SMT202000131T1 - 6-cloro-3-(fenil-d5)-inden-1-one e loro uso - Google Patents
6-cloro-3-(fenil-d5)-inden-1-one e loro usoInfo
- Publication number
- SMT202000131T1 SMT202000131T1 SM20200131T SMT202000131T SMT202000131T1 SM T202000131 T1 SMT202000131 T1 SM T202000131T1 SM 20200131 T SM20200131 T SM 20200131T SM T202000131 T SMT202000131 T SM T202000131T SM T202000131 T1 SMT202000131 T1 SM T202000131T1
- Authority
- SM
- San Marino
- Prior art keywords
- inden
- chloro
- phenyl
- Prior art date
Links
- VBFPHOYPKVNWMJ-RALIUCGRSA-N 6-chloro-3-(2,3,4,5,6-pentadeuteriophenyl)inden-1-one Chemical compound [2H]C1=C([2H])C([2H])=C([2H])C([2H])=C1C1=CC(=O)C2=CC(Cl)=CC=C12 VBFPHOYPKVNWMJ-RALIUCGRSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
- C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261739095P | 2012-12-19 | 2012-12-19 | |
| DKPA201200811 | 2012-12-19 | ||
| PCT/EP2013/077314 WO2014096151A2 (en) | 2012-12-19 | 2013-12-19 | 6-chloro-3-(phenyl-d5)-inden-1-one and use thereof |
| EP13811511.8A EP2943460B1 (en) | 2012-12-19 | 2013-12-19 | 6-chloro-3-(phenyl-d5)-inden-1-one and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT202000131T1 true SMT202000131T1 (it) | 2020-05-08 |
Family
ID=59295365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM20200131T SMT202000131T1 (it) | 2012-12-19 | 2013-12-19 | 6-cloro-3-(fenil-d5)-inden-1-one e loro uso |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US9309165B2 (it) |
| EP (1) | EP2943460B1 (it) |
| JP (1) | JP6290921B2 (it) |
| KR (1) | KR102212096B1 (it) |
| CN (1) | CN104955796B (it) |
| AR (1) | AR094054A1 (it) |
| AU (1) | AU2013366693B2 (it) |
| BR (1) | BR112015014384A2 (it) |
| CA (1) | CA2893224C (it) |
| CL (1) | CL2015001720A1 (it) |
| CY (1) | CY1122715T1 (it) |
| DK (1) | DK2943460T3 (it) |
| HR (1) | HRP20200385T1 (it) |
| IL (1) | IL239097A (it) |
| LT (1) | LT2943460T (it) |
| MX (1) | MX365707B (it) |
| PL (1) | PL2943460T3 (it) |
| PT (1) | PT2943460T (it) |
| RS (1) | RS59982B1 (it) |
| RU (1) | RU2681221C2 (it) |
| SG (1) | SG11201504437SA (it) |
| SI (1) | SI2943460T1 (it) |
| SM (1) | SMT202000131T1 (it) |
| WO (1) | WO2014096151A2 (it) |
| ZA (1) | ZA201504405B (it) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8575174B2 (en) | 2011-06-20 | 2013-11-05 | H. Lundbeck A/S | Deuterated 1-piperazino-3-phenyl-indanes for treatment of schizophrenia |
| CN104628630B (zh) * | 2015-03-16 | 2017-01-18 | 哈尔滨工业大学 | 一种茚衍生物1‑吡啶基‑2‑溴茚及其合成方法 |
| CN104892492A (zh) * | 2015-06-18 | 2015-09-09 | 哈尔滨工业大学 | 一种茚衍生物1-吡啶基-6-甲基茚及其合成方法 |
| US20210147366A1 (en) * | 2018-04-06 | 2021-05-20 | H. Lundbeck A/S | Process for preparation of 2,2-dimethylpiperazine |
| WO2020089147A1 (en) * | 2018-10-29 | 2020-05-07 | H. Lundbeck A/S | Amorphous compounds of formula (i) and amorphous compounds of formula (i) salts |
| US11535600B2 (en) | 2018-12-03 | 2022-12-27 | H. Lundbeck A/S | Prodrugs of 4-((1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1R,3S)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1H-inden-1-yl)-2,2-dimethyl-1-(methyl-d3)piperazine |
| KR102051783B1 (ko) * | 2019-09-02 | 2019-12-03 | 부산대학교 산학협력단 | 3,10-이치환 벤조풀벤 유도체의 신규 합성방법 |
| CN116251081A (zh) * | 2021-12-09 | 2023-06-13 | 复旦大学 | 3-芳基茚酮类化合物及其药物用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE60571T1 (de) * | 1984-12-04 | 1991-02-15 | Sandoz Ag | Inden-analoga von mevalonolakton und ihre derivate. |
| DE19538218A1 (de) * | 1995-10-13 | 1997-04-17 | Bayer Ag | Cyclopentan-1,3-dion-Derivate |
