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SA112330457B1 - مشتقات فينيل- ايزواوكسازول وعملية تحضيرها - Google Patents

مشتقات فينيل- ايزواوكسازول وعملية تحضيرها

Info

Publication number
SA112330457B1
SA112330457B1 SA112330457A SA112330457A SA112330457B1 SA 112330457 B1 SA112330457 B1 SA 112330457B1 SA 112330457 A SA112330457 A SA 112330457A SA 112330457 A SA112330457 A SA 112330457A SA 112330457 B1 SA112330457 B1 SA 112330457B1
Authority
SA
Saudi Arabia
Prior art keywords
phenyl
preparation process
formula
isoxazol
derivatives
Prior art date
Application number
SA112330457A
Other languages
English (en)
Inventor
ام اهن تشونج
لي جونج-يال
تشو داي-جين
كيم دونج-يون
مو كيم سونج
وو سيوك-هون
بين يون سيونج
يون لي هاي
كيم هونج-يوب
Original Assignee
إل-يانج فارماسوتيكال كو.، ليمتد
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46514985&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SA112330457(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by إل-يانج فارماسوتيكال كو.، ليمتد filed Critical إل-يانج فارماسوتيكال كو.، ليمتد
Publication of SA112330457B1 publication Critical patent/SA112330457B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

يتم الكشف عن مركب من مشتقات فينيل أيزوكسازول phenyl-isoxazol الممثَّل بالصيغة 1 أدناه، والذي يكون مفيداً كمادة معالجة لعدوى الفيروس virus infection، وخاصة، العدوى من فيروس الانفلونزا influenza virus، أو أي من مشتقاته المقبولة صيدلانياً pharmaceutically acceptable derivative، وطريقة تحضيره، ويتم الكشف عن تركيب صيدلاني pharmaceutical composition يستخدم في علاج المرض، حيث يتضمن التركيب المركب compound ذي الصيغة 1 بصفته مكون نشط active ingredient : الصيغة 1 حيث في الصيغة أعلاه R1 R2، R3،، R4 و R8 هي نفسها كما تم تحديدها في المواصفة.
SA112330457A 2011-04-19 2012-04-16 مشتقات فينيل- ايزواوكسازول وعملية تحضيرها SA112330457B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020110036172A KR101369584B1 (ko) 2011-04-19 2011-04-19 페닐-이속사졸 유도체 및 그의 제조방법

Publications (1)

Publication Number Publication Date
SA112330457B1 true SA112330457B1 (ar) 2015-08-19

Family

ID=46514985

Family Applications (1)

Application Number Title Priority Date Filing Date
SA112330457A SA112330457B1 (ar) 2011-04-19 2012-04-16 مشتقات فينيل- ايزواوكسازول وعملية تحضيرها

Country Status (21)

Country Link
US (1) US9132126B2 (ar)
EP (1) EP2699566B1 (ar)
JP (1) JP5833143B2 (ar)
KR (1) KR101369584B1 (ar)
CN (1) CN103313982B (ar)
AR (1) AR086029A1 (ar)
AU (1) AU2012246914B2 (ar)
CA (1) CA2824757A1 (ar)
CL (1) CL2013001910A1 (ar)
CO (1) CO6771432A2 (ar)
EA (1) EA022336B1 (ar)
IL (1) IL227711A0 (ar)
MX (1) MX340098B (ar)
PE (1) PE20140629A1 (ar)
PH (1) PH12013501883A1 (ar)
SA (1) SA112330457B1 (ar)
SG (1) SG192134A1 (ar)
TW (1) TWI434836B (ar)
UY (1) UY34023A (ar)
WO (1) WO2012144752A1 (ar)
ZA (1) ZA201305277B (ar)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018141854A1 (en) 2017-02-02 2018-08-09 Janssen Vaccines & Prevention B.V. Piperazine derivatives for influenza virus inhibition
EP3577107A1 (en) 2017-02-02 2019-12-11 Janssen Vaccines & Prevention B.V. Piperazine derivatives for influenza virus inhibition
ES2910136T3 (es) * 2017-02-08 2022-05-11 Biotron Ltd Métodos de tratamiento de la gripe
TWI765323B (zh) * 2019-08-22 2022-05-21 大陸商四川海思科製藥有限公司 抗流感病毒化合物及其製備方法和用途
CN111704587B (zh) * 2020-06-29 2023-04-07 遵义医科大学 一种三氟甲基化1,3-噁嗪类化合物的合成方法
CN112300147B (zh) * 2020-11-19 2021-12-24 中国医学科学院医药生物技术研究所 一种吡啶类化合物及其制备方法和应用、药物组合物
US20240043416A1 (en) 2021-02-04 2024-02-08 Sichuan Haisco Pharmaceutical Co., Ltd. Salt and crystal form of ha inhibitor compound

