TWM560885U - Blood sugar detection device - Google Patents

Abstract

A blood glucose detecting device comprises a carrier, a flow guiding actuator, a microneedle patch, a sensor and a control wafer, wherein the carrier has an inflow channel, a liquid storage channel, a pressure chamber and a liquid storage chamber, and the pressure chamber communicates into the flow a channel and a liquid storage channel, the liquid storage channel is connected to the liquid storage chamber; the flow guiding actuator closes the pressure chamber; the microneedle patch is connected to the inflow channel, and has a plurality of hollow microneedles; the sensor is disposed in the liquid storage In the chamber; the control wafer is disposed on the carrier. A plurality of hollow microneedles are minimally invasively inserted into the human skin, and the control wafer is controlled to actuate the flow-guiding actuator, so that a plurality of hollow micro-needles are inhaled into the tissue fluid, and then transported to the liquid storage chamber, and the blood glucose level monitoring of the tissue fluid is monitored by the sensor. The value is finally passed to the control chip to enable the control chip to calculate the monitoring information.

Description

Blood glucose detecting device

The present invention relates to a blood glucose detecting device, and more particularly to a blood glucose detecting device for detecting blood sugar in a human body.

Self-testing of blood glucose plays a very important role in the management of blood sugar, but the blood glucose meter used to measure blood sugar is not easy to carry, so it is difficult for patients to detect blood sugar when they go out, and in the process of measuring blood sugar, Sometimes there is a needle but there is no bleeding or too little blood. Therefore, it is necessary to puncture the needle again or forcefully squeeze out the blood. This may cause the psychological fear of the patient, and it is necessary to improve.

In response to the above-mentioned shortcomings, the present invention develops a safe, portable and painless intelligent blood glucose detecting device, which provides a patient with the ability to measure blood sugar levels at any time and in daily life, and solves the above-mentioned conventional problem of measuring blood sugar.

In order to solve the problem that the traditional blood glucose measurement method causes the patient to suffer from pain and inconvenience, the present invention provides a blood glucose detecting device, comprising: a carrier having a liquid guiding channel, a pressure chamber and a liquid storage chamber, the liquid guiding channel The inlet channel and the liquid storage channel are disposed apart from each other on the carrier, and the pressure chamber communicates with the inlet channel and the liquid storage channel, and the liquid storage channel is connected to the liquid storage chamber; a flow guiding actuation Constructed on the carrier, enclosing the pressure chamber, a microneedle patch attached to the carrier and communicating with the inflow channel, and having a plurality of hollow microneedles for minimally invasive insertion into the human skin to extract a tissue fluid; a sensor, a system is packaged on the carrier and positioned in the reservoir to monitor a monitored value of blood glucose levels in the tissue fluid; and a control wafer is system-on-packaged on the carrier to control the flow-guiding actuator Transmitting and receiving the monitored value of the sensor; thereby, the microneedle patch is minimally wound into the human skin by the plurality of hollow microneedles, and the control wafer controls the actuation of the flow guiding actuator at the pressure The chamber forms a pressure difference, and the plurality of hollow microneedles are sucked into the tissue fluid, and are taken to the inflow channel, and then sent to the liquid storage chamber, and the monitored value of the blood glucose level of the tissue fluid is monitored by the sensor, and finally The monitoring value is transmitted to the control chip, so that the control chip calculates a monitoring information and provides the user with knowledge.

3‧‧‧ Carrier

31‧‧‧ catheter channel

311‧‧‧ Inflow channel

312‧‧‧ liquid storage channel

32‧‧‧pressure chamber

33a, 33b‧‧‧ convex structure

4‧‧‧Liquid chamber

5‧‧‧drain actuator

51‧‧‧Actuating element

52‧‧‧Carrier

6‧‧‧ valve

61‧‧‧ valve hole

62‧‧‧Central Department

63‧‧‧Connecting Department

7‧‧‧Microneedle patch

71‧‧‧ hollow microneedles

8‧‧‧Sensor

9‧‧‧Control chip

10‧‧‧Transmission module

100‧‧‧ blood glucose detecting device

200‧‧‧External devices

Figure 1 is a schematic view showing the structure of the blood glucose detecting device of the present invention.

Figure 2 is a schematic diagram of the use of the blood glucose detecting device of the present invention.

Fig. 3 is a schematic view showing the structure of the valve piece of the blood glucose detecting device of the present invention.

4A and 4B are schematic diagrams showing the operation flow of the blood glucose detecting device shown in Fig. 1.

