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UA70919C2 - Композиція для лікування та запобігання артеріальному тромбозу з використанням інгібітора фактора ха окремо або в комбінації з препаратом, що унеможливлює агрегацію тромбоцитів - Google Patents

Композиція для лікування та запобігання артеріальному тромбозу з використанням інгібітора фактора ха окремо або в комбінації з препаратом, що унеможливлює агрегацію тромбоцитів

Info

Publication number
UA70919C2
UA70919C2 UA99126569A UA99126569A UA70919C2 UA 70919 C2 UA70919 C2 UA 70919C2 UA 99126569 A UA99126569 A UA 99126569A UA 99126569 A UA99126569 A UA 99126569A UA 70919 C2 UA70919 C2 UA 70919C2
Authority
UA
Ukraine
Prior art keywords
factor
combination
platelet aggregation
selective inhibitors
alone
Prior art date
Application number
UA99126569A
Other languages
English (en)
Russian (ru)
Inventor
Андре БЕРНА
Жан-Марк Ербер
Моріс Петіту
Амстердам Рональд ван
Original Assignee
Санофі-Сентелябо
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофі-Сентелябо filed Critical Санофі-Сентелябо
Publication of UA70919C2 publication Critical patent/UA70919C2/uk

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Винахід стосується використання прямих або непрямих селективних інгібіторів фактора Ха, окремо або у комбінації з сполуками, що інгібують агрегацію тромбоцитів, для приготування фармацевтичних препаратів, призначених для профілактики або лікування тромбоемболічних артеріальних захворювань. Винахід також стосується фармацевтичних композицій, що містять один або більше прямих або непрямих селективних інгібіторів фактора Ха, які діють через антитромбін ІІІ у комбінації з сполуками, що інгібують агрегацію тромбоцитів, і, як варіант, з одним або більше фармацевтично прийнятними носіями.
UA99126569A 1997-06-13 1998-06-09 Композиція для лікування та запобігання артеріальному тромбозу з використанням інгібітора фактора ха окремо або в комбінації з препаратом, що унеможливлює агрегацію тромбоцитів UA70919C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9707368A FR2764511B1 (fr) 1997-06-13 1997-06-13 Compositions pour le traitement et la prevention de la thrombose arterielle et utilisation d'un inhibiteur du facteur xa seul et/ou en combinaison avec un antiagregant plaquettaire
PCT/FR1998/001172 WO1998056365A1 (fr) 1997-06-13 1998-06-09 INHIBITEUR DU FACTEUR Xa SEUL OU EN COMBINAISON AVEC UN ANTIAGREGANT PLAQUETTAIRE, CONTRE LA THROMBOSE ARTERIELLE

Publications (1)

Publication Number Publication Date
UA70919C2 true UA70919C2 (uk) 2004-11-15

Family

ID=9507960

Family Applications (1)

Application Number Title Priority Date Filing Date
UA99126569A UA70919C2 (uk) 1997-06-13 1998-06-09 Композиція для лікування та запобігання артеріальному тромбозу з використанням інгібітора фактора ха окремо або в комбінації з препаратом, що унеможливлює агрегацію тромбоцитів

Country Status (43)

