DE202007002146U1 - Herbal composition, useful to treat, e.g. cancer, comprises extracts of Ginseng flowers and roots, Astragalus, Atractylodes, Angelica, Citrus reticulata, Bupleurum chinenis, sweet woodrose and Cimicifuga root - Google Patents

Abstract

Herbal composition (I) comprises extracts of Ginseng flowers, Ginseng roots, Astragalus membranaceus, Atractylodes macrocephala, Angelica dahurica root, Citrus reticulata, Bupleurum chinensis root, sweet woodrose and Cimicifuga root. ACTIVITY : Immunostimulant; Cytostatic; Cardiovascular-Gen.; Antidiabetic; Nootropic; Virucide; Endocrine-Gen; Gastrointestinal-Gen; Vulnerary; Antiemetic; Antitussive. No biological data given. MECHANISM OF ACTION : None given.

Description

Territory of invention

The Invention relates to an herbal composition, which ginseng flower, Ginseng root, Astragalus membranaceu, Atractylodes macrocephala, Chinese angelica (Chinese Angelica), tangerine peel, Radix bupleuri chinensis, licorice root and Cimicifuga root.

background the invention

at of the mixture, which Astragalus membranaceu, Atractylodes macrocephala, Chinese angelica, tangerine peel, Radix bupleuri chinensis, licorice and Cimicifuga root, is a traditional one Chinese medicine for the strengthening of the immune system and lowering blood pressure. The mix is one Formulation that is important in a traditional Chinese Plant, Pi Wei Lun (treatise on the spleen and stomach, 1249 A.D.). It has been reported that the mixture is one anti-cancer effect (Zhongguo Zhong Yao Za Zhi. 1989 Mar; . 14 (3): 48 to 51.64). The Left results suggest that anti-cancer agents are effective chemotherapeutic agents in combination with the above mentioned Mixture increase the healing effect and the toxicity can reduce.

ginseng is a herbal medicine, which is obtained from the root of the plant genus Panax. she was over used for several thousand years in Asia, and their alleged medical properties have assumed mystical proportions. The English name "ginseng" comes from the Chinese Term "rénshẽn." Ginseng was originally the general term for different plants due to their medicinal properties estimated but is most specifically associated with the genus Panax brought. The roots of ginseng (Panax ginseng, C. A. Mayer and other species) either in their natural form (for example pulverized for the preparation of infusions and decoctions) or in the form of derivatives, such as in the form of various extract species (eg., Alcoholic or watery Extracts either in liquid or dried or atomised form) in the pharmaceutical, dietetics and cosmetics widely used. Ginseng becomes practical for everyone Usage recommended, including overall health, fatigue, Immune function, cancer, cardiovascular disease, diabetes mellitus, cognitive function, viral infections, sexual and athletic performance.

Indeed there is a need to develop an herbal composition offers the benefits of improving health.

Summary the invention

The Invention provides an herbal composition, which ginseng flower, Ginseng root, Astragalus membranaceu, Atractylodes macrocephala, Chinese Angelica, tangerine skin, Radix bupleuri chinensis, licorice root and Cimicifuga root.

Summary the drawing

1 shows the HPLC spectrum of the herbal composition of the invention.

detailed Description of the invention

The Invention provides an herbal composition, which ginseng flower, Ginseng root, Astragalus membranaceu, Atractylodes macrocephala, Chinese Angelica, tangerine skin, Radix bupleuri chinensis, licorice root and Cimicifuga root. In particular, come ginseng, ginseng root, Astragalus membranaceu, Atractylodes macrocephala, Chinese angelica, tangerine peel, Radix bupleuri chinensis, licorice root and Cimicifuga root in a ratio of 2: 2: 6: 2: 2: 2: 1: 4: 1 in front.

