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UA104021C2 - ПРОИЗВОДНЫЕ ТИЕНО[2,3-b]ПИРИДИНА КАК ИНГИБИТОРЫ РЕПЛИКАЦИИ ВИРУСА - Google Patents

ПРОИЗВОДНЫЕ ТИЕНО[2,3-b]ПИРИДИНА КАК ИНГИБИТОРЫ РЕПЛИКАЦИИ ВИРУСА

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Publication number
UA104021C2
UA104021C2 UAA201113390A UAA201113390A UA104021C2 UA 104021 C2 UA104021 C2 UA 104021C2 UA A201113390 A UAA201113390 A UA A201113390A UA A201113390 A UAA201113390 A UA A201113390A UA 104021 C2 UA104021 C2 UA 104021C2
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UA
Ukraine
Prior art keywords
heading
compounds
relates
thieno
normal
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UAA201113390A
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English (en)
Ukrainian (uk)
Inventor
Дороте Бардьо
Патрик Шальтен
Фрауке Христ
Зегер Дебизер
Мэер Марк де
Арно Маршон
Дамен Маршон
Арну Во
Original Assignee
Католике Университейт Льовен
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40834066&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA104021(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Католике Университейт Льовен filed Critical Католике Университейт Льовен
Publication of UA104021C2 publication Critical patent/UA104021C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Представленное изобретение касается ряда новых соединений, которые имеют противовирусную активность, более особенно способность ингибировать репликацию ВИЧ (вирус иммунодефицита человека).Изобретение также касается способов получения таких соединений, также как и новых промежуточных соединений, полезных на одной или более стадиях таких синтезов.Изобретение также касается фармацевтических композиций, содержащих эффективное количество таких соединений в качестве активных ингредиентов.Это изобретение также касается применения таких соединений как медикаментов или при приготовлении медикамента, полезного для лечения животных, страдающих вирусными инфекциями, в частности ВИЧ.Это изобретение также касается способов лечения вирусных инфекций у ж�
UAA201113390A 2009-05-15 2010-05-17 ПРОИЗВОДНЫЕ ТИЕНО[2,3-b]ПИРИДИНА КАК ИНГИБИТОРЫ РЕПЛИКАЦИИ ВИРУСА UA104021C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0908394.0A GB0908394D0 (en) 2009-05-15 2009-05-15 Novel viral replication inhibitors
PCT/EP2010/056754 WO2010130842A1 (en) 2009-05-15 2010-05-17 Thieno [2, 3-b] pyridine derivatives as viral replication inhibitors

Publications (1)

Publication Number Publication Date
UA104021C2 true UA104021C2 (ru) 2013-12-25

Family

ID=40834066

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201113390A UA104021C2 (ru) 2009-05-15 2010-05-17 ПРОИЗВОДНЫЕ ТИЕНО[2,3-b]ПИРИДИНА КАК ИНГИБИТОРЫ РЕПЛИКАЦИИ ВИРУСА

Country Status (29)

Country Link
US (2) US8785638B2 (ru)
EP (1) EP2430029B1 (ru)
JP (2) JP2012526778A (ru)
KR (2) KR20140127905A (ru)
CN (2) CN102459280B (ru)
AP (1) AP2939A (ru)
BR (1) BRPI1010833A2 (ru)
CA (1) CA2759500A1 (ru)
CL (1) CL2011002878A1 (ru)
CO (1) CO6460769A2 (ru)
CR (1) CR20110601A (ru)
CU (1) CU24117B1 (ru)
DO (1) DOP2011000343A (ru)
EA (1) EA201171376A1 (ru)
EC (1) ECSP11011456A (ru)
GB (1) GB0908394D0 (ru)
GE (1) GEP20146115B (ru)
IL (1) IL216357A0 (ru)
MA (1) MA33274B1 (ru)
MX (1) MX2011012146A (ru)
MY (1) MY161085A (ru)
NI (1) NI201100194A (ru)
NZ (1) NZ596392A (ru)
PE (1) PE20120779A1 (ru)
SG (1) SG175255A1 (ru)
TN (1) TN2012000074A1 (ru)
UA (1) UA104021C2 (ru)
WO (1) WO2010130842A1 (ru)
ZA (1) ZA201107618B (ru)

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