| JP2001517666A (ja) * | 1997-09-23 | 2001-10-09 | 藤沢薬品工業株式会社 | チアゾール誘導体 |
| SE9904850D0 (sv) * | 1999-12-30 | 1999-12-30 | Pharmacia & Upjohn Ab | Novel process and intermediates |
| MXPA06001838A (es) * | 2003-08-18 | 2006-05-04 | Lundbeck & Co As H | Sales de succinato y malonato de la trans-4- ((ir, 3s)-6 -cloro-3- fenilindan -1-il)-1, 2, 2- trimetilpiperazina y su uso como medicamento. |
| RU2366654C2 (ru) * | 2004-06-08 | 2009-09-10 | ЭнЭсЭйБи, ФИЛИАЛ АФ НЕУРОСЕРЧ СВИДЕН АБ, СВЕРИЙЕ | Новые дизамещенные фенилпиперидины/пиперазины в качестве модуляторов допаминовой нейротрансмиссии |
| TWI453198B (zh) * | 2005-02-16 | 2014-09-21 | Lundbeck & Co As H | 製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s）-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法 |
| CN101273024A (zh) * | 2005-07-29 | 2008-09-24 | 康瑟特制药公司 | 新颖苯并[d][1,3]-二氧杂环戊烯衍生物 |
| WO2008086158A1 (en) * | 2007-01-04 | 2008-07-17 | Smithkline Beecham Corporation | Benzodihydroquinazoline as pi3 kinase inhibitors |
| TW201102370A (en) | 2009-07-07 | 2011-01-16 | Lundbeck & Co As H | Manufacture of 4-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and 1-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-3,3-dimethyl piperazine |
| KR101149529B1 (ko) * | 2009-09-11 | 2012-05-25 | 한국화학연구원 | 인덴온 유도체 및 이를 포함하는 약학적 조성물 |
| CN103209949B (zh) | 2010-11-09 | 2016-08-10 | 株式会社钟化 | 卤化茚酮类及使用其的光学活性茚满酮类或光学活性茚满醇类的制造方法 |
| WO2012093165A1 (en) | 2011-01-07 | 2012-07-12 | H. Lundbeck A/S | Method for resolution of 4-((1r,3s)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and 1-((1r,3s)-6-chloro-3-phenyl-indan, 1-yl)-3,3-dimethyl-piperazine |
| US8575174B2 (en) * | 2011-06-20 | 2013-11-05 | H. Lundbeck A/S | Deuterated 1-piperazino-3-phenyl-indanes for treatment of schizophrenia |
-
2013
- 2013-12-17 AR ARP130104787A patent/AR094054A1/es active IP Right Grant
- 2013-12-19 AU AU2013366693A patent/AU2013366693B2/en active Active
- 2013-12-19 KR KR1020157015940A patent/KR102212096B1/ko active Active
- 2013-12-19 PT PT138115118T patent/PT2943460T/pt unknown
- 2013-12-19 CN CN201380065995.3A patent/CN104955796B/zh active Active
- 2013-12-19 LT LTEP13811511.8T patent/LT2943460T/lt unknown
- 2013-12-19 BR BR112015014384A patent/BR112015014384A2/pt not_active IP Right Cessation
- 2013-12-19 JP JP2015548555A patent/JP6290921B2/ja active Active
- 2013-12-19 RU RU2015123308A patent/RU2681221C2/ru active
- 2013-12-19 RS RS20200220A patent/RS59982B1/sr unknown
- 2013-12-19 HR HRP20200385TT patent/HRP20200385T1/hr unknown
- 2013-12-19 SM SM20200131T patent/SMT202000131T1/it unknown
- 2013-12-19 SI SI201331680T patent/SI2943460T1/sl unknown
- 2013-12-19 CA CA2893224A patent/CA2893224C/en active Active
- 2013-12-19 MX MX2015007727A patent/MX365707B/es active IP Right Grant
- 2013-12-19 DK DK13811511.8T patent/DK2943460T3/da active
- 2013-12-19 PL PL13811511T patent/PL2943460T3/pl unknown
- 2013-12-19 WO PCT/EP2013/077314 patent/WO2014096151A2/en active Application Filing
- 2013-12-19 EP EP13811511.8A patent/EP2943460B1/en active Active
- 2013-12-19 SG SG11201504437SA patent/SG11201504437SA/en unknown
- 2013-12-19 US US14/653,318 patent/US9309165B2/en active Active
-
2015
- 2015-05-31 IL IL239097A patent/IL239097A/en active IP Right Grant
- 2015-06-18 CL CL2015001720A patent/CL2015001720A1/es unknown
- 2015-06-18 ZA ZA2015/04405A patent/ZA201504405B/en unknown
-
2020
- 2020-03-05 CY CY20201100198T patent/CY1122715T1/el unknown
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