AR006705A1 - Compuestos de 3-[4-(2-fenil-indol-1-ilmetil)-fenil]-acrilamida y 2-fenil-1-[4-(amino-1-il-alqu-1-inil)-bencil]-1h-indol-5-ol, metodo para preparar medicamentos y composiciones farmaceuticas que los contiene - Google Patents
Compuestos de 3-[4-(2-fenil-indol-1-ilmetil)-fenil]-acrilamida y 2-fenil-1-[4-(amino-1-il-alqu-1-inil)-bencil]-1h-indol-5-ol, metodo para preparar medicamentos y composiciones farmaceuticas que los contieneInfo
- Publication number
- AR006705A1 AR006705A1 ARP970101579A ARP970101579A AR006705A1 AR 006705 A1 AR006705 A1 AR 006705A1 AR P970101579 A ARP970101579 A AR P970101579A AR P970101579 A ARP970101579 A AR P970101579A AR 006705 A1 AR006705 A1 AR 006705A1
- Authority
- AR
- Argentina
- Prior art keywords
- phenyl
- alkyl
- compounds
- indol
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Nuevos compuestos de 3-[4-(2-Fenil-Indol-1-ilmetil)-Fenil]-Acrilamida y nuevos compuestos de 2-Fenil-1-[4-(amino-1il-alqu-1-inil)bencil]-1H-indol-5-ol,que son útiles como agentes estrógenos, así como también con composiciones farmacéuticasy métodos de preparación de medicamentos utilizando estoscompuestos, teniendo los compuestos las fórmulas I y II, en donde R1 es seleccionado de H, OH o los alquil éteres o ésteres C1-C4 de los mismos, ohalógeno; R2, R3, R4, R5 y R6 sonindepe ndientemente seleccionados de H, OH o los alquil éteres o ésteres C1-C4 de los mismos, halógeno, ciano, alquilo C1-C6o trifluormetilo, con la condición de que, cuando R1 es H, R2 no es OH; n es 2 o 3 ; X es seleccionado de H, alquiloC1-C6, ciano, nitro trifluormetilo,halógeno; Z es seleccionado de la fórmula III a) la porción -NR7R8en donde R7 y R8 son independientemente seleccionados del grupo de H alquilo C1-C6 fenilo ocombinados por -(CH2)p, en donde p es un entero de desde2 a 6, de mane ra de formar un anillo, siendo el anillo opcionalmente substituido por hasta tressubstituyentes seleccionados del grupo de hidrógeno, hidróxilo, halo, alquilo C1-C4 trihalomelilo, alcoxi, C1-C4, trihalometoxi, alquiltioC1-C4alquilsulfinil C1-C4 , alquilsulfonil C1-C4, hidroxi alquilo (C1-C4)-CO2H-CN- CONHalquilo (C1-C4)-NH2, alquilamino C1-C4, dialquilamino C1-C4-NHOS2alquilo (C1-C4), -NHCOalquilo(C1-C4), y -NO2; b) un heterociclo de cinco, seis o sietemiembros saturado, insaturado o parcialmente insaturado, que contien hasta dosheteroátomos seleccionados del grupo que consiste en -O-, -NH-Nalquilo C1C4)-, N= y -S(O)m en donde m es un entero de desde 0-2 opcionalmente substituido con1-3substituyentes independientemente selecc ionados del grupo que consiste de hidrógeno, hidroxilo, halo, alquilo C1-C4, trihalomelilo, alcoxi C1-C4
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63397296A | 1996-04-19 | 1996-04-19 | |
| US63397696A | 1996-04-19 | 1996-04-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR006705A1 true AR006705A1 (es) | 1999-09-08 |
Family