Country Link
US (2) US6541488B1 (uk)
EP (1) EP0986376B1 (uk)
JP (1) JP3988803B2 (uk)
KR (1) KR100598451B1 (uk)
CN (1) CN1253150C (uk)
AR (1) AR012247A1 (uk)
AT (1) ATE384528T1 (uk)
AU (1) AU728826B2 (uk)
BR (1) BR9810520A (uk)
CA (1) CA2293415C (uk)
CO (1) CO4940476A1 (uk)
CY (1) CY1107912T1 (uk)
CZ (1) CZ299518B6 (uk)
DE (1) DE69839046T2 (uk)
DK (1) DK0986376T3 (uk)
DZ (1) DZ2512A1 (uk)
EE (1) EE04737B1 (uk)
ES (1) ES2299209T3 (uk)
FR (1) FR2764511B1 (uk)
GT (1) GT199800171A (uk)
HK (1) HK1032750A1 (uk)
HR (1) HRP980322B1 (uk)
HU (1) HU227956B1 (uk)
ID (1) ID29309A (uk)
IL (1) IL133452A (uk)
IS (1) IS2619B (uk)
ME (1) ME00685B (uk)
MY (1) MY124648A (uk)
NO (1) NO323739B1 (uk)
NZ (1) NZ501452A (uk)
PL (1) PL193405B1 (uk)
PT (1) PT986376E (uk)
RS (1) RS49902B (uk)
RU (1) RU2212886C2 (uk)
SA (1) SA98190552B1 (uk)
SI (1) SI0986376T1 (uk)
SK (1) SK286311B6 (uk)
TR (1) TR199903087T2 (uk)
TW (1) TW565442B (uk)
UA (1) UA70919C2 (uk)
UY (1) UY25044A1 (uk)
WO (1) WO1998056365A1 (uk)
ZA (1) ZA985137B (uk)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2764511B1 (fr) * 1997-06-13 2000-09-08 Sanofi Sa Compositions pour le traitement et la prevention de la thrombose arterielle et utilisation d'un inhibiteur du facteur xa seul et/ou en combinaison avec un antiagregant plaquettaire
WO2000047207A1 (en) 1999-02-09 2000-08-17 Bristol-Myers Squibb Company LACTAM INHIBITORS OF FXa AND METHOD
US6344450B1 (en) 1999-02-09 2002-02-05 Bristol-Myers Squibb Company Lactam compounds and their use as inhibitors of serine proteases and method
FR2793687B1 (fr) * 1999-04-26 2001-08-24 Sanofi Sa Nouvelle composition injectable d'un anticoagulant
FR2800074B1 (fr) * 1999-10-22 2001-12-21 Aventis Pharma Sa Nouveaux oligosaccharides, leur preparation et les compositions pharmaceutiques les contenant
US6544981B2 (en) 2000-06-09 2003-04-08 Bristol-Myers Squibb Company Lactam inhibitors of factor Xa and method
US6511973B2 (en) 2000-08-02 2003-01-28 Bristol-Myers Squibb Co. Lactam inhibitors of FXa and method
ATE352309T1 (de) * 2001-02-28 2007-02-15 John H Griffin Plasmaglucosylceramiddefizienz als risikofaktor für thrombose und modulator von anticoagulant protein c
UA80399C2 (en) * 2001-11-13 2007-09-25 Glaxo Group Ltd Use of specific dose of fondaparinux sodium for the treatment of acs
AU2003270861A1 (en) 2002-10-02 2004-04-23 Bristol-Myers Squibb Company Novel combination of a factor xa inhibitor and clopidogrel
US20070004736A1 (en) * 2002-11-22 2007-01-04 Keiji Kubo Imidazole derivative, process for producing the same, and use
CA2538366A1 (en) * 2003-09-19 2005-03-31 Kissei Pharmaceutical Co., Ltd. Concurrent drugs
WO2005087266A1 (en) * 2004-03-05 2005-09-22 Vddi Pharmaceuticals Combination therapy for inhibition of platelet aggregation
AU2005236997B2 (en) * 2004-04-23 2010-04-29 Hitoshi Kiya Moving picture data encoding method, decoding method, terminal device for executing them, and bi-directional interactive system
TWI396686B (zh) * 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
US7563780B1 (en) * 2004-06-18 2009-07-21 Advanced Cardiovascular Systems, Inc. Heparin prodrugs and drug delivery stents formed therefrom
JP5557410B2 (ja) * 2004-07-13 2014-07-23 第一三共株式会社 経口投与による血栓・塞栓の予防治療剤
US20070105825A1 (en) * 2004-09-16 2007-05-10 Yuji Hoyano Concurrent drugs
US20090111769A1 (en) * 2005-10-10 2009-04-30 De Kort Martin Antithrombotic Compound
WO2010029552A1 (en) * 2008-09-10 2010-03-18 Transpharma Medical Ltd. Transdermal delivery of oligosaccharides
WO2011149110A1 (en) 2010-05-28 2011-12-01 Daiichi Sankyo Company, Limited Novel composition for the prevention and/or treatment of thromboembolism
KR101968190B1 (ko) * 2014-10-30 2019-04-11 청두 바이위 파머수티컬 씨오., 엘티디 징코라이드 B(Ginkgolide B)와 Ⅹa 인자 억제제를 포함한 약물 조성물 및 그 제조방법과 용도
CN106860868B (zh) * 2015-12-11 2019-11-22 北京百奥药业有限责任公司 沙班类药物与蚓激酶的药物组合物、制剂及其应用
US11654036B2 (en) 2020-05-26 2023-05-23 Elixir Medical Corporation Anticoagulant compounds and methods and devices for their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2548189B1 (fr) * 1983-07-01 1986-04-11 Choay Sa Nouveaux produits contenant des oligosaccharides, leur preparation et leurs applications biologiques et biochimiques
ZA928276B (en) 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
FR2728901B1 (fr) * 1994-12-28 1997-03-28 Sanofi Sa Derives de phenyl-4-thiazoles substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
DK0946185T4 (da) 1996-11-27 2010-08-30 Aventis Pharma Inc Farmaceutisk præparat, som omfatter en forbindelse med anti-Xa-aktivitet og en blodpladeaggregations antagonistforbindelse
FR2764511B1 (fr) * 1997-06-13 2000-09-08 Sanofi Sa Compositions pour le traitement et la prevention de la thrombose arterielle et utilisation d'un inhibiteur du facteur xa seul et/ou en combinaison avec un antiagregant plaquettaire

