TW297771B - Method for manufacturing acyclovir transdermal delivery - Google Patents

Abstract

A method for manufacturing acyclovir transdermal delivery system, which comprises: 0.1 wt% to 30 wt% (acyclovic,ACV), (Ganciclovir,DHPG), (2,3,-Dideoxyinosine, DDI), Ribaviriv, Amantidine, Vidarbine,Zidovudine ZDV, etc.; 0.05 wt% to 20 wt% enhancers, 2 wt% to 99.95 wt% plasticizers; such as PEG, CMC Na, ethylene glycol (E.G.), enhancers chosen from Ursolic acid, Oleanolic acid, glycyrrhizin (beta)-myrcen, oleic acid, cineole, etc, Pharmaceutical acceptable vehicles such as gel, ointment, folution, suspension, etc.

Description

A6 B6 Printed by the Beigong Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economy V. Description of invention () In this world, Kineki virus has been washed away by the palace, and it is a pity that no matter whether it is simple pimple (HSV-1) or hepatitis , Or acquired immunodeficiency virus (HIV, AIDS) are difficult to treat. At present, the known antiviral drugs can be divided into vocal bite antagonists, purine antagonists, natural biological agents, antibiotics, and hemp. Among them, Acyclovir (Acyclovir, ACV * D1), Dansikov (Danciclovir, D3), Ara-A (9-cold-D-arabinofuranosyl -9H-purin-6-ainine, D4), Di Diyi (2 ·, 3 |-still (^ < Cai 111〇81 off, 001, 07), Di Dihe (2 |, 3 | 41 (^ (Qing adnosine, DDA, 2 ', 3'- Dideoxy-9- / 3-ribofuranosyl-9H -purin-6-amine, D6), Fox grams and (Ganciclovir, DHPG, 9- (1,3-D i hydroxy-2-propoxy-methy 1) guan i ne, D2), Carbovir (D5), Cardycepin (D8), Deoxyguanosine (D9), Cytarabine (Dll), Didixi (21, 3'-Dideoxycytidine , DDC, D12), Di Si Ti (2 ·, 3 · -DidehydrO-2 ', 3'-deoxythyinidine, DHH, D14), ^ # ii * (9- (3-Hydroxy-2-phosphony 1 methoxy 1 propy 1) adenosine, HPMPA, DIO), zidudin (ZDovudine, ZDV, D13), deoxythymidine (D15), gas breaking hugs and bites ⑵ ^^ ⑽! ^-5-idoaracytosine, HIAC , D17), Podixi (5-1〇 (3〇-2 · -deoxycytidine, IDC, D18), bromovinyldeoxy uridine (BVDU, D16), ethodeoxy grade Disease (2'-Deoxyu "idine, EDI !, D19), trimethylfluorocholesterol (5-Trifluor * omethyl-2'-deoxy uridine, F3T, D20), afluti (l- / SD-Arabinofur * anosyl thymine , Ara-T, D21), Leibohe (Ribaviriv, D23), Qijia (9- (3-Hydroxy-2-phosphonylmethoxy 1 propy l) cyt idinc, HPMPC D22), Leibaomai (Riboxamide, D24), Amantidine (D25), Rimantidine (D26), and Domandine 2 paper scales using the Chinese national standard (CNS> A4 specifications (210x297 mm) {Please read the precautions on the back before filling Nest page) • Binding. Thread A6B6

Please read the precautions on the back first and then fill in * Write this page to be printed by the Ministry of Economic Affairs Central Standards Bureau Ά X Xiaof Cooperative Printed D2 Ganciclovir D3 Detcidovir D 4 VkUrabine DS Carbovir 06 2 '3'- DideoKyadnoitne D 7 2_, 3'Dide < nyinotine D Cordycepin D, Oe〇xy | u «nosine 020 (9- < 3 · Hydf〇xy * 2-pho < phonylmechoiylprop) > i)« dei > 〇e > neJ Dll CyUrabtne D12 2 *, 3 ' -DKleonycytidiiK D13 Ztdovtidine D14 Z.3 DideKydro-J ^ '-deoxyihymidine D15 Deoxythymidine D16 Brom〇viny! Deoxyuridine DI7 2' · Ruoro- 5 * iod〇4r * cy tosine OlS S-lodo-^-dcoxycyudine 019 Deoxy Tnilaoromethyl-2 '-< le〇] iyundine D21 l * beu-D- Arabinofunnoiylihym ine D22 (9 (3Hydroxy-2-phosphonylmethoxy) propyl) cy (»dnKi D23 Ribivirin D24 Riboumide 025 Am» ntidine D26 Rimaniidine D27 Tromanudine D2t Arildone dihydio > 9 > (2-hy4roaycihoiy) 6H-punn-6 <one; «eydo-fiunocine9 * (13 * DihyA〇ty ^ p * cp〇 & y * (neihyl) tu« Aine; 2 ** mino- l * 9-dihydn > * 9. (丨 * 3) · Can 丨) 6H-purin > 6-one2-((Z · Amino > 9H- > pttna »-^ yl) -meihoxy) ethtnol. deoxytcyckwir 9 * beu-D-anib0Mfuran〇iy) * 9HiMnne-6-imine; -9-beu · D-irabindTuranocyladenine;« denine «rebinoside Carbocydk Z ^ '-didehydr ^ U-dideony repeated uanosine T ^ 'OideoKy ^ beu-ribofuranocyl ^ H-punn-e-tmine 2 * J'-DNleoxy < 9-beu-ribofunno $ yl-1,9-dihydn >-^ H -purin < 6 -one T-Deoxyftdcnosine; 9-cordyotpoeid〇idenine (9 > (3 < Hydn »y-2-phosphony | meihoxyJpropyi) adenosine) 4-Amino > l · 6βlλ · [>-· ηΒΐηοίυηηο« γ1 · 2 (1 H ) -pyrimi < li · none; l-beu-D * trtbino (urenosylcyto $ ine, l-beta «cyiosine« rabinoiide? ^ '* Oideoxy-4 * «mino · I > beul > riboiur > nocyi) > 2 > (l H) · pyenidinone I • p-Aado-S ^ -dideoxy · beu · D-cry ihro-pemofur < nosy)) lhymine; 3, Azid < v3'-0eoiyihymidtnf! • (2t3 > < iMle ^ dv 〇-3- < ie〇iiy beu-D-eryihro-pemofurano tyl) (hyfnifie $ > (2-Brom〇vinyl) -Z-deoxyundine? .Rooio * 5-iodo ~ 4- «mino · l.beu -IX «rab) nofuranosyl. 2 (1 H > -pyrimidinone: 2 · fluAr〇 > 5-i〇 (io. L« beu- «rftbino > furanosy lcytosine 2 * .De6xy-5, iod < > > 4.Mmnu > l.bcta-D-ribofur «nosy ", 2 · (lH) * pyrimidinone 7-Deoxyuridine; l- (2 > deoxy beu-D- eryihro * pentofursiK > · syj) ur »cil; i '(2-deoxy-beu-D-nb〇ruranocyl) urecU; uracil deoxyriboside

DHPG

Vir «.A

Ara-A

DDA DDI

Alexan; Anbitin; Aracyline, Ara-C; Aracytidine et «1

HPMPA An-C ZDV,

d4T

BVDU FIAC

IDC

(9- (3-Hydroxy > 2 < phosphonylmeih〇Aylpropyl) cylidine) l-beU-D-Ribofuranosyl * 1 Η · 1,2,4-tnazole 3-carfoox «midc 2.beu-D * RibofurinosyM.thii2〇lcaboxan ) ide: tUzofurin Tricyclo (3.3.1.1) decan l> amine. I «damaruanamine. 1-aminotdamanunr X-Me (hyUricyclo (3.3.li | dccan-l-mcthanamine; x-melhyl lidamanunmethy timinc Ν.1 · Α4νηΜΐ) τΙ-Ν · 2 · (4ίτηβϋ)) τΙιπιίηο > «ιΚο & χ】 《〇 € ll > ηηι0 £ 4. (6- (2 * Chloro-4 > (neth〇Kyphcnoxy) hexyi | 3,5 * hcpurx > .-dione N '(Aminoiminon) Cihyl) * mnrph〇luiccarKt \ imiJ jmidc; abiiylguamdc 6 > ((Hyd (〇 & yimino) fhcn > i ».c: hyl | -l-t < l * mtihylcth > i) sulkmyl |-(11 l) -hun7. > mt «Jx / oi 2 > amii» c Dthydroxyphottphincca ^ ixlic icid oxide trisoJium sail; Imodium phutphonoloyTiuic_

Viramid ei «1. Amazolon: Manudix ei al Meradan

Hioxim :: Viroml. Virusinm d «I.

F3T Ara-T HPMPC RTCA TCAR

ABOB 3 _This paper size is applicable to the B B family sample standard (which) A 4 ^ X210X297 Gong ")

V. Description of the invention () A6 B6 Printed 5i by the China Industrial Standards Bureau of the Ministry of Economic Affairs

Cj " roman tad i ne 'D27), Aquandone (D28), Anoxydine (D29), Enviran (0nviroxime, D30), Foscaroct sodium (D31), as shown in Table 1 All shown are antiviral drugs of similar structure. The route of administration of these drugs: oral, injection and topical application, but the toxicity is extremely high and even inhibits the central nervous system lines, the chemical structure of the kidney, bismuth, silver, helium and (ACV) is It contains 9-[(2-Hydroxyethoxy) methyl] Guanine compound with Purine ring and 2'-Deoxyxyguanosine structure as shown in Fig. 1. Cong Kehe (ACV) for type 1 and type 2 simple cancer therapy viruses (hsv 1, 2), water cancer banded anaphylactic virus (Varicella roster virus, VZV), Epstein barr virus , EBV) with Cytomegalovirus (CMC) has an inhibitory effect, and its drug effect is stronger for herpes simplex virus type 1 (HSV 1), followed by herpes simplex virus type 2 (HSV 2 ), Varicella zoster virus (foot), Epstein-Barr virus (EBV) and cytoplasmic virus (CMV). According to Zhao Nei's experimental skills, Satoshi, Kehe (ACV) is better than HIAC or Guankehe (DHPG) in the treatment of simple school sore virus. And it can fight against herpes simplex virus type 2 and type 1, which is better than bromovinyl deoxyuridine: different ability. As for the use of Zac and (acv) to inhibit the varicella zoster virus (VZV), there were very different results in different experiments. Usually under the gift test, the cheek and (ACV) pair (please read the precautions on the back before filling out this page)-binding ..................... line ......... This paper scale adopts the Chinese National Standard (CNS) A4 specification (21〇297mm)

A6 B6 Fifth, the description of the invention () The curative effect of anti-convulsant virus (CMV) is more potent than that of "Idoxuridine, trifluorofluorocarbon"