ID=27092024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970101579A AR006705A1 (es) | 1996-04-19 | 1997-04-18 | Compuestos de 3-[4-(2-fenil-indol-1-ilmetil)-fenil]-acrilamida y 2-fenil-1-[4-(amino-1-il-alqu-1-inil)-bencil]-1h-indol-5-ol, metodo para preparar medicamentos y composiciones farmaceuticas que los contiene |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0802184B1 (es) |
| JP (1) | JPH1036347A (es) |
| KR (1) | KR970069986A (es) |
| CN (1) | CN1103756C (es) |
| AR (1) | AR006705A1 (es) |
| AT (1) | ATE219485T1 (es) |
| AU (1) | AU718888B2 (es) |
| BR (1) | BR9701879A (es) |
| CO (1) | CO4950540A1 (es) |
| CZ (1) | CZ293065B6 (es) |
| DE (1) | DE69713441T2 (es) |
| DK (1) | DK0802184T3 (es) |
| EA (1) | EA000815B1 (es) |
| ES (1) | ES2179273T3 (es) |
| HK (1) | HK1002862A1 (es) |
| HU (1) | HUP9700779A1 (es) |
| ID (1) | ID16618A (es) |
| IL (1) | IL120699A0 (es) |
| NO (1) | NO308214B1 (es) |
| NZ (1) | NZ314595A (es) |
| PT (1) | PT802184E (es) |
| SK (1) | SK282765B6 (es) |
| TW (1) | TW397821B (es) |
| UA (1) | UA47413C2 (es) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6069153A (en) * | 1998-05-12 | 2000-05-30 | American Home Products Corporation | Indenoindoles and benzocarbazoles as estrogenic agents |
| CN1173973C (zh) * | 1998-05-12 | 2004-11-03 | 惠氏公司 | 苯并咔唑和茚并吲哚衍生的雌激素药 |
| US6479535B1 (en) | 1998-05-15 | 2002-11-12 | Wyeth | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations |
| AU3894299A (en) * | 1998-05-15 | 1999-12-06 | American Home Products Corporation | Compositions comprising 2-phenyl-indole compounds and estrogen formulations |
| AP1424A (en) * | 1998-05-15 | 2005-06-06 | Wyeth Corp | 2-Phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens. |
| US7005428B1 (en) | 1998-06-11 | 2006-02-28 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
| US6465445B1 (en) * | 1998-06-11 | 2002-10-15 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
| AU2004200099B2 (en) * | 1998-06-11 | 2006-11-02 | Endorecherche, Inc. | Medical Uses of A Selective Estrogen Receptor Modulator in Combination with Sex Steroid Precursors |
| NZ517645A (en) * | 1999-09-13 | 2003-09-26 | Wyeth Corp | Glucopyranosides conjugates of 2-(4-hydroxy-phenyl)-1- [4-(2-amin-1-yl-ethoxy)-benzyl]-1H-indol-5-ols |
| US6376486B1 (en) | 2000-07-06 | 2002-04-23 | American Home Products Corporation | Methods of inhibiting sphincter incontinence |
| US6369051B1 (en) | 2000-07-06 | 2002-04-09 | American Home Products Corporation | Combinations of SSRI and estrogenic agents |
| US6455568B2 (en) | 2000-07-06 | 2002-09-24 | Wyeth | Combination therapy for inhibiting sphincter incontinence |
| EP1656938A1 (en) | 2000-07-06 | 2006-05-17 | Wyeth | Combinations of SSRI and estrogenic agents |
| AR030064A1 (es) * | 2000-07-06 | 2003-08-13 | Wyeth Corp | Metodos para inhibir los efectos uterotroficos de los agentes estrogenicos |
| WO2002003986A2 (en) * | 2000-07-06 | 2002-01-17 | Wyeth | Use of substituted indole compounds for treating breast disorders |
| AU2001273074A1 (en) | 2000-07-06 | 2002-01-21 | Wyeth | Combinations of ssri and estrogenic agents |
| WO2002003990A2 (en) * | 2000-07-06 | 2002-01-17 | Wyeth | Use of substituted insole compounds for treating excessive intraocular pressure |
