2001-07-18 KR KR1020037000945A patent/KR100781403B1/ko not_active IP Right Cessation
- 2001-07-18 RU RU2003105691/04A patent/RU2276149C2/ru not_active IP Right Cessation
- 2001-07-18 AT AT01967203T patent/ATE266018T1/de active
- 2001-07-18 HU HU0301497A patent/HUP0301497A3/hu unknown
- 2001-07-18 RS YUP-30/03A patent/RS50861B/sr unknown
- 2001-07-18 CZ CZ20030268A patent/CZ301087B6/cs not_active IP Right Cessation
- 2001-07-18 CN CNB018134564A patent/CN1204135C/zh not_active Expired - Fee Related
- 2001-07-18 PT PT01967203T patent/PT1307441E/pt unknown
- 2001-07-18 SK SK89-2003A patent/SK286794B6/sk not_active IP Right Cessation
- 2001-07-18 ES ES01967203T patent/ES2219562T3/es not_active Expired - Lifetime
2002
- 2002-12-18 IL IL153515A patent/IL153515A/en not_active IP Right Cessation
2004
- 2004-03-05 HK HK04101653A patent/HK1058797A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP2004505073A (ja)	2004-02-19
ES2219562T3 (es)	2004-12-01
MXPA02012920A (es)	2004-04-20
KR20030016425A (ko)	2003-02-26
US20040038989A1 (en)	2004-02-26
DE60103164T2 (de)	2005-05-04
EE05178B1 (et)	2009-06-15
HUP0301497A3 (en)	2005-08-29
PL206307B1 (pl)	2010-07-30
AU2001287638A1 (en)	2002-02-13
ATE266018T1 (de)	2004-05-15
PL361172A1 (en)	2004-09-20
IL153515A (en)	2006-12-10
CN1204135C (zh)	2005-06-01
ITMI20001734A0 (it)	2000-07-28
US6835734B2 (en)	2004-12-28
KR100781403B1 (ko)	2007-12-03
CZ2003268A3 (cs)	2003-06-18
HK1058797A1 (en)	2004-06-04
JP5107497B2 (ja)	2012-12-26
DE60103164D1 (de)	2004-06-09
EP1307441B1 (en)	2004-05-06
RS50861B (sr)	2010-08-31
ITMI20001734A1 (it)	2002-01-28
HUP0301497A2 (hu)	2003-09-29
DK1307441T3 (da)	2004-08-09
SI21040A (sl)	2003-04-30
BR0112765A (pt)	2004-01-13
EP1307441A1 (en)	2003-05-07
RU2276149C2 (ru)	2006-05-10
PT1307441E (pt)	2004-09-30
CZ301087B6 (cs)	2009-11-04
EE200300036A (et)	2004-10-15
WO2002010149A1 (en)	2002-02-07
CN1444578A (zh)	2003-09-24
TR200401315T4 (tr)	2004-07-21
IT1318650B1 (it)	2003-08-27
IL153515A0 (en)	2003-07-06
YU3003A (sh)	2006-05-25
SK892003A3 (en)	2003-09-11
SK286794B6 (sk)	2009-05-07

Publication	Publication Date	Title
US3268582A (en)	1966-08-23	Phenylalkyl-carboxylic acid amides
UA73789C2 (en)	2005-09-15	1,3-dioxolans with antitussive activity
EP1307440B1 (en)	2005-03-09	2,2-disubstituted 1,3-dioxolanes as antitussive agents
JPS649993B2 (et)	1989-02-21
JPH0510344B2 (et)	1993-02-09
JPH054949A (ja)	1993-01-14	光学活性シクロブチルアミン類の製造方法
WO1993016056A1 (en)	1993-08-19	3-(piperazin-1-yl)-propane-1,2-diol n-oxydes and n,n'-dioxides