Friduridine, Vidarabine or DHPG are worse. ACV can also inhibit the productive cycle of aba virus, but it cannot show the effect for the virus in the incubation period. Cheek and (ACV) and other analgesic poisons form a dry hormone and are used to fight against certain cancer viruses, including cytoplasmic viruses (α 丨 v), which have a synergistic effect. At present, the bases commonly used in commercially available ACV ointment include polyethylene glycol 'PEG, Olodification aqueous cream and Pimethyl sulfoxide * WfiO. . Corey L. et al., 1982, American J. of Medicine, Volume 73, Nos. 326-334, reported that the strain was locally administered 4-6 times a day with polyethylene biscuit cream containing 5% cheeks for 5 to 7 days. Although it can be absorbed in the skin infected with herpes • However, the amount of absorption is very small and its blood concentration is less than 0.023 rag / L. In addition, Poirror R.Η. et al. Reported in the same publication No. 393 of the same year that 25 patients with a combined posterior fornix were administered once every 5 hours with a polyethylene dizygote cream containing 3% cheek and polyethylene. (4-6 times a day), within 5 minutes after the last dose, cataract extraction (〔ataract extration) was performed, and the average concentration of Satoshi Kehe (ACV) in Aqueous humour was determined to be 1.7 mg / L, showing that a very high penetration can be obtained. In 1986, DJ et al., J. of Infectious Diseases, Volume 153, pages 64-70, studied the penetration of excipients to topical formulations (Flux) per unit time per unit area (Flux) * Compared to 5 % Cheek and (ACV) water-based cold cream base (Mod ifi cat i on aqueous cream), or polyethylene glycol * PEG preparation 'and 6% 克克 和 (ACV) 二甲3 kinds of [DMSO * dimethyl sulfoxide] [this paper ruler Lu Shi_] ?! China National Sample (CNS) f4 specifications (21 () X297 g • 5

Install 1ΤΓ (please read the precautions on the back before filling in this page) A6 B6

2977, U V. Description of the invention () Dosage form * It is found that the unit surface of polyethylene diacid (PEG) guesses that the penetration per unit time is the smallest while the other two dosage forms are 8 times and 10 times the penetration per unit time respectively . According to the study published by Greg E. et al. In J. Invest. Dennatorl, 1992, Volume 98, pages 856-863. • It was found that clinical treatment of herpes simplex virus type 1 (HSV 1) was administered orally to Congke and (ACV) is better than topical application, and the degree of drug loss on the epidermis of the affected area is 2 to 3 times lower than oral administration. And 18 papers published by 祀 佑 (review) collected the topical application method and applied Satoshi * Gram and (ACV) system #], but Jfc Gram and (ACV) did not work on the dermis, this report is practical Currently available ACV (ACV) ointment is invalid. It can be seen that the development of ACV (ACV) percutaneous absorption preparations so that the drugs can enter the tissues of deeper debris to produce therapeutic effects is of great development significance. The present invention is a percutaneous absorption preparation. It is a conventional topical dosage form containing antiviral drugs. A transdermal absorption accelerator is added to improve the transdermal absorption effect. The transdermal drug delivery system is a controlled drug delivery system (Drug Delivery System) * After it is applied locally, the drug can be continuously and slowly released to the epidermis The area that has reached the treatment target through the vascular system shows the curative effect. The biggest advantage of this type of dosage form is that it is easy to use and safe. It is usually applied to the skin or administered locally. If necessary, it can be torn off at any time so as not to cause the sudden release of a large amount of drugs that exceed the critical dose. The total skin area of an average adult is about 2 π2, and the blood flow of the microenteric tube accounts for about one-third of the whole body. Therefore, in recent years, the transdermal drug delivery system has become a drug route with considerable potential. At the same time, the design of the transdermal medicine system also has the advantage of improving or removing the side effects of the general traditional dosage forms, and can release the medicine in a timely manner and in an appropriate amount to exert the least effective effect, so it has received an excellent evaluation on the bed. -Binding. Binding, Ministry of Economic Affairs, Central Bureau of Standards, Beigong Consumer Co., Ltd. Printed paper, the paper size is used in the National Sample Standard (CNS) A 4 specifications (210x297 mm) --- Α6 Β6 V. Description of invention () However, The transdermal drug delivery system is also affected by the physical and chemical properties of the drug, such as partition coefficient, molecular weight, roll, molecular polarity; or the physical and chemical properties of the percutaneous drug system, such as the polarity of the base, the solubility of the drug in the base, and the composition of the system Ingredients, base residual viscosity; even affected by skin physiology and pathological symptoms, such as the staggered effect of the stratum corneum • Lipid smilax on the skin surface, skin hydration process skin • skin temperature, differences in the application of dry patches, skin trauma, pathology Factors such as injury and drug metabolism in the skin are affected. At present, the most common problem of the transdermal absorption wheel drug system is the lack of a strong and safe transdermal absorption accelerator. In recent years, with the rapid development of medicine, people's evaluation of Oriental medicine has been significantly improved. For example, in 1975, Japan's Ministry of Health, Welfare and Welfare agreed to apply 210 kinds of traditional Chinese medicine to national health insurance. The traditional Chinese medicine treatment methods include sweat, vomiting, diarrhea, down, care, tonic, reconciliation and other compound prescriptions. Among these prescriptions, 150 kinds of prescriptions contain ganji, and the frequency of occurrence is 71,4%. After that, it was 42.9% in raw, 35.2% in Poria, 32.9% in peony, 31.9% in jujube, and 29.5% in Guizhi. In addition, the frequency of appearance of the 93 compound prescriptions contained in the notes of the second revised edition of the Japanese National Medicine Collection is still the highest. The second place is ginger. The first six orders of the raw medicine are exactly the same as the above. The order below the level is also similar to the frequency of the Chinese medicine compound applied to the National Health Insurance. Printed by the Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs (please read the precautions on the back before filling the nest page). 4 The Chinese herbal medicine compound is used more frequently. The main component of glycyrrhizae yaadix is licorice Triterpene saponin (Si% lycyrrhizin), glycyrrhizin (sub-lycyrrhetinic acid) and other triterpene saponin structures. The second is ginger (Zingiberis rhizoma), which contains the main ingredients. The paper size is applicable to the National Standard (CNS) A 4 specifications (210X297 mm) ST year P; U order stop A6 sleeve brother B6 V. Invention description () Economy Essential oils such as ot-Pinene, / 3-Myrcene, and Cineole are the main printing products of the Ministry of Standards and Labor Cooperatives. The main components of the commonly used Zizyphi ructus are 0 (leanolic acid) and ursolic acid (triterpenoid). The main components in leditsia sinensis | aro.) Are three IS-like dragon dads and tannins (^ ledinin), 6leditschia saponin (). The main components contained in eloelen are (buricoic acid), acetyldehydrotumulosic acid (3 / 3-0 • acetyldehydrotumulosic acid), and aspartic acid (3-zhao-〇_acetyltumulosic acid), Triterpenoids such as Pehydroeburicoic acid and frgosterol are rushing. The main ingredients contained in paeoniae radix are paeon if lor in, paeoniflorin fAlbiflorin, ftypaeoniflorin, prescription medicine () ^ 01 ^ 1〇, foot 101 ^), Paeonif lorin (61120 雅卜 paeonif lorin), 4 ~ Ί 技 疊 · 食 子 随 束 galloylglucose), anti-catechin ((+)-Catechin), the original car fine gall plaque (pV * 〇cyanicHn B -1), monoterpene glycoside and other tannins. The main components of cinnamon (Ginnamoni cortex et caul is) are essential oil components such as Cinnaray 1 acetate and Cinnamaldehyde. And · meat sticks ^ 0nncassiol A), hydrogenated cassia cassis 111 ^ 〇) "0 (^ 111 ^ 6: / 13) 1〇1), dehydro cassia cassia thinning Wnhydrocinnzeylanine), gui · piscine (Cinnzeylanine), Cinnzeylanol and other kneading ingredients. The main ingredients of the above-mentioned medicinal materials include the monoterpenes with kurray, the triterpenes with the beginning of the chain, the three sores, the kneading, the essential oil and the second station. 8 Please read the precautions on the back before filling the nest. The gage of this page is in accordance with Chinese national standards (CN S) A4 specifications (210X297mm1, l: Α6 Β6 V. Description of the invention) The nature of surfactants can reduce the surface tension of the skin, assist the drug to reach the deeper layer of twisting through the skin, increase the penetration of the drug and Treating the cause of the disease. Essential oil, glycyrrhizic acid and glycyrrhetinic acid have anti-inflammatory effects in the external test. Among them, glycyrrhizic acid and glycyrrhetinic acid have the ability to inhibit paw swelling. Segal R 1987 · Alternatively, the gel sword with 0.2% dilutidine (IDU), 2% glycyrrhizic acid, 0.1% benzoic acid (Bonzoicacid) ^ 1) preparation can be administered orally to treat simple sore net (HSV) Patent No. 4,678,772. In the same year, Segal R. et al. Reported in J. Clinic Phann. Vol. 12, pages 1-7, 2% gelatin for thymidine (brain) and glycyrrhizic acid, and 5% breakout The treatment of Viruson ointment compares the results of simple lip or supine nasal therapy. It is found that the former can not only shorten the healing time, but also reduce the pain. And Touitou E. et al. Design and Delivery Vol. 3, pages 267-272 indicate that the complete nude skin is at 34 ° C and 25 The in vitro diffusion experiment at ° C found that the penetration amount (^ lux) of the gel of 2% iodophosphoridine (IDU) and glycyrrhizic acid per unit area per unit time (^ lux) was 6 times that of the latter, depending on the ambient temperature. 20 times. Printed by the Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs (please read the back-end notes before filling in the nest page). The present invention considers the safety and finds effective transdermal absorption enhancers in the commonly used Chinese medicine "Medicine Primer M" The transdermal absorption enhancer of the present invention is to add antiviral drugs, Chinese medicine "medicine primers" to the fog fog sword, ointment (CJintmeirt), coagulant (& el), solution profile (| ^> gtution) 、 Suspending agent (This paper scale is applicable to China National Standard (CNS) A4 specifications (210X297 mm 1 A6 B6 Printed by Beigong Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs

