CN104491318A - Traditional Chinese preparation used for treating asthma and preparation method of traditional Chinese preparation - Google Patents
Traditional Chinese preparation used for treating asthma and preparation method of traditional Chinese preparation Download PDFInfo
- Publication number
- CN104491318A CN104491318A CN201510030667.0A CN201510030667A CN104491318A CN 104491318 A CN104491318 A CN 104491318A CN 201510030667 A CN201510030667 A CN 201510030667A CN 104491318 A CN104491318 A CN 104491318A
- Authority
- CN
- China
- Prior art keywords
- parts
- herba
- preparation
- asthma
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 208000006673 asthma Diseases 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title claims abstract description 40
- 239000003814 drug Substances 0.000 claims abstract description 56
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 14
- 244000249585 Elaeagnus conferta Species 0.000 claims abstract description 12
- 239000002775 capsule Substances 0.000 claims description 17
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 12
- 239000009636 Huang Qi Substances 0.000 claims description 11
- 241001643642 Viticis Species 0.000 claims description 11
- 241000208340 Araliaceae Species 0.000 claims description 10
- 241000628997 Flos Species 0.000 claims description 10
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 10
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 10
- 235000008434 ginseng Nutrition 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000012567 medical material Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 239000008213 purified water Substances 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 4
- 239000000047 product Substances 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 240000000377 Tussilago farfara Species 0.000 abstract description 2
- 235000004869 Tussilago farfara Nutrition 0.000 abstract description 2
- 241000758794 Asarum Species 0.000 abstract 1
- 241000045403 Astragalus propinquus Species 0.000 abstract 1
- 235000007627 Caesalpinia Nutrition 0.000 abstract 1
- 241000522234 Caesalpinia Species 0.000 abstract 1
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 235000002722 Dioscorea batatas Nutrition 0.000 abstract 1
- 235000006536 Dioscorea esculenta Nutrition 0.000 abstract 1
- 240000001811 Dioscorea oppositifolia Species 0.000 abstract 1
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 abstract 1
- 241001465251 Ephedra sinica Species 0.000 abstract 1
- 241000124846 Evolvulus alsinoides Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 241001125690 Marsdenia tenacissima Species 0.000 abstract 1
- 241001046984 Meconopsis horridula Species 0.000 abstract 1
- 241001522129 Pinellia Species 0.000 abstract 1
- 241001080798 Polygala tenuifolia Species 0.000 abstract 1
- 244000197580 Poria cocos Species 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 244000058281 Ulmus pumila Species 0.000 abstract 1
- 235000001547 Ulmus pumila Nutrition 0.000 abstract 1
- 244000248021 Vitex negundo Species 0.000 abstract 1
- 235000013427 Vitex negundo var incisa Nutrition 0.000 abstract 1
- 235000014961 Vitex negundo var negundo Nutrition 0.000 abstract 1
- 241001247821 Ziziphus Species 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
- 230000000588 effect on asthma Effects 0.000 abstract 1
- 235000014956 negundo chastetree Nutrition 0.000 abstract 1
- 206010011224 Cough Diseases 0.000 description 27
- 229940079593 drug Drugs 0.000 description 16
- 238000012360 testing method Methods 0.000 description 15
- 206010062717 Increased upper airway secretion Diseases 0.000 description 12
- 208000026435 phlegm Diseases 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 210000000952 spleen Anatomy 0.000 description 10
- 206010012735 Diarrhoea Diseases 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 239000008280 blood Substances 0.000 description 8
- 208000004880 Polyuria Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 230000035619 diuresis Effects 0.000 description 7
- 210000004072 lung Anatomy 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 6
- 206010030113 Oedema Diseases 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 210000000038 chest Anatomy 0.000 description 5
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 5
- 230000000306 recurrent effect Effects 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 206010007247 Carbuncle Diseases 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 206010047700 Vomiting Diseases 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 208000008203 tachypnea Diseases 0.000 description 4
- 206010043089 tachypnoea Diseases 0.000 description 4
- 210000002700 urine Anatomy 0.000 description 4
- 206010036790 Productive cough Diseases 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 208000013116 chronic cough Diseases 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 208000001848 dysentery Diseases 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 238000007619 statistical method Methods 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 230000008736 traumatic injury Effects 0.000 description 3
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 206010033557 Palpitations Diseases 0.000 description 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 238000012742 biochemical analysis Methods 0.000 description 2
- 206010006451 bronchitis Diseases 0.000 description 2
- 208000019902 chronic diarrheal disease Diseases 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 208000012839 conversion disease Diseases 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 206010013990 dysuria Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 239000003172 expectorant agent Substances 0.000 description 2
- 230000003419 expectorant effect Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 208000035861 hematochezia Diseases 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 201000007227 lymph node tuberculosis Diseases 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- OEHAYUOVELTAPG-UHFFFAOYSA-N methoxyphenamine Chemical compound CNC(C)CC1=CC=CC=C1OC OEHAYUOVELTAPG-UHFFFAOYSA-N 0.000 description 2