| AR029539A1 (es) | 2000-07-06 | 2003-07-02 | Wyeth Corp | Combinaciones de estatinas y agentes estrogenicos |
| US6358991B2 (en) | 2000-07-06 | 2002-03-19 | American Home Products Corporation | Methods of treating neuropeptide Y-related conditions |
| BR0112360A (pt) * | 2000-07-06 | 2003-05-06 | Wyeth Corp | Método para aumentar a atividade da sintase de óxido nìtrico |
| WO2002003989A2 (en) * | 2000-07-06 | 2002-01-17 | Wyeth | Use of substituted indole compounds for treating sphincter incontinence |
| AR029538A1 (es) | 2000-07-06 | 2003-07-02 | Wyeth Corp | Composiciones farmaceuticas de agentes estrogenicos |
| AU2001271784A1 (en) * | 2000-07-06 | 2002-01-21 | Wyeth | Therapy for prosthesis-related bone degeneration |
| EA014224B1 (ru) * | 2000-08-24 | 2010-10-29 | Юниверсити Оф Теннесси Рисерч Фаундейшн | Селективные модуляторы андрогенового рецептора и способы их применения |
| US7056931B2 (en) | 2001-05-22 | 2006-06-06 | Eli Lilly And Company | 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods |
| ES2236536T3 (es) | 2001-05-22 | 2005-07-16 | Eli Lilly And Company | Derivados tetrahidroquinolino para la inhibicion de enfermedades asociadas con la privacion de estrogenos o con una respuesta fisiologica aberrante a estrogenos endogenos. |
| US7683052B2 (en) | 2004-04-07 | 2010-03-23 | Wyeth | Crystalline polymorph of bazedoxifene acetate |
| WO2005100316A1 (en) | 2004-04-07 | 2005-10-27 | Wyeth | Crystalline polymorph of a bazedoxifene acetate |
| WO2005100315A1 (en) | 2004-04-08 | 2005-10-27 | Wyeth | Bazedoxifene ascorbate as selective estrogen receptor modulator |
| KR20070083484A (ko) | 2004-07-14 | 2007-08-24 | 피티씨 테라퓨틱스, 인크. | Ｃ형 간염 치료 방법 |
| US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| JP2008507518A (ja) | 2004-07-22 | 2008-03-13 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｃ型肝炎を治療するためのチエノピリジン |
| EA014878B1 (ru) | 2004-10-20 | 2011-02-28 | Эндорешерш, Инк. | Предшественники половых стероидов, одни или в сочетании с селективным модулятором эстрогеновых рецепторов и/или с эстрогенами и/или ингибитором цгмф-фосфодиэстераз 5 типа, для профилактики и лечения вагинальной сухости и половой дисфункции у женщин в постменопаузе |
| JP4568361B2 (ja) | 2005-04-22 | 2010-10-27 | アラントス・ファーマシューティカルズ・ホールディング・インコーポレーテッド | ジペプチジルペプチダーゼ−ｉｖ阻害剤 |
| US8268806B2 (en) | 2007-08-10 | 2012-09-18 | Endorecherche, Inc. | Pharmaceutical compositions |
| US20100317635A1 (en) | 2009-06-16 | 2010-12-16 | Endorecherche, Inc. | Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators |
| US11576891B2 (en) | 2010-06-16 | 2023-02-14 | Endorecherche, Inc. | Methods of treating or preventing estrogen-related diseases |
| US9744177B2 (en) | 2014-03-10 | 2017-08-29 | Endorecherche, Inc. | Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM |
| RU2733741C2 (ru) | 2015-05-29 | 2020-10-06 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Тетразамещенные алкеновые соединения и их применение |
| PL3355884T3 (pl) | 2015-10-01 | 2021-11-29 | Olema Pharmaceuticals, Inc. | Tetrahydro-1H-pirydo[3,4-b]indolowe leki antyestrogenowe |
