SK13952002A3 - Farmaceutická kompozícia na liečenie akútnej, chronickej a/alebo neuropatickej bolesti a migrén - Google Patents
Farmaceutická kompozícia na liečenie akútnej, chronickej a/alebo neuropatickej bolesti a migrén Download PDFInfo
- Publication number
- SK13952002A3 SK13952002A3 SK1395-2002A SK13952002A SK13952002A3 SK 13952002 A3 SK13952002 A3 SK 13952002A3 SK 13952002 A SK13952002 A SK 13952002A SK 13952002 A3 SK13952002 A3 SK 13952002A3
- Authority
- SK
- Slovakia
- Prior art keywords
- triene
- methyl
- hexahydro
- methano
- pyrido
- Prior art date
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19573800P | 2000-04-07 | 2000-04-07 | |
PCT/IB2001/000391 WO2001076576A2 (fr) | 2000-04-07 | 2001-03-16 | Composition pharmaceutique servant a traiter une douleur chronique aigue et/ou une douleur neurophatique ou des migraines |
Publications (1)
Publication Number | Publication Date |
---|---|
SK13952002A3 true SK13952002A3 (sk) | 2003-12-02 |
Family
ID=22722582
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK1395-2002A SK13952002A3 (sk) | 2000-04-07 | 2001-03-16 | Farmaceutická kompozícia na liečenie akútnej, chronickej a/alebo neuropatickej bolesti a migrén |
Country Status (35)
Country | Link |
---|---|
US (2) | US20010036943A1 (fr) |
EP (1) | EP1272218B1 (fr) |
JP (1) | JP2003530345A (fr) |
KR (1) | KR20030040201A (fr) |
CN (1) | CN1468111A (fr) |
AP (1) | AP2002002642A0 (fr) |
AR (1) | AR027773A1 (fr) |
AT (1) | ATE291438T1 (fr) |
AU (1) | AU3768001A (fr) |
BG (1) | BG107138A (fr) |
BR (1) | BR0109837A (fr) |
CA (1) | CA2405142A1 (fr) |
CR (1) | CR6767A (fr) |
CZ (1) | CZ20023214A3 (fr) |
DE (1) | DE60109589T2 (fr) |
EA (1) | EA004930B1 (fr) |
EE (1) | EE200200579A (fr) |
ES (1) | ES2236185T3 (fr) |
GT (1) | GT200100055A (fr) |
HU (1) | HUP0301822A3 (fr) |
IL (1) | IL152076A0 (fr) |
IS (1) | IS6560A (fr) |
MA (1) | MA26889A1 (fr) |
MX (1) | MXPA02009817A (fr) |
NO (1) | NO20024734D0 (fr) |
OA (1) | OA12241A (fr) |
PA (1) | PA8515001A1 (fr) |
PE (1) | PE20011307A1 (fr) |
PL (1) | PL365957A1 (fr) |
SK (1) | SK13952002A3 (fr) |
SV (1) | SV2002000377A (fr) |
TN (1) | TNSN01053A1 (fr) |
WO (1) | WO2001076576A2 (fr) |
YU (1) | YU74602A (fr) |
ZA (1) | ZA200207996B (fr) |
Families Citing this family (111)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9710536A (pt) | 1996-07-24 | 1999-08-17 | Warner Lambert Co | Isobutilgaba e seus derivados para o tratamento da dor |
US6464986B1 (en) * | 2000-04-14 | 2002-10-15 | Allegan Sales, Inc. | Method for treating pain by peripheral administration of a neurotoxin |
US7074961B2 (en) | 2000-09-26 | 2006-07-11 | The Brigham And Women's Hospital, Inc. | Antidepressants and their analogues as long-acting local anesthetics and analgesics |
WO2002026020A2 (fr) * | 2000-09-26 | 2002-04-04 | The Brigham And Women's Hospital, Inc. | Antidepresseurs tricycliques et leurs analogues comme anesthesiques et analgesiques locaux de longue duree |
AU2002234836B2 (en) * | 2001-04-20 | 2007-08-23 | Pfizer Products Inc. | Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds |
US8309570B2 (en) * | 2001-06-07 | 2012-11-13 | Analgesic Neuropharmaceuticals, Llc | Treatment of central neuropathic pain |
AR036040A1 (es) | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen |
SE521512C2 (sv) | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
US20040138239A1 (en) * | 2001-08-23 | 2004-07-15 | Bruce Frome | Compositions and methods for targeting cerebral circulation and treatment of headache |
