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UA109464C2 - Спірооксіндольні антагоністи mdm2 - Google Patents

Спірооксіндольні антагоністи mdm2

Info

Publication number
UA109464C2
UA109464C2 UAA201307447A UAA201307447A UA109464C2 UA 109464 C2 UA109464 C2 UA 109464C2 UA A201307447 A UAA201307447 A UA A201307447A UA A201307447 A UAA201307447 A UA A201307447A UA 109464 C2 UA109464 C2 UA 109464C2
Authority
UA
Ukraine
Prior art keywords
mdm2
antagonists
spirooxindol
compounds
compositions
Prior art date
Application number
UAA201307447A
Other languages
English (en)
Russian (ru)
Inventor
Шаомен Ван
Юйцзюнь ЧЖАО
Вей Сунь
Санджив Кумар
Ленс Леопольд
Лоран Дебюсш
Седрік Баррьєр
Жан-Крістоф Каррі
Кваме Еманінг
Мін Го
Original Assignee
Дзе Ріджентс Оф Дзе Юніверсіті Оф Мічіган
Есента Лайсенсінг Корпорейшн
Санофі
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дзе Ріджентс Оф Дзе Юніверсіті Оф Мічіган, Есента Лайсенсінг Корпорейшн, Санофі filed Critical Дзе Ріджентс Оф Дзе Юніверсіті Оф Мічіган
Publication of UA109464C2 publication Critical patent/UA109464C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

У цьому документі представлені сполуки, композиції і способи в галузі медичної хімії. Сполуки і композиції, представлені в цьому документі, стосуються спіроксіндолів, які діють як антагоністи взаємодії між р53 і MDM2, і їх використання як терапевтичних засобів для лікування раку і інших захворювань.
UAA201307447A 2010-11-12 2011-11-11 Спірооксіндольні антагоністи mdm2 UA109464C2 (uk)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41309410P 2010-11-12 2010-11-12
US201161451968P 2011-03-11 2011-03-11
US201161451958P 2011-03-11 2011-03-11
US201161470992P 2011-04-01 2011-04-01
PCT/US2011/060300 WO2012065022A2 (en) 2010-11-12 2011-11-11 Spiro-oxindole mdm2 antagonists

Publications (1)

Publication Number Publication Date
UA109464C2 true UA109464C2 (uk) 2015-08-25

Family

ID=46048358

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201307447A UA109464C2 (uk) 2010-11-12 2011-11-11 Спірооксіндольні антагоністи mdm2

Country Status (27)

Country Link
US (2) US8680132B2 (uk)
EP (1) EP2638046A4 (uk)
JP (1) JP2014500870A (uk)
KR (1) KR101929188B1 (uk)
CN (1) CN103298818B (uk)
AR (1) AR083849A1 (uk)
AU (1) AU2011326395B2 (uk)
CA (1) CA2817585A1 (uk)
CO (1) CO6721010A2 (uk)
CR (1) CR20130271A (uk)
DO (1) DOP2013000104A (uk)
EA (1) EA201390682A1 (uk)
EC (1) ECSP13012678A (uk)
GT (1) GT201300118A (uk)
IL (1) IL226275A0 (uk)
MA (1) MA34732B1 (uk)
MX (1) MX2013005238A (uk)
NI (1) NI201300041A (uk)
NZ (1) NZ611866A (uk)
PE (1) PE20140408A1 (uk)
PH (1) PH12013500955A1 (uk)
SG (1) SG190230A1 (uk)
TW (1) TWI535723B (uk)
UA (1) UA109464C2 (uk)
UY (1) UY33725A (uk)
WO (1) WO2012065022A2 (uk)
ZA (1) ZA201304042B (uk)

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