- 229960005405 methoxyphenamine Drugs 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000004206 stomach function Effects 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 1
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 241000758795 Aristolochiaceae Species 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 229930003347 Atropine Natural products 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 208000031648 Body Weight Changes Diseases 0.000 description 1
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 241000269417 Bufo Species 0.000 description 1
- 241000269420 Bufonidae Species 0.000 description 1
- 241001517299 Bulbophyllum Species 0.000 description 1
- 241000345998 Calamus manan Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 241000207782 Convolvulaceae Species 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- 241000234272 Dioscoreaceae Species 0.000 description 1
- 241001415432 Duttaphrynus melanostictus Species 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 241000723281 Ephedra equisetina Species 0.000 description 1
- 241000218670 Ephedraceae Species 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010060710 Galactostasis Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 241000146384 Glaux Species 0.000 description 1
- 208000018779 Globus Sensation Diseases 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 1
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- 208000004356 Hysteria Diseases 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 241001247900 Marsdenia Species 0.000 description 1
- 241001247783 Meconopsis Species 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 1
- 208000001140 Night Blindness Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 241001529246 Platymiscium Species 0.000 description 1
- 240000000103 Potentilla erecta Species 0.000 description 1
- 235000016551 Potentilla erecta Nutrition 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 241000219100 Rhamnaceae Species 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 241001093501 Rutaceae Species 0.000 description 1
- 241000576755 Sclerotia Species 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 206010044302 Tracheitis Diseases 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 208000009911 Urinary Calculi Diseases 0.000 description 1
- 241001073567 Verbenaceae Species 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 1
- 244000126002 Ziziphus vulgaris Species 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 208000012876 acute enteritis Diseases 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 208000037883 airway inflammation Diseases 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 1
- 229960000396 atropine Drugs 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- 208000002894 beriberi Diseases 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000004579 body weight change Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 208000023652 chronic gastritis Diseases 0.000 description 1
- 229940121657 clinical drug Drugs 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 208000013219 diaphoresis Diseases 0.000 description 1
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 description 1
- 229960004166 diltiazem Drugs 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000000222 eosinocyte Anatomy 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 229960001361 ipratropium bromide Drugs 0.000 description 1
- KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 231100001252 long-term toxicity Toxicity 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000037306 mature skin Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 208000028261 multifactorial inheritance Diseases 0.000 description 1
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 1
- 229960001597 nifedipine Drugs 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 235000012950 rattan cane Nutrition 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 210000001995 reticulocyte Anatomy 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
- 229960002646 scopolamine Drugs 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/65—Amphibians, e.g. toads, frogs, salamanders or newts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/69—Polygalaceae (Milkwort family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a traditional Chinese preparation used for treating asthma and a preparation method of the traditional Chinese preparation, and relates to the technical field of traditional Chinese medicine. The traditional Chinese preparation is composed of 19 types of traditional Chinese medicine including Chinese ephedra, asarum, evolvulus alsinoides, Elaeagnus conferta Roxb, pinellia ternate, tangerine peel, marsdenia tenacissima, toad skin, poria cocos, Chinese yam, Meconopsis racemosa Maxim, astragalus membranaceus, jujubes, tussilago farfara, negundo chastetree fruit, caesalpinia, siberian elm leaves, polygala tenuifolia and honey-fried licorice roots. The traditional Chinese preparation has a quite obvious curative effect on asthma, the preparation process is easy and convenient, and the preparation is high in stability, convenient to carry and take and easy to apply and popularize.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for the treatment of asthma and preparation method thereof.
Technical background
Bronchial asthma (bronchial asthma, asthma) be by the various kinds of cell particularly chronic airway inflammation that participates in of mastocyte, eosinophilic granulocyte and T lymphocyte, in susceptible person, this kind of inflammation can cause the symptoms such as the panting of recurrent exerbation, tachypnea, uncomfortable in chest and (or) cough, how to occur at night and (or) morning, but symptom can be alleviated voluntarily or through treatment.About there are 100,000,000 asthmatic patients in the whole world, and asthma has become a kind of major chronic illnesses of serious threat public health, and the prevalence of China's asthma is about 1%, child Ke Da 3%, about has more than 1,000 ten thousand asthmatic patients according to the measuring and calculating whole nation.