Fig. 5 is a block diagram showing the electrical connection relationship of related components of the blood glucose detecting device of the present invention.

Some exemplary embodiments embodying the features and advantages of the present invention are described in detail in the following description. It is to be understood that the present invention is capable of various modifications in various aspects, and is not to be construed as a limitation.

The present invention is a blood glucose detecting device. Referring to FIG. 1 , the blood glucose detecting device 100 includes a carrier 3 , a liquid storage chamber 4 , a flow guiding actuator 5 , a microneedle patch 7 , a sensor 8 , and A control wafer 9 is provided. Wherein, the carrier 3 has a liquid guiding channel 31 and a pressure chamber 32, The liquid passage 31 further includes an inflow passage 311 and a liquid storage passage 312 which are disposed on the carrier 3 spaced apart from each other and communicate with the flow passage 311 and the liquid storage passage 312 through the pressure chamber 32, and the liquid storage passage 312 Connected to the liquid storage chamber 4, the liquid storage chamber 4 may be recessed by the carrier 3 or embedded in the carrier 3 for storing liquid; and the flow guiding actuator 5 is constructed on the carrier 3 and covers the pressure chamber 32. When the flow guiding actuator 5 is actuated, a drawing force is generated for extracting the liquid; and the microneedle patch 7 is attached to the carrier 3, communicates with the inflow channel 311, and has a plurality of hollow microneedles 71, The plurality of hollow microneedles 71 are inserted into the human skin through non-invasive or minimally invasive; further, the sensor 8 and the control wafer 9 are integrated into the carrier 3 by a micro-electromechanical process (MEMS), and the sensor 8 is packaged on the carrier 3 through the system. And located inside the liquid storage chamber 4, the control wafer 9 is also disposed on the carrier 3 in a system package for controlling the flow guiding actuator 5 and receiving and analyzing the data monitored by the sensor 8.

Referring to FIG. 1 and FIG. 2 simultaneously, in the embodiment, when the plurality of hollow microneedles 71 of the microneedle patch 7 are punctured into the human body, and the control wafer 9 drives the deflector 5 to vibrate vertically, The volume of the pressure chamber 32 can be expanded and compressed by the flow guiding actuator 5 to change the internal pressure to generate a suction force, so that the inflow channel 311 generates suction force, and the tissue fluid that is inhaled into the human body through the hollow microneedle 71 flows through the pressure chamber 32 and The liquid storage channel 312 enters the inside of the liquid storage chamber 4. At this time, the sensor 8 detects the components in the tissue fluid, and analyzes the blood sugar content value therein, and finally transmits the monitoring value of the blood sugar content to the control wafer 9, to Generate calculation information and provide users with information on obtaining inspection information. Wherein, the tissue fluid is a tissue fluid under the skin of a human body.

The plurality of hollow microneedles 71 of the above-mentioned microneedle patch 7 are micron-sized pinholes capable of piercing the skin, and the material thereof may be, but not limited to, a polymer, a metal or a crucible, preferably a high The biocompatible cerium oxide, the pore size of the hollow microneedle 71 is permeable to the tissue fluid under the skin of the human body. Preferably, the inner diameter of the hollow microneedle 71 is between 10 micrometers (μm) and 550 micrometers (μm). The hollow microneedles 71 have a length of between 400 micrometers (μm) and 900 micrometers (μm), and can be inserted. It enters the subcutaneous tissue of the human body and penetrates deeply into the human body, so it does not cause pain at all. A plurality of hollow microneedles 71 are arranged on the microneedle patch 7 and arranged in an array manner. Each of the hollow microneedles 71 is required to be larger than 200 micrometers apart from each other, so that there is no mutual influence on the flow guiding interference, so the array mode is set. The plurality of hollow microneedles 71 do not have the function of injecting fluid by blocking one of the hollow microneedles 51, and other hollow microneedles 71 can continue to have the function of injecting fluid.