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8427618D0 (en) * 1984-11-01 1984-12-05 Shell Int Research Anticoccidial compositions
SK282950B6 (sk) 1990-04-24 2003-01-09 Biota Scientific Management Pty Ltd Deriváty alfa-D-neuramínovej kyseliny, spôsob ich prípravy, ich použitie a farmaceutické prípravky na ich báze
MX9706496A (es) 1995-02-27 1997-11-29 Gilead Sciences Inc Nuevos inhibidores selectivos de las neuroaminidasas virales o bacterianas.
UA74912C2 (en) 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
ES2180456B1 (es) * 2001-07-20 2004-05-01 Laboratorios S.A.L.V.A.T., S.A. Isoxazoles sustituidos y su utilizacion como antibioticos.
AU2002337843A1 (en) 2001-10-12 2003-04-22 Onconova Therapeutics, Inc. Processes for the preparation of substituted isoxazoles and 2-isoxazolines
WO2004002965A1 (de) 2002-06-29 2004-01-08 Zentaris Gmbh Aryl- und heteroarylcarbonylpiperazine und deren verwendung zur behandlung gutartiger und bösartiger tumorerkrankungen
WO2004099186A1 (en) 2003-05-06 2004-11-18 Il Yang Pharm Co., Ltd. N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof
KR20050051729A (ko) 2003-11-28 2005-06-02 일양약품주식회사 사이클로 옥시게나제-2 억제제인 페닐 헤테로사이클의제조방법
CN1687075A (zh) * 2005-03-24 2005-10-26 天津药物研究院 3－苯基异噁唑－5－甲酰胺基取代β－内酰胺类衍生物及其用途
WO2007008541A2 (en) 2005-07-08 2007-01-18 Kalypsys, Inc. Cellular cholesterol absorption modifiers
KR100674813B1 (ko) 2005-08-05 2007-01-29 일양약품주식회사 Ｎ-페닐-2-피리미딘-아민 유도체 및 그의 제조방법
AU2007275301A1 (en) * 2006-07-20 2008-01-24 Amgen Inc. Substituted azole aromatic heterocycles as inhibitors of 11-beta-HSD-1
WO2009084024A2 (en) 2007-11-02 2009-07-09 Glenmark Generics Limited A process for the preparation of r-sit agliptin and its pharmaceutically acceptable salts thereof
US20090192326A1 (en) 2007-11-13 2009-07-30 Nurit Perlman Preparation of sitagliptin intermediate
AU2008345225A1 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
KR101044880B1 (ko) 2008-06-12 2011-06-28 일양약품주식회사 항궤양제 화합물의 합성에 유용한 중간체의 제조방법
KR20100021321A (ko) 2008-08-14 2010-02-24 일양약품주식회사 Ν-페닐-2-피리미딘-아민 유도체의 제조방법
TW201107342A (en) * 2009-05-20 2011-03-01 Chimerix Inc Compounds, compositions and methods for treating viral infection
CN102596946B (zh) * 2009-08-05 2015-06-17 港大科桥有限公司 抗病毒化合物及其制备和使用方法
GB2474748B (en) 2009-10-01 2011-10-12 Amira Pharmaceuticals Inc Polycyclic compounds as lysophosphatidic acid receptor antagonists
US8362004B2 (en) 2010-09-08 2013-01-29 Bristol-Myers Squibb Company Piperazine analogs as broad-spectrum influenza antivirals
ES2564257T3 (es) * 2010-09-28 2016-03-21 Bristol-Myers Squibb Company Nuevos análogos de piperazina con grupos heteroarilo sustituidos como antivirales de amplio espectro de la gripe
KR101956586B1 (ko) 2012-03-27 2019-03-11 일양약품주식회사 약제학적 조성물 및 이의 제조방법

Also Published As

Publication number Publication date
WO2012144752A1 (en) 2012-10-26
US20140031364A1 (en) 2014-01-30
US9132126B2 (en) 2015-09-15
NZ613314A (en) 2015-09-25
MX2013007661A (es) 2013-08-12
JP5833143B2 (ja) 2015-12-16
AU2012246914A1 (en) 2013-08-15
AU2012246914B2 (en) 2015-09-24
ZA201305277B (en) 2014-09-25
CA2824757A1 (en) 2012-10-26
KR20120118665A (ko) 2012-10-29
SG192134A1 (en) 2013-08-30
EP2699566A1 (en) 2014-02-26
JP2014503601A (ja) 2014-02-13
EP2699566A4 (en) 2014-09-03
EP2699566B1 (en) 2017-02-22
PE20140629A1 (es) 2014-05-22
HK1188998A1 (zh) 2014-05-23
EA201300805A1 (ru) 2013-11-29
PH12013501883A1 (en) 2019-06-03
TWI434836B (zh) 2014-04-21
CL2013001910A1 (es) 2014-04-21
TW201309658A (zh) 2013-03-01
MX340098B (es) 2016-06-27
CO6771432A2 (es) 2013-10-15
KR101369584B1 (ko) 2014-03-06
IL227711A0 (en) 2013-09-30
UY34023A (es) 2012-06-29
EA022336B1 (ru) 2015-12-30
CN103313982B (zh) 2016-02-03
CN103313982A (zh) 2013-09-18
AR086029A1 (es) 2013-11-13

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