TR200102178T2 - CRF reseptör antagonistleri ve bunlarla ilgili yöntemler. - Google Patents

CRF reseptör antagonistleri ve bunlarla ilgili yöntemler.

Info

Publication number: TR200102178T2
Authority: TR; Turkey
Prior art keywords: receptor antagonists; related methods; crf receptor; compounds; treatment
Prior art date: 1998-11-12

Application number

TR2001/02178T

Other languages

English (en)

Turkish (tr)

Inventor

Haddach Mustapha

Guo Zhiqiang

R. Mccarthy James

Original Assignee

Neurocrine Biosciences, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-12

Filing date

1999-11-12

Publication date

2002-01-21

1999-11-12 Application filed by Neurocrine Biosciences, Inc. filed Critical Neurocrine Biosciences, Inc.

2002-01-21 Publication of TR200102178T2 publication Critical patent/TR200102178T2/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Addiction (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

TR2001/02178T 1998-11-12 1999-11-12 CRF reseptör antagonistleri ve bunlarla ilgili yöntemler. TR200102178T2 (tr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US19095898A	1998-11-12	1998-11-12
US40074499A	1999-09-21	1999-09-21

Publications (1)

Publication Number	Publication Date
TR200102178T2 true TR200102178T2 (tr)	2002-01-21

Family

ID=26886600

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TR2001/02178T TR200102178T2 (tr)	1998-11-12	1999-11-12	CRF reseptör antagonistleri ve bunlarla ilgili yöntemler.

Country Status (19)

Country	Link
US (3)	US6348466B1 (fr)
EP (1)	EP1129096B1 (fr)
JP (1)	JP2002529469A (fr)
KR (1)	KR20010080402A (fr)
CN (1)	CN1178941C (fr)
AT (1)	ATE240958T1 (fr)
AU (1)	AU755997B2 (fr)
BR (1)	BR9915129A (fr)
CA (1)	CA2349904A1 (fr)
DE (1)	DE69908173T2 (fr)
DK (1)	DK1129096T3 (fr)
ES (1)	ES2196898T3 (fr)
HK (1)	HK1038925B (fr)
IL (1)	IL143105A0 (fr)
NO (1)	NO20012228L (fr)
NZ (1)	NZ511267A (fr)
PT (1)	PT1129096E (fr)
TR (1)	TR200102178T2 (fr)
WO (1)	WO2000027850A2 (fr)