The cause of disease of primary disease is more complicated, mostly thinks a kind of disease of multifactorial inheritance, by the double influence of inherited genetic factors and environmental factors.Research shows, its heritability of asthma is about 70% ~ 80%; Its environment motivating factor has: inhalation (inhalatio), infection, food, climate change, Nervous and Mental Factors and motion etc.
At present, the Western medicine for the treatment of asthma has: atropine, scopolamine, 654-2 and ipratropium bromide and diltiazem grass, verapamil, nifedipine etc., but it is mostly only for one or more symptoms of asthma, and the toxic and side effects of long-term taking is comparatively large, can not reach the object for the treatment of both the principal and secondary aspects of a disease.
The traditional Chinese medical science is thought, asthma is because impairment of dispersing and descending function of the lung, disorder of QI movement, for a long time Yu Huahuo, burning hot Tianjin of burning are expectorant, cause the resistance of mechanism of qi numbness, stagnantly then become the stasis of blood for a long time.In recent years, more emphasize that endo synergism makes asthma recurrent exerbation.Endogenous cause of ill is lung, spleen, the dirty virtual loss of kidney three, instability of surface, the turbid interior life of expectorant; Outer be admittedly six climate exopathogens, seven emotions, improper diet and overtiredness and with the inconsistent Cucumber of patient etc.The present invention is just according to dialectical above, and take into account multiple syndrome, meticulous compatibility forms.
Summary of the invention
The object of the invention is to provide a kind of steady quality, curative effect to treat the Chinese medicine preparation of asthma reliably, the present invention also aims to the preparation technology that this Chinese medicine preparation is provided, this technique is simple and feasible, meet oral drugs body absorption process, make final obtained Chinese medicine preparation good stability, curative effect is reliable.
The present inventor according to the traditional Chinese medical science to the dialectical understanding of asthma and self clinical practice of Chinese medicine for many years, on the basis of summing up traditional proved recipe, again compatibility medical material, and repeatedly grope adjustment in clinical practice, finally obtain one has remarkable therapeutic effect Chinese prescription to asthma; Inventor, according to the advantage of the absorption characteristics of oral formulations and Modern preparations technique, has invented simple process, has taken into account the Modern preparations technique of stability and curative effect.Chinese prescription in technical solution of the present invention is (with parts by weight): Herba Ephedrae 10-14 part, Herba Asari 8-12 part, Herba Evolvuli Alsinoides 10-14 part, elaeagnus conferta fruits 10-14 part, Rhizoma Pinelliae 8-12 part, Pericarpium Citri Reticulatae 15-18 part, Caulis Marsdeniae Tenacissimae 8-12 part, Cutis Bufonis 4-8 part, Poria 8-12 part, Rhizoma Dioscoreae 10-14 part, snow ginseng 8-12 part, Radix Astragali 15-18 part, Fructus Jujubae 8-12 part, Flos Farfarae 8-12 part, Fructus Viticis Cannabifoliae 10-14 part, Herba Bulbophylli reptantis 8-12 part, Folium ulmi pumilae 15-20 part, Radix Polygalae 8-12 part, Radix Glycyrrhizae Preparata 20-25 part.
Have 2 proportioning therapeutic effect the most remarkable in clinical practice, these 2 proportionings are respectively (with parts by weight):
1,12 parts, Herba Ephedrae, Herba Asari 10 parts, 12 parts, Herba Evolvuli Alsinoides, elaeagnus conferta fruits 12 parts, the Rhizoma Pinelliae 11 parts, Pericarpium Citri Reticulatae 16 parts, Caulis Marsdeniae Tenacissimae 10 parts, Cutis Bufonis 7 parts, 10 parts, Poria, Rhizoma Dioscoreae 12 parts, snow ginseng 10 parts, the Radix Astragali 16 parts, 10 parts, Fructus Jujubae, Flos Farfarae 10 parts, Fructus Viticis Cannabifoliae 12 parts, Herba Bulbophylli reptantis 10 parts, Folium ulmi pumilae 17 parts, Radix Polygalae 10 parts, Radix Glycyrrhizae Preparata 23 parts;
2,13 parts, Herba Ephedrae, Herba Asari 11 parts, 11 parts, Herba Evolvuli Alsinoides, elaeagnus conferta fruits 12 parts, the Rhizoma Pinelliae 10 parts, Pericarpium Citri Reticulatae 17 parts, Caulis Marsdeniae Tenacissimae 9 parts, Cutis Bufonis 6 parts, 10 parts, Poria, Rhizoma Dioscoreae 13 parts, snow ginseng 11 parts, the Radix Astragali 17 parts, 10 parts, Fructus Jujubae, Flos Farfarae 11 parts, Fructus Viticis Cannabifoliae 12 parts, Herba Bulbophylli reptantis 10 parts, Folium ulmi pumilae 18 parts, Radix Polygalae 11 parts, Radix Glycyrrhizae Preparata 24 parts.
