SI9400029A - Plaster containing nitroglycerine, procedure for its preparation and its use - Google Patents

Plaster containing nitroglycerine, procedure for its preparation and its use Download PDF

Info

Publication number: SI9400029A
Authority: SI; Slovenia
Prior art keywords: active substance; nitroglycerin; reservoir; patch according; adhesive
Prior art date: 1993-01-23

Application number

SI9400029A

Other languages

English (en)

Slovenian (sl)

Inventor

Reinhold Meconi

Tina Rademacher

Original Assignee

Lohmann Therapie Syst Lts

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-01-23

Filing date

1994-01-21

Publication date

1994-09-30

1994-01-21 Application filed by Lohmann Therapie Syst Lts filed Critical Lohmann Therapie Syst Lts

1994-09-30 Publication of SI9400029A publication Critical patent/SI9400029A/sl

Links

SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 title claims abstract description 43
229960003711 glyceryl trinitrate Drugs 0.000 title claims abstract description 43
238000002360 preparation method Methods 0.000 title claims description 18
238000000034 method Methods 0.000 title claims description 5
239000011505 plaster Substances 0.000 title abstract 2
239000013543 active substance Substances 0.000 claims abstract description 27
229920005989 resin Polymers 0.000 claims abstract description 24
239000011347 resin Substances 0.000 claims abstract description 24
239000000853 adhesive Substances 0.000 claims abstract description 19
230000001070 adhesive effect Effects 0.000 claims abstract description 18
239000010410 layer Substances 0.000 claims abstract description 8
239000011241 protective layer Substances 0.000 claims abstract description 6
239000008240 homogeneous mixture Substances 0.000 claims abstract 3
239000000203 mixture Substances 0.000 claims abstract 2
239000000006 Nitroglycerin Substances 0.000 claims description 40
239000004840 adhesive resin Substances 0.000 claims description 8
229920006223 adhesive resin Polymers 0.000 claims description 8
239000004014 plasticizer Substances 0.000 claims description 7
239000012790 adhesive layer Substances 0.000 claims description 5
229920001169 thermoplastic Polymers 0.000 claims description 5
239000004416 thermosoftening plastic Substances 0.000 claims description 5
230000001225 therapeutic effect Effects 0.000 claims description 4
DMBSFYPSHNCYAR-RJMJUYIDSA-N 1,3-dinitrooxypropan-2-yl nitrate (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O DMBSFYPSHNCYAR-RJMJUYIDSA-N 0.000 claims description 3
239000003795 chemical substances by application Substances 0.000 claims description 3
238000002560 therapeutic procedure Methods 0.000 claims description 3
230000003712 anti-aging effect Effects 0.000 claims description 2
239000000155 melt Substances 0.000 claims description 2
238000013270 controlled release Methods 0.000 claims 1
239000003814 drug Substances 0.000 claims 1
239000003974 emollient agent Substances 0.000 abstract 1
239000012943 hotmelt Substances 0.000 abstract 1
239000002904 solvent Substances 0.000 description 6
KBAYQFWFCOOCIC-GNVSMLMZSA-N [(1s,4ar,4bs,7s,8ar,10ar)-1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,7,8,8a,9,10,10a-dodecahydrophenanthren-1-yl]methanol Chemical compound OC[C@@]1(C)CCC[C@]2(C)[C@H]3CC[C@H](C(C)C)C[C@H]3CC[C@H]21 KBAYQFWFCOOCIC-GNVSMLMZSA-N 0.000 description 5
239000011159 matrix material Substances 0.000 description 4
150000002148 esters Chemical class 0.000 description 3
238000004898 kneading Methods 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
239000013032 Hydrocarbon resin Substances 0.000 description 2
-1 Resin acid methyl esters Chemical class 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
239000002253 acid Substances 0.000 description 2
229920006271 aliphatic hydrocarbon resin Polymers 0.000 description 2
XYLMUPLGERFSHI-UHFFFAOYSA-N alpha-Methylstyrene Chemical compound CC(=C)C1=CC=CC=C1 XYLMUPLGERFSHI-UHFFFAOYSA-N 0.000 description 2
229920006272 aromatic hydrocarbon resin Polymers 0.000 description 2
239000011248 coating agent Substances 0.000 description 2
238000000576 coating method Methods 0.000 description 2
238000001704 evaporation Methods 0.000 description 2
230000008020 evaporation Effects 0.000 description 2
229920006270 hydrocarbon resin Polymers 0.000 description 2
239000012528 membrane Substances 0.000 description 2
239000007787 solid Substances 0.000 description 2
RSWGJHLUYNHPMX-UHFFFAOYSA-N 1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,10,10a-octahydrophenanthrene-1-carboxylic acid Chemical class C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
238000002485 combustion reaction Methods 0.000 description 1
239000000470 constituent Substances 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
238000001035 drying Methods 0.000 description 1
238000003912 environmental pollution Methods 0.000 description 1
239000002360 explosive Substances 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
239000007788 liquid Substances 0.000 description 1
238000011068 loading method Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
229940057917 medium chain triglycerides Drugs 0.000 description 1
150000004702 methyl esters Chemical class 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
HJWLCRVIBGQPNF-UHFFFAOYSA-N prop-2-enylbenzene Chemical compound C=CCC1=CC=CC=C1 HJWLCRVIBGQPNF-UHFFFAOYSA-N 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
238000011084 recovery Methods 0.000 description 1
239000013557 residual solvent Substances 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
230000008719 thickening Effects 0.000 description 1
238000011282 treatment Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Dermatology (AREA)
Emergency Medicine (AREA)
Botany (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Adhesives Or Adhesive Processes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