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AU2001232271A1 (en) *	2000-02-14	2001-08-20	Japan Tobacco Inc.	Preventives/remedies for postoperative stress
AU2001255673A1 (en) *	2000-05-01	2001-11-12	Dupont Pharmaceuticals Company	Tricyclic fused pyridine and pyrimidine derivatives as crf receptor antagonists
US6500839B2 (en)	2000-05-18	2002-12-31	Neurocrine Biosciences, Inc.	CRF receptor antagonists and methods relating thereto
DE60102231T2 (de)	2000-05-18	2005-04-14	Neurocrine Biosciences, Inc., San Diego	Crf rezeptor-antagonisten und darauf bezogene methoden
ES2279835T3 (es) *	2000-11-03	2007-09-01	Neurocrine Biosciences, Inc.	Antagonistas del receptor de crf y metodos relacionados.
WO2002064592A1 (fr) *	2000-12-28	2002-08-22	Neurocrine Biosciences, Inc.	Antagonistes du recepteur de crf tricycliques
PT1354884E (pt)	2000-12-28	2007-12-24	Ono Pharmaceutical Co	Composto de ciclopenta (d) pirazolo [1,5-a] piramida como antagonista de receptor de crf
CN1512883A (zh) *	2001-04-30	2004-07-14		Crf受体拮抗剂
US7273871B2 (en)	2001-07-17	2007-09-25	Sb Pharmco Puerto Rico Inc.	Phenyl-5,6,6A,7,8,9-hexahydro-4H-1,4,9-triaza-phenalene derivatives as CRF antagonists
GB0117395D0 (en) *	2001-07-17	2001-09-05	Glaxo Group Ltd	Chemical compounds
ATE478873T1 (de)	2003-06-25	2010-09-15	Ono Pharmaceutical Co	Methansulfonsäuresalz einer pyrazolopyrimidinverbindung, kristall davon und verfahren zu deren herstellung
US20060024661A1 (en) *	2003-07-30	2006-02-02	The Regents Of The University Of California	Modulation of CRF potentiation of NMDA receptor currents via CRF receptor 2
WO2005063749A1 (fr) *	2003-12-22	2005-07-14	Sb Pharmco Puerto Rico Inc	Antagonistes du recepteur de crf et procedes correspondants
CN102453763A (zh)	2004-06-03	2012-05-16	阿什洛米克斯控股有限公司	诊断应激的药物和方法
US7869958B2 (en) *	2004-08-09	2011-01-11	Research Development Foundation	Structure-based modulators of B1 G-protein coupled receptors
SG185992A1 (en)	2004-08-25	2012-12-28	Ardea Biosciences Inc	S-TRIAZOLYL α-MERCAPTOACETANILIDES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE
WO2007050087A1 (fr)	2004-08-25	2007-05-03	Ardea Biosciences, Inc.	Acides N[S(4-aryltriazol-3-yl)α-mercaptoacétyl]-p-aminobenzoïques EN TANT QU'INHIBITEURS DE TRANSCRIPTASE INVERSE DE VIH
CA2607021C (fr)	2005-05-05	2013-10-29	Ardea Biosciences, Inc.	Diaryl-purine, -azapurines et -deazapurines inhibiteurs non nucleosidiques de la transcriptase inverse utilises dans le traitement du vih
CA2668997C (fr)	2006-11-09	2012-10-09	Ardea Biosciences, Inc.	Composes heterocycliques bicycliques 4-cyanophenylamino-substitues utilises comme inhibiteurs du vih
AU2008329673C1 (en)	2007-11-27	2012-10-25	Ardea Biosciences, Inc.	Novel compounds and compositions and methods of use
US8207178B2 (en)	2007-12-14	2012-06-26	Ardea Biosciences, Inc.	Fused pyrimidines as reverse transcriptase inhibitors

Family Cites Families (27)