The preparation technology of Chinese medicine preparation of the present invention is following steps:
The medical materials such as Herba Ephedrae, Herba Asari, Herba Evolvuli Alsinoides, elaeagnus conferta fruits, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Caulis Marsdeniae Tenacissimae, Cutis Bufonis, Poria, Rhizoma Dioscoreae, snow ginseng, the Radix Astragali, Fructus Jujubae, Flos Farfarae, Fructus Viticis Cannabifoliae, Herba Bulbophylli reptantis, Folium ulmi pumilae, Radix Polygalae, Radix Glycyrrhizae Preparata are taken by Chinese prescription of the present invention, pulverize respectively, mixing, add the purified water of 6-10 times of weight, backflow decocts 1-3 hour, filters; Filtering residue adds the purified water of 4-8 times of initial medical material weight, backflow decocts 1-2 hour, filter, by twice filtrate mixing, 1/4 of simmer down to original volume, obtains extracting solution, this extracting solution being concentrated into density is 1.20-1.36(70-80 DEG C of survey), be Chinese medical concrete, then, Chinese medical concrete added adjuvant and make finished product Chinese medicine preparation.
The preparation that Chinese medicine of the present invention is made, its dosage form can be: tablet, capsule, granule, powder, oral liquid, suck agent, electuary.
The character of the present invention's Chinese crude drug used and effect:
Herba Ephedrae: diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.For anemofrigid cold, uncomfortable in chestly to breath with cough, edema due to wind pathogen edema; Bronchial asthma.Herba ephedrae nourishing the lung to arrest cough.Be used for table disease to separate, asthma and cough.Select the dry herb stem of Ephedraceae plant plait Herba Ephedrae, epheday intermedia or ephedra equisetina.
Herba Asari: dispel the wind, cold expelling, row water, has one's ideas straightened out.Control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.Select the dry rhizome of aristolochiaceae plant Herba Asari.
Herba Evolvuli Alsinoides: relieving cough and asthma, clearing away heat-damp and promoting diuresis, scattered silt pain relieving.For bronchial asthma, cough, jaundice, stomachache, dyspepsia, acute enteritis, dysentery, urinary system infection, leucorrhea, traumatic injury, lumbago and skelalgia.Select Convolvulaceae Herba Evolvuli Alsinoides platymiscium Herba Evolvuli Alsinoides all herbal medicine.
Elaeagnus conferta fruits: relieving cough and asthma, astringing to arrest diarrhea.Cure mainly asthma, void is coughed, chronic bronchitis, enteritis, diarrhoea, treating swelling and pain by traumatic injury, rheumatalgia, jaundice.Also haematemesis can be controlled, spitting of blood, laryngopharynx swelling and pain, flu, infantile convulsion, the diseases such as skin ulcer tinea.Select Elaeangnaceae elaeagnus conferta fruits, with root, really, leaf is used as medicine.
The Rhizoma Pinelliae: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, vomiting regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus; Raw with external treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI.Select the dry tuber of the aroid Rhizoma Pinelliae.
Pericarpium Citri Reticulatae: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Select the dry mature skin of rutaceae orange and variety thereof.
Caulis Marsdeniae Tenacissimae: relieving cough and asthma, lactogenesis diuresis, anticancer.For upper respiratory tract infection, bronchitis, bronchial asthma, galactostasis, dysuria, cancerous protuberance; Carbuncle furuncle infections is controlled in leaf external.Asclepiadaceae Marsdenia plant Caulis Marsdeniae Tenacissimae is selected to be used as medicine with rattan.
Cutis Bufonis: heat-clearing and toxic substances removing; Inducing diuresis to remove edema.Main carbuncle; Toxic swelling; Scrofula; Swollen scrofula; Infantile malnutrition abdominal distention; Chronic tracheitis.Select the dry body of Bufonidae animal Bufo siccus or Bufo melanostictus removing internal organs.
