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SK282765B6 - 3-[4-(2-Fenyl-indol-1-ylmetyl)-fenyl]akrylamidy a 2-fenyl-1-[4- (amino-1-yl-alk-1-inyl)-benzyl]-1H-indol-5-oly, farmaceutický prostriedok s ich obsahom a ich použitie - Google Patents

3-[4-(2-Fenyl-indol-1-ylmetyl)-fenyl]akrylamidy a 2-fenyl-1-[4- (amino-1-yl-alk-1-inyl)-benzyl]-1H-indol-5-oly, farmaceutický prostriedok s ich obsahom a ich použitie Download PDF

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Publication number
SK282765B6
SK282765B6 SK471-97A SK47197A SK282765B6 SK 282765 B6 SK282765 B6 SK 282765B6 SK 47197 A SK47197 A SK 47197A SK 282765 B6 SK282765 B6 SK 282765B6
Authority
SK
Slovakia
Prior art keywords
phenyl
alkyl
methyl
compound
hydroxy
Prior art date
Application number
SK471-97A
Other languages
English (en)
Slovak (sk)
Other versions
SK47197A3 (en
Inventor
Chris Paul Miller
Michael David Collini
Bach Dinh Tran
Original Assignee
Wyeth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth filed Critical Wyeth
Publication of SK47197A3 publication Critical patent/SK47197A3/sk
Publication of SK282765B6 publication Critical patent/SK282765B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
SK471-97A 1996-04-19 1997-04-15 3-[4-(2-Fenyl-indol-1-ylmetyl)-fenyl]akrylamidy a 2-fenyl-1-[4- (amino-1-yl-alk-1-inyl)-benzyl]-1H-indol-5-oly, farmaceutický prostriedok s ich obsahom a ich použitie SK282765B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63397296A 1996-04-19 1996-04-19
US63397696A 1996-04-19 1996-04-19

Publications (2)

Publication Number Publication Date
SK47197A3 SK47197A3 (en) 1997-11-05
SK282765B6 true SK282765B6 (sk) 2002-12-03

Family

ID=27092024

Family Applications (1)

Application Number Title Priority Date Filing Date
SK471-97A SK282765B6 (sk) 1996-04-19 1997-04-15 3-[4-(2-Fenyl-indol-1-ylmetyl)-fenyl]akrylamidy a 2-fenyl-1-[4- (amino-1-yl-alk-1-inyl)-benzyl]-1H-indol-5-oly, farmaceutický prostriedok s ich obsahom a ich použitie

Country Status (24)

Country Link
EP (1) EP0802184B1 (cs)
JP (1) JPH1036347A (cs)
KR (1) KR970069986A (cs)
CN (1) CN1103756C (cs)
AR (1) AR006705A1 (cs)
AT (1) ATE219485T1 (cs)
AU (1) AU718888B2 (cs)
BR (1) BR9701879A (cs)
CO (1) CO4950540A1 (cs)
CZ (1) CZ293065B6 (cs)
DE (1) DE69713441T2 (cs)
DK (1) DK0802184T3 (cs)
EA (1) EA000815B1 (cs)
ES (1) ES2179273T3 (cs)
HK (1) HK1002862A1 (cs)
HU (1) HUP9700779A1 (cs)
ID (1) ID16618A (cs)
IL (1) IL120699A0 (cs)
NO (1) NO308214B1 (cs)
NZ (1) NZ314595A (cs)
PT (1) PT802184E (cs)
SK (1) SK282765B6 (cs)
TW (1) TW397821B (cs)
UA (1) UA47413C2 (cs)

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US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
US6369051B1 (en) 2000-07-06 2002-04-09 American Home Products Corporation Combinations of SSRI and estrogenic agents
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
EP1656938A1 (en) 2000-07-06 2006-05-17 Wyeth Combinations of SSRI and estrogenic agents
AR030064A1 (es) * 2000-07-06 2003-08-13 Wyeth Corp Metodos para inhibir los efectos uterotroficos de los agentes estrogenicos
WO2002003986A2 (en) * 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating breast disorders
AU2001273074A1 (en) 2000-07-06 2002-01-21 Wyeth Combinations of ssri and estrogenic agents
WO2002003990A2 (en) * 2000-07-06 2002-01-17 Wyeth Use of substituted insole compounds for treating excessive intraocular pressure
AR029539A1 (es) 2000-07-06 2003-07-02 Wyeth Corp Combinaciones de estatinas y agentes estrogenicos
US6358991B2 (en) 2000-07-06 2002-03-19 American Home Products Corporation Methods of treating neuropeptide Y-related conditions
BR0112360A (pt) * 2000-07-06 2003-05-06 Wyeth Corp Método para aumentar a atividade da sintase de óxido nìtrico
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WO2005100316A1 (en) 2004-04-07 2005-10-27 Wyeth Crystalline polymorph of a bazedoxifene acetate
WO2005100315A1 (en) 2004-04-08 2005-10-27 Wyeth Bazedoxifene ascorbate as selective estrogen receptor modulator
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US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
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EA014878B1 (ru) 2004-10-20 2011-02-28 Эндорешерш, Инк. Предшественники половых стероидов, одни или в сочетании с селективным модулятором эстрогеновых рецепторов и/или с эстрогенами и/или ингибитором цгмф-фосфодиэстераз 5 типа, для профилактики и лечения вагинальной сухости и половой дисфункции у женщин в постменопаузе
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HRP20221462T1 (hr) 2015-12-09 2023-01-20 The Board Of Trustees Of The University Of Illinois Selektivni nishodni regulatori receptora estrogena na bazi benzotiofena
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WO2018081168A2 (en) 2016-10-24 2018-05-03 The Board Of Trustees Of The University Of Illinois Benzothiophene-based selective mixed estrogen receptor downregulators
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Also Published As

Publication number Publication date
JPH1036347A (ja) 1998-02-10
EP0802184B1 (en) 2002-06-19
IL120699A0 (en) 1997-08-14
KR970069986A (ko) 1997-11-07
ATE219485T1 (de) 2002-07-15
DE69713441D1 (de) 2002-07-25
EA000815B1 (ru) 2000-04-24
AU718888B2 (en) 2000-04-20
HK1002862A1 (en) 1998-09-25
CZ293065B6 (cs) 2004-02-18
NO308214B1 (no) 2000-08-14
HU9700779D0 (en) 1997-06-30
NO971814D0 (no) 1997-04-18
DK0802184T3 (da) 2002-09-16
AR006705A1 (es) 1999-09-08
EA199700043A1 (ru) 1997-12-30
HUP9700779A1 (hu) 1999-09-28
EP0802184A1 (en) 1997-10-22
NO971814L (no) 1997-10-20
CO4950540A1 (es) 2000-09-01
CN1168373A (zh) 1997-12-24
SK47197A3 (en) 1997-11-05
PT802184E (pt) 2002-09-30
CN1103756C (zh) 2003-03-26
NZ314595A (en) 2000-04-28
TW397821B (en) 2000-07-11
AU1892197A (en) 1997-10-23
DE69713441T2 (de) 2002-11-07
BR9701879A (pt) 1998-09-29
ID16618A (id) 1997-10-23
UA47413C2 (uk) 2002-07-15
CZ117697A3 (en) 1997-12-17
ES2179273T3 (es) 2003-01-16

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