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TW340842B - Substituted benzylaminopiperidine compounds - Google Patents

Substituted benzylaminopiperidine compounds

Info

Publication number
TW340842B
TW340842B TW085106675A TW85106675A TW340842B TW 340842 B TW340842 B TW 340842B TW 085106675 A TW085106675 A TW 085106675A TW 85106675 A TW85106675 A TW 85106675A TW 340842 B TW340842 B TW 340842B
Authority
TW
Taiwan
Prior art keywords
halo
alkoxy
alkyl
substituted
carbon atoms
Prior art date
Application number
TW085106675A
Other languages
English (en)
Inventor
Kunio Satake
Yuji Kanto
Hiroaki Wakahayashi
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of TW340842B publication Critical patent/TW340842B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW085106675A 1995-08-24 1996-06-04 Substituted benzylaminopiperidine compounds TW340842B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9500683 1995-08-24

Publications (1)

Publication Number Publication Date
TW340842B true TW340842B (en) 1998-09-21

Family

ID=11004362

Family Applications (1)

Application Number Title Priority Date Filing Date
TW085106675A TW340842B (en) 1995-08-24 1996-06-04 Substituted benzylaminopiperidine compounds

Country Status (42)

Country Link
US (1) US6506775B1 (zh)
EP (2) EP1114817B1 (zh)
JP (1) JP3084069B2 (zh)
KR (1) KR100288673B1 (zh)
CN (1) CN1153764C (zh)
AP (1) AP643A (zh)
AR (1) AR006305A1 (zh)
AT (2) ATE258166T1 (zh)
AU (1) AU702698B2 (zh)
BG (1) BG64126B1 (zh)
BR (1) BR9609989A (zh)
CA (1) CA2227814C (zh)
CO (1) CO4480738A1 (zh)
CZ (1) CZ297543B6 (zh)
DE (2) DE69631390T2 (zh)
DK (2) DK0861235T3 (zh)
DZ (1) DZ2086A1 (zh)
ES (2) ES2211684T3 (zh)
HK (1) HK1014935A1 (zh)
HR (1) HRP960386B1 (zh)
HU (1) HU225480B1 (zh)
IL (1) IL119078A (zh)
IS (1) IS1947B (zh)
MA (1) MA23961A1 (zh)
MX (1) MX9801467A (zh)
MY (1) MY114800A (zh)
NO (1) NO310720B1 (zh)
NZ (1) NZ308207A (zh)
OA (1) OA10666A (zh)
PE (2) PE20010700A1 (zh)
PL (1) PL186773B1 (zh)
PT (2) PT861235E (zh)
RO (1) RO119299B1 (zh)
RU (1) RU2152930C2 (zh)
SI (2) SI0861235T1 (zh)
SK (1) SK282925B6 (zh)
TN (1) TNSN96107A1 (zh)
TR (1) TR199800300T1 (zh)
TW (1) TW340842B (zh)
UA (1) UA48981C2 (zh)
WO (1) WO1997008144A1 (zh)
YU (1) YU49122B (zh)

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RS49964B (sr) 1999-05-17 2008-09-29 Pfizer Products Inc., Postupak za dobijanje 2-fenil-3-aminopiridina,njegovih supstituisanih fenil derivata, i njegovih soli
AU775861B2 (en) 1999-05-21 2004-08-19 Pfizer Products Inc. 1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives
JP2001172178A (ja) * 1999-10-25 2001-06-26 Pfizer Prod Inc 偏頭痛治療用のｎｋ−１レセプターアンタゴニスト及びエレトリプタン
US20020049211A1 (en) * 2000-09-06 2002-04-25 Sobolov-Jaynes Susan Beth Combination treatment for depression and anxiety
EP1192952A3 (en) * 2000-09-28 2003-03-26 Pfizer Products Inc. Combination, for treating depression and anxiety, containing an NK-3 receptor antagonist and a CNS penetrant NK-1 receptor antagonist
US6911544B2 (en) 2002-10-23 2005-06-28 Pfizer Inc. Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine
CN1777584A (zh) 2003-04-18 2006-05-24 伊莱利利公司 作为5－ht1f激动剂的(哌啶氧基)苯基、(哌啶氧基)吡啶基、(哌啶硫基)苯基和(哌啶硫基)吡啶基化合物
CA2566920A1 (en) * 2004-05-21 2005-12-01 Pfizer Products Inc. Metabolites of (+)-(2s, 3s)-3-(2-methoxy-5-trifluoromethoxybenzylamino)-2-phenyl-piperidine
MX2007000428A (es) 2004-07-15 2008-03-05 Amr Technology Inc Tetrahidroisoquinolinas sustituidas con arilo y heteroarilo y uso de las mismas para bloquear la captacion de norepinefrina, dopamina y serotonina.
ES2382814T3 (es) 2005-05-17 2012-06-13 Merck Sharp & Dohme Ltd. Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer
UA95454C2 (uk) 2005-07-15 2011-08-10 Амр Текнолоджи, Інк. Арил- і гетероарилзаміщені тетрагідробензазепіни і їх застосування для блокування зворотного захоплення норепінефрину, допаміну і серотоніну
EP1940842B1 (en) 2005-09-29 2012-05-30 Merck Sharp & Dohme Corp. Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
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EP2083831B1 (en) 2006-09-22 2013-12-25 Merck Sharp & Dohme Corp. Method of treatment using fatty acid synthesis inhibitors
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
AU2008204380B2 (en) 2007-01-10 2013-08-15 Msd Italia S.R.L. Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors
AU2008233662B2 (en) 2007-04-02 2012-08-23 Msd K.K. Indoledione derivative
JP5501227B2 (ja) 2007-06-27 2014-05-21 メルク・シャープ・アンド・ドーム・コーポレーション ヒストンデアセチラーゼ阻害剤としての４−カルボキシベンジルアミノ誘導体
JP2011515343A (ja) 2008-03-03 2011-05-19 タイガー ファーマテック チロシンキナーゼ阻害薬
EP2264029A4 (en) 2008-03-31 2011-08-24 Kowa Co 1,3-dihydroisobenzofuran DERIVATIVE
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
MX2011011901A (es) 2009-05-12 2012-01-20 Albany Molecular Res Inc Tetrahidroisoquinolinas aril, heteroaril, y heterociclo sustituidas y uso de las mismas.
KR20120023072A (ko) 2009-05-12 2012-03-12 브리스톨-마이어스 스큅 컴퍼니 （Ｓ）-7-（〔1,2,4〕트리아졸〔1,5-ａ〕피리딘-6-일）-4-（3,4-디클로로페닐）-1,2,3,4-테트라하이드로이소퀴놀린의 결정형 및 이의 용도
MX2011011907A (es) 2009-05-12 2012-01-20 Albany Molecular Res Inc 7-([1,2,4,]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2, 3,4-tetrahidroisoquinolina y uso de la misma.
MY174452A (en) 2009-10-14 2020-04-19 Schering Corp Substituted piperidines that increase p53 activity and the uses thereof
US8999957B2 (en) 2010-06-24 2015-04-07 Merck Sharp & Dohme Corp. Heterocyclic compounds as ERK inhibitors
WO2012018754A2 (en) 2010-08-02 2012-02-09 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
AU2011292261B2 (en) 2010-08-17 2015-05-14 Sirna Therapeutics, Inc. RNA interference mediated inhibition of Hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)
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Also Published As