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US4605642A (en)	1984-02-23	1986-08-12	The Salk Institute For Biological Studies	CRF antagonists
US5013737A (en) *	1988-02-22	1991-05-07	American Cyanamid Company	2,4,8-Trisubstituted-3H,6H-1,4,5A,8A-tetraazaacenaphtylene-3,5-(4H)-diones and 2,4-8-trisubstituted-4,5-dihydro-5-thioxo-3H,6H-1,4,5A,8A-tetrazaacenaphthylen-3-ones
US4904658A (en)	1988-04-15	1990-02-27	American Cyanamid Company	Substituted-6H,8H-pyrimido-[1,2,3-cd]purine-8,10-(9H)-diones and substituted-6H,10H-pyrimido[1,2-cd]purin-10-ones
US5063245A (en)	1990-03-28	1991-11-05	Nova Pharmaceutical Corporation	Corticotropin-releasing factor antagonism compounds
FR2692893B1 (fr)	1992-06-24	1994-09-02	Sanofi Elf	Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
TW370529B (en)	1992-12-17	1999-09-21	Pfizer	Pyrazolopyrimidines
CZ284157B6 (cs)	1992-12-17	1998-08-12	Pfizer Inc.	Pyrazolové a pyrazolopyrimidinové sloučeniny jako takové a pro léčbu chorob a farmaceutické prostředky na jejich bázi
DK0674641T3 (da) *	1992-12-17	1999-09-27	Pfizer	Pyrrolopyrimidiner som CRF-antagonister
JP2781661B2 (ja)	1992-12-17	1998-07-30	フアイザー・インコーポレイテツド	Ｃｒｆアンタゴニストとしての置換ピラゾール
TW336932B (en)	1992-12-17	1998-07-21	Pfizer	Amino-substituted pyrazoles
JP3398152B2 (ja)	1993-10-12	2003-04-21	ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー	１ｎ−アルキル−ｎ−アリールピリミジンアミンおよびその誘導体
TW574214B (en)	1994-06-08	2004-02-01	Pfizer	Corticotropin releasing factor antagonists
WO1995034563A1 (fr) *	1994-06-16	1995-12-21	Pfizer Inc.	Pyrazolo et pyrrolopyridines
DE69603240T2 (de)	1995-05-12	2000-01-05	Neurogen Corp., Branford	Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden
FR2735777B1 (fr)	1995-06-21	1997-09-12	Sanofi Sa	Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
CA2249598A1 (fr)	1996-03-26	1997-10-02	Paul Joseph Gilligan	Pyridines et pyrimidines a fusion aryloxy et arylthio et derives de ces dernieres
US6326368B1 (en)	1996-03-27	2001-12-04	Dupont Pharmaceuticals Company	Aryloxy- and arylthiosubstituted pyrimidines and triazines and derivatives thereof
US6107300A (en)	1996-03-27	2000-08-22	Dupont Pharmaceuticals	Arylamino fused pyrimidines
ZA973884B (en) *	1996-05-23	1998-11-06	Du Pont Merck Pharma	Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders
EP0915880B1 (fr)	1996-07-24	2007-10-10	Bristol-Myers Squibb Pharma Company	Azolo triazines et pyrimidines
CZ292806B6 (cs)	1996-08-06	2003-12-17	Pfizer Inc.	Pyrido- nebo pyrimido-6,6- nebo -6,7-bicyklické deriváty, farmaceutické kompozice na jejich bázi
TW477787B (en)	1996-08-27	2002-03-01	Pfizer	Pyrido six-membered nitrogen-containing cyclic ring derivatives having corticotropin releasing factor antagonist activity and pharmaceutical composition containing same
ATE340176T1 (de)	1996-08-28	2006-10-15	Pfizer	Substituierte 6,5-heterobicyclische-derivate
JP2001502300A (ja)	1996-09-16	2001-02-20	デュポンファーマシューティカルズカンパニー	ピラジノン類およびトリアジノン類およびその誘導体類
FR2754258B1 (fr)	1996-10-08	1998-12-31	Sanofi Sa	Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
US5760225A (en)	1996-11-15	1998-06-02	Neurogen Corporation	Certain pyrazole derivatives as corticotropin-releasing factor receptor CRF1 specific ligands
US5723608A (en)	1996-12-31	1998-03-03	Neurogen Corporation	3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands

1999
- 1999-11-12 JP JP2000581028A patent/JP2002529469A/ja active Pending
- 1999-11-12 PT PT99961675T patent/PT1129096E/pt unknown
- 1999-11-12 TR TR2001/02178T patent/TR200102178T2/xx unknown
- 1999-11-12 BR BR9915129-4A patent/BR9915129A/pt not_active IP Right Cessation
- 1999-11-12 CA CA002349904A patent/CA2349904A1/fr not_active Abandoned
- 1999-11-12 NZ NZ511267A patent/NZ511267A/xx unknown
- 1999-11-12 DK DK99961675T patent/DK1129096T3/da active
- 1999-11-12 EP EP99961675A patent/EP1129096B1/fr not_active Expired - Lifetime
- 1999-11-12 DE DE69908173T patent/DE69908173T2/de not_active Expired - Lifetime
- 1999-11-12 AU AU18199/00A patent/AU755997B2/en not_active Ceased
- 1999-11-12 KR KR1020017005818A patent/KR20010080402A/ko not_active Application Discontinuation
- 1999-11-12 WO PCT/US1999/026984 patent/WO2000027850A2/fr not_active Application Discontinuation
- 1999-11-12 US US09/439,841 patent/US6348466B1/en not_active Expired - Fee Related
- 1999-11-12 CN CNB998131725A patent/CN1178941C/zh not_active Expired - Fee Related
- 1999-11-12 IL IL14310599A patent/IL143105A0/xx unknown
- 1999-11-12 ES ES99961675T patent/ES2196898T3/es not_active Expired - Lifetime
- 1999-11-12 AT AT99961675T patent/ATE240958T1/de not_active IP Right Cessation
2001
- 2001-05-04 NO NO20012228A patent/NO20012228L/no not_active Application Discontinuation
- 2001-12-20 US US10/027,789 patent/US6723721B2/en not_active Expired - Lifetime
2002
- 2002-01-29 HK HK02100689.4A patent/HK1038925B/zh not_active IP Right Cessation
2004
- 2004-02-23 US US10/785,386 patent/US20040229879A1/en not_active Abandoned