Suspension), patch and other local administration preparations. In addition to the single ingredients of 6 kinds of traditional Chinese medicines including licorice, raw yip, poria, paeonia, jujube, and twigs, the "medicine primer" of the traditional Chinese medicine of Shangmi can also contain Triterpenoid saponins, tannins, essential oils. Since the saponin-containing plants have 50 marriages_ 400 plants in the family. After screening Chinese herbal compound prescriptions, they are selected to cover the umbrella j j. 3 shown in f is used for the branches of saponin, tannin, $ oil or in the Chinese herbal compound prescriptions. Terpene Chinese medicine "medicine primer". The antiviral drugs that can be used as the transdermal absorber of the present invention include Tobacco (ACV), and other drugs with similar structures that are nucleoside (Fig. 2). Kehe (D2), Dansikhe (D3), Araa (D4), Kabaohe (D5), Didihe (D6), Didiyi (D7), Kadibin (D8), deoxygenation Kehe (D9), Phosphora (D) 0), Setabin (D11), Didixi (D12), Cidudine (M3), Disimidine (D14), Deoxypyrimidine (D15) , Bromophenone (D16), fluoroiodine cytosine (D17), iodix (D18), etodexamine (D19), trimethoprim (D20), aflutide (D21>, phosphazepine Greek (D22), Leibohe (D23), Leibomai (D24), Omandine (D25), Rummandine (D26), Domandine (D27), Aradon (D28), Afindine (D29) ), Enhuian (D30), Fulcana (D31) 〇The most suitable drugs for making transdermal absorbers are cheek and (ACV, D1), guanke and (DHPG, D2), Ara (Ara -A, D4), trimethyl phosphinopyridine (F3T, 1) 20), fluoropyrimidine (HIAC, D17), bromophosphine (BVDU, D16). 10 The scale of this paper is in accordance with Chinese National Standard ⑷ 昍) A 4 specifications βαχ297 mm) ..................................... ...................................... ^ ..... ................. • 玎 ........................ (Please read the precautions on the back first Fill this page)

Α7 Β.7 V. Description of the invention () The percutaneous absorption enhancer of the present invention is added to the local administration type known as f, such as ointment, suspension, gel, solution, patch, spray, etc. 0.1 ~ 30% of antiviral drugs are the main ingredients. Among them, gram and (ACV), bromoviny (deoxyur 丨 dine), fox and (DHPG), vidabine (Vidarabine), tfrifluridine, trimethylfluoropyridine (F3T), fluorine The content of HIAC is most suitable from 0.1% to 0.1%. Regardless of the excipients added in any dosage form, 95% is appropriate; Contains 5% ethylene glycol (EG, ethylene glycol), 42.5 ~ 45% polyethylene glycol (PEG 400, poly fythylene glycoO and 42.5 ~ 45% polyethylene glycol (PEG 4000) can be made into an ointment. The excipient used in the gel agent is selected from the group consisting of carboxylic acid methyl ester oryzae sodium (QC Na), polyethylene glycol (PEG), glycerin glycerin) and ethylene glycol (EG) can be presented in three types; in addition to keeping the appropriate amount of water in each type, the first type contains 2 to 6% carboxyroethyl cellulose sodium 'CMC Na) with 50% glycerin); the second type of plastic contains 2% ethoxyethylene glycol (EG * ethylene glyco) with 2% carboxylic acid methyl ester oryzanol sodium (CMC Na); the third type is mainly composed of 20% ethylene glycol (EG). The suspending agent is composed of 50 ~ 9δ% ethylene glycol (EG) and an appropriate amount of water. In addition, the wave dissolving agent is sufficiently dissolved and mixed with an ultrasonic oscillator with sufficient water. The content of the accelerator in each dosage form is from 0.05% to 20% as the fluorine circumference, and the most suitable content is 0.1% to δ%. The "antiviral drug Shikehe (ACV) percutaneous absorption preparation of the present invention is a medicine composition containing Zhikehe (ACV) percutaneous absorption pharmaceutical composition, which includes _iiL · ^ _ ——J --- -{Install ------ ordered (please read the precautions on the back before filling out this page) The paper standard printed by the Employee Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs is applicable to the Chinese National Standard (CNS) A4 specification (2 ^ VX : 297 Gong ^ 'Guang ·.,

5. Description of the invention (Group of upright and detachable double-layer glass containers. The lower container is filled with a quantitative 0.15 N vaporized sodium aqueous solution filled with antibiotics. • A magnet is placed at the bottom to produce a mixing effect of 600 rpm. The inflamed layer in the middle is circulated with water to maintain the temperature. The upper container is placed with 0.25 g or 0.5 g of different dosage forms. * The upper opening is covered with plastic wrap from the top. The upper and lower two; The material or human skin required for the inspection is used as the barrier for the wheat penetration, and it is fixed by the use of metal solid history. A sample of 200 liters of vaporized sodium solution is taken from the sampling port (Yi ^ Shu Qiudai) within the specified time, and Immediately add 200 uL of sodium chloride solution to the container to maintain a fixed amount of solution. Each sample taken was then added 200wL, 5 wg / ml of Acetaminophen f as a multi-standard product. The high-pressure liquid wide analysis method (HPLC) is used to analyze the quality of the inspection products containing fresh materials, ⑽ the material is in the main (how to read the precautions on the back and then fill the nest page) • Install. • Order. Line. Ministry of Economic Affairs Printed on paper by the Central Standards Bureau, Fei Gongxiao fr Cooperative Society (CNS) A 4 size (210x297 well

A6 B6 Material m :: Positive—Ten Diameters Fifth, Description of the Invention () In order to determine whether the antiviral drug in the preparation has undergone a 72-hour in vitro transdermal penetration test, whether the enzyme metabolism of some of the drug ’s skin or the experimental process exists The acetylene trap is sufficient to cause the loss of drugs, and the following formula is used to calculate A'total R% =-χ 100¾ A total A'total = A'donor + A'skin + A'receptor A total = A donor R: drug recovery Rate A total • The total dose before the experiment A donor: the amount of the drug supplied to the phase before the experiment A'total: the total amount of the drug after the experiment A donor *: the residual amount of the drug after the experiment A'skin: the skin area after the experiment Contained dose A'receptor: the dose of the received phase after the experiment. The present invention selects the sheep's noodles that were removed when pregnant women were split, or the skin of whole snake skin, guinea pigs at 25 and 80 And the abdominal skin of ICR or Balb / C Mudmice owing to squatting for 7 to 9 weeks is used as the test skin (warm) material to study the experience of transdermal absorbers made by antiviral drugs and Chinese medicine "medicine" Skin absorption, and quantify the penetration of antiviral drugs by high-pressure liquid chromatography (HPLC) Volume. In addition to 'rabbit ................................................. ...................................._....... ............., 玎 ..................... Line < Please read the notes on the back before filling this page 1. The paper printed by the Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs applies the Chinese National Standard (CNS) A4 specifications (210X297 mm) gr year green.

. \ LI Ή A6 B6 Printed by the staff of the Central Provincial Bureau of the Ministry of Economic Affairs Cooperative Society V. Description of the invention () Conducted an intra-colonial experiment, the drug was encased in the ears of rabbits, and the cortex and cortex of the ears were measured after 72 hours And the wave of drugs in the organization. The preparation of the present invention shows that the traditional Chinese medicine "Medicine Primer" has been promoted by Zhao Wai's experiment to promote percutaneous absorption of rose hips, for example, 0.01% gram and (ACV) water-soluble wave prescription (# 1) preparation made with 0.01% glycyrrhizin and lycyrrhizin). After 28.75 hours of snake skin Zhao external penetration test, as shown in Figure 3, the cumulative area penetration of 4.8 ag / Cm2 was twice (previously) the prescription of the control group without glycyrrhizic acid. If using 2% carboxylic acid methyl ester sodium pheasant sodium (CMC correction base 2% cheek and (ACV) knee coagulant, use 80-day-old, 25-day-old guinea pig skin * and 7 to 7 The history of the 9-year-old mother tree II compares the percutaneous absorption strategy. After 72 hours, as shown in Figure 4, nude skin penetration strategy is better; and sheep warm or 80-day-old, 25-day-old pig skin is better Ke and _ percutaneous absorption effects are very poor. At present, the commercially available bases containing cheek and (ACV) commonly used bases are polyethylene glycol (PEG), aqueous cold cream base (modification aqueous cream) and dimethyl Dimethyl sulfoxide (DtSO). In the present invention, 2% carboxylic acid methyl ester sodium CMC sodium (CMC Na) is used as a base to make a knee coagulant to improve the polyethylene glycol (PEG) as a base. The phenomenon of poor transdermal absorption effect. As shown in Figure 5, comparing the two preparations after 72 hours of testing, the cumulative penetration per unit area is 34.9 Mg / cm2 and -5.3 called / 〇112, with 2 % Carboxylic acid methyl ester oryzanol sodium (££) as a base gel made of polyethylene glycol (PEG) as a base can achieve 7 times better percutaneous inflammation results . And even if the two are drunk with polyethylene pEG) Adding different amounts of glycyrrhizic acid in the soft foundation of KIC (2 i η), after an in vitro penetration test, there is no statistically significant difference, showing that the addition of glycyrrhizic acid in polyethylene glycol ointment still results in a glycyrrhizic acid Unable to play promotion script ........................................... ....................................... install ... ............. Booking ..................... line (chair read the notes on the back first and then fill out this page) The size of this paper is applicable to China National Standard (CNS) Grade A (21〇297297mm: --- ~~ 1

V. Description of the invention (The effect of A6 B6 skin absorption. However, the gelling agent based on 2¾ carboxylic acid methyl ester cellulose ^ (CMCt (a) as the base agent is added with aglycolic acid. The cumulative amount of area penetration is statistically significant, but the addition rate of glycyrrhizic acid in such gels is higher than 2¾, but there is no statistically significant difference from the control group. The penetration promoting effect of glycyrrhizic acid is shown. The mechanism of action is dose-dependent (Dose dependent). The knee coagulant with 2% carboxylic acid methyl ester oryzanol sodium (CMC Na) as the base agent, respectively selects different kinds of different proportions of traditional Chinese medicine "medicine" as Transdermal absorption enhancers such as snail lettuce, grass root, mint, perilla leaves, jujube, pepper, Magnolia officinalis, Xinyi, white cardamom, zedoary, ginger, fragrant monkshood, saffron (⑸-Maogui [ Qs) -㈠-a-pinene]; Urs〇Hc acid (Urs〇Hc acid) contained in Xiongcao leaves, Shanceen, and jujube; 18-glycyrrhizin-glyCyrrhetinic acid combined in Chinese licorice) , Glycyrrhizic acid (々lycyrrhizin); oleanolic acid contained in forsythia, cornel, clove, and jujube ); Pressed by "Cineole; contained in Xinyi, turmeric and saffron; (+)-¾ weld (α- (O-pinene) contained in fennel, nutmeg; in cork, Atractylodes, Angelica , P Dongpi, Chuanxiong, Meiyuanzhi, Yinchenhao, Chamomile, Woody, Nepeta, Fennel, Clove, Eucalyptus, Fructus Aurantii, Fructus Corni, Flower Board, Asarum, Ivy League, Schisandra, Yi Zhi Ren The essential oil contained in the sand; the two post-type soaps contained in Yu Zexi, Kansui, West Yellow Tengjiao, Zhiren, Cimicifuga, Sangbaipi | (triter.pene saponin); Yuhubu, Baidouzi and 1 contained>] twigs (point-; tannins in ingredients such as dips, medicinal herbs, cinnamon and rhubarb); the cumulative amount of penetration of each preparation in a unit area of 72 hours after the experiment is shown in Figure 7 As shown, the prescription (and 1) is 605-3 ug / cm2, and prescription ⑽ is 206.4 wg / cra2,-f I ..................... .................................................. ............... ^ .........................- 玎 .......... ........... ^ {Please read the precautions on the back before filling out this page) The paper standard of the printed copy of the printed copy of the employee consumer cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs China National Standard (CNS) Grade 4 specifications (210x297 mm)