| HRP20221462T1 (hr) | 2015-12-09 | 2023-01-20 | The Board Of Trustees Of The University Of Illinois | Selektivni nishodni regulatori receptora estrogena na bazi benzotiofena |
| WO2017162206A1 (zh) * | 2016-03-25 | 2017-09-28 | 南京明德新药研发股份有限公司 | 作为雌激素受体降解剂的吲哚并取代哌啶类化合物 |
| WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
| EP4483875A2 (en) | 2016-05-10 | 2025-01-01 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| WO2017197051A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Amine-linked c3-glutarimide degronimers for target protein degradation |
| CN109562107A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的杂环降解决定子体 |
| CN109789143A (zh) | 2016-07-01 | 2019-05-21 | G1治疗公司 | 基于嘧啶的抗增殖剂 |
| WO2018081168A2 (en) | 2016-10-24 | 2018-05-03 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective mixed estrogen receptor downregulators |
| WO2018097273A1 (en) | 2016-11-28 | 2018-05-31 | Eisai R&D Management Co., Ltd. | Salts of indazole derivative and crystals thereof |
| EP3565558B1 (en) | 2017-01-06 | 2023-12-06 | G1 Therapeutics, Inc. | Combination therapy with a serd compound and a cdk4/6 inhibitor for the treatment of cancer |
| AU2018217809A1 (en) | 2017-02-10 | 2019-08-22 | G1 Therapeutics, Inc. | Benzothiophene estrogen receptor modulators |
| RU2019142591A (ru) | 2017-06-29 | 2021-07-29 | Г1 Терапьютикс, Инк. | Морфологические формы g1t38 и способы их получения |
| CN113453679A (zh) | 2018-12-20 | 2021-09-28 | C4医药公司 | 靶向蛋白降解 |
| CN118344370A (zh) | 2019-12-20 | 2024-07-16 | C4医药公司 | 用于egfr降解的异吲哚啉酮和吲唑化合物 |
| MX2022010952A (es) | 2020-03-05 | 2022-10-07 | C4 Therapeutics Inc | Compuestos para la degradacion dirigida de brd9. |
| WO2024030968A1 (en) | 2022-08-03 | 2024-02-08 | Brystol-Myers Squibb Company | Compounds for modulating ret protein |
| WO2024097980A1 (en) | 2022-11-04 | 2024-05-10 | Bristol-Myers Squibb Company | Ret-ldd protein inhibitors |
| WO2024097989A1 (en) | 2022-11-04 | 2024-05-10 | Bristol-Myers Squibb Company | Ret-ldd protein degraders |
| WO2025006753A2 (en) | 2023-06-30 | 2025-01-02 | Merck Patent Gmbh | Heterobifunctional compounds for the degradation of kras protein |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3232968A1 (de) * | 1981-09-10 | 1983-06-09 | Degussa Ag, 6000 Frankfurt | Neue 2-(hydroxy-phenyl)-indole und verfahren zu deren herstellung |
| DE3821148A1 (de) * | 1988-06-23 | 1989-12-28 | Erwin Von Dr Angerer | Aminoalkylindole, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
| GB9108811D0 (en) * | 1991-04-24 | 1991-06-12 | Erba Carlo Spa | N-imidazolyl derivatives of substituted indole |
| RU2061694C1 (ru) * | 1991-09-11 | 1996-06-10 | Е.Р.Сквибб энд Санз, Инк., | Производные индола |
| FR2708605A1 (fr) * | 1993-07-30 | 1995-02-10 | Sanofi Sa | Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
| EP0639567A1 (en) * | 1992-05-08 | 1995-02-22 | Otsuka Pharmaceutical Factory, Inc. | Indole derivative |
| GB9326332D0 (en) * | 1993-12-23 | 1994-02-23 | Karo Bio | Indole derivatives |