According to the invention, the following plants are referred to by the term "ginseng", but they either come from another family or from a different genus: Eleutherococcus senticosus (Siberian ginseng), Pseudostellaria heterophylla (Prinzenginseng), Angelica sinensis (female ginseng also known as Dong Quai), Withania somnifera (Indian ginseng also known as Ashwagandha), Pfaffia paniculata (Brazilian ginseng) Lepidium meyenii (Peruvian ginseng also known as Maca) and Gynostemma pentaphyllum (Southern ginseng also known as Jiaogulan) Ginseng has 3 leaflets as a seedling and 5 leaflets per leaflet as a mature plant, the number of leaves being related to the age of the plant Ginseng plants start to bloom in the second year It is known that the flowers of oriental ginseng are very small are 2-3 mm in cross-section, with 5 sepals green, 5 Petals, creamy-yellow, ovate, blunt tip; 5 stamens, spermatozoa, short; 1 postmark, subordinate ovary, 2-fold; 2 styluses, united at the base; cupped. A typical flowering 4-year-old American ginseng plant can carry 30-40 berries in an umbel with an average of two creamy-white seeds, 5-6 mm long and 4-5 mm wide, in each berry. The ginseng plant has a fleshy taproot, which often has two to five lateral secondary roots, and its color is pale yellow-white. The dry weight fraction of the root is 30% (the Gat Panax (ginseng) in Chinese medicine. Econ. Bot. 30: 11-28). Ginseng root is commonly used as an elixir and is effective in gastrointestinal diseases, diabetes and circulatory insufficiency, and is used more as an adjunct to prevent many diseases than as a cure for disease. Thus, ginseng is recognized as a highly effective medicine for the maintenance of health and for a long life. It is known that the root contains various saponins and sapogenins. Among them, ginsenoside Rb has a sedative effect while ginsenoside Rg has a stimulating effect. Panax ginseng is marketed and used to maintain natural energy, increase mental and physical ability, improve mood and promote overall health and wellbeing. Panax ginseng has been used in a series of randomized clinical trials investigating its effects on physical and psychomotor performance, cognitive function, immunomodulation, diabetes mellitus and herpes simplex type II infections. Many of these indications have produced ambiguous results (Journal of Clinical Pharmacy & Therapeutics Volume 28, Issue 1, page 5 - February 2003).

Astragalus, with the scientific name Astragalus membranaceu, is a Herb used for self-medication together with conventional therapies for breast, Cervix- and lung cancer is used. Astragalus seems to be the immune system to strengthen, especially in cases of immunodeficiency by restoring suppressed T-cell function (Chu, Wong & Mavligit, 1988; Sun et al .; 1983). Typical dosages are apparently at 1-30 g per Day.

The Name Atractylodes refers mainly to Atractylodes macrocephala, known in China as baizhu. Less commonly used is Atractylodes lancea or its less desirable Replacement forms such as A. chinensis, A. japonicum and A. ovata, known in China as cangzhu. The two main functions, which continues for both baizhu as well for cangzhu are recognized, consist in the ability to assemble together to get around moisture (preventing moisture) and the To promote digestion (disperse food). According to reports, Atractylodes macrocephala the body so influence that he feels light and to treat Jaundice can be used. The statement "the body feels light" refers to the role of the herb as an elixir for long life and practices the Taoists who cause weight loss and loss of appetite (usually through the consumption of heavy metals in alchemical mixtures) to lead. Jaundice is indicated by yellowing of the skin, which, like known today, caused by hepatitis or biliary obstruction is, in traditional Chinese medicine but this was considered weakness the spleen, which is the organ for the earth element, that with the color yellow communicates. One of the indicators of use of Atractylodes in a diuretic formulation, if a limited Urinary excretion in case of excessive sweating is present. Atractylodes lancea is an example of a species whose natural population size is due to intensive collection has decreased threateningly. Mainly becomes this plant for the treatment of indigestion and used stomach disorders.

