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SK281865B6 - Indolový derivát a jeho optický izomér, spôsob jeho prípravy a farmaceutický prostriedok - Google Patents

Indolový derivát a jeho optický izomér, spôsob jeho prípravy a farmaceutický prostriedok Download PDF

Info

Publication number
SK281865B6
SK281865B6 SK656-97A SK65697A SK281865B6 SK 281865 B6 SK281865 B6 SK 281865B6 SK 65697 A SK65697 A SK 65697A SK 281865 B6 SK281865 B6 SK 281865B6
Authority
SK
Slovakia
Prior art keywords
group
formula
salt
indole derivative
lower alkyl
Prior art date
Application number
SK656-97A
Other languages
English (en)
Slovak (sk)
Other versions
SK65697A3 (en
Inventor
Shiro Kato
Hiroshi Harada
Yoshimi Hirokawa
Naoyuki Yoshida
Hitoshi Kawashima
Original Assignee
Dainippon Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co., Ltd. filed Critical Dainippon Pharmaceutical Co., Ltd.
Publication of SK65697A3 publication Critical patent/SK65697A3/sk
Publication of SK281865B6 publication Critical patent/SK281865B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK656-97A 1994-11-29 1995-11-27 Indolový derivát a jeho optický izomér, spôsob jeho prípravy a farmaceutický prostriedok SK281865B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP06321402 1994-11-29
PCT/JP1995/002400 WO1996016938A1 (en) 1994-11-29 1995-11-27 Indole derivative

Publications (2)

Publication Number Publication Date
SK65697A3 SK65697A3 (en) 1998-01-14
SK281865B6 true SK281865B6 (sk) 2001-08-06

Family

ID=18132155

Family Applications (1)

Application Number Title Priority Date Filing Date
SK656-97A SK281865B6 (sk) 1994-11-29 1995-11-27 Indolový derivát a jeho optický izomér, spôsob jeho prípravy a farmaceutický prostriedok

Country Status (28)

Country Link
US (1) US5817689A (xx)
EP (1) EP0801059B1 (xx)
JP (1) JP3100165B2 (xx)
KR (1) KR100388747B1 (xx)
CN (1) CN1070477C (xx)
AT (1) ATE202559T1 (xx)
AU (1) AU688165B2 (xx)
BR (1) BR9509827A (xx)
CA (1) CA2206307A1 (xx)
CY (1) CY2247B1 (xx)
CZ (1) CZ290871B6 (xx)
DE (1) DE69521529T2 (xx)
DK (1) DK0801059T3 (xx)
ES (1) ES2159648T3 (xx)
FI (1) FI972275L (xx)
GR (1) GR3036148T3 (xx)
HU (1) HUT77308A (xx)
IL (1) IL116178A (xx)
NO (1) NO309648B1 (xx)
NZ (1) NZ295749A (xx)
PL (1) PL181963B1 (xx)
PT (1) PT801059E (xx)
RO (1) RO118426B1 (xx)
RU (1) RU2137759C1 (xx)
SK (1) SK281865B6 (xx)
TW (1) TW349091B (xx)
WO (1) WO1996016938A1 (xx)
ZA (1) ZA9510130B (xx)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20010580A1 (es) * 1999-09-03 2001-05-25 Takeda Chemical Industries Ltd Composicion farmaceutica para tratar la diabetes
SK7362002A3 (en) * 1999-11-30 2003-02-04 Dianippon Pharmaceutical Co Lt Solid pharmaceutical preparation
US6458824B1 (en) * 1999-11-30 2002-10-01 Dainippon Pharmaceutical Co., Ltd. Solid preparation
JP2004331500A (ja) * 2001-02-16 2004-11-25 Dainippon Pharmaceut Co Ltd 血中濃度制御製剤
EP2335700A1 (en) * 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
AU2003225277A1 (en) * 2002-05-02 2003-11-17 Robert Harris Lipid removal from the body
US7217724B2 (en) * 2002-06-12 2007-05-15 Dainippon Sumitomo Pharma Co., Ltd. Indole, indazole, and benzazole derivative
DE602004009295T2 (de) * 2003-01-14 2008-07-03 Arena Pharmaceuticals, Inc., San Diego 1,2,3-trisubstituierte aryl- und heteroarylderivate als modulatoren des metabolismus zur vorbeugung und behandlung von metabolismus-bedingten krankheiten wie diabetes oder hyperglykämie
EP1927594A1 (en) * 2003-01-14 2008-06-04 Arena Pharmaceuticals, Inc. 1,2,3-Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
US7223785B2 (en) * 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7098231B2 (en) * 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
WO2004089936A1 (ja) * 2003-04-10 2004-10-21 Dainippon Pharmaceutical Co., Ltd. ヘテロアリールスルホン酸アニリド誘導体及びそれを含有する医薬組成物
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
BRPI0416639A (pt) * 2003-11-19 2007-01-16 Metabasis Therapeutics Inc tiromiméticos contendo fósforo
CA2553879C (en) 2004-02-20 2011-02-22 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
DOP2006000010A (es) 2005-01-10 2006-07-31 Arena Pharm Inc Procedimiento para preparar eteres aromáticos
MY148521A (en) 2005-01-10 2013-04-30 Arena Pharm Inc Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
US8076365B2 (en) * 2005-08-12 2011-12-13 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
KR101871011B1 (ko) 2010-09-22 2018-06-25 아레나 파마슈티칼스, 인크. Ｇｐｒ１１９ 수용체의 조절제 및 그와 관련된 장애의 치료
ES2394349B1 (es) 2012-08-29 2013-11-04 Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii Uso de agonistas selectivos de receptores beta-3 adrenérgicos para el tratamiento de hipertensión pulmonar
WO2015199097A1 (ja) * 2014-06-24 2015-12-30 花王株式会社 Ｕｃｐ－１発現促進剤
US10758519B2 (en) 2014-06-24 2020-09-01 Kao Corporation UCP-1 expression promoter
JP6660668B2 (ja) * 2014-06-24 2020-03-11 花王株式会社 Ｕｃｐ−１発現促進剤
MX386419B (es) 2015-01-06 2025-03-18 Arena Pharm Inc Metodos de condiciones de tratamiento relacionadas con el receptor s1p1.
US10301262B2 (en) 2015-06-22 2019-05-28 Arena Pharmaceuticals, Inc. Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compund1) for use in SIPI receptor-associated disorders
BR112020024762A2 (pt) 2018-06-06 2021-03-23 Arena Pharmaceuticals, Inc. métodos de tratamento de condições relacionadas ao receptor s1p1