V. Description of invention (2 A6 B6 prescription (ί3) is 186.0 g / cm2, prescription (material) is 173.1 wg / cm prescription (# 5) is 125.5 " g / cm2, prescription (other) is 72.5 M / cm2 , Prescription (# 7) is 61.0, with g / cm2, prescription (54.5) g / cm2, prescription (of) 53.4 wg / cm2; and polyethylene dizygase (PEG) as the base cream in Figure 5 The cumulative amount of penetration per hour in the 72-hour unit surface is 5.3M / cm2. It can be found that the increase in the cumulative amount of penetration of each formulation is 114 times, 38.9 times, 35 times, 32.6 times, 23.6 times, 13.7 Times,: 11.5 times, 10.3 times, 10.8 times. Among them, 2% glycyrrhizic acid (# 1) and 2% oleanolic acid (Oleanolic acid) 0 0 can produce maximum penetration effect. In the formulation of 2% cheek and (ACV) knee coagulant, based on the prescription (0) containing 2% glycofuric acid accelerator, add other accelerators such as prescription (ttl) and add 1% azilosacid, prescription (Milk) 1% ursolic acid in the curtain, 5% colonization in the prescription (he), 20% pimethyl sulfoxide (DFBO) in the prescription (we), and 2% containing 2% glycolic acid Roche and (ACV) Suspension Prescription 0® are compared; the results are as As shown in 8, after 72 hours, the cumulative guessing amount of each unit surface is 2687.7 / ^ / 〇112, 594.4 / ^ / <: 1112, 449.5) ^ / <: 1112, 221.5wg / cm2, Π8 .6 " g / cm2, 241.0 “g / cm2; compared with the cumulative penetration of 5.3 // s / cm2 in 72 hours per area of polyethylene glycol (PEG) as the base ointment in FIG. 5 can be found in FIG. 8 The increase in penetration penetration of each preparation was 507 times, 112 times, 85 times, 41.8 times, 22.4 times, and 45.5 times in sequence. Among them, the place containing oleanolic acid can produce the largest wear. Through effect. In addition, add 2% cheek and (ACV) knee coagulant containing 2% glycylic acid and 1% () and 2% (character 2) of the angle of interest (red leditsia sinensis). The paper scale is applicable to the Chinese national standard (CNS ) A 4 specifications (210X297 mm.) .............................................. .........-: ...-......................... Pretend ... ............. Order ............................................. (please first Read the precautions on the back and fill this page) Printed by the Employee Consumer Cooperative of the Central Standards Bureau of the Ministry of Economy and Economy / h. «4 -WA; ϊ 7 7 Vi A6 B6 —__ $! 女 .jagger V. Description of invention () I am.) Extraction talk, compared with the prescription without saponin control group M) The external penetration test at the beginning of 72 hours is narrowed. The results are shown in B 9. Prescription 0 »1 · 2) The cumulative penetration per unit area The amount is 2523.9 / ig / cm2, 1158.9ug / cro2, 221.5 as / crn2 in order; the cumulative amount of penetration per unit area in each area is sequentially increased to 476.2 times by comparing with polyethylene dihydrazine (PEG) soft jelly as described above , 218.6 times, 41.8 per cent. Obviously, soap corners can promote cheek and transdermal absorption. Among them, 1% soap corners are effective for extracting JL from liquid. And as shown in Figure 10, even if the above prescription (Lin 2) is replaced by 1% oleanolic acid (Oleanolicacid) • Compare the formula containing 1% qi guao acid (# 1) with the 1% saponin extract Prescription ¢ 2) It is found that the transdermal absorption effect of the two is equally good, which proves that the saponin extract is an excellent transdermal absorption accelerator. As shown in Fig. 11 • The reward of diligence performed by covering the gas of the rabbit with the medicine gas was measured after 72 hours. The degree of penetration of the stratum corneum is the most inadequate with a prescription containing 2% glycyrrhizic acid.The cumulative amount of penetration per unit area is 389.8 zig / cro2; and the epidermal layer and the dermal layer are added with 1% chlorophenolic acid and 2 % Glycolic acid is the best square. 2) The best, the cumulative guessing amount per unit surface is 389.8 wg / cm2 ;. As shown in Figure 12, the concentration of the drug in each tissue, whether it contains 2% glycyrrhizic acid, 2% ember and (ACV) coagulant prescription (ttl) * or to which is added 1% zishu fruit acid (tf2) two The concentration of the preparations of the former increased significantly at 72 hours. The cumulative amount of the former was 0.53 ± 0.02 / ig / mi in 72 hours. The cumulative guess of the control group was 0.35 ± 0.03 wg / ml, which was 1.5 times the effective dose. The latter 0.48 ± 0.03 " g / ml is 1.4 times that of the control group. In addition, after measuring the blood concentration of gavage and (ACV) in various organs of rabbits, it was found that the content of 2% carboxylic acid methyl ester cellulose sodium (QC Na) prescription containing 2% glycyrrhizic acid (Oil) in the leaf organs For all kinds of organs up to 6.89 ± 0.38 wg / g only compared with the control group. The paper size is selected by the Chinese National Standard (CNS) f 4 specifications (210x297 mm 1 'door ^ ........... .................................................. ...................... installed ........................ ordered ... ................. Line < Please read the notes on the back before filling the nest page) Printed by the Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs

A6 B6 Printed by the consumer cooperation of the Central Bureau of Economic Affairs of the Ministry of Economic Affairs 5. The description of the invention (the content of the prescription (material) 3.60 soil 0.36 ag / g increased 2_2 ~ 1.64 times; and based on polyethylene dihydrate (PEG) The dosage of 2% glycyrrhizic acid and oleanolic acid (# 2) in the heart is up to 8.22 ± 1.38 wg / g in various organs, which is only 3.90 ± 1.00 compared with the control prescription W). M / s increased by 3.31 ~ 1.39 times; even when the liver content was 6.42 ± 0.51 / ig / g, it was only increased by 4.22 ~ 1.10 times compared with the control content of 2.49 ± 0.85iUg / g, and there was no risk of poisoning. As shown in Figure 13, 2% Satoshi, Kewa (ACV) gel containing 2% glycyrrhizic acid in human skin, the cheek and concentration in the skin after 72 hours increased significantly by 6 times compared with the control group. Since the drug can be absorbed through the sebaceous tract transdermally, or the more polar accelerator in the preparation may assist the drug to produce greater transdermal absorption through the polar channel, it should be. The present invention uses the high-pressure liquid chamber analysis method (HPLC) method to obtain the fat solubility index of the drug accelerator, the values of which are listed in circle 14, Table 4. It can be seen from the dissolution of the drugs and accelerators in the table and the fat solubility index, the formula is formed by adding 2% chlorhexidine (ACV), adding glycyrrhizic acid as the base, and 1% Oleanolic acid Youmin good transdermal absorption effect is based on the less polar of glycyrrhizic acid to help cheek and pass through the pole passage (p〇lar pathway), but the polarity of zigzag fruit acid is low, can «: help gram and through non The polar channel (0 // rpolarpathway) is passed, and the two complement each other to maximize the transdermal absorption and effect of Kangke and coagulating agent. Due to the poor percutaneous penetration effect of Satoshi Kehe (ACV) itself, and the main treatment site after the attack is the dermal eyebrow of the skinny c 3 Cheek and (ACV) ointment available before the market regardless of the use of polyethylene Glycol (PEG), Modified aqueous cream (Modification aqueous cream) or Dimethyl Island ^ (|) Road 〇) 97 mm) __ .. 一 ____________________

^ r — ---------— I .................................... .................................................. To install ..................... Order ................................. (Read the notes on the back first Refill this page)

2. Description of the invention () Bases • There is a phenomenon of poor treatment. "Terpenes", tannin Cfarmins, essential oils, terpene glycoside, etc. are added to the present invention as "medicine is introduced to M as percutaneous absorption and collection promotion Agents. Penetrate tests on various skins and verify the concentration in the blood. The cumulative amount of penetration per unit surface produced by this type of preparation is about 500 times greater than that of traditional gram and pian ointment. Use local administration before Π The antiviral drugs include Vidarabine, Jrifluridine, and IDU. The low toxicity of these drugs is very suitable for the local administration method of the present invention. This stirrup can be used in Including local preparations such as softener, suspending agent, knee coagulant, solution, patch, spray, etc., and the added "medicine primer" percutaneous absorption enhancer can use one kind of Chinese medicine "medicine primer", or mix with a variety of Chinese medicine "Medicine primer" to increase the percutaneous absorption of various antiviral drugs. The following specific examples illustrate the invention using different bases, adding different concentrations and different types of Chinese medicine "medicine primer" to make effective percutaneous inflammation Formulation 0 : (X ............................................... ................................. Pretend .......... ............ Order .................. Line ... f Please first "read the notes on the back and then fill the nest" Page) | Exhausted: The chemical structure of the Ministry of Economic Affairs, Central Bureau of Economic Development, R Industry and Consumer Cooperatives Co., Ltd. «. Figure 3 1 · Writing Code 2. Inspection Product 3. Transdermal Absorption Area 4. Skin f Sui 5 · # 口 6. Reception Groove 7. Water outlet 8. Circulating water flow 9. Inlet mouth 10 • Magnet 9. Water inlet 10 • Magnet gram and (ACV) water dissolves in snakeskin 4 beginning 1. 0.01% gill 1_ winter soluble ginseng + 0.01% glycyrrhizic acid (^^ 2 ... 0.01% cheek and aqueous solution, see Figure 4 Cheek and (ACV) dosage form in different kinds of penetration test xcyrrhizin) CNS) T4 specification (210X297mm)

