[go: up one dir, main page]

RS50861B - 1,3-dioksolani kao sredstva protiv kašlja - Google Patents

1,3-dioksolani kao sredstva protiv kašlja

Info

Publication number
RS50861B
RS50861B YUP-30/03A YUP3003A RS50861B RS 50861 B RS50861 B RS 50861B YU P3003 A YUP3003 A YU P3003A RS 50861 B RS50861 B RS 50861B
Authority
RS
Serbia
Prior art keywords
dioxolanes
antitussive activity
antitussive
activity
phenyl
Prior art date
Application number
YUP-30/03A
Other languages
English (en)
Inventor
Marcello Allegretti
Maria Candida Cesta
Roberto Curti
Lugi PELLEGRINI
Gabriella Melillo
Original Assignee
Dompe Pha.R.Ma S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompe Pha.R.Ma S.P.A. filed Critical Dompe Pha.R.Ma S.P.A.
Publication of YU3003A publication Critical patent/YU3003A/sh
Publication of RS50861B publication Critical patent/RS50861B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Glass Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Jedinjenja formule (1)gde:svaki Ra i Rb, koji može biti isti ili različiti, predstavlja vodonik, C1-6-alkil, fenil, ili Ra i Rb zajedno sa C atomom za koji su vezani, grade četvoročlani do sedmočlani supstituisani karbociklični prsten.Prijava sadrži još 7 patentnih zahteva.
YUP-30/03A 2000-07-28 2001-07-18 1,3-dioksolani kao sredstva protiv kašlja RS50861B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000MI001734A IT1318650B1 (it) 2000-07-28 2000-07-28 1,3-diossolani ad attivita' antitosse.

Publications (2)

Publication Number Publication Date
YU3003A YU3003A (sh) 2006-05-25
RS50861B true RS50861B (sr) 2010-08-31

Family

ID=11445591

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-30/03A RS50861B (sr) 2000-07-28 2001-07-18 1,3-dioksolani kao sredstva protiv kašlja

Country Status (27)

Country Link
US (1) US6835734B2 (sr)
EP (1) EP1307441B1 (sr)
JP (1) JP5107497B2 (sr)
KR (1) KR100781403B1 (sr)
CN (1) CN1204135C (sr)
AT (1) ATE266018T1 (sr)
AU (1) AU2001287638A1 (sr)
BR (1) BR0112765A (sr)
CZ (1) CZ301087B6 (sr)
DE (1) DE60103164T2 (sr)
DK (1) DK1307441T3 (sr)
EE (1) EE05178B1 (sr)
ES (1) ES2219562T3 (sr)
HK (1) HK1058797A1 (sr)
HU (1) HUP0301497A3 (sr)
IL (2) IL153515A0 (sr)
IT (1) IT1318650B1 (sr)
MX (1) MXPA02012920A (sr)
PL (1) PL206307B1 (sr)
PT (1) PT1307441E (sr)
RS (1) RS50861B (sr)
RU (1) RU2276149C2 (sr)
SI (1) SI21040A (sr)
SK (1) SK286794B6 (sr)
TR (1) TR200401315T4 (sr)
UA (1) UA73789C2 (sr)
WO (1) WO2002010149A1 (sr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1318651B1 (it) * 2000-07-28 2003-08-27 Dompe Spa Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.
TWI496776B (zh) * 2007-11-15 2015-08-21 Astrazeneca Ab 製備(3aR,4S,6R,6aS)-6-胺基-2,2-二甲基四氫-3aH-環戊并[d][1,3]二氧雜環戊烯-4-醇之純非對映異構性之二苯甲醯-L-酒石酸鹽之方法
EP2070915A1 (en) * 2007-12-03 2009-06-17 A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.p.A. New process for the synthesis of moguisteine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049660A (en) * 1971-06-18 1977-09-20 Delalande S.A. N-substituted derivatives of 4 (N-piperazinylmethyl) spiro dibenzocycloheptadi- (or tri-) ene-5, 2-dioxolane (1,3) their method of preparation and their application in therapeutics
IT1203721B (it) * 1983-12-29 1989-02-23 Dompe Farmaceutici Spa Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono
NL8801622A (nl) * 1988-06-25 1990-01-16 Stamicarbon Bereiding van enantiomeren van dropropizine.
IT1226570B (it) * 1988-08-01 1991-01-24 Bidachem Spa Procedimento di preparazione della levo- e destro-dropropizina
IT1254452B (it) * 1992-02-14 1995-09-25 Dompe Farmaceutici Spa N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli
IT1254993B (it) * 1992-06-24 1995-10-11 Procedimento per la preparazione degli enantiomeri della dropropizina
IL111730A (en) * 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
IT1318651B1 (it) * 2000-07-28 2003-08-27 Dompe Spa Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.