Publication number Publication date
US6506775B1 (en) 2003-01-14
DK1114817T3 (da) 2004-04-26
HRP960386A2 (en) 1998-04-30
AU702698B2 (en) 1999-03-04
PL186773B1 (pl) 2004-02-27
EP1114817B1 (en) 2004-01-21
DZ2086A1 (fr) 2002-07-22
SK282925B6 (sk) 2003-01-09
PL325332A1 (en) 1998-07-20
OA10666A (en) 2002-11-25
TR199800300T1 (xx) 1998-06-22
PT1114817E (pt) 2004-05-31
CO4480738A1 (es) 1997-07-09
DE69616817D1 (de) 2001-12-13
SK20798A3 (en) 1999-03-12
KR100288673B1 (ko) 2001-05-02
ATE208377T1 (de) 2001-11-15
HUP9901159A3 (en) 2000-05-29
MA23961A1 (fr) 1997-04-01
JPH10510554A (ja) 1998-10-13
MY114800A (en) 2003-01-31
NO980751L (no) 1998-02-23
HRP960386B1 (en) 2002-04-30
NO980751D0 (no) 1998-02-23
RO119299B1 (ro) 2004-07-30
IS1947B (is) 2004-10-13
CZ297543B6 (cs) 2007-02-07
JP3084069B2 (ja) 2000-09-04
EP1114817A1 (en) 2001-07-11
YU49122B (sh) 2004-03-12
ES2163017T3 (es) 2002-01-16
IS4644A (is) 1997-12-30
HU225480B1 (en) 2006-12-28
MX9801467A (es) 1998-05-31
IL119078A0 (en) 1996-11-14
HK1014935A1 (en) 1999-10-08
DE69631390D1 (de) 2004-02-26
EP0861235A1 (en) 1998-09-02
WO1997008144A1 (en) 1997-03-06
DE69616817T2 (de) 2002-04-04
HUP9901159A2 (hu) 1999-07-28
AR006305A1 (es) 1999-08-25
CA2227814C (en) 2002-12-31
NO310720B1 (no) 2001-08-20
DE69631390T2 (de) 2004-11-25
BR9609989A (pt) 1999-07-06
ATE258166T1 (de) 2004-02-15
BG64126B1 (bg) 2004-01-30
CA2227814A1 (en) 1997-03-06
KR19990044077A (ko) 1999-06-25
SI1114817T1 (en) 2004-06-30
RU2152930C2 (ru) 2000-07-20
PT861235E (pt) 2002-03-28
CZ52198A3 (cs) 1999-01-13
NZ308207A (en) 1998-07-28
AP643A (en) 1998-04-24
EP0861235B1 (en) 2001-11-07
TNSN96107A1 (fr) 2005-03-15
PE20010700A1 (es) 2001-07-09
AP9600850A0 (en) 1996-10-31
SI0861235T1 (en) 2002-04-30
CN1153764C (zh) 2004-06-16
BG102288A (en) 1998-09-30
DK0861235T3 (da) 2001-12-27
CN1193961A (zh) 1998-09-23
UA48981C2 (uk) 2002-09-16
PE1398A1 (es) 1998-02-27
AU5776996A (en) 1997-03-19
YU47896A (sh) 1998-12-23
ES2211684T3 (es) 2004-07-16
IL119078A (en) 2003-11-23

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