JP2005504058A (ja) | 2001-08-24 | 2005-02-10 | ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー | 疾患の治療のための置換ヘテロアリール−7−アザ[2.2.1]ビシクロヘプタン |
CZ2004408A3 (cs) | 2001-10-02 | 2005-03-16 | Pharmacia & Upjohn Company | Azabicyklicky substituované kondenzované heteroarylsloučeniny |
TWI312285B (en) | 2001-10-25 | 2009-07-21 | Depomed Inc | Methods of treatment using a gastric retained gabapentin dosage |
US7612112B2 (en) | 2001-10-25 | 2009-11-03 | Depomed, Inc. | Methods of treatment using a gastric retained gabapentin dosage |
US6849620B2 (en) | 2001-10-26 | 2005-02-01 | Pfizer Inc | N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease |
US6602911B2 (en) | 2001-11-05 | 2003-08-05 | Cypress Bioscience, Inc. | Methods of treating fibromyalgia |
JP2005510523A (ja) | 2001-11-09 | 2005-04-21 | ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー | アザ二環式フェニル縮合複素環式化合物、及びα7NACHRリガンドとしての当該化合物の使用 |
WO2003049753A1 (fr) * | 2001-12-13 | 2003-06-19 | Council Of Scientific And Industrial Research | Le zingiber officinale de linn et ses extraits et fractions en tant que renforçateurs de biodisponibilite |
CN1627944A (zh) * | 2002-01-17 | 2005-06-15 | 神经能质公司 | 取代的喹唑啉-4-基胺类似物作为辣椒辣素调节剂 |
WO2003066040A1 (fr) * | 2002-02-05 | 2003-08-14 | Ajinomoto Co.,Inc. | Compositions medicinales contenant une gabapentine ou une pregabaline et antagoniste a canal de calcium de type n |
EP1482921A1 (fr) * | 2002-02-12 | 2004-12-08 | Cypress Bioscience, Inc. | Methodes de traitement du trouble d'hyperactivite avec deficit de l'attention (thada) |
WO2003070728A2 (fr) | 2002-02-15 | 2003-08-28 | Pharmacia & Upjohn Company | Composes aryle substitues permettant de traiter une maladie |
AU2003217275A1 (en) | 2002-02-19 | 2003-09-09 | Pharmacia And Upjohn Company | Azabicyclic compounds for the treatment of disease |
AU2003219690A1 (en) | 2002-02-19 | 2003-09-09 | Pharmacia And Upjohn Company | Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease |
MXPA04011529A (es) * | 2002-04-24 | 2005-08-15 | Cypress Bioscience Inc | Prevencion y tratamiento de trastornos somaticos funcionales, incluyendo trastornos relacionados con la tension. |
US6921538B2 (en) * | 2002-05-10 | 2005-07-26 | Allergan, Inc. | Therapeutic treatments for neuropsychiatric disorders |
WO2003097038A1 (fr) * | 2002-05-14 | 2003-11-27 | Ralph Ryback | Procede de traitement de dermatoses et de dommages tissulaires |
JP2006504634A (ja) * | 2002-05-15 | 2006-02-09 | アボット・ラボラトリーズ | 神経障害性疼痛の治療 |
MXPA04011416A (es) | 2002-05-17 | 2005-09-30 | Othera Pharmaceuticals Inc | Mejora del desarrollo de las cataratas y otras enfermedades oftalmicas. |
JP2006509735A (ja) * | 2002-10-17 | 2006-03-23 | ノバルティス アクチエンゲゼルシャフト | オクスカルバゼピンまたはその誘導体およびcox2インヒビターからなる疼痛処置用医薬組成物 |
JP4565087B2 (ja) | 2002-12-02 | 2010-10-20 | ゼノム リミティッド | 新規なχ−コノトキシン・ペプチド(−I) |
EP1578787B1 (fr) | 2002-12-02 | 2012-11-14 | Xenome Ltd | Nouveaux peptides de chi-conotoxine (-ii) |
US20040204411A1 (en) * | 2002-12-17 | 2004-10-14 | Pharmacia Corporation | Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of reboxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof |
JP4708795B2 (ja) | 2002-12-20 | 2011-06-22 | ニコノヴァム エービー | 物理的および化学的に安定なニコチン−含有粒状物質 |
WO2004078201A1 (fr) * | 2003-03-06 | 2004-09-16 | Botulinum Toxin Research Associates, Inc. | Traitement des cephalees et des douleurs faciales chroniques associees a la sinusite au moyen de toxine botulinique |