SI9400029A 1993-01-23 1994-01-21 Plaster containing nitroglycerine, procedure for its preparation and its use SI9400029A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4301781A DE4301781C2 (de)	1993-01-23	1993-01-23	Nitroglycerinhaltiges Pflaster, Verfahren zu seiner Herstellung und Verwendung

Publications (1)

Publication Number	Publication Date
SI9400029A true SI9400029A (en)	1994-09-30

Family

ID=6478779

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9400029A SI9400029A (en)	1993-01-23	1994-01-21	Plaster containing nitroglycerine, procedure for its preparation and its use

Country Status (26)

Country	Link
US (1)	US5670164A (fi)
EP (1)	EP0680319B1 (fi)
JP (1)	JPH08505631A (fi)
KR (1)	KR960700049A (fi)
AT (1)	ATE149829T1 (fi)
AU (1)	AU687775B2 (fi)
CA (1)	CA2153571A1 (fi)
CZ (1)	CZ284899B6 (fi)
DE (2)	DE4301781C2 (fi)
DK (1)	DK0680319T3 (fi)
ES (1)	ES2102199T3 (fi)
FI (1)	FI953532A0 (fi)
GR (1)	GR3023505T3 (fi)
HR (1)	HRP940030B1 (fi)
HU (1)	HU220768B1 (fi)
IL (1)	IL108233A (fi)
MY (1)	MY110391A (fi)
NO (1)	NO952908D0 (fi)
NZ (1)	NZ259710A (fi)
PH (1)	PH31559A (fi)
PL (1)	PL174806B1 (fi)
SI (1)	SI9400029A (fi)
SK (1)	SK279839B6 (fi)
WO (1)	WO1994016691A1 (fi)
YU (1)	YU48663B (fi)
ZA (1)	ZA94415B (fi)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19814084B4 (de) *	1998-03-30	2005-12-22	Lts Lohmann Therapie-Systeme Ag	D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung
ATE302598T1 (de) *	1999-04-01	2005-09-15	Alza Corp	Transdermale vorrichtung zur arzneistoffverabreichung mit einem polyurethanwirkstoffreservoir
DE10041478A1 (de)	2000-08-24	2002-03-14	Sanol Arznei Schwarz Gmbh	Neue pharmazeutische Zusammensetzung
EP3406249A1 (en)	2001-02-19	2018-11-28	Novartis AG	Treatment of breast tumors with a rapamycin derivative in combination with an aromatase inhibitor
US8246979B2 (en)	2002-07-30	2012-08-21	Ucb Pharma Gmbh	Transdermal delivery system for the administration of rotigotine
DE10234673B4 (de) *	2002-07-30	2007-08-16	Schwarz Pharma Ag	Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren
US8246980B2 (en) *	2002-07-30	2012-08-21	Ucb Pharma Gmbh	Transdermal delivery system
US8211462B2 (en) *	2002-07-30	2012-07-03	Ucb Pharma Gmbh	Hot-melt TTS for administering rotigotine
ES2239196T3 (es) *	2002-12-02	2005-09-16	Schwarz Pharma Ag	Suministro iontoforetico de rotigotina para el tratamiento de la enfermedad de parkinson.
DE10261696A1 (de) *	2002-12-30	2004-07-15	Schwarz Pharma Ag	Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base
EP2921184A1 (de)	2014-03-19	2015-09-23	LTS LOHMANN Therapie-Systeme AG	Überpflaster mit verbesserter Verträglichkeit und einer langen Haftungsdauer und Verfahren zu seiner Herstellung

