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SMT201900726T1 - Derivati di isocromene come inibitori della fosfoinositide 3-chinasi - Google Patents

Derivati di isocromene come inibitori della fosfoinositide 3-chinasi

Info

Publication number
SMT201900726T1
SMT201900726T1 SM20190726T SMT201900726T SMT201900726T1 SM T201900726 T1 SMT201900726 T1 SM T201900726T1 SM 20190726 T SM20190726 T SM 20190726T SM T201900726 T SMT201900726 T SM T201900726T SM T201900726 T1 SMT201900726 T1 SM T201900726T1
Authority
SM
San Marino
Prior art keywords
phosphoinositide
kinases inhibitors
isochromene
derivatives
isochromene derivatives
Prior art date
Application number
SM20190726T
Other languages
English (en)
Inventor
Matteo Biagetti
Anna Maria Capelli
Alessandro Accetta
Laura Carzaniga
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of SMT201900726T1 publication Critical patent/SMT201900726T1/it

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/52—Purines, e.g. adenine
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
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    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Epidemiology (AREA)
  • Pulmonology (AREA)
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  • Oncology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SM20190726T 2013-12-18 2014-12-17 Derivati di isocromene come inibitori della fosfoinositide 3-chinasi SMT201900726T1 (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13197986 2013-12-18
PCT/EP2014/078288 WO2015091685A1 (en) 2013-12-18 2014-12-17 Isochromene derivatives as phosphoinositide 3-kinases inhibitors
EP14823973.4A EP3083617B1 (en) 2013-12-18 2014-12-17 Isochromene derivatives as phosphoinositide 3-kinases inhibitors

Publications (1)

Publication Number Publication Date
SMT201900726T1 true SMT201900726T1 (it) 2020-01-14

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SM20190726T SMT201900726T1 (it) 2013-12-18 2014-12-17 Derivati di isocromene come inibitori della fosfoinositide 3-chinasi

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US (1) US9321776B2 (it)
EP (1) EP3083617B1 (it)
JP (1) JP6617973B2 (it)
KR (1) KR102371570B1 (it)
CN (1) CN105829308B (it)
AR (1) AR098776A1 (it)
AU (1) AU2014368725B2 (it)
CA (1) CA2934135C (it)
CL (1) CL2016001543A1 (it)
CY (1) CY1122098T1 (it)
DK (1) DK3083617T3 (it)
EA (1) EA035173B1 (it)
ES (1) ES2755355T3 (it)
GE (1) GEP20196954B (it)
HR (1) HRP20192151T1 (it)
HU (1) HUE046470T2 (it)
IL (1) IL246263B (it)
LT (1) LT3083617T (it)
MA (1) MA47356B1 (it)
MX (1) MX370900B (it)
MY (1) MY181602A (it)
PE (1) PE20160689A1 (it)
PH (1) PH12016501160A1 (it)
PL (1) PL3083617T3 (it)
PT (1) PT3083617T (it)
RS (1) RS59720B1 (it)
SA (1) SA516371350B1 (it)
SG (1) SG11201604908UA (it)
SI (1) SI3083617T1 (it)
SM (1) SMT201900726T1 (it)
TN (1) TN2016000245A1 (it)
TW (1) TWI672297B (it)
UA (1) UA120751C2 (it)
WO (1) WO2015091685A1 (it)
ZA (1) ZA201604084B (it)

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EP3964507A1 (en) 2013-10-04 2022-03-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US9775844B2 (en) 2014-03-19 2017-10-03 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
US9968604B2 (en) 2015-04-16 2018-05-15 Chiesi Farmaceutici S.P.A. Chromene derivatives as phoshoinositide 3-kinases inhibitors
HK1261923A1 (zh) 2015-09-14 2020-01-10 Twelve Therapeutics, Inc. 异喹啉酮衍生物的固体形式、其制备方法、包含其的组合物及其使用方法
EP3411375B1 (en) 2016-02-04 2020-08-05 Chiesi Farmaceutici S.p.A. Pyrazole derivatives as phosphoinositide 3-kinases inhibitors
US10759806B2 (en) 2016-03-17 2020-09-01 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN108623573A (zh) * 2017-03-16 2018-10-09 河北农业大学 一种异香豆素衍生物及其合成方法
GB201706102D0 (en) * 2017-04-18 2017-05-31 Glaxosmithkline Ip Dev Ltd Chemical compounds
ES2969709T3 (es) 2018-10-30 2024-05-22 Chiesi Farm Spa Aparato para administrar fármacos a pacientes ventilados mecánicamente
CN113874376A (zh) * 2019-04-04 2021-12-31 奇斯药制品公司 作为磷酸肌醇3-激酶抑制剂的异色烯衍生物
EP4034079A1 (en) 2019-09-24 2022-08-03 Chiesi Farmaceutici S.p.A. Novel carrier particles for dry powder formulations for inhalation
CN114195818B (zh) * 2021-12-24 2023-11-24 盐城工学院 一种4-芳硫基香豆素类化合物及其制备方法

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