Poria is the dry sclerotia of On Polyporaceae Poria, is used as medicine and has the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.
Rhizoma Dioscoreae: spleen invigorating, tonifying the lung, reinforces the kidney, benefit essence.Control diarrhea due to hypofunction of the spleen, chronic dysentery, cough due to consumptive disease, quench one's thirst, seminal emission, leukorrhagia, frequent micturition.Select the tuber of Dioscoreaceae plant Rhizoma Dioscoreae.
Snow ginseng: QI invigorating; Kidney tonifying.Main chronic diarrhea; Proctoptosis; Inappetence; Have blood in stool; Edema; Chronic cough; Asthma; Dizzy and nyctalopia.Select the root of the total shape Herba meconopsis integrifoliae of bloodroot.
The Radix Astragali: there is invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst.Select the dry root of leguminous plant Radix Astagali or Radix Astragali.
Fructus Jujubae: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.Select the dry mature fruit of Rhamnaceae jujube Fructus Jujubae.
Flos Farfarae: nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm.Cough for new chronic cough, dyspnea and cough with excessive sputum, chronic cough hemoptysis.Select the dry flower of feverfew coltsfoot.
Fructus Viticis Cannabifoliae: Cleering damp and dissolving phlegm; Relieving cough and asthma; Regulating QI to relieve pain.Main cough and asthma; Stomachache; Have loose bowels; Dysentery; Colicky; Beriberi swelling; Leucorrhea; Nebulousurine.Select the fruit of Verbenaceae Herba Viticis Cannabifoliae.
Herba Bulbophylli reptantis: nourishing the lung to arrest cough; Nourishing the stomach to promote the production of body fluid; Reunion of fractured tendons and bones.Main cough spitting of blood; Chronic pharyngalgia; Chronic gastritis; Traumatic injury; Fracture.Orchid is selected to lie prostrate the herb of raw Bulbophyllum.
Folium ulmi pumilae: clearing away heat and promoting diuresis; Calm the nerves; Expelling phlegm for arresting cough.Main edema; Dysuria; Stranguria caused by urinary stone; Turbid urine; Insomnia; Summer-heat is stranded vexed; Abundant expectoration is coughed; Wine (looking into skin) nose.Select the leaf of Ulmaceae elm.
Radix Polygalae: bitter in the mouth, pungent, warm in nature; GUIXIN, kidney, lung meridian; To calm the nerves Fructus Alpiniae Oxyphyllae, eliminate the phlegm, detumescence.This product is the dry root of milk wort Radix Polygalae or ovum leaf Radix Polygalae.
Radix Glycyrrhizae Preparata: spleen reinforcing stomach function regulating, Yiqi and vein recovery.For weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.Selecting the Preparation process product of Radix Glycyrrhizae, is similar round or oval section, and the brown or taupe brown of surface red, micro-glossy, tangent plane is yellow to buff, and cambium ring is obvious, ray irradiation shape.Matter is slightly glutinous.Tool burnt odor gas, taste is sweet.
Chinese medicine of the present invention is with relieving cough and asthma on medical material is selected, and drying dampness to eliminate phlegm is main, has invigorating the spleen and replenishing QI concurrently, and effect of nourishing blood to tranquillize the mind promotes drug effect after ladies and gentlemen's drug matching, reaches the object for the treatment of asthma; Compared with prior art, Chinese medicine preparation of the present invention have therapeutic effect good, have no side effect, the significantly technical advantage such as good, the premunition enhancing of patient body conditioning, clinical trial result in concrete visible embodiment.
Detailed description of the invention
Embodiment 1,
By Chinese prescription actual production Chinese medicine capsules of the present invention, capsule numbering A, B are 2 preferred version proportioning preparations, and capsule numbering C, D are that prescription is minimum, maximum magnitude proportioning preparation, and often kind of capsule proportioning raw materials is as shown in table 1.
Table 1 capsule proportioning raw materials table (unit: kg)
The medical materials such as Herba Ephedrae, Herba Asari, Herba Evolvuli Alsinoides, elaeagnus conferta fruits, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Caulis Marsdeniae Tenacissimae, Cutis Bufonis, Poria, Rhizoma Dioscoreae, snow ginseng, the Radix Astragali, Fructus Jujubae, Flos Farfarae, Fructus Viticis Cannabifoliae, Herba Bulbophylli reptantis, Folium ulmi pumilae, Radix Polygalae, Radix Glycyrrhizae Preparata are taken by table 1 Chinese prescription, pulverize respectively, mixing, add the purified water of 8 times of weight, backflow decoction 2 hours, filters; Filtering residue adds the purified water of 6 times of initial medical material weight, backflow decoction 1.5 hours, filters, by twice filtrate mixing, 1/4 of simmer down to original volume, obtain extracting solution, this extracting solution being concentrated into density is 1.20-1.36(75 DEG C of survey), be Chinese medical concrete, Chinese medical concrete is dried and pulverizes, add adjuvant and make capsule, specification is 0.2g/ grain, amounts to crude drug content and is about 1g/ grain.