Description of the invention (1) Naked posture 2 ... 80-year-old pigskin 3 ... 25-year-old pigskin gel dosage form using 2% carboxymethyl methyl ester oryzanol sodium (CMC NA) as a base Of 2% cheek and knee coagulation el) Figure 5 Luke and (ACV) in the ointment form and gel shoveling shovel outside test 1 .. Weave with 2% carboxylic acid methyl ester Vitamin C (iCMC NA) is 2% of the base and the base agent (2). Using polyethylene diferment (PEG) as the base Cong Ke and ointment © intment) Figure β glycyrrhizic acid i ^ rlycyrrhizin) content Yingchuncong * Kewa (A ^ V) gel dosage form percutaneous absorption 1. Based on carboxylic acid S & ester oryzanol (CMC NA) as a base + 2% glycyrrhizic acid (such as cxcnhizin) 2% cheek and umbilical gel (gel) 2: 2% carboxymethyl carboxylate cellulose ester (CMC ΝΑ) as 2% cheek and knee coagulant el) 3. 2% Carboxylic acid methyl ester oryzanol sodium (CMC Μ) is used as a base and ^^ agent * ^ 1) Printed by the Gonggong Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs (please read the notes * on the back before filling the nest (Each page) Figure 7 Percutaneous absorption of Jinjin Fenke and (ACV) knee coagulant tablets 1. .. using 2% carboxylic acid methyl ester Zhizhisu (d-NA) as the base + 2% Licorice Su 6 (yarriii ^ in) of 2% gram Coagulation agent wins "1) .. 2. In carboxylate drill weave prime pheasant d NA) of

This paper scale is applicable to China National Standards (CNS) Grade 4 (210x297 g; L: ϋ ....... —_ | · | —

Description of the invention (printed by A6 B6 Employee Consumer Cooperative of the Central Standards Bureau of the Ministry of Hydrocarbon Economy 8 base agent + 2% galactic acid (〇 丨 coffee 〇1 chemical acid) 2% part grams and gel agent _1) 3. · 2% carboxymethyl methyl ester oryzanol sodium (CMC ΝΑ) as a base + 2% ursolic acid (Ursolic acid) 2% cheek and gel & el) 4. to 2 % Methyl retinoic acid sodium ester oryzanol (CMC ΝΑ) as a base + 5% eucalyptus (Creole) 2% cheek and knee coagulant ~ 1) 5. .. 2% methyl retinoic acid Oryzanol Sodium (CMC NA) as a base + 5% laurel dilute (point-myrcene) 2% cheek and gel 6el) 6. .. 2% carboxylic acid methyl ester: ester oryzanol sodium ( CMC ΝΑ) as a base +5; langene ((+)-. Cx of 2% Λ and gelling agent ($ el) 7... 2% sodium methyl cellulose carboxylate (CMC ΝΑ) Is ^ L ^ »j +5% 3 ^^ ((-)-a-pinene) 8. .. using 2% carboxylic acid methyl ester oryzanol sodium (CMC ΝΑ) as a base + 2% glycyrrhetinic acid (18- 召 -Glycyrrhetinic acid) ^ Gram and knee coagulant (㈣ 9. .. 2% cheek and gel based on 2% sodium methyl cellulose carboxylate (CMC NA) as the base, 1) Transdermal glycyrrhizic acid (Slycyrrhizin) containing the final gram fe (ACV) gel with different kinds or different contents Close glycyrrhizin (^ lycyrrhizin) + 1% QI teach t Please read the back of the precautions to fill out this page) This paper scale applicable Chinese National Standard (CNS) A 4 size (210X297 mm)

Fifth Ministry of Economic Affairs, China National Bureau of Standards and Staff, Employee Consumer Cooperative printed the "㈣" 'full charge, description of invention () Zac acid (〇1 钟 nolic acid) 克克 and coagulated knee sword (令 el) 2. 2% glycyrrhizic acid Oflycyrrhizin) + 2% Cong Ke and the next Ethylene Glycol (EG) suspension agent ... 2% glycyrrhizin ycyrrhizin) + 20%-2¾ g of Methylene (DMS0) and knee coagulant 1), 4 ·· 2% glycyrrhizic acid bee ycyrrh izin) 2% gram and bribe (right el) 5. 2% glycyrrhizic acid (i ^ ycyr, r'hizin) + 1% ursolic acid ( Ursolic acid) 2% Satoshi '^ * ^ Adhesive (^ 1) 6. 2% glycyric acid (^ lycyrrhizin) + triprene ((+)-〇 (jpinene) 2%-, Satoshi, g And gel (^ el) Figure '9 containing gluconate (cycyrrhizin) gram and (Ο) gel, with different content of Gleditsia sinensis Um.) Accelerator percutaneous absorption 1. 1% saponin ("leditsia sinensis haia.) + 2% of glycyrrhizic acid (^ lycyrrhizin) 2% chaohe and gel (Gel) 2 ·. · 2% quanjiao 6leditsia sinensis | am ·) + glycyrrhizin Glycyrrhizin) 2% Youke and gel) 3 ··· 2% cheek and gelling agent (Glossary 1) Figure 10 Accelerator affects cheek and (ACV) gel fee 1 Soap absorption ............................................. ................................ Pretend .............. ........... Order ..................... line (please read the precautions on the back before filling this page) This paper The scale is applicable to China National Standards (CNS) Grade 4 (210 × 297 g *) {丨 士 fc:

L. Description of the invention () A6 B6 (§leditsia sinensis lam.) Extract 1 · .1% oleic acid (〇leanoiic acid) + 2% glycyrrhizic acid (containing 17〇71 ^ 11 丨 2 丨 1> 1) Of 2% Satoshi > g and gel (2). Extraction of angle of interest (j ^ leditsia sinensis lam.) + 2% of glycyrrhizic acid (^ lycyrrhizin) 2¾ g and knee gel (gel) 3. .2. Glycolic acid (^ lycyrrhizin) + 0.332% cheek and knee coagulant gel) 4.2% 2% glycyrrhizic acid (j ^ lycyrrhizin) 2% gram and knee coagulant (iv) Figure Π patch on rabbit The distribution of the dose of the cortex of the ear after 72 hr, the number of the Toku No. indicates the comparison with it .... 2% carboxymethyl sodium carboxylate (CMC NA) as the base agent + 2% Gan掩 酸 (j ^ lycyrrhizin) 's permissible gel and gel' ... two ratios) 2. Using 2% carboxylic acid methyl ester crocodile sodium (CMQNA) as a base + 2% chloroacetate jQleanoiic acid) of 2% gram and gelatin (n = 6) 3 ... 2% glycerine $ lycyrThizin) of 2% gram and coagulant (n = 6) 4. .. with 2% carboxylic acid Methyl ester oryzanol sodium (CMC ΝΑ) is 2% of the base and coagulant (η = 13). Figure 12 The patch is applied to each skin of the rabbit ear and the patch is 72 hr · post #medium concentration ^ 栝The number of the number indicates its comparison Party 1 .. 2% Yue carboxylic ester sodium carboxymethylcellulose (CMC NA) of the present paper Bu scale with 0 China Standards (CNS) A <. 4 size (210x297 mm)

V. Description of the invention () A6 B6 base + 2% glycyrrhizic acid (ftycyrrhizin) 2% gram and knee coagulant (n = 6) 2 .. 2% glycyrrhizic acid silo lycyrrhizin) + 1% valeric acid (Gleanolic acid) gram and gel (n = 3) 3 .. 2. 2% glycyrrhizic acid (Olycyrrhizin) 2% gram and coagulant (n = 3) 4 .. with 2% carboxylic acid Methyl ester pheasant sodium CMC ΝΑ) is the base of 2% gram and knee coagulant (η = 6). Fig. 13 Gas and tissue concentration of the patch after sliding on the skin of the rabbit ear for 72 hr • The numbers in parentheses indicate where they are compared. 1. .. Using 2% sodium carboxylate methyl cellulose (CMC NA) as the base + 2% glycyrrhizic acid (Glycyrrhizin), Ginkgo and gel (n = 6) ) 2 · 2% glycyrrhizic acid (¾) ycyrrh iziη) + 1% chloropic acid (〇 丨 6311〇3 Bu 3 (： 丨 〇1) 2% gram and gel sword (η = 3) 3 .. 2% glycyrrhizin lycyrrhizin) 2% gram and coagulant (ηθ) 4 · .. 2% knee with 2% carboxylic acid methyl brewerine platinum (cmc ΝΑ) as the base Kehe coagulation agent (η = 6) Figure 14: Fat secretion index of accelerator 1 · .. licorice sparse 2 ... Glycolic acid 3. ·· pinene 4 .. · zhao-myrcene A 4 specifications ( 210x297mm]… ιΛ {Please read the notes on the back first Item refill page> .. Binding Ministry of Economic Affairs Zhongshang Standards Bureau Employee Consumption Cooperation Th Indo 3 A6 B6 Printed by the Employee Consumer Cooperative of the Central Standards Bureau of the Ministry of Economy V. Description of Invention () Example 1 Soft Soap ( Ointment) The dosage form is prepared by dissolving 5% by weight and ACV in a solution of 5% by weight of ethyl ethanedihydroxide (EG) which has been heated to 75t: 45% by weight in another container PEG 400 and 45% by weight PEG of yeast _ mixed and heated to 75t: · Then mix evenly and add the prepared gram and mixed liquid, in 25 ^ It is made by rapid cooling and stirring. Examples 2 to 5 Preparation of the ointment containing accelerators. According to the preparation method of Example 1, add 1% by weight of the spring liquid (Gleditsia sinensis Lam.) Extract, or 1%, 2 %, 5% by weight of glycerin acid (Giycyrrhizin), dissolve at 75t times 6-glyoxal (EG). Examples 6 ~ 8 Preparation of the first type of plastic gel containing glycerol «} elJ dosage form Weigh 2¾ weight percent of the gram sum (ACV) and 2%, 4%, 6% weight percent of the resulting acid methyl ester cellulose sodium (CMC Na) * In water in a separate container was weighed 50% glycerol by weight percent of (GlyCeriu) · g and then the mixture mixed uniformly partridge has made Buddha, a suitable amount of water to 2〇 mi. Examples 9 ~ 10 The modulation standard of the first type of gel agent containing glycyrrhizic acid (Ge 1) was prepared using the Chinese National Standard (CNS) A 4 specifications (U10 X 297 g; f): ~ :: Han { Please read the precautions on the back before filling in this page). Binding. Binding. Line Α6 Β6 2377 / ί 5. Description of the invention () According to the recipe preparation method of Example 6 * Weigh the 2% by weight to give acid CMC Na is used to dissolve 2% and 5% by weight of Glycyrrhizin (Glycyrrhizin) in water to prepare the first type of Glycyrrhizin (Gel) agent containing glycyrrhizic acid. Example 11 Preparation of the second type of Glycogen Residue (Gel) dosage form containing ethylenediethylenzyme Weigh 2% by weight of gram and (ACV) dissolved in 20% by weight of ethylenediethylenzyme ( EG), in a separate container, weigh 2% by weight of carboxylic acid methyl ester sodium carboxylate sodium (CMC Na) dissolved in water, 苒 evenly> hole into the prepared gram and the mixture , Add appropriate amount of water to 20 ml. Examples 12 to 19 The preparation of the second type of gel (Gel) containing the accelerator was prepared according to the preparation method of Example 11, and 55% by weight were weighed and contained in the snail lettuce flower, expanded root, mint and perilla leaves. , Owe date, pepper, Magnolia officinalis, Xinyi, white cardamom, Curcuma, 1, fragrant, saffron pinene [(ls) -㈠-or-pinene] The weight percentage is contained in bearberry leaves, Ursolic acid of Shancezhi and Jujube; 2% by weight contained in glycerol acid (18-e-Glycyrrhetinic acid) or 2Y weight percent glycerol acid ((Uycyrrh izi η); 2% of the amount of spare parts is contained in Oleanolic acid in Forsythia suspensa, Cornelian cherries, cloves, and jujubes; 5% by weight is contained in Kubu, White Cardamom, and I suppository Dilute (mvrcene); 5% by weight contained in fennel, nutmeg [pine] [Bu] The paper size is ?? National Standards (CNS) A 4 regulations ϋ210 > < 297 public hops) ------ ίί., {.............................................. ................................. Pretend .......... ............ order .................. line {please read the back first Please fill in this page again) A6 B6 printed by the Central Standards Bureau of the Ministry of Economic Affairs and Industry and Consumer Cooperatives. B6 Printed by the R and Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economy V. Description of the invention () -α-Pinene]; 5% by weight Cineole of Xinyi, turmeric and saffron is dissolved in ethylene glycol (EG). Example 20 Preparation of the third type of plastic gel (Gel) containing only ethyl ethanedithione (EG) as the base plastic Weigh 0.247% by weight of the cheek and (ACV) dissolved in 5% by weight of alfalfa Ethylene glycol fraction ⑽), and then evenly mix 2% by weight of glycyrrhizin (Glycyrrhizin) with an appropriate amount of water in the mortar 3L, centrifuge at 3,000 rpm for 30 minutes to take the supernatant. Example 21: Prepare a third type of gel (Gel) with different main ingredients. The dosage form is the same as the preparation method of Example 20. Weigh 0.683% by weight of gram and (ACV) in ethyl ethyl glycol. (EG), then mix evenly with 1% by weight of glycyrrhizic acid (Glycyrrhizin). • Centrifuge at 3,000 rpm for 30 minutes to take the supernatant. Benshi Example 22 prepares the third type of gel (Gel) with different main ingredients. The dosage form is the same as the preparation method of Example 20, and it quits 0.852% by weight of ash and (ACV) and dissolves in ethyl ethyl dihydroxide. (EG) * Add 3% weight t percentage of glycyrrhizin (Glycyrrhizin) to homogenize, centrifuge at 3,000 rpm for 30 minutes to take supernatant. , F Please first "Read the notes on the back and fill the nest page" {. 装. 定. 线