Please refer to FIG. 1 and FIG. 3 , the blood glucose detecting device 100 can respectively provide a valve plate 6 in the inflow channel 311 and the liquid storage channel 312 , and a plurality of valve holes 61 are formed on the valve plate 6 , and the carrier 3 is A convex portion structure 33a, 33b is disposed in the inflow channel 311 and the liquid storage channel 312, respectively, wherein the convex portion structure 33a of the inlet flow path 311 and the convex portion structure 33b of the liquid storage channel 312 are convexly opposite, in this embodiment. The protrusion structure 33a located in the inlet passage 311 is upwardly convex, and the convex portion structure 33b of the liquid storage passage 312 is downwardly convex, and the valve piece 6 is provided with a plurality of valves in a part of the corresponding pressure chamber 32. The hole 61 is provided with a central portion 62 connected by a plurality of connecting portions 63, and a plurality of valve holes 61 are disposed between the plurality of connecting portions 63, so that the connecting portion 63 provides the central portion 62 elastically supported, so that The above-mentioned two protruding structures 33a, 33b abut against the valve plate 6 and close the respective valve holes 61 thereof, and generate a pre-force abutting action. With the above arrangement, when the flow guiding actuator 5 is not actuated, the central portion 62 of the valve plate 6 on the inlet passage 311 and the liquid storage passage 312 can respectively close the insulating inlet passage 311 and the liquid storage passage 312, thereby preventing The tissue fluid is countercurrent to the reservoir channel 311 and the reservoir channel 312.

The flow guiding actuator 5 further includes an actuating member 51 and a carrier member 52. The carrier member 52 seals the pressure chamber 32 and attaches an actuating member 51 to the surface thereof to generate deformation by the actuating member 51. The driving carrier 51 vibrates up and down, changing the volume of the pressure chamber 32, and changing the pressure inside the pressure chamber 32 to generate a drawing force to transport the tissue fluid. In this embodiment, the actuating element 51 can be a piezoelectric element, but is not limited thereto.

Referring to FIGS. 4A and 4B, after the flow guiding actuator 5 receives the driving signal sent by the control wafer 9, the actuating element 51 of the flow guiding actuator 5 begins to deform due to the piezoelectric effect, and the interlocking is tight. The attached carrier 52 is bent and vibrated up and down. Referring first to Figure 4A, when the carrier 52 is displaced upward by the actuating member 51, the volume of the pressure chamber 32 is increased, and a negative pressure is generated to drive the valve plate 6 of the inflow passage 311 upward to be centered. The portion 62 (shown in FIG. 3) is separated from the convex portion structure 33a. At this time, the inflow passage 311 and the pressure chamber 32 are in communication. Since the pressure chamber 32 is in a negative pressure relationship, the microneedle stuck under the flow passage 311 is attached. The tissue fluid in the sheet 7 passes through the inflow channel 311 and enters the pressure chamber 32 via the valve hole 61 (as shown in FIG. 3); as shown in FIG. 4B, the driving wafer 9 continues to output the driving signal to the guide. The flow actuator 5, the actuating member 51 interlocks the carrier sheet 52 to be displaced downward, at which time the volume of the pressure chamber 32 is compressed, generating a thrust pushing the valve plate 6 in the reservoir passage 312 downwardly, and The central portion 62 (shown in Fig. 3) is separated from the convex portion structure 33b, and the tissue fluid located in the pressure chamber 32 is pushed into the liquid storage passage 312 via the valve hole 61 (as shown in Fig. 3), and finally enters. Liquid storage chamber 4.

The block diagram of the component connection relationship of the blood glucose detecting device of the present invention is shown in FIG. 1 and FIG. 5 . In this embodiment, the blood glucose detecting device further includes a transmission module 10 and a control chip 9 architecture. On the carrier 3, and electrically connected to the flow guiding actuator 5, the sensor 8, the transmission module 10, the sensor 8 monitors the blood glucose level in the tissue fluid of the human subcutaneous tissue to generate a corresponding monitoring value, and After being sent to the control chip 9, after the control chip 9 receives the monitored value of the sensor 8, the control chip 9 parses the monitored value to generate a monitoring information, and then transmits the monitoring information to the transmission module 10, using the transmission module 10 The monitoring information of the blood sugar level is transmitted to an external device 200, and the external device 200 can be one of a cloud system, a portable device, a computer system, a display device, an insulin injection device, and the like. The control wafer 9 may further include a graphene battery (not shown) to provide a power source.

In addition, the foregoing transmission module 10 can be transmitted to the external device 200 through wired transmission or wirelessly. The wired transmission mode is as follows, for example, a wired transmission module such as USB, mini-USB, micro-USB, or the like, or a wireless transmission method such as a Wi-Fi module, a Bluetooth module, or a radio frequency identification module. A wireless transmission module of one of a group, a near field communication module, and the like.