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB861428A (en) * 1958-07-14 1961-02-22 Searle & Co Improvements in or relating to indole derivatives
US4055658A (en) * 1976-05-17 1977-10-25 Mead Johnson & Company Cyanomethylphenethanolamines
DE3061334D1 (en) * 1979-06-16 1983-01-20 Beecham Group Plc Ethanamine derivatives, their preparation and use in pharmaceutical compositions
FR2541999B1 (fr) * 1983-03-04 1986-09-19 Bristol Myers Co Phenethanolamines et leurs utilisations
JPH06345731A (ja) * 1992-04-28 1994-12-20 Dainippon Pharmaceut Co Ltd ２−〔２−（インドール−３−イル）エチルアミノ〕−１−フェニルエタノール誘導体
JPH0634531A (ja) * 1992-07-14 1994-02-08 Yokogawa Electric Corp 赤外線水分計

Also Published As

Publication number Publication date
JP3100165B2 (ja) 2000-10-16
CZ290871B6 (cs) 2002-11-13
CN1070477C (zh) 2001-09-05
CN1174549A (zh) 1998-02-25
ATE202559T1 (de) 2001-07-15
NZ295749A (en) 1998-05-27
BR9509827A (pt) 1997-09-30
NO972427D0 (no) 1997-05-28
PL320461A1 (en) 1997-09-29
EP0801059A4 (en) 1998-01-21
ZA9510130B (en) 1996-06-11
DE69521529T2 (de) 2001-10-11
RU2137759C1 (ru) 1999-09-20
PL181963B1 (pl) 2001-10-31
AU3936695A (en) 1996-06-19
RO118426B1 (ro) 2003-05-30
CZ165597A3 (en) 1997-11-12
SK65697A3 (en) 1998-01-14
HUT77308A (hu) 1998-03-30
ES2159648T3 (es) 2001-10-16
MX9703858A (es) 1997-09-30
IL116178A0 (en) 1996-01-31
WO1996016938A1 (en) 1996-06-06
GR3036148T3 (en) 2001-09-28
IL116178A (en) 2000-07-26
HK1003886A1 (en) 1998-11-13
DE69521529D1 (de) 2001-08-02
KR100388747B1 (ko) 2004-03-30
US5817689A (en) 1998-10-06
FI972275A7 (fi) 1997-05-29
NO972427L (no) 1997-07-28
NO309648B1 (no) 2001-03-05
EP0801059A1 (en) 1997-10-15
AU688165B2 (en) 1998-03-05
FI972275A0 (fi) 1997-05-29
CY2247B1 (en) 2003-07-04
PT801059E (pt) 2001-10-30
DK0801059T3 (da) 2001-09-24
EP0801059B1 (en) 2001-06-27
TW349091B (en) 1999-01-01
FI972275L (fi) 1997-05-29
CA2206307A1 (en) 1996-06-06

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