The animal toxicity test of embodiment 2, Chinese medicine capsules of the present invention
(1) test drug: Chinese medicine capsules obtained by the embodiment of the present invention 1, abolishes capsule shells, medicated powder is added purified water and is modulated into scattered paste shape, for subsequent use.
Test animal used: regular grade NIH mice, body weight 21g ± 6g, male and female half and half, female mice is all without pregnant; SD rat, original body mass 218 ± 9g, male and female half and half, female rats is all without pregnant.
(2) acute toxicity test
Application mice carries out acute toxicity testing and shows: mouse stomach Chinese medicine magma of the present invention, under 714.6g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none dead mouse, and overall health of patients, diet, take the photograph water, urine and body weight increase all normal.Experimental result shows: the maximum dosage-feeding of mouse stomach Chinese medicine oral liquid of the present invention is 714.6g crude drug/kg/d(LD
50> 714.6g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.20g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 3573 times of clinical patient.Point out this medicine acute toxicity extremely low, clinical drug safety.
(3) long term toxicity test
Select SD rat, give the Chinese medicine oral liquid of the present invention of Three doses: 36.0g crude drug/kg, 12.0g crude drug/kg, 4.0g crude drug/kg(per weight dosage is by 20 times of calculating of clinical application amount, and clinical application amount is according to Pharmacopoeia of the People's Republic of China version in 2010).Every day gavage once, continuous 90 days, after last administration 24 hours respectively group live and kill 1/2 animal (male and female half and half), all the other 1/2 animals continue that observations are alive after 2 weeks kills.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal; Within after administration 90 days, within 2 weeks, carry out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.
Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test: Chinese medicine preparation of the present invention has no significant effect rat in high, medium and low three dosage (36.0g crude drug/kg, 12.0g crude drug/kg, 4.0g crude drug/kg) administration in continuous 90 days, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention very high.
The clinical effectiveness test of embodiment 3 Chinese medicinal capsule of the present invention
1, the source of experimenter and grouping
All experimenters all from certain the People's Hospital of city, in the asthmatic patient that year October in May, 2011 to 2013 accepts for medical treatment, therefrom filter out be applicable to test patient 165 example, wherein, man 100 example, age 49-76 year, female 65 example, age 53-75 year.All experimenters are divided into 5 groups, are numbered matched group, A group, B group, C group, D group respectively.
2, test drug
(1) compound methoxyphenamine capsules, the accurate word H20033669 of traditional Chinese medicines, the one or three is total to pharmaceutical Co. Ltd;
(2) capsule obtained by the embodiment of the present invention 1, is numbered A, B, C, D.
3, test method
Matched group takes compound methoxyphenamine capsules, every day 3 times, each 2.A-D group takes the capsule of the made numbering A-D of embodiment 1 respectively, every day 3 times, each 4 (amount to crude drug and be about 4g).Within 4 weeks, be a course for the treatment of, continuously 3 courses for the treatment of of treatment, in therapeutic process, conscientious record patient take medicine after sensation, health.
4, judgment criteria
Cure: the symptoms of asthma such as the panting of recurrent exerbation, tachypnea, uncomfortable in chest and (or) cough disappear completely, and patient recovers normal completely;
Effective: symptoms of asthma is even generation for the panting of recurrent exerbation, tachypnea, uncomfortable in chest and (or) cough etc., but be improved significantly, patient needs continual cure;
Invalid: the symptoms of asthma such as the panting of recurrent exerbation, tachypnea, uncomfortable in chest and (or) cough does not obtain any improvement, even more serious.
5, therapeutic outcome statistical analysis
After test all terminates, result of the test statistical analysis is in table 2.
Table 2 result of the test statistical analysis table
6, conclusion (of pressure testing)
As can be seen from above result of the test, the therapeutic effect of Chinese medicinal capsule of the present invention is obviously better than contrasting medicine, and average cure rate (23.5%) is 2.5 times of matched group, and average total effective rate (93.2%) is higher than matched group by 30%, and patient has no adverse reaction after taking.Therefore, Chinese medicine of the present invention particularly embodiment A group and B group prescription, relative to prior art, has significant technical advantage, has shown good technique effect.