| CA2183731C (en) * | 1994-02-22 | 2000-03-21 | Alan J. Bitonti | Novel indole derivatives useful to treat estrogen-related neoplasms and disorders |
| DE4426625A1 (de) * | 1994-07-27 | 1996-03-14 | Schering Ag | 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
-
1997
- 1997-04-09 TW TW086104511A patent/TW397821B/zh active
- 1997-04-14 NZ NZ314595A patent/NZ314595A/xx unknown
- 1997-04-15 AT AT97302577T patent/ATE219485T1/de not_active IP Right Cessation
- 1997-04-15 EP EP97302577A patent/EP0802184B1/en not_active Expired - Lifetime
- 1997-04-15 ES ES97302577T patent/ES2179273T3/es not_active Expired - Lifetime
- 1997-04-15 SK SK471-97A patent/SK282765B6/sk unknown
- 1997-04-15 PT PT97302577T patent/PT802184E/pt unknown
- 1997-04-15 DK DK97302577T patent/DK0802184T3/da active
- 1997-04-15 DE DE69713441T patent/DE69713441T2/de not_active Expired - Fee Related
- 1997-04-17 CZ CZ19971176A patent/CZ293065B6/cs not_active IP Right Cessation
- 1997-04-17 ID IDP971302A patent/ID16618A/id unknown
- 1997-04-17 AU AU18921/97A patent/AU718888B2/en not_active Ceased
- 1997-04-17 CO CO97020214A patent/CO4950540A1/es unknown
- 1997-04-17 UA UA97041832A patent/UA47413C2/uk unknown
- 1997-04-18 NO NO971814A patent/NO308214B1/no not_active IP Right Cessation
- 1997-04-18 HU HU9700779A patent/HUP9700779A1/hu unknown
- 1997-04-18 EA EA199700043A patent/EA000815B1/ru not_active IP Right Cessation
- 1997-04-18 JP JP9101557A patent/JPH1036347A/ja active Pending
- 1997-04-18 IL IL12069997A patent/IL120699A0/xx unknown
- 1997-04-18 CN CN97111251A patent/CN1103756C/zh not_active Expired - Fee Related
- 1997-04-18 KR KR1019970014302A patent/KR970069986A/ko not_active Application Discontinuation
- 1997-04-18 AR ARP970101579A patent/AR006705A1/es not_active Application Discontinuation
- 1997-04-22 BR BR9701879A patent/BR9701879A/pt not_active Application Discontinuation
-
1998
- 1998-03-10 HK HK98101957A patent/HK1002862A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH1036347A (ja) | 1998-02-10 |
| EP0802184B1 (en) | 2002-06-19 |
| IL120699A0 (en) | 1997-08-14 |
| KR970069986A (ko) | 1997-11-07 |
| ATE219485T1 (de) | 2002-07-15 |
| DE69713441D1 (de) | 2002-07-25 |
| EA000815B1 (ru) | 2000-04-24 |
| AU718888B2 (en) | 2000-04-20 |
| HK1002862A1 (en) | 1998-09-25 |
| CZ293065B6 (cs) | 2004-02-18 |
| NO308214B1 (no) | 2000-08-14 |
| HU9700779D0 (en) | 1997-06-30 |
| NO971814D0 (no) | 1997-04-18 |
| DK0802184T3 (da) | 2002-09-16 |
| EA199700043A1 (ru) | 1997-12-30 |
| HUP9700779A1 (hu) | 1999-09-28 |
| EP0802184A1 (en) | 1997-10-22 |
| NO971814L (no) | 1997-10-20 |
| CO4950540A1 (es) | 2000-09-01 |
| CN1168373A (zh) | 1997-12-24 |
| SK47197A3 (en) | 1997-11-05 |
| PT802184E (pt) | 2002-09-30 |
| CN1103756C (zh) | 2003-03-26 |
| NZ314595A (en) | 2000-04-28 |
| TW397821B (en) | 2000-07-11 |
| AU1892197A (en) | 1997-10-23 |
| DE69713441T2 (de) | 2002-11-07 |
| BR9701879A (pt) | 1998-09-29 |
| SK282765B6 (sk) | 2002-12-03 |
| ID16618A (id) | 1997-10-23 |
| UA47413C2 (uk) | 2002-07-15 |
| CZ117697A3 (en) | 1997-12-17 |
| ES2179273T3 (es) | 2003-01-16 |
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