The Chinese angelica is also known as Dong Quai, Dong Qua, Danqqui, Dang Gui, Tang Kuei and Tan Kue Bai Zhi. Her scientific name is Angelica sinensis. Angelica is a genus of plants of the family Parsley family, which is used in Western medicine as well as traditional Chinese medicine. Usually the dried root is used for medical purposes. The most common type of Angelica used in Western healing is the European species: Angelica archangelica. Occasionally the North American species, A. atropurpurea, is used in the same way as A. archangelica. Other names for Angelica species occurring in the west include: European angelica, garden angelica, red angelica, Alexander's angelica, masterwort, wild angelica and wild celery. The medication is mildly laxative, although it was originally used as a uteroprotective and anticonvulsant, and it has alterative (blood-purifying) effects. The chemical study identified seven different coumarin derivatives in the Chinese angelica including oxypeucedanin, osthol, imperatorin, psoralen and bergapten. Many coumarins are known to act as vasodilators and antispasmodics; others, such as Osthol, exert a stimulating effect on the central nervous system. Thus, at least some of the alleged effects of Chinese angelica could be traced back to these compounds. Chinese angelica is the best Chinese herbal elixir for women, though it can also be used by men, and it is the most valued blood elixir in the East. The Chinese angelica regulates hormones and menstruation - helps with late or suppressed periods and resolves menstrual cramps - and can be taken during menopause. When eaten raw or as a tincture, the Chinese angelica relaxes the uterus, when used with water it tones the uterus and stimulates the uterine contractions, which increases blood circulation and cramps be solved in the pelvic area. It is best not to take Chinese angelica during pregnancy.

The Tangerine peel has been in the traditional for centuries used Chinese medicine. It is said that they are the river of "Qi" (life force) and normalized. In France and other parts of Europe, the Mandarin husk in particular known as a cure for children and older ones People both in digestive problems as well as to calm overwrought young minds. Mandarin husk is an ingredient in many traditional Chinese Elixirs. The tangerine affects the lungs and spleen. It helps to clear the lungs of mucus and hiccups. She can as Appetizer can be used, which promotes digestion and remedy in case of nausea and gas formation creates. Tangerine peel is commonly used to Indigestion, Vomiting, diarrhea and other forms of stomach disorders, To treat hiccups as well as cough and constipation. The usage The shell in a pack supports healing processes and relieves inflammation in connection with muscle strains and sprains, overstretched Tendons and other sports-related injuries.

With the essential oil can the same states be treated and it stimulates the lymphatic system, eliminating excessive amounts of fluid, elevated the urine delivery and fights obesity. Mandarin oil is milder than other citrus oils and is used by pregnant women for relaxation and reassurance. It can be helpful in treating nervous tension, emotional Stress, depression and insomnia. The oil also works in the treatment different skin conditions, such as scars, stretch marks and acne. In the Aromatherapy becomes tangerine oil used for refreshment, relaxation and revival. The Cup of young greens Mandarin is called Qing Pi and is helpful in the treatment chest pain, fracture-related pain and low Blood pressure. In combination with other ingredients is the tangerine peel also good for the treatment of gout, morning sickness and sexual problems in men.

When Licorice or Licorice is called the root of Glycyrrhiza glabra, from which is a sweet flavor can be extracted. The licorice plant is a vegetable species (related to beans and peas) in southern Europe and parts of Asia is native. It is a perennial that grows up to 1 meter high with pinnate leaves, the about 7-15 Centimeters (3-6 Inches) and 9-17 Single leaflets consist. The blossoms are 0.8-1.2 cm (1/3 to 1/2 inch) long, red to pale blue and in a loose inflorescence arranged. The fruit is an elongated pod, the 2-3 inches (about 1 inch) long, and contains several seeds. Licorice is also a light one Laxative. Height Doses of glycyrrhizic acid and glycyrrhetinic acid in sweet wood extract can to hypokalaemia and lead to a significant increase in blood pressure, a syndrome which as overt mineral corticoid surplus is known. These side effects result from the inhibition of Enzyme 11β-hydroxysteroid dehydrogenase (type 2) and a subsequent increase in the effect of cortisol the kidneys. Normally, the cortisol in the kidneys is through the 11β-hydroxysteroid dehydrogenase inactivated, therefore leads the inactivation of this enzyme by licorice to a seemingly elevated cortisol concentration. Cortisol acts in the kidneys on the same receptor as the hormone Aldosterone, therefore the effects mimic an aldosterone surplus although the aldosterone concentration during a liquorice overdose low or normal remains. The amount of cortisol increases not really; only the cortisol effect in the kidneys increases due to the inhibition of this enzyme. To the possibility of this serious Decreasing side effects are deglycyrrhizinated licorice (DGL) preparations available.