In summary, the present invention provides a blood glucose detecting device. When the microneedle patch penetrates into the subcutaneous tissue of the human body, a pressure gradient is generated by the action of the flow guiding actuator to make a plurality of hollow microneedles in the microneedle patch. The extraction force is generated to absorb the tissue fluid of the subcutaneous tissue, and then enters the liquid storage chamber through the flow guiding actuator, and the monitoring value of the blood sugar content in the tissue fluid is detected by a sensor located in the liquid storage chamber, and the wafer is monitored and monitored to generate monitoring information. And the monitoring information is transmitted to the transmission module via the control chip to provide the user with the knowledge, and through the setting of the graphene battery, the novel can be easily, simply, and can measure blood sugar at any time and anywhere without the need of plugging. The user measures the trouble of blood sugar. In addition, the present invention uses non-invasive or minimally invasive micro-needle patches to obtain tissue fluid of the subcutaneous tissue to detect blood sugar, thereby reducing the burden on the user, avoiding the generation of wounds and reducing the risk of infection.

This case has been modified by people who are familiar with the technology, but it is not intended to be protected by the scope of the patent application.

Claims (14)

A blood glucose detecting device comprises: a carrier having a liquid guiding channel, a pressure chamber and a liquid storage chamber, wherein the liquid guiding channel comprises an inflow channel and a liquid storage channel spaced apart from each other on the carrier, and The pressure chamber communicates with the inflow channel and the liquid storage channel, and the liquid storage channel is connected to the liquid storage chamber; a flow guiding actuator is arranged on the carrier to close the pressure chamber, a microneedle patch Attached to the carrier and connected to the inflow channel, and having a plurality of hollow microneedles for minimally invasive insertion into the human skin to extract a tissue fluid; a sensor, the system is packaged on the carrier and placed in the reservoir Monitoring a value of one of the blood glucose levels in the tissue fluid; and a control wafer packaged on the carrier to control actuation of the flow director and receive the monitored value of the sensor; The microneedle patch is minimally wound into the human skin by the plurality of hollow microneedles, and the control wafer controls the actuation of the flow guiding actuator to form a pressure difference in the pressure chamber to make the plurality of hollow microneedles Inhale the tissue fluid and Taking the inflow channel and transporting it to the liquid storage chamber, the monitoring device monitors the monitoring value of the blood glucose content of the tissue fluid, and finally transmits the monitoring value to the control wafer, so that the control wafer calculates a monitoring information. And provide users with information. The blood glucose detecting device according to claim 1, wherein the tissue fluid is a human body subcutaneous tissue fluid. The blood glucose detecting device of claim 1, wherein the flow guiding actuator comprises a carrier and an actuating member, the bearing member covers the pressure chamber, and the surface is attached to the surface a moving element, wherein the actuating element is coupled to the power source to deform and interlock the carrier to form a deformation resonance to compress the pressure chamber volume to form a pumping force to transport the tissue fluid to the reservoir. The blood glucose detecting device of claim 3, wherein the actuating element is a piezoelectric element. The blood glucose detecting device of claim 1, further comprising a valve plate disposed in the inflow channel and the liquid storage channel, the valve plate sealing and blocking the inflow channel and the liquid storage channel to control the inflow channel And the switching state of the liquid storage channel. The blood glucose detecting device according to claim 5, wherein the carrier has a convex structure at the inflow channel and the liquid storage channel, so as to contact the valve plate to generate a pre-force effect, thereby preventing the tissue fluid from flowing backward. . The blood glucose detecting device of claim 1, wherein the control wafer comprises a graphene battery to provide a power source. The blood glucose detecting device of claim 1, wherein the control chip comprises a transmission module, and the monitoring information is transmitted to an external device. The blood glucose detecting device of claim 8, wherein the transmission module is at least one of a USB, a mini-USB, and a micro-USB. The blood glucose detecting device of claim 8, wherein the transmitting module is at least a Wi-Fi module, a Bluetooth module, a radio frequency identification module, and a near field communication module. One of the wireless transmission modules. The blood glucose detecting device of claim 8, wherein the external device is at least one of a cloud system, a portable device, a computer system, a display device, an insulin injection device, and the like. The blood glucose detecting device of claim 1, wherein each of the plurality of hollow microneedles of the microneedle patch has an inner diameter of from 10 micrometers to 550 micrometers and a length of from 400 micrometers to 900 micrometers. . The blood glucose detecting device of claim 1, wherein the plurality of hollow microneedles are arranged in an array, and each of the plurality of hollow microneedles is adjacent to each other by more than 200 micrometers. The blood glucose detecting device according to claim 1, wherein the plurality of hollow microneedles are made of a cerium oxide material.