Also Published As

Publication number	Publication date
NZ511267A (en)	2002-12-20
ES2196898T3 (es)	2003-12-16
IL143105A0 (en)	2002-04-21
EP1129096A2 (fr)	2001-09-05
US20040229879A1 (en)	2004-11-18
DE69908173T2 (de)	2004-08-19
AU1819900A (en)	2000-05-29
JP2002529469A (ja)	2002-09-10
EP1129096B1 (fr)	2003-05-21
DE69908173D1 (de)	2003-06-26
CN1178941C (zh)	2004-12-08
BR9915129A (pt)	2001-08-07
DK1129096T3 (da)	2003-09-15
NO20012228D0 (no)	2001-05-04
HK1038925B (zh)	2003-12-05
CA2349904A1 (fr)	2000-05-18
US6723721B2 (en)	2004-04-20
NO20012228L (no)	2001-05-04
KR20010080402A (ko)	2001-08-22
WO2000027850A3 (fr)	2000-08-03
US6348466B1 (en)	2002-02-19
PT1129096E (pt)	2003-09-30
US20020143008A1 (en)	2002-10-03
ATE240958T1 (de)	2003-06-15
AU755997B2 (en)	2003-01-02
HK1038925A1 (en)	2002-04-04
WO2000027850A2 (fr)	2000-05-18
CN1326458A (zh)	2001-12-12

Publication	Publication Date	Title
TR200102178T2 (tr)	2002-01-21	CRF reseptör antagonistleri ve bunlarla ilgili yöntemler.
NO20012194D0 (no)	2001-05-03	CRF-reseptorantagonister og tilhörende fremgangsmåter
WO2001066534A3 (fr)	2003-10-16	Antagonistes du recepteur d'histamine-3 diamino cycliques et bicycliques
SE9900100D0 (sv)	1999-01-15	New compounds
AP2002002637A0 (en)	2002-09-30	Novel piperazine
MA26846A1 (fr)	2004-12-20	Derives de 2,4-diaminopyrimidine utiles comme agents immunosuppresseurs.
MXPA03006991A (es)	2003-11-18	Derivados de piperidina como antagonistas de neurocinina 1.
ATE343578T1 (de)	2006-11-15	Tri- und tetraaza-acenaphthylen-derivate als crf- rezeptor-antagonisten
MXPA04006571A (es)	2004-10-04	Derivado de pirimidina biciclica fusionada.
TR200101654T2 (tr)	2002-03-21	Vitronektin reseptr antagonistleri
EA200400822A1 (ru)	2004-12-30	Производные 3,4-дигидро-1h-изохинолин-2-ила
DE60100811D1 (de)	2003-10-23	Crf rezeptor-antagonisten und darauf bezogene methoden
ATE260918T1 (de)	2004-03-15	Crf rezeptor-antagonisten und darauf bezogene methoden
SE0103795D0 (sv)	2001-11-02	Compounds and method for the treatment of överactive bladder
EA200400764A1 (ru)	2004-12-30	1,3-диарилпроп-2-ен-1-оны, композиция на их основе и применение
ITUD20020265A1 (it)	2003-03-20	Procedimento per la realizzazione di un pilastro e di un nodo a struttura mista, e pilastro cosi' ottenuto
DE602004012318D1 (de)	2008-04-17	Crf-rezeptorantagonisten und diese betreffende verfahren
IT1317050B1 (it)	2003-05-26	Tetraline 2,6,7-sostituite utili per la preparazione di un medicamentoad attivita' inibitrice della fosfodiesterasi iv.
IT1311584B1 (it)	2002-03-13	Metodo per la realizzazione di calzature, e calzature ottenute contale metodo.