Claims (5)
1. treat a Chinese medicine preparation for asthma, it is characterized in that being prepared from by the raw material of following weight portion: Herba Ephedrae 10-14 part, Herba Asari 8-12 part, Herba Evolvuli Alsinoides 10-14 part, elaeagnus conferta fruits 10-14 part, Rhizoma Pinelliae 8-12 part, Pericarpium Citri Reticulatae 15-18 part, Caulis Marsdeniae Tenacissimae 8-12 part, Cutis Bufonis 4-8 part, Poria 8-12 part, Rhizoma Dioscoreae 10-14 part, snow ginseng 8-12 part, Radix Astragali 15-18 part, Fructus Jujubae 8-12 part, Flos Farfarae 8-12 part, Fructus Viticis Cannabifoliae 10-14 part, Herba Bulbophylli reptantis 8-12 part, Folium ulmi pumilae 15-20 part, Radix Polygalae 8-12 part, Radix Glycyrrhizae Preparata 20-25 part.
2. treat the Chinese medicine preparation of asthma as claimed in claim 1, it is characterized in that being prepared from by the raw material of following weight portion: 12 parts, Herba Ephedrae, Herba Asari 10 parts, 12 parts, Herba Evolvuli Alsinoides, elaeagnus conferta fruits 12 parts, the Rhizoma Pinelliae 11 parts, Pericarpium Citri Reticulatae 16 parts, Caulis Marsdeniae Tenacissimae 10 parts, Cutis Bufonis 7 parts, 10 parts, Poria, Rhizoma Dioscoreae 12 parts, snow ginseng 10 parts, the Radix Astragali 16 parts, 10 parts, Fructus Jujubae, Flos Farfarae 10 parts, Fructus Viticis Cannabifoliae 12 parts, Herba Bulbophylli reptantis 10 parts, Folium ulmi pumilae 17 parts, Radix Polygalae 10 parts, Radix Glycyrrhizae Preparata 23 parts.
3. treat the Chinese medicine preparation of asthma as claimed in claim 1, it is characterized in that being prepared from by the raw material of following weight portion: 13 parts, Herba Ephedrae, Herba Asari 11 parts, 11 parts, Herba Evolvuli Alsinoides, elaeagnus conferta fruits 12 parts, the Rhizoma Pinelliae 10 parts, Pericarpium Citri Reticulatae 17 parts, Caulis Marsdeniae Tenacissimae 9 parts, Cutis Bufonis 6 parts, 10 parts, Poria, Rhizoma Dioscoreae 13 parts, snow ginseng 11 parts, the Radix Astragali 17 parts, 10 parts, Fructus Jujubae, Flos Farfarae 11 parts, Fructus Viticis Cannabifoliae 12 parts, Herba Bulbophylli reptantis 10 parts, Folium ulmi pumilae 18 parts, Radix Polygalae 11 parts, Radix Glycyrrhizae Preparata 24 parts.
4. one kind prepare as arbitrary in claim 1-3 as described in the method for Chinese medicine preparation for the treatment of asthma, it is characterized in that comprising following processing step: take Herba Ephedrae, Herba Asari, Herba Evolvuli Alsinoides, elaeagnus conferta fruits, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Caulis Marsdeniae Tenacissimae, Cutis Bufonis, Poria, Rhizoma Dioscoreae, snow ginseng, the Radix Astragali, Fructus Jujubae, Flos Farfarae, Fructus Viticis Cannabifoliae, Herba Bulbophylli reptantis, Folium ulmi pumilae, Radix Polygalae, Radix Glycyrrhizae Preparata by weight, pulverize respectively, mixing, add the purified water of 6-10 times of weight, backflow decocts 1-3 hour, filters; Filtering residue adds the purified water of 4-8 times of initial medical material weight, backflow decocts 1-2 hour, filter, by twice filtrate mixing, 1/4 of simmer down to original volume, obtains extracting solution, this extracting solution being concentrated into 70-80 DEG C of survey density is 1.20-1.36, be Chinese medical concrete, then, Chinese medical concrete added adjuvant and make finished product Chinese medicine preparation.