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3742951A (en) *	1971-08-09	1973-07-03	Alza Corp	Bandage for controlled release of vasodilators
FR2435950A1 (fr) *	1978-06-05	1980-04-11	Riker Laboratories Inc	Pansement medical comprenant une composition a base de nitroglycerine, sa fabrication et son application
US4725272A (en) *	1981-06-29	1988-02-16	Alza Corporation	Novel bandage for administering beneficial drug
DE3315272C2 (de) *	1983-04-27	1986-03-27	Lohmann Gmbh & Co Kg, 5450 Neuwied	Pharmazeutisches Produkt und Verfahren zu seiner Herstellung
DE3315245A1 (de) *	1983-04-27	1984-10-31	Lohmann Gmbh & Co Kg, 5450 Neuwied	Pharmazeutisches produkt
US4701509A (en) *	1984-09-17	1987-10-20	Johnson & Johnson Products, Inc.	N-vinyl caprolactam-containing hot melt adhesives
EP0204968B1 (de) *	1985-05-24	1989-09-27	Beiersdorf Aktiengesellschaft	Nitro-Pflaster
US4666441A (en) *	1985-12-17	1987-05-19	Ciba-Geigy Corporation	Multicompartmentalized transdermal patches
DE3786199T2 (de) *	1986-04-03	1993-09-23	Hercon Lab	Artikel fuer die verabreichung pharmakologisch aktiver substanzen.
CH672888A5 (fi) *	1986-11-07	1990-01-15	Mepha Ag
US5306502A (en) *	1987-09-01	1994-04-26	Lts Lohmann Therapie-Systeme Gmbh & Co. Kg	Apparatus for delivering nitroglycerin to the skin, processes for the production thereof and the use thereof
US5273757A (en) *	1987-09-01	1993-12-28	Lts Lohmann Therapie-Systeme Gmbh & Co. Kg	Apparatus for the delivery of substances, processes for the production thereof and use thereof
DE3743946A1 (de) *	1987-09-01	1989-03-09	Lohmann Gmbh & Co Kg	Vorrichtung zur abgabe von nitroglycerin an die haut, verfahren zu ihrer herstellung sowie ihre verwendung
DE3743945A1 (de) *	1987-09-01	1989-03-09	Lohmann Gmbh & Co Kg	Vorrichtung zur abgabe von stoffen, verfahren zu ihrer herstellung sowie ihre verwendung
DE3905051A1 (de) *	1989-02-18	1990-08-30	Lohmann Therapie Syst Lts	Therapeutisches system zur verzoegerten und gesteuerten transdermalen oder transmucosalen verabreichung von wirkstoffen (i)