A6 B6 Printed by the Ministry of Economic Affairs, Central Bureau of Standards, and Employee Consumer Cooperation V. Description of the invention () Example 23 The preparation of the third type of gel (Gel) dosage form containing two accelerators is compared with the Buddha preparation method of Example 20, respectively Weigh 0.305% by weight of Satoshi, Kehe (ACV), 1% by weight of amarine acid, 5% by weight of oleic acid (Oleic acid) and mix in a research pot, taking 3,000 ι Take the supernatant by centrifuging for 30 minutes. Example 24: Prepare a third type of coagulant (Gel) containing two accelerators. Compare with the wound-making method of Example 20. Weigh 0.648% by weight of your grams (ACV) and 2% by weight. Glycyrrhizic acid and 2% by weight of glycyrrhetinic acid (18 · ^ -Glycyrrhetinic acid) were mixed in the grind spider and centrifuged at 3,000 rpm for 30 minutes to shovel the supernatant. Example 25 Preparation of the third type of gel (Gei) containing only ethylidene glycol (EG) as the base. Weigh 1% by weight of the gram and (ACV) dissolved in 5% by weight of sub-B Ethylene Glycolate (EG), and then mix evenly with 2% by weight of glycyrrhizic acid (〇 ^ > "." 11 丨 * 2 丨 / 1), mix it with appropriate amount of water in Yanfen, and centrifuge at 3,000 rpin Take the clear wave in 30 minutes. Appreciation (26 ~ 32) Prepare a gel (Gel) dosage form with different footing agents based on ethyl ethyl diazoxide. Please read "Precautions on the back side and fill in the wooden page" first .Binding and binding. The size of the line paper is applicable to the aa family standard (CNS) A4 specification (210x297 mm). · J-丨, A6 B6 Printed by Beigong Consumer Cooperative of Central Jining Bureau, Ministry of Economic Affairs Description () According to the preparation method of Example 25, weigh Satoshi · Kehe (ACV) dissolved in ethyl ethanedihydroxide (EG) · Add 1% and 2% by weight to Glycyrrhizin respectively Oleanolic acid (Oleanolic acid) weight percentage [(+)-a-Pinene];, 2% weight percentage (Gleditsia sinensis Lam.); 20% weight percentage of dimethyl ^) 丨 111 Du 1 slave 181111> 〇) (丨 (1); 1% by weight of Ursoic acid (Ursoic acid) dissolved in ethylidene ethylene oxide) Finally add the appropriate amount of water ^^ Scientific spider The middle waves are evenly combined. Example 33 Preparation of Suspension Formulation Weigh 2% by weight of gram and (ACV) dissolved silt and 98% by weight of sub-ethyl ethylene glycol (EG) in the research pottery Mix them evenly. Example 34 Prepare the Suspension containing different accelerators according to the preparation method of Example 33. Mix 50% by weight of ethylene glycol (EG) in a uniform amount of 2% by weight. Example: (iiiicyrrhizin) ° Example 35: Suspension formulation with different accelerators prepared by netting. According to the method of preparation of example 33 in Example 33, at a weight percentage of 96% by weight of ethylene glycol (EG ), Mixed with 2% by weight of yam yam (please read the precautions on the back and then this page) -install.book-line A6 B6 Printed by Beigong Consumer Cooperatives, Central Bureau of Standards, Ministry of Economic Affairs System V. Description of the invention () Glycyrrhetinic acid (18-e-Glycyrrhetinic acid). Ben Shi Example 36 · Tune & contains different promotion dramas Suspension (Suspension) dosage form according to the preparation method of Example 33 * Weigh 5% by weight of Zongke and (ACV) dissolved in 94% by weight of ethylene glycol (EG), evenly mixed into 1% by weight The soap angle ((Heditsia sinensis Lam.). Example 37 Preparation of the remaining type of the solution (Solution) Weigh 0.1% by weight of leg grams and (ACV) dissolved in an appropriate amount of water, and completely dissolve and mix with an ultrasonic oscillator. Example 38 The preparation of a solution containing different accelerators (Solution) is prepared according to the preparation method of Example 37, and the glycyrrhizic acid ((}) is evenly added to the 0.1% by weight ¥ fraction in the cheek and (acv) solution. 1 point: ^ outer 4111) 〇 Example 32 The preparation of a solution containing different accelerators (Solution) agent Xu according to the method of making Buddha in Example 37, weighed 0.05% by weight Luke sum (ACV) Dissolve in an appropriate amount of water. {Please read the precautions on the back before filling the nest page). Binding. Binding. The size of the line paper is applicable to the National Standard (CNS) A 4 specifications (210X297mm Central Standards Bureau of the Ministry of Economic Relief) Printed by the industrial and consumer cooperatives A6 B6 -------, V. Description of the invention () Example 40 The formulation of a solution containing different accelerators (Solution) is compared with the Buddha-making method in Example 39. In the Kehe (ACV) lotion, evenly add 0.005% by weight of the saponin (Gleditsia sinensis Lam.) To extract the liquid. Example 41 Comparatively apply the soft greening agent, coagulating agent of Examples 1 to 37, Suspension agent, solution preparation method #Replace Vibrabine and Trifiuridine antiviral drugs ^ (ACV) Prepared as a transdermal absorption dosage form. Example 42 The method for preparing percutaneous absorption residual plastic according to Examples 1 to 37. Use single shells with sparse zhao, triterpenes with sparse bodies, triterpenoid saponins, tannins , Essential oil, instead of glycyrrhizic acid (Glycyrrhizin) and glycyrrhetinic acid (18-cold-Glycyrrhetinic acid) contained in the licorice; lianqi,] wheat, big abandoned mountain cornflower traditional Chinese medicine qi failure policy acid); fennel, nutmeg pinto ((+)-a-pinene); saponin (Gleditsia sinensis Lara.); bearberry leaves, mountain cornel, jujube ursolic acid (Ursoic scicl)., please First of all, the back of J? Tl: ¾.% If Then again this page). Binding-binding

This paper uses the Chinese National Standard (CNS) A4 specifications (210X297 g *) A6 B6 5. Description of the invention () Example 43 Inflammation on the upper and lower two layers of the male external percutaneous penetration test device People's skin, sheep warmed by pregnant women, or whole skin of snakes, skin shoulders of Guinea pigs on the 25th and 80th, and ICR or Balb / C breeds owed by bees of 7-9 The skin of nude mice (Nude Mice) is used as a test skin (warm) material to study antiviral drugs and medicaments as a barrier to penetration, and is fixed by metal fixation. A 72-hour penetration test was carried out with various percutaneous absorption dosage forms, and a 200 / i 1 sample of vaporized sodium solution was taken from the sampling port at each time, and subjected to high pressure gray state chromatography (HPLC) Analyze the content of the main ingredients, convert the drug penetration according to the calibration curve, and judge the release degree of the preparation. Example 44 A percutaneous transdermal absorption dosage form was applied to the ears of rabbits, and the concentration of ACG in each layer of the ear was measured after 72 hours. The blood and various organs were analyzed by high pressure wave chromatography (HPLC) for the concentration and (ACV) concentration to assess the penetration of the body containing the accelerator and the distribution of various organs. < Please read the precautions on the back before filling the nest page). Binding. Binding. Printed by the Central Standards Bureau of the Ministry of Economic Affairs and the Engaged Consumer Cooperatives *. This paper size is applicable to the Chinese National Standard (CNS> A4 specifications (210X297 1) 2j9 μ] / 〇2 Therefore " 1 benefit§ table, 2-l as a percutaneous absorption accelerator Chinese herbal medicine (Arteoisiae Capillaris Herba): (essential oi 1); capi 11 in, capi 1 lene, capi 1 lone, capi 1 larin, Nw'capi 1 lene, capi 1 lanol (Qirysantheium): essential oil; ㈠-tx-Bisabolol, 〇 (-Farnesene, Matricin Matricarin, Chanazulene, ie (Cinae Flos) : Essential oil: ㈠-〇c-Pipene, Terpinene, Terpineol, Carvacrol, a-Thujone, ㈠-Camphor, (Saussureae Radix): • Γ ----: ----- installed | (please Read the note $ item on the back before drawing) Essential oil (essential oi 1); Aplotaxene, Costic acid, Costunol ide, Costus lactone 'Dehydrocostus lactone' Dihydrocostus lac1 Phellandrene, α-Ionone, / 3-Ionone, σ-Costol, Camph ^ ie, actone (Valerianae Radix): jHHi (ess ential oil); (+) B «niylisoval« 'ate ^ Bornylacetate' Kessane '㈠-Campehne, (+-)-Liaonene, ot-Twpineol, α-Kessylaicdiioi, cx-fesylalcdiol acetate, Kessanol, Kessoglycol, Valeranwie, Fauer ^ Cryptofauronol 'Kanokonyl acetate' Linalool, / 3-Pi_e, Kandwml, a-Pinoie Mint (Maithae Herba): m (essential oil) :, (-)-ifenthol, Acetyllnenthol, ㈠-Moithone, ㈠-Liaoiene, (+ ) -tethol Puleg (»ie, Piperitoie, Is« Baitiione, Cdnphene, 3-0ctanol, γ-Hexenyi, Penylacetate, a-Pinene,