The Cimicoota root has a pungent smell and a sweet taste, slightly cool by nature, and affects the lungs, spleen and gastric channels. she is sharp and cool to enhance mood and diversion and to add sweetness and coolness Heat and excretion of toxic substances. It shows one weak effect in repelling exogenous and a considerable strong effect in highlighting the yang and supporting its Breakthrough.

The herbal composition of the invention may further contain pharmaceutically acceptable excipients, fillers, binders and blending agents such as the hydrous or anhydrous form of lactose, starches, glucose, sucrose, mannitol, sorbitol, silicic acid, microcrystalline celluloses, sodium carboxymethylcelluloses, sodium starch glycolate and derivatives and mixtures thereof. It is preferred that the pharmaceutical composition of the present invention be used by combining independently formulated drugs or by preparing a combination formulation consisting of a mixture of drugs. When the pharmaceutical composition of the present invention is used in the real world, dosage forms must be formulated for units suitable for oral administration, and administration must be appropriately within the conventions of the art proper pharmaceutical sector. To achieve this, the oral formulation comprises a hard or soft capsule, tablet, powder, etc. In addition to ginseng flower, ginseng root, Astragalus membranaceu, Atractylodes macrocephala, Chinese angelica, tangerine peel, Radix bupleuri chinensis, licorice and Cimicifuga root active agents contain one or more pharmacologically inactive conventional carrier media. For example, the oral formulation may contain as additives: starch, lactose, carboxymethylcellulose, kaolin and similar carriers; Water, gelatin, alcohol, glucose, gum arabic, gum tragacanth and similar binders; Starch, dextrin, sodium alginate and similar disintegrants; Talc, stearic acid, magnesium stearate, liquid paraffin and similar lubricants. Further, disintegrating agents may be added.

The daily Dosage of herbal composition the invention is dependent of numerous factors, such as the extent of liver damage of the patient, the time of onset of hepatitis, the age, health, complications, etc. To the average adult becomes the herbal composition but once or twice a day with a daily dosage from a total of 4000 mg to 6000 mg, especially from 10,000 mg to 12,000 mg administered. However, the present invention from the scope of the above-mentioned pharmaceutical composition in patients with severe liver damage, or when considered to be Recurrent agent after an ectomy of a liver carcinoma used, and even higher dosages can be used become. In particular, one or two dosage units, the Oltipraz 25 mg and DDB 5 mg, given orally twice daily.

EXAMPLE

Analysis of the pharmaceutical Composition of the invention with high performance liquid chromatography (HPLC)

Ginseng flower, ginseng root, Astragalus membranaceu, Atractylodes macrocephala, Chinese angelica, mandarin zest, Radix bupleuri chinensis, licorice, and cimicoota root were prepared as a powder and then mixed in a ratio of 2: 2: 6: 2: 2: 2: 1: 4: 1 , 10 ml of 70% methanol was added to the resulting mixture for extraction. After 30 minutes, the resulting solution was filtered and made up to 100 ml with water. The filtered solution was analyzed by HPLC (Hitach L-7400) with the column: LiChrospher 100, RP-18e (5 μm), mobile phase: 1 water: 35 acetonitrile, flow rate: 0.5 ml / min and UV (203 nm) certainly. The resulting HPLC spectrum was analyzed in 1 shown. According to detection by HPLC, the pharmaceutical composition contains 0.724 mg / g ginsenoside.

Claims (4)

Herbal composition, which ginseng flower, Ginseng root, Astragalus membranaceu, Atractylodes macrocephala, Chinese angelica, tangerine peel, Radix bupleuri chinensis, licorice root and Cimicifuga root. herbal composition of claim 1, wherein ginseng blossom, Ginseng root, Astragalus membranaceu, Atractylodes macrocephala, Chinese angelica, tangerine peel, Radix bupleuri chinensis, licorice and Cimicifuga root in a ratio of 2: 2: 6: 2: 2: 2: 1: 4: 1 occurrence. herbal composition of claim 1 which is in the dosage in the range of 4000 mg to 6000 mg is administered per day. herbal composition of claim 1 which is in the dosage in the range of 10,000 mg to 12,000 mg per day is administered.