Also Published As

Publication number Publication date
JP2004505073A (ja) 2004-02-19
ES2219562T3 (es) 2004-12-01
MXPA02012920A (es) 2004-04-20
KR20030016425A (ko) 2003-02-26
US20040038989A1 (en) 2004-02-26
DE60103164T2 (de) 2005-05-04
EE05178B1 (et) 2009-06-15
HUP0301497A3 (en) 2005-08-29
PL206307B1 (pl) 2010-07-30
AU2001287638A1 (en) 2002-02-13
ATE266018T1 (de) 2004-05-15
PL361172A1 (en) 2004-09-20
IL153515A (en) 2006-12-10
CN1204135C (zh) 2005-06-01
ITMI20001734A0 (it) 2000-07-28
US6835734B2 (en) 2004-12-28
KR100781403B1 (ko) 2007-12-03
CZ2003268A3 (cs) 2003-06-18
HK1058797A1 (en) 2004-06-04
JP5107497B2 (ja) 2012-12-26
DE60103164D1 (de) 2004-06-09
EP1307441B1 (en) 2004-05-06
ITMI20001734A1 (it) 2002-01-28
HUP0301497A2 (hu) 2003-09-29
DK1307441T3 (da) 2004-08-09
SI21040A (sl) 2003-04-30
BR0112765A (pt) 2004-01-13
EP1307441A1 (en) 2003-05-07
RU2276149C2 (ru) 2006-05-10
PT1307441E (pt) 2004-09-30
CZ301087B6 (cs) 2009-11-04
EE200300036A (et) 2004-10-15
WO2002010149A1 (en) 2002-02-07
CN1444578A (zh) 2003-09-24
TR200401315T4 (tr) 2004-07-21
IT1318650B1 (it) 2003-08-27
IL153515A0 (en) 2003-07-06
YU3003A (sh) 2006-05-25
UA73789C2 (en) 2005-09-15
SK892003A3 (en) 2003-09-11
SK286794B6 (sk) 2009-05-07

Similar Documents

Publication Publication Date Title
ATE270817T1 (de) Fungizide
ATE269850T1 (de) 3-thiocarbamoylpyrazol-derivate als pestiziden
DE69801048D1 (de) Fungizide trifluorophenyl-triazolopyrimidine
EE9900217A (et) Sulfiinhappe derivaadid, nende valmistamine ja kasutamine
DE59709414D1 (de) Oxyiminopregnancarbolactone
ATE228111T1 (de) M-amidinophenyl-analoga als faktor-xa-inhibitoren
RS51136B (sr) Supstituisani pirolopiridini, kompozicije koje ih sadrže, postupak za njihovo dobijanje i upotreba
EA200300836A1 (ru) Производные фталазинон-пиперидина в качестве ингибиторов pde4
HRP20080602T3 (en) Amidomethyl-substituted 2-(4-sulfonilamino)-3-hidroxy-3,4-dihydro-2h-chromium-6-yl-derivatives and drugs containing said compounds
RS50229B (sr) Analozi vitamina d3
EE200000335A (et) Dihüdrobensofuraanid, nende kasutamine ravimite valmistamiseks ning neid sisaldavad ravimid
HRP20000585B1 (en) Substituted bisindolymaleimides for the inhibition of cell proliferation
ATE287403T1 (de) 6-phenylbenzonaphthyidine
RS50861B (sr) 1,3-dioksolani kao sredstva protiv kašlja
CO5680420A2 (es) Compuestos de 6-amino-1h-indazol y 4-aminobenzenofurano como inhibidores de la fosfodiesterasa 4
TR200402547T4 (tr) Pantoprazol ve ara maddelerini hazırlamak için bir işlem.
HRP20030381B1 (en) 3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A
DE59803066D1 (de) Substituierte benzyloxyimino-verbindungen
HUP0500082A2 (hu) Endotelin-antagonista aktivitású alkán-szulfonamidok és alkalmazásuk
ATE247649T1 (de) Disubstituierte biphenyloxazoline
RS50862B (sr) 2,2-disupstituisani 1,3-dioksolani kao sredstva protiv kašlja
BR0110328A (pt) Compostos heterocìclicos com atividade antiinflamatória
ATE349427T1 (de) Tryptaseinhibitoren
PT1075476E (pt) Novos benzimidazoles e benzoxazoles
ATE238781T1 (de) Verwendung von katecholderivaten als proteinaseinhibitoren