Also Published As

Publication number Publication date
US20040092477A1 (en) 2004-05-13
ME00685B (me) 2008-08-07
IL133452A0 (en) 2001-04-30
RU2212886C2 (ru) 2003-09-27
EP0986376B1 (fr) 2008-01-23
UY25044A1 (es) 2000-10-31
SI0986376T1 (sl) 2008-06-30
HUP0002175A3 (en) 2003-05-28
FR2764511A1 (fr) 1998-12-18
AR012247A1 (es) 2000-09-27
CO4940476A1 (es) 2000-07-24
CA2293415C (en) 2011-08-09
HRP980322B1 (en) 2003-12-31
KR100598451B1 (ko) 2006-07-10
MY124648A (en) 2006-06-30
NO323739B1 (no) 2007-07-02
CA2293415A1 (en) 1998-12-17
HK1032750A1 (en) 2001-08-03
CY1107912T1 (el) 2013-09-04
TW565442B (en) 2003-12-11
SA98190552B1 (ar) 2006-09-09
CZ299518B6 (cs) 2008-08-20
TR199903087T2 (xx) 2000-05-22
DE69839046T2 (de) 2009-01-15
CZ446099A3 (cs) 2000-04-12
GT199800171A (es) 2000-04-21
KR20010013690A (ko) 2001-02-26
ES2299209T3 (es) 2008-05-16
HU227956B1 (en) 2012-07-30
IS5280A (is) 1999-11-30
ID29309A (id) 2001-08-16
EE04737B1 (et) 2006-12-15
EE9900574A (et) 2000-08-15
CN1274281A (zh) 2000-11-22
CN1253150C (zh) 2006-04-26
AU728826B2 (en) 2001-01-18
EP0986376A1 (fr) 2000-03-22
YU63699A (sh) 2002-06-19
HUP0002175A1 (hu) 2000-11-28
JP2002504110A (ja) 2002-02-05
AU7924698A (en) 1998-12-30
PL193405B1 (pl) 2007-02-28
ZA985137B (en) 1999-01-07
IL133452A (en) 2004-09-27
WO1998056365A1 (fr) 1998-12-17
BR9810520A (pt) 2000-09-19
US6541488B1 (en) 2003-04-01
DK0986376T3 (da) 2008-05-13
NO996137L (no) 2000-02-14
IS2619B (is) 2010-05-15
ATE384528T1 (de) 2008-02-15
RS49902B (sr) 2008-08-07
PL337288A1 (en) 2000-08-14
NO996137D0 (no) 1999-12-10
DE69839046D1 (de) 2008-03-13
SK170999A3 (en) 2000-07-11
DZ2512A1 (fr) 2003-02-01
HRP980322A2 (en) 1999-04-30
JP3988803B2 (ja) 2007-10-10
FR2764511B1 (fr) 2000-09-08
NZ501452A (en) 2002-06-28
PT986376E (pt) 2008-04-01
SK286311B6 (en) 2008-07-07

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