US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
WO2004092122A2 (fr) * | 2003-04-08 | 2004-10-28 | Algorx Pharmaceuticals, Inc. | Preparation et purification de capsicine synthetique |
WO2004105690A2 (fr) * | 2003-05-23 | 2004-12-09 | Cypress Bioscience, Inc. | Traitement de douleurs chroniques au moyen de chimiotherapie ou de radiotherapie |
US8030300B2 (en) | 2003-06-10 | 2011-10-04 | Georgetown University | Ligands for nicotinic acetylcholine receptors, and methods of making and using them |
US20050004219A1 (en) * | 2003-07-01 | 2005-01-06 | Medtronic, Inc. | Pump systems including injectable gabapentin compositions |
US20050004221A1 (en) * | 2003-07-01 | 2005-01-06 | Medtronic, Inc. | Intrathecal gabapentin compositions |
US20050043407A1 (en) * | 2003-08-22 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
US20050043406A1 (en) * | 2003-08-22 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss |
US20050058696A1 (en) * | 2003-09-12 | 2005-03-17 | Allergan, Inc. | Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions |
US7268109B2 (en) * | 2003-10-02 | 2007-09-11 | Elan Pharmaceuticals, Inc. | Method for reducing pain |
US20050090549A1 (en) * | 2003-10-23 | 2005-04-28 | Medtronic, Inc. | Intrathecal gabapentin for treatment of pain |
US20050090548A1 (en) * | 2003-10-23 | 2005-04-28 | Medtronic, Inc. | Intrathecal gabapentin for treatment of epilepsy |
JP2007511520A (ja) | 2003-11-13 | 2007-05-10 | ザ ジェネラル ホスピタル コーポレーション | 疼痛を治療するための方法 |
US8871224B2 (en) | 2003-12-09 | 2014-10-28 | Allergan, Inc. | Botulinum toxin therapy for skin disorders |
HU230403B1 (hu) * | 2003-12-19 | 2016-04-28 | Pál Kocsis | Nátrium csatorna blokkoló és szerotonin újrafelvétel gátló tartalmú gyógyszerkészítmény |
US20100266638A1 (en) * | 2004-02-26 | 2010-10-21 | Allergan, Inc. | Headache treatment method |
US20050220734A1 (en) * | 2004-04-02 | 2005-10-06 | Allergan, Inc. | Therapy for melanin related afflictions |
EP1765300A2 (fr) * | 2004-06-10 | 2007-03-28 | Duramed Pharmaceuticals, Inc. | Formulations de sumatriptan absorbables au travers des membranes biologiques, et methodes de production et d'utilisation desdites formulations |
MY147767A (en) | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
WO2006047279A2 (fr) * | 2004-10-21 | 2006-05-04 | University Of Iowa Research Foundation | Systeme d'administration in situ de medicaments a liberation controlee |
WO2006053012A2 (fr) * | 2004-11-10 | 2006-05-18 | Trinity Laboratories, Inc. | Nouvelles compositions pharmaceutiques destinees a traiter la douleur chronique acquise et la dysphorie associee |
EA200701131A1 (ru) * | 2004-11-24 | 2007-12-28 | Алгоркс Фармасьютикалз, Инк. | Гелеобразная препаративная форма капсаициноида и способы её применения |
US20060252745A1 (en) | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
AU2006249577A1 (en) | 2005-05-20 | 2006-11-30 | Janssen Pharmaceutica N.V. | Process for preparation of sulfamide derivatives |
US7994220B2 (en) | 2005-09-28 | 2011-08-09 | Cypress Bioscience, Inc. | Milnacipran for the long-term treatment of fibromyalgia syndrome |
US8716231B2 (en) | 2005-12-19 | 2014-05-06 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain |
US8691867B2 (en) | 2005-12-19 | 2014-04-08 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction |
US8937096B2 (en) | 2005-12-19 | 2015-01-20 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder |
US8492431B2 (en) | 2005-12-19 | 2013-07-23 | Janssen Pharmaceutica, N.V. | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity |
US8497298B2 (en) | 2005-12-19 | 2013-07-30 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels |
US20090176882A1 (en) * | 2008-12-09 | 2009-07-09 | Depomed, Inc. | Gastric retentive gabapentin dosage forms and methods for using same |
GB0603008D0 (en) * | 2006-02-14 | 2006-03-29 | Portela & Ca Sa | Method |
WO2007104573A2 (fr) | 2006-03-16 | 2007-09-20 | Niconovum Ab | Composition améliorée de tabac à priser |
JP2007308403A (ja) * | 2006-05-17 | 2007-11-29 | Kenji Yoshida | 皮膚外用剤 |
WO2007137167A2 (fr) | 2006-05-19 | 2007-11-29 | Janssen Pharmaceutica N.V. | Thérapie combinée pour le traitement de l'épilepsie et de troubles apparentés |
CN101074935B (zh) * | 2006-05-19 | 2011-03-23 | 清华大学 | 探测器阵列及设备 |
FR2902341B1 (fr) | 2006-06-16 | 2011-02-25 | Scras | Utilisation therapeutique simultanee, separee ou etalee dans le temps d'au moins une neurotoxine botulique, et d'au moins un derive opiace |
WO2008010223A2 (fr) * | 2006-07-17 | 2008-01-24 | Ramot At Tel Aviv University Ltd. | Conjugués de gaba anti-douleur |
WO2008020651A1 (fr) * | 2006-08-17 | 2008-02-21 | Kyushu University, National University Corporation | antagoniste de récepteur P2X4 |
SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
US7645767B2 (en) * | 2006-08-31 | 2010-01-12 | Trinity Laboratories, Inc. | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy |
US20080119820A1 (en) | 2006-09-20 | 2008-05-22 | Phan Phillip C | Methods for Delivering Volatile Anesthetics for Regional Anesthesia and/or Pain Relief |
US20100048605A1 (en) * | 2006-12-11 | 2010-02-25 | University Of Kentucky Research Foundation | Synergistic effects of combinations of nornicotine and opioids for the treatment of pain |
FR2910327B1 (fr) | 2006-12-22 | 2013-04-26 | Scras | Utilisation d'au moins une neurotoxine botulique pour traiter la douleur induite par les traitements therapeutiques du virus du sida. |
GB0700773D0 (en) | 2007-01-15 | 2007-02-21 | Portela & Ca Sa | Drug therapies |
MX2010002692A (es) | 2007-09-13 | 2010-06-01 | Concert Pharmaceuticals Inc | Sintesis de catecoles deuterados y derivados de benzo[d][1,3]dioxoles de los mismos. |
US20100312073A1 (en) * | 2008-01-31 | 2010-12-09 | David Yarnitsky | Method of predicting pain medication efficacy |
FR2930447B1 (fr) | 2008-04-25 | 2010-07-30 | Sod Conseils Rech Applic | Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur dans le cas de la neuropathie diabetique |
ES2563061T3 (es) | 2008-04-28 | 2016-03-10 | Zogenix, Inc. | Nuevas formulaciones para el tratamiento de la migraña |
EA018567B1 (ru) | 2008-06-23 | 2013-08-30 | Янссен Фармацевтика Нв | Кристаллическая форма (2s)-(-)-n-(6-хлор-2,3-дигидробензо[1,4]диоксин-2-илметил)сульфамида |
US8815939B2 (en) | 2008-07-22 | 2014-08-26 | Janssen Pharmaceutica Nv | Substituted sulfamide derivatives |
US20100184685A1 (en) * | 2009-01-19 | 2010-07-22 | Zavala Jr Gerardo | Systems and methods for treating post- operative, acute, and chronic pain using an intra-muscular catheter administrated combination of a local anesthetic and a neurotoxin protein |
PT2582366E (pt) | 2010-06-15 | 2016-01-26 | Gruenenthal Gmbh | Combinação terapêutica para o tratamento da dor |
US8916610B2 (en) | 2010-09-22 | 2014-12-23 | Ramot At Tel-Aviv University Ltd. | Acid addition salt of a nortriptyline-GABA conjugate and a process of preparing same |
