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DK2943460T3 - 6-chlor-3-(phenyl-d5)-inden-1-on og anvendelse deraf - Google Patents

6-chlor-3-(phenyl-d5)-inden-1-on og anvendelse deraf Download PDF

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Publication number
DK2943460T3
DK2943460T3 DK13811511.8T DK13811511T DK2943460T3 DK 2943460 T3 DK2943460 T3 DK 2943460T3 DK 13811511 T DK13811511 T DK 13811511T DK 2943460 T3 DK2943460 T3 DK 2943460T3
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DK
Denmark
Prior art keywords
inden
chlor
phenyl
Prior art date
Application number
DK13811511.8T
Other languages
English (en)
Inventor
Mikkel Fog Jacobsen
Sebastian Brandes
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Application granted granted Critical
Publication of DK2943460T3 publication Critical patent/DK2943460T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK13811511.8T 2012-12-19 2013-12-19 6-chlor-3-(phenyl-d5)-inden-1-on og anvendelse deraf DK2943460T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261739095P 2012-12-19 2012-12-19
DKPA201200811 2012-12-19
PCT/EP2013/077314 WO2014096151A2 (en) 2012-12-19 2013-12-19 6-chloro-3-(phenyl-d5)-inden-1-one and use thereof

Publications (1)

Publication Number Publication Date
DK2943460T3 true DK2943460T3 (da) 2020-03-16

Family

ID=59295365

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13811511.8T DK2943460T3 (da) 2012-12-19 2013-12-19 6-chlor-3-(phenyl-d5)-inden-1-on og anvendelse deraf

Country Status (26)

Country Link
US (1) US9309165B2 (da)
EP (1) EP2943460B1 (da)
JP (1) JP6290921B2 (da)
KR (1) KR102212096B1 (da)
CN (1) CN104955796B (da)
AR (1) AR094054A1 (da)
AU (1) AU2013366693B2 (da)
BR (1) BR112015014384A2 (da)
CA (1) CA2893224C (da)
CL (1) CL2015001720A1 (da)
CY (1) CY1122715T1 (da)
DK (1) DK2943460T3 (da)
HK (1) HK1217688A1 (da)
HR (1) HRP20200385T1 (da)
IL (1) IL239097A (da)
LT (1) LT2943460T (da)
MX (1) MX365707B (da)
PL (1) PL2943460T3 (da)
PT (1) PT2943460T (da)
RS (1) RS59982B1 (da)
RU (1) RU2681221C2 (da)
SG (1) SG11201504437SA (da)
SI (1) SI2943460T1 (da)
SM (1) SMT202000131T1 (da)
WO (1) WO2014096151A2 (da)
ZA (1) ZA201504405B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME02513B (me) 2011-06-20 2017-02-20 H Lundbeck As Deuterizovani 1-piperazino-3-fenil indani za tretiranje šizofrenije
CN104628630B (zh) * 2015-03-16 2017-01-18 哈尔滨工业大学 一种茚衍生物1‑吡啶基‑2‑溴茚及其合成方法
CN104892492A (zh) * 2015-06-18 2015-09-09 哈尔滨工业大学 一种茚衍生物1-吡啶基-6-甲基茚及其合成方法
JP2021520382A (ja) * 2018-04-06 2021-08-19 ハー・ルンドベック・アクチエゼルスカベット ２，２−ジメチルピペラジンの調製方法
EP3873885A1 (en) * 2018-10-29 2021-09-08 H. Lundbeck A/S Amorphous compounds of formula (i) and amorphous compounds of formula (i) salts
WO2020114853A1 (en) 2018-12-03 2020-06-11 H. Lundbeck A/S Prodrugs of 4-((1r,3s)-6-chloro-3-phenyl-2,3-dihydro-1h-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1/r,3s)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1h-inden-1-yl)-2,2-dimethy-1-(methyl-d3)piperazine
KR102051783B1 (ko) * 2019-09-02 2019-12-03 부산대학교 산학협력단 3,10-이치환 벤조풀벤 유도체의 신규 합성방법
CN116251081A (zh) * 2021-12-09 2023-06-13 复旦大学 3-芳基茚酮类化合物及其药物用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3581638D1 (de) * 1984-12-04 1991-03-07 Sandoz Ag Inden-analoga von mevalonolakton und ihre derivate.
DE19538218A1 (de) * 1995-10-13 1997-04-17 Bayer Ag Cyclopentan-1,3-dion-Derivate
JP2001517666A (ja) * 1997-09-23 2001-10-09 藤沢薬品工業株式会社 チアゾール誘導体
SE9904850D0 (sv) * 1999-12-30 1999-12-30 Pharmacia & Upjohn Ab Novel process and intermediates
CA2536144C (en) * 2003-08-18 2010-09-14 H. Lundbeck A/S Succinate and malonate salt of trans-4-(ir,3s)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and the use as a medicament
RU2366654C2 (ru) * 2004-06-08 2009-09-10 ЭнЭсЭйБи, ФИЛИАЛ АФ НЕУРОСЕРЧ СВИДЕН АБ, СВЕРИЙЕ Новые дизамещенные фенилпиперидины/пиперазины в качестве модуляторов допаминовой нейротрансмиссии
TWI453198B (zh) * 2005-02-16 2014-09-21 Lundbeck & Co As H 製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s）-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法
CA2616383C (en) * 2005-07-29 2015-06-09 Concert Pharmaceuticals Inc. Novel benzo[d][1,3]-dioxol derivatives
WO2008086158A1 (en) * 2007-01-04 2008-07-17 Smithkline Beecham Corporation Benzodihydroquinazoline as pi3 kinase inhibitors
TW201102370A (en) 2009-07-07 2011-01-16 Lundbeck & Co As H Manufacture of 4-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and 1-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-3,3-dimethyl piperazine
KR101149529B1 (ko) * 2009-09-11 2012-05-25 한국화학연구원 인덴온 유도체 및 이를 포함하는 약학적 조성물
EP2639216B1 (en) 2010-11-09 2018-07-11 Kaneka Corporation Halogenated indenones and method for producing optically active indanones or optically active indanols by using same
AU2012204839A1 (en) 2011-01-07 2013-08-22 H. Lundbeck A/S Method for resolution of 4-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and 1-((1R,3S)-6-chloro-3-phenyl-indan- 1-yl)-3,3-dimethyl-piperazine
ME02513B (me) * 2011-06-20 2017-02-20 H Lundbeck As Deuterizovani 1-piperazino-3-fenil indani za tretiranje šizofrenije