5. the Chinese medicine preparation for the treatment of asthma as described in as arbitrary in claim 1-3, is characterized in that: described Chinese medicine preparation is tablet, capsule, granule, powder, oral liquid, suck agent or electuary.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510030667.0A CN104491318A (en) | 2015-01-22 | 2015-01-22 | Traditional Chinese preparation used for treating asthma and preparation method of traditional Chinese preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510030667.0A CN104491318A (en) | 2015-01-22 | 2015-01-22 | Traditional Chinese preparation used for treating asthma and preparation method of traditional Chinese preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104491318A true CN104491318A (en) | 2015-04-08 |
Family
ID=52932832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510030667.0A Withdrawn CN104491318A (en) | 2015-01-22 | 2015-01-22 | Traditional Chinese preparation used for treating asthma and preparation method of traditional Chinese preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104491318A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105561010A (en) * | 2016-02-19 | 2016-05-11 | 覃淑兰 | Chinese herbal preparation for treating asthma and preparing method thereof |
| CN108721306A (en) * | 2018-07-10 | 2018-11-02 | 云南中医学院 | Application of the Arenobufagin in preventing/treating asthmatic medicament |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647979A (en) * | 2009-09-14 | 2010-02-17 | 胡慧梅 | Traditional Chinese medicine for treating bronchial asthma |
-
2015
- 2015-01-22 CN CN201510030667.0A patent/CN104491318A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647979A (en) * | 2009-09-14 | 2010-02-17 | 胡慧梅 | Traditional Chinese medicine for treating bronchial asthma |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105561010A (en) * | 2016-02-19 | 2016-05-11 | 覃淑兰 | Chinese herbal preparation for treating asthma and preparing method thereof |
| CN108721306A (en) * | 2018-07-10 | 2018-11-02 | 云南中医学院 | Application of the Arenobufagin in preventing/treating asthmatic medicament |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101711850B (en) | Traditional Chinese medicine composition for treating symptoms of myocardial ischemia, palpitation and severe palpitation and preparation method | |
| CN101181393A (en) | Chinese medicine preparation for curing common cold and producing method thereof | |
| CN103893722A (en) | Traditional Chinese medicinal composition for treating solar dermatitis and preparation method thereof | |
| CN104825914A (en) | Traditional Chinese medicinal preparation for assisted treatment of breast cancer | |
| CN105497261A (en) | Matrix of patch for external use and patch and sleeping-aid patch made from matrix | |
| CN104491672A (en) | Traditional Chinese medicine preparation for treating chronic tracheitis and preparation method thereof | |
| CN104491236A (en) | Traditional Chinese medicine preparation for treating essential hypertension and preparation method for traditional Chinese medicine preparation | |
| CN104491318A (en) | Traditional Chinese preparation used for treating asthma and preparation method of traditional Chinese preparation | |
| CN104984296A (en) | Pharmaceutical composition for treating female climacteric syndrome and preparation method thereof | |
| CN104706976A (en) | Traditional Chinese medicine preparation capable of benefiting qi for tranquillization to treatinsomnia and preparation method of traditional Chinese medicine preparation | |
| CN105944020B (en) | Traditional Chinese medicine for treating ovarian function decline | |
| CN104623314A (en) | Medicine composition for treating dry mouth and bitter taste and preparation method thereof | |
| CN114748603A (en) | A medicine and food homologous composition and application for preventing and treating new coronavirus pneumonia mutation or rejuvenation | |
| CN104998005A (en) | Traditional Chinese medicine oral liquid special for treating constipation and preparation method thereof | |
| CN104645080A (en) | Traditional Chinese medicine preparation for treating dizziness and preparation method of traditional Chinese medicine preparation | |
| CN105521246A (en) | Medicinal preparation for treating lung cancer and applications of medicinal preparation | |
| CN104547859A (en) | Application of traditional Chinese medicine preparation in preparation of medicine for treating chronic tracheitis | |
| CN104887950A (en) | Mastitis treatment traditional Chinese medicine compound | |
| CN104606600A (en) | Traditional Chinese medicine composition for treating interstitial lung disease and preparation method of composition | |
| CN104306847A (en) | Six-ingredient qi-tonifying capsule and preparation process thereof | |
| CN104162090B (en) | Pharmaceutical composition and preparation method thereof | |
| CN115252729B (en) | Traditional Chinese medicine composition for treating diabetes and application thereof | |
| CN104083469B (en) | A kind of Chinese medicine being used for the treatment of Senile Functional Constipation | |
| CN105582379A (en) | Traditional Chinese medicine composition for treating liver-stomach disharmony and preparation method of traditional Chinese medicine composition | |
| CN105770815A (en) | Folium artemisiae argyi-containing traditional Chinese medicine composition for treating postpartum collapse and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20150408 |