AP3815A (en) | 2010-12-22 | 2016-09-30 | Purdue Pharma Lp | Encased tamper resistant controlled release dosage forms |
PH12013501345A1 (en) | 2010-12-23 | 2022-10-24 | Purdue Pharma Lp | Tamper resistant solid oral dosage forms |
CN103764136A (zh) * | 2011-02-18 | 2014-04-30 | 雀巢产品技术援助有限公司 | 用于治疗、减轻或预防动物神经系统损害的方法和组合物 |
ES2387973B1 (es) * | 2011-03-18 | 2013-10-01 | Dr Healthcare España, S. L. | Composiciones tópicas que contienen diaminooxidasa para el tratamiento o la prevención de enfermedades asociadas a un nivel de histamina elevada que comportan un aumento del dolor. |
WO2013023155A1 (fr) | 2011-08-11 | 2013-02-14 | Xenoport, Inc. | Formes cristallines anhydres et hémihydratées d'un promédicament (r)-baclofène, procédés de synthèse et procédés d'utilisation |
KR20150042269A (ko) * | 2012-08-16 | 2015-04-20 | 얀센 파마슈티카 엔.브이. | N형 칼슘 채널 차단제로서의 치환된 피라졸 |
US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
US10751287B2 (en) | 2013-03-15 | 2020-08-25 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
CA3042642A1 (fr) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Comprime extrude anti-abus a liberation immediate |
US9453002B2 (en) | 2013-08-16 | 2016-09-27 | Janssen Pharmaceutica Nv | Substituted imidazoles as N-type calcium channel blockers |
US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
WO2015095391A1 (fr) | 2013-12-17 | 2015-06-25 | Pharmaceutical Manufacturing Research Services, Inc. | Comprimé extrudé anti-abus à libération prolongée |
CA2955229C (fr) | 2014-07-17 | 2020-03-10 | Pharmaceutical Manufacturing Research Services, Inc. | Forme posologique remplie de liquide anti-abus a liberation immediate |
EP3209282A4 (fr) | 2014-10-20 | 2018-05-23 | Pharmaceutical Manufacturing Research Services, Inc. | Forme galénique anti-abus de remplissage de liquide à libération prolongée |
CN104758933A (zh) * | 2014-10-29 | 2015-07-08 | 吴鑫欣 | 治疗神经卡压、神经瘤疼痛的药物和给药系统 |
WO2018175696A1 (fr) * | 2017-03-22 | 2018-09-27 | Bonti, Inc. | Neurotoxines de botulinum pour le traitement de lésions traumatiques |
WO2018183320A1 (fr) * | 2017-03-31 | 2018-10-04 | Depco, Inc. | Mastic thérapeutique à analgésiques et/ou révulsifs |
WO2018191480A1 (fr) * | 2017-04-12 | 2018-10-18 | Synergistic Therapeutics. Llc | Lotion thérapeutique contre la douleur neuropathique |
KR101944113B1 (ko) | 2017-09-28 | 2019-01-30 | 동의대학교 산학협력단 | 급성 안면통증 예방 및 개선용 조성물 |
KR102156627B1 (ko) | 2018-12-20 | 2020-09-16 | 동의대학교 산학협력단 | 보스웰리아 추출물 및 산자나무 추출물을 포함하는 급성 안면통증 예방 및 개선용 조성물 |
KR102156438B1 (ko) | 2018-12-20 | 2020-09-16 | 동의대학교 산학협력단 | 급성 안면통증 예방 및 개선용 조성물 |
CN115054601B (zh) * | 2022-03-21 | 2024-04-26 | 中山大学附属第三医院 | 一种可注射的缓释镇痛复合物及其制备方法、应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3621707B2 (ja) * | 1996-10-30 | 2005-02-16 | ファイザー・インク | ピリドン―縮合したアザ二環式―またはシチシン誘導体、その製法および嗜癖治療におけるその用途 |
EP0955301A3 (fr) * | 1998-04-27 | 2001-04-18 | Pfizer Products Inc. | Dérivés de 7-aza-bicyclo[2.2.1]-heptane, leur préparation et utilisation sur la base d'affinité pour les recepteurs de l'acetylcholine nicotinique neuronaux |
KR100420423B1 (ko) * | 1998-04-29 | 2004-03-04 | 화이자 프로덕츠 인코포레이티드 | 아릴 축합된 아자 다환식 화합물 |
IL137937A0 (en) * | 1999-08-27 | 2001-10-31 | Pfizer Prod Inc | A pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal |
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- 2001-03-16 CN CNA01816840XA patent/CN1468111A/zh active Pending
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