Also Published As

Publication number Publication date
CA2893224A1 (en) 2014-06-26
US20150336867A1 (en) 2015-11-26
MX2015007727A (es) 2015-09-07
SI2943460T1 (sl) 2020-04-30
CN104955796A (zh) 2015-09-30
CA2893224C (en) 2021-01-26
JP2016501901A (ja) 2016-01-21
RU2681221C2 (ru) 2019-03-05
CL2015001720A1 (es) 2015-08-21
EP2943460B1 (en) 2020-02-12
SMT202000131T1 (it) 2020-05-08
RU2015123308A (ru) 2017-01-26
HK1217688A1 (zh) 2017-01-20
HRP20200385T1 (hr) 2020-06-12
US9309165B2 (en) 2016-04-12
PL2943460T3 (pl) 2020-06-29
RS59982B1 (sr) 2020-03-31
AU2013366693A1 (en) 2015-06-11
SG11201504437SA (en) 2015-07-30
CY1122715T1 (el) 2021-05-05
AR094054A1 (es) 2015-07-08
MX365707B (es) 2019-06-11
ZA201504405B (en) 2016-11-30
WO2014096151A2 (en) 2014-06-26
IL239097A0 (en) 2015-07-30
KR20150097511A (ko) 2015-08-26
PT2943460T (pt) 2020-03-25
AU2013366693B2 (en) 2017-07-13
LT2943460T (lt) 2020-04-10
JP6290921B2 (ja) 2018-03-07
WO2014096151A3 (en) 2014-08-28
EP2943460A2 (en) 2015-11-18
KR102212096B1 (ko) 2021-02-04
IL239097A (en) 2017-04-30
CN104955796B (zh) 2017-05-24
BR112015014384A2 (pt) 2020-06-16

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