MentherKXte Printing and Printing Cooperative of the Ministry of Economic Affairs of the Ministry of Economic Affairs (Perillae H ^ ba): Fen oil (essential oil) · (-) HPo * illalddiyde, (+)-LUrai «ie, cxHMnene P ^ i 1 laket (me ^ naginataketxmeN egonaketone (Schizonepetae Herba) 'Mustard (essential oil); (+)-MenthoneN (±) -Henthonel Λ (+) HLieonene ^ (-)-Pulegone (Evodiae Fructus)-1 ^ j ^ (ess » itial oil); Evod «ie _ This paper scale is free to use the Chinese national rate (CNS> A4 specification (210X297 public envy)) _ * Month Π i / 8an-% j Table A9 B9 C9 D9 Central Ministry of Economics Printed by the quasi-administrative Beigong Consumer Cooperative «. '' ',' Fooiiculi Fructus: essential oil; Anethole'Estragole '(+)-a-Pinene' (+)-Fenchone, (±) -Lieonene, Anisalde Hyde (Cary «> hylli Flos) * Essential oils: Eugenol, Eugenol acetate, Eugenol salicylate, Methy 1 sal icy late, Vani 11 in, / 3 -Caryophyl loie, Humulene, Methyl amyl ketone, Chav i col, a-Ylangene Eucalyptus (Eucalypti Folium): Essential oil: 1,8-CineoleN P-Cym ene'Terpineol ^ Cuuinal ^ Phelland'al, Pinene US 6 ^ igae Radix): essential oil, Methyl salicylate saponin: S «iegin-I, Senegin-II, Senegin-III, S «Iegin-IV flower (Zanthoxyli Fructus): pepper guess oil (essential oil); Geraniol, Limonene, Cumic alcohol fine (Asari H ^ ba cun Radice): Xin Youyou (essential oil) · · Eucarvone, Safrole, Methyleugenol, Elenicin , Asaricin, Do-pinene, (+)-bomeol, Croeacin Fructus (Piperis Fructus): Right 11¾ (essential oil); ㈠-a ~ Phellandrene, / 3-pinene, Linalool 蕺 Qknittuyniae Herba: Vegetable oil (essential oil) ); Decanoylacetalddiyde, Hethylnonyl ketone, Laurinalddiyde Schisandra (Sdiizand ^ e Fructus): essential oil; Htral, oc-Cha «igmie, / 3 ~ Cha * igraie, Chamigroie, Sesquicarene, / 3-Chanigrenal Xin (Hagnoliae Flos) * > Yi H ^ Cess ^ itial oil); MethyldiavicolN Caaphor'1,8-cineole 'p-cymoie f ··-. (): (Please read the note $ item on the back first and then stew)% Book Paper-scale free use of China Beech quasi (CNS} A4 «L grid (210X297mm) * Jade,% Zhouhan (Travel ji: n A9 B9 C9 D9 Table 2-3 Economic control and bureau rate, labor and consumer cooperatives printed It Hu (Lupuli Strobilus) V cloth oil (ess ^ itial oil): α-hunul such as e, ^ -huoulene'Huniladi Newone, f (Alpiniae Fructus): Ren (ess ^ itial oil): Hootkatwie, Zingiberaie, ZingiboOl, a-humul «ie Anomi Senen: Essential oil: (+)-bomeol 'Bomylacetate' N-'eroldiol (Curcumae Tuber): Jin You 'You (essential oil); Tunoerone, (+)-artunnerone, Zingiberne, (+)-a -phel lancfr'ene (Zedoariae Rhizoma): Sesquiterpaioid: Curzerenone, Curdione, Curcolone, Furanodienone, Furanogerroenone, 1,4-cineole, Zed ^ one, Curcumol ΰχ (Cyperi Rhizoma) : Hi sub (essential oi 1); Cyperol 'α-Cyperone' Cyperene Λ Cyperotundone 'Cyp «x) lone ^ Sugaiolacetate' Kobusone (Croci Stigma): Flower (essential oil); Safranal far (Polygalae Radix): Zhi soap hair ( saponin); Onjisap〇nin A ~ G (A = senegin IV), B = senegin III), frosenegeni, Tenuifolin, Senegenin, yellow (Astragali Radix): saponin; Astragaloside I-VIII, Soyasaponin I cow (Adiyranthis Radix): saponin: 01eanolic acid glycoside (Anenarrhenae Rhizona): Female rabbit hair (saponin): Tiaosaponin AI, Tiaosaponin A-III, Markogenin, Neogitogaiin glycosides ^ / ττκ ^ ___ 2 Factory {--------- Install I (please read the back of H first Note $ item is drawn again) The size of the paper used in this book is the Chinese rubbing rate (CNS) A4 «L grid (210X297mm) Α9 Β9 C9 D9 Printed Table 2-4 of the Beigong Consumer Cooperative of the Central Rubbing Rate Bureau of the Ministry of Economic Affairs (Houtan Radicis Cw * tex) '1 Single? Δ (Monoterpenoid); Oxypaeoniflorin Benzoylpaeoniflorin, Benzoyloxypaoxiif lorin' Paeonif lwin Gan (Eio ^ iorbiae Kansui Radix) * > Class II (ditQTene); Kansuinin A, B, 2 (H) eoxyingeno bu 3-benzoate, Ingenol-3- (2,4-decadienoate) -20-acetate ^ 20-Deoxy ingeno 1 H5-benzoate triterpene; oc-Luphol, Tirucallol, Euphorbaclienol, / 3-Eiiphorbol with (Aconi ti Tuber): diterpene: disapenine, Hypaiaitine, Jesaconitine, Heopel 1 ine, Kobusine, Pseuctobusine, Telatisine, Songorine, .Atidine, Napel 1 ine, Heteratisine, Lignanine, Hypognavine, Atisine ^ Aconi ): Triterpene I; Tragoside I, Tragoside II wheat (Ophiopogonis Tuber) η winter ghost hair (saponin); ophiopoqwin A, ophiopooonin B, oriiiwoqc ^ in C, ophiopoqonin B ', 6phiopoqonin C', ophiopoqon , (^ LiopocKmin D Peach (Persicae Senen): Rensan? Class S (triterpene); 24-methylenecycloaartanol l (Cinicifugae Rhizona): To three types (trit〇T3ene); Cii > igaK) l xyloside, 12-hydr < wyci «dgenol, 12-hydOxyciBigaK) l xyloside ^ Dahurinol 'Is 24t) -acet ^ l isodahurinol 'Ciaig ^ iol mulberry (Mw * i Radicis C «* tex) *. Θ triterpoie; ot-aayrinacetate, Betulinic acid grass (Laperatde Rhizona): root trigeminal ( triterpene): CyliruHn, Arundoin, Femenol, Simiarenol, IsosurbcM'inol --------- {». I (please read the note $ item on the back first and then install it) Rate (CNS) Λ4 specifications (210X297 public) Table: 3-1