1993
- 1993-01-23 DE DE4301781A patent/DE4301781C2/de not_active Expired - Fee Related
- 1993-12-30 IL IL10823393A patent/IL108233A/xx active IP Right Grant
1994
- 1994-01-10 PL PL94309602A patent/PL174806B1/pl unknown
- 1994-01-10 ES ES94904650T patent/ES2102199T3/es not_active Expired - Lifetime
- 1994-01-10 HU HU9501966A patent/HU220768B1/hu unknown
- 1994-01-10 AU AU58606/94A patent/AU687775B2/en not_active Ceased
- 1994-01-10 CA CA002153571A patent/CA2153571A1/en not_active Abandoned
- 1994-01-10 KR KR1019950703007A patent/KR960700049A/ko not_active Abandoned
- 1994-01-10 CZ CZ951841A patent/CZ284899B6/cs unknown
- 1994-01-10 NZ NZ259710A patent/NZ259710A/en unknown
- 1994-01-10 SK SK891-95A patent/SK279839B6/sk unknown
- 1994-01-10 US US08/492,004 patent/US5670164A/en not_active Expired - Fee Related
- 1994-01-10 DE DE59402070T patent/DE59402070D1/de not_active Expired - Fee Related
- 1994-01-10 JP JP6516613A patent/JPH08505631A/ja active Pending
- 1994-01-10 EP EP94904650A patent/EP0680319B1/de not_active Expired - Lifetime
- 1994-01-10 DK DK94904650.2T patent/DK0680319T3/da active
- 1994-01-10 WO PCT/EP1994/000053 patent/WO1994016691A1/de active IP Right Grant
- 1994-01-10 AT AT94904650T patent/ATE149829T1/de not_active IP Right Cessation
- 1994-01-17 MY MYPI94000114A patent/MY110391A/en unknown
- 1994-01-19 PH PH47632A patent/PH31559A/en unknown
- 1994-01-20 ZA ZA94415A patent/ZA94415B/xx unknown
- 1994-01-20 HR HRP4301781.9A patent/HRP940030B1/xx not_active IP Right Cessation
- 1994-01-21 SI SI9400029A patent/SI9400029A/sl unknown
- 1994-01-21 YU YU2594A patent/YU48663B/sh unknown
1995
- 1995-07-21 FI FI953532A patent/FI953532A0/fi unknown
- 1995-07-21 NO NO952908A patent/NO952908D0/no not_active Application Discontinuation
1997
- 1997-05-21 GR GR970401155T patent/GR3023505T3/el unknown

Also Published As

Publication number	Publication date
ATE149829T1 (de)	1997-03-15
YU48663B (sh)	1999-06-15
PL174806B1 (pl)	1998-09-30
DK0680319T3 (da)	1997-09-01
IL108233A0 (en)	1994-04-12
CZ184195A3 (en)	1996-03-13
CA2153571A1 (en)	1994-08-04
EP0680319B1 (de)	1997-03-12
DE4301781C2 (de)	1995-07-20
AU5860694A (en)	1994-08-15
HU9501966D0 (en)	1995-09-28
HUT72983A (en)	1996-06-28
US5670164A (en)	1997-09-23
NO952908L (no)	1995-07-21
EP0680319A1 (de)	1995-11-08
HRP940030B1 (en)	1999-10-31
PL309602A1 (en)	1995-10-30
AU687775B2 (en)	1998-03-05
SK279839B6 (sk)	1999-04-13
FI953532L (fi)	1995-07-21
CZ284899B6 (cs)	1999-04-14
GR3023505T3 (en)	1997-08-29
NZ259710A (en)	1996-06-25
YU2594A (sh)	1996-10-18
PH31559A (en)	1998-11-03
WO1994016691A1 (de)	1994-08-04
NO952908D0 (no)	1995-07-21
SK89195A3 (en)	1996-06-05
JPH08505631A (ja)	1996-06-18
ES2102199T3 (es)	1997-07-16
HU220768B1 (hu)	2002-05-28
MY110391A (en)	1998-04-30
HRP940030A2 (en)	1996-06-30
DE59402070D1 (de)	1997-04-17
IL108233A (en)	1997-08-14
KR960700049A (ko)	1996-01-19
DE4301781A1 (de)	1994-07-28
FI953532A0 (fi)	1995-07-21
ZA94415B (en)	1994-08-31

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