-i «&lt; 1-'lJ A9 B9 C9 D9,«. Ministry of Economic Affairs, Central Consumer Affairs Bureau, i Consumer Cooperative Seal «. Gan (Clycyrrhizae Radix): Triterpoie sapoiin: Glycyrrhizin, glycyrrhetinic acid, 18- / 3-glycyrrhetinic acid 1 (Zingiberis Rhizona): Essential oil: ct-Pinene, / 3-Myrcene, Cineole (Zizyphi Fructus): Triterpenoids: 01eanolic acid, Ursolic acid t saponin ( saponin); Zizyphus saponin I, Zizyphus saponin II, Zizyphus saponin III 'Jujuboside B'inaslinic acid' Betulonic acid soap (Gleditsia sinensis Lam.): triterp ^ e sapiMiin: Gledinin, Gleditschia Saponin (Tannins): Cetylalc ^ ol, Nwia6osane, Stigeast ^ ol, Sitosterol Hoelen Triterpene saponin: Eburicoic add, Dehydroeburicoic acid, 3 cold-O ^ abetylddiydO tumulosic acid, Ergoster3, Ergosteroi -〇-acetyltuiulosic acid pea (paemiae radix): single ¢ 1 class with male skills (wMioterpaie glycoside): Albiflorin, Paeonif lcrin, Oxypaeoniflorin 'Paeon if lor igaioneN B «izoylpae〇nif lorin Tannins: Tetraundeca, gal loylglucose, (+)-Catechin, Procyanidin Bl (Cinnaaoni Cortex et caul is): (essential oil); Cinnaaaldehycle ^ Cinnaiiyl acetate ^ Phenylpropyl acetate Tannins: Cinnzeylanol, Cinnzeylanine, Anhydrocinnzeylanine, Cinncassiol A 'Cinncassiol B' Cinncassiol Cl ^ Procyanidin Cl 'Cinncassiol A 19 ~ «onoacetate, Cinncassiol C3, Cinncassiol D1, Cinncassiolc 19 &D; 〇-glucoside ^ Cinncassiol B 19-0-glucoside 'Cinncassiol D2 19-0-glucoside' Cinncassiol Cl 19-0-glucoside'Anhydrocinnzeylanol 'Gallic acid Cinncassiol D4 ^ Cinncassiol E ^ Cinncassiol ^^ Cinncassiol D2 ^ Cinncassiol 2 ^ Procyanidin B-5N Apigenin 3,7-dirhamoside N Protocatechuic acidN (-) HEpicatechin (please note the item on the back first, and then install it) This paper size is not used in China National Rubbing Rate (CNS) A phase I grid (210X297 mm) ρττ- Ά <'.. .A1 .1' Order D9 £ ^ Bfj Ιι ββ Table 3-2 ; J- Printed Cardamom (CardaiKXDi Fructus) by the Belgian Consumer Cooperative of the Ministry of Economic Affairs of the Ministry of Economic Affairs: guess oil (essoitial oij); (+)-ot-Terpinyl acetate, l, 8-Cineole, Sabinene Uaonoie, (+ )-&lt; x-Terpineol (Atractylodis Rhizona): essential oil (essoitial oil); Atractyl («, Eudesina ~ 4 (14), Atractylenolide I, Hinesol, Atractylenolide II'Atractylenolide III, Eiemol, 3 &gt; 3-acetoxyatractylonN 3 / 3-hydOxyatractylonΛ ^ -eudesinol 'Atractylodine ^ Atractylcxiinol' acetylatractylodinol '7 (ll) -Oien-8- &lt; Mie Dang (Angel icae Sinensis radix): Gui (essoitial oil); Butyliden ^ &gt; hthalide'Aic ~ di2.4 anhydride'n-Val «x &gt; phenone-0 ^ carboxylie acid person (Ginseng Radix): saponin; Heptaedeca-l ~ oi-4, 6-Dihn-3, 9- ^ diol panaxydol, 20- glucoginsenoside-Rf 'Qioline' / 3-Sitosterol glucosideN Ginsenoside-Rx (x = 〇, al, a2, bl, b2, b3, c, d, e, f, gl, g2, hl), Nicotinic acid, Zhao-Sitosterol , / 3-Eiemene 'Panaxynol, Chen (Citri Exocarpium): Skin price A (essential oil); d-li nonene, Linalool, Citral, Hesperidin, Neohesperidin, Naringin, Poncirin, Umbel 1 iferone, Auraptene, gijroptene, Imperatorin, Isoinperatorin, Isoponciaarine, (-)-Synerfirine'Citric acid yellow (Scutellariae Radix): ketones Baicalin, Stigmasterol, Wogoin glucuronide, Wogonin, Baicalein, Oroxylin A, Oroxylin A glucuronide, 5,8-DihydOxy-6,7-diBethoxy-flav (Mie 'Skullcap-Flavon I' 5,7,4'-Trihydroxy-8- Bethoxy flavone, Scullcap-Flavwi II, 5,7,2 ', 6'-Tetrahydroxy flavone'Canpest ^ ol, Zhao-Sitosterol, Kogan ^ ananin Chai (Bupleuri Radix) * Sapoiin * Saikosapwiin a , C, d · Oleic acid, a-Spinasterol, △ 7-StigBasterol, Linolenic acid, Lignoceric acid, Adonitol, Saikogenin F, E, G · Longi Indiainogenin lignoceric acid, Palmitic acid, Angel icin, Stearic acid Sichuan (Ligustici Rhizona ): Essential oil: Cnidiua lactone, Ferulic acid, Cnidilide, Neocnidilide (please read the note $ item on the back and then do the dragon suit)-paper The Zhang scale applies to China's «home rubbing rate (CNS & A4 specification (210X297mm) phase j A9 B9 C9 D9

j * ground (Rdunanniae Radix et Hiiz (»a): f lavonoid): Rdinannoside A, B * Aucubin, Nel ittoside, Rehnannioside ^ LenuorideCatalpol half (Pinelliae Tub» *) ϊ Honog such as tisic acid glucoside, 3 , 4-Dihyd * 〇3〇d) aizalddiyde, tk »og« itisic acid, 3,4H) ihydroxyb «izalddiyde digkicoside, zhao-Sitost« Olglucoside, E ^ edrine, Qwl ine, / 3-Sitosterol X owed (Rhei Rhizona ) * Scallion K ^ (anthraquinone): Chrysor ^ ianol, Aloe-eeodin, Hiysciwi, Emodin, Chrysoriianol 1-glucoside 'Chrysophanol 8-glucoside ^ Rhein' Aloe-emodin-8-glucoside ^ Citreorosein 'Physcion-8-glucoside' Emodin -l-glucoside ^ Enodin-8-glucoside ^ Rhein-8-glucoside 'Rhein-8- (6 * ^ oxai-yl) glucoside, S ^ tinoside A, B, C, D, E, F (please read (Notes on the back Λ $ items will be painted again) Huang Zhuanzhi (Tannins): (-)-Epicatechin, (-)-pi &gt; icatediin-3-0 ~ gallate, Procyanidin Bl 3-0-gal late '(+)-Catechin Magnoliae Cortot: essential oil): / 3-Eudesnol, ot-Pinene, Lu-Pinene, Caaphene Bornylacetate 'Cary &lt; »&gt; hyl leneepoxide ^ Cryptoaeridiol' Liawiene Magnolol, Honddol, Itoocurarine, Hagnoflorine, Anonaii Liriodenine, Salicifoline, oc- £ ude9nol, Hidielarbine odenine, Salicifoline ^ jraudine (ot) essential oil): d-Liffl〇n «ie, Linalool, Citral, (other common leather) ^ latycodi Radix): Saponin; Platycodin A, C, D, D2» Polygalacin D, D2 »Inul in _a-Spinasterol 'α-Spinasterol glucoside ^ Stigeiast-7-enoi'

Betulin (Alisnatis Rhiz (»Da): Zhongji Ministry of Central and Central Bureau of the Central Bureau of the Belgian Consumption Cooperative Society of Oxygen Diarrhea Cardamom White Cardamom Triterpene · Alisol A, B · Lecithin, Alisol B eonoacetate Alisol C nonoacetate ^ Alisol A nonoacetateΛ Choi ine ^ (Hyristicae Semen) ίίϋ (essential 〇Π.). ί (+)-Caiarfiene ^ (+) Linalool ^ Safrole 'Eug ^ iol &gt; Hyristicin' (+)-a-Pinene ' (+)-^ 3-Pinene &gt; (+)-Limonaie 'Xylan (+)-Borneol, Geraniol, α-Terpineol, Myristin olein, Pentosan Furfural, Pectin, Lipase, Sapbnin (Anoni Cardancni Fructus): (essential oil) ; (+)-Caephor '(+)-^ orneol &gt; Huaulaie epoxide' 1,8-Cineole 'α-Pinene' / 3-Pinene 'Caryophyllene' Myrcene ^

Babinene, Humulene, Carvone, this paper scale use Chinese «Household Rate (CNS &gt; Α4Λ grid (210X297 ^ supplementary eight A9 B9 C9 D9 £, ffi meeting: i call the table umbrella :: draw the Central Rubbing Rate Bureau of the Ministry of Economic Affairs Dissolution of calcined oxygen accelerator (cal / cm3) ^ of Beigong Consumer Cooperatives... · Caffeine index β-Myrcenc 7.91 3.06 aneole 8.36 • b a-Pinene 8.83 2.95 Oleanolic acid 9.95 a b 18-B-GIycynhetinic acid 10.5 2.86 Ursolic acid 10.9 —b Glycyirbizin 12.9 1.32

-------- ^ Pack | (Please read the precautions on the back before drawing)-The size of this paper is applicable to China National Standard (CNS) Α4 specification (210Χ297mm)

Claims (1)

-: w's patent application range of percutaneous absorption pharmaceutical composition, which includes gram and (Acyciovir *, ACV), fox and (Ganciclovir '0 is 〇, Di Diyi (2', 3 '-| ^ Also father: ^ 11〇3] * 1 ^, 001), Lei Baohe (fcbaWriv), Omandine (/ \ mantidine), Vidarabine (Vidarabine) order, (^ idovudine, ZDV one Primarily into ϋ medicine primer /, and 2% -99.95% percutaneous absorption excipient; the medicine primer is selected from (〇-Tirene [(Is)-(-) -〇f-pinene], Orsolic acid, glycyrrhizic acid (6lycyrr * hizin), 18-glycyrrhetinic acid (18- / S- &lt;? IlycyrThetinic acid), chlorophyllin (Cineole), oleanolic acid (Oleanolic acid) , (+)-¾ene (《-(+) 'pinene); excipients are selected from polyethylene glycol (PEG), carboxymethyl cellulose sodium (CMC Na), glycerin, and hypoethyl Ethylene glycol (Lthylene glycol). For example, please collect the pharmaceutical composition in which up to 20% of the drug primer &quot; 7 &quot; ^^ 99.95% percutaneous absorption excipient; wherein the drug primer is selected from bearberry Acid (Ursol ic acid), (IS) -¾ene [Qs)-(-)-〇ip: inenc5], Cineole, Glycyrrhizin (4lycyrrh izin), 〇leanolic acid (18- / 3-fiflycyrrhetinic acid), (+) _ falling ene (a ~ (+) _ pinene); the excipient is selected from polyethylene di Fermentation (PTO, sodium methyl cellulose acetate (CMC Na), glycerin, and Ethylene glycol) ° This paper scale is applicable to the Chinese National Standard (CNS &gt; 8 4 specifications (2 丨 0X 297 Gong Chu (please read the notes on the back before filling this page) Printed by the Staff Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs Α8 Β8 C8 D8 六 、 Apply for patent scope ........ fling tL · 3 · -a local medicinal composition with drug introduction, of which to 30 grams and (Acyclovir, ACV), pulse grams And (tranciclovir, 01 ^), Didiyi (2 ', 3 *-[) 1 € | 6 (^ 111〇8 ^, 001), Ribaviriv, Amanding (4mantidine), Vida (Vidarabine), Carrying Teaching ^ Spot Correction Younet * ZDV is the main one ^ Primer 4 ^ 1 ^ 99.95% percutaneous absorption excipient; the drug primer is selected from (1S)-^ ene [(ls )-(-)-〇f-pinene], Ursolic acid, 18-glycyrrhetinic acid (18- 召-^ ycyrrhetinic acid), Cineole, &amp; lycic acid (&amp;lyc:; yrrhizin), Wleanolic acid), (+)-Zanggui (〇?-(+) 10 ~ 1 ^ Cong); the excipients are selected from polyethylene dizyme (PEG), carboxylic acid methyl Ester cellulose sodium (CMC Na), glycerin, and ethylene glycol (B thy 1 ene g 1 yco 1). 4. The topical medicinal composition according to Item 3 of the Chinese Patent Proposal includes ointments, suspensions, gels, solutions, nebulizers, and patches. Topical administration preparations. % Printed by the Employee Consumption Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs (please read the precautions on the back before filling in this f) _1 (CNS) A4 specification (210X 297mm)