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KR960700049A - 니트로글리세린-함유 패치, 그것의 제조 방법 및 사용 방법(nitroglycerine-containing plaster, process for producing the same and its use) - Google Patents

니트로글리세린-함유 패치, 그것의 제조 방법 및 사용 방법(nitroglycerine-containing plaster, process for producing the same and its use)

Info

Publication number
KR960700049A
KR960700049A KR1019950703007A KR19950703007A KR960700049A KR 960700049 A KR960700049 A KR 960700049A KR 1019950703007 A KR1019950703007 A KR 1019950703007A KR 19950703007 A KR19950703007 A KR 19950703007A KR 960700049 A KR960700049 A KR 960700049A
Authority
KR
South Korea
Prior art keywords
reservoir
containing patch
active material
nitroglycerin
resins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
KR1019950703007A
Other languages
English (en)
Inventor
메코니 라인홀트
라데마헤르 티나
Original Assignee
프랑크 베하ㆍ베르너 베슬링
엘테에스 로만 테라피-지스테메 게엠베하 운트 콤파니 카게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 프랑크 베하ㆍ베르너 베슬링, 엘테에스 로만 테라피-지스테메 게엠베하 운트 콤파니 카게 filed Critical 프랑크 베하ㆍ베르너 베슬링
Publication of KR960700049A publication Critical patent/KR960700049A/ko
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Botany (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

본 발명은 니트로글리세린의 방출 조절을 위한 활성 물질-함유 패치에 관한 것으로, 그들은 불투과 후면층, 그것들 위에 접착되고 압력-민감 고온 용융 접착제 및 활성 물질을 함유한 저장기, 및 제거 가능한 보호 층으로 구성되어 있는데 패체에서 저장기는 균질화된 혼합물 상태에서 하기 a), b), c)를 함유한다:
a) 얇은 판으로 된 경 및/또는 중 수지들, b) 가소제들, c) 니트로글리세린 제조제.

Description

니트로글리세린-함유 패치, 그것의 제조 방법 및 사용 방법(NITROGLYCERINE-CONTAINING PLASTER, PROCESS FOR PRODUCING THE SAME AND ITS USE)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (15)

  1. 비투과 후면 층, 그것들에 결합되고 압력-민감 고온 용융물 접착제 및 활성 물질을 함유한 저장기, 및 제거가능한 보호층으로 구성되며, 상기 저장기는 균질화된 혼합물 상태로 하기 a),b),c)를 함유하는 것을 특징으로 하는 피부로 니트로글리세린의 방출을 조절하기 위한 활성 물질-함유 패치: a) 얇은 판으로 만드는 연수지 및/또는 중 수지들, b) 가소제들, c) 니트로글리세린 제조제.
  2. 제1항에 있어서, 접착 수지는 연수지인 것을 특징으로 하는 활성 물질-함유 패치.
  3. 제1항에 있어서, 접착 수지는 경수지인 것을 특징으로 하는 활성 물질-함유 패치.
  4. 제1항 내지 제3항에 있어서, 점착 수지들은 연수지들과 경수지들의 혼합물로 구성되는 것을 특징으로 하는 활성 물질-함유 패치.
  5. 제1항 내지 제4항에 있어서, 점착 수지들의 비율이 10 내지 43중량% 범위에 있는 것을 특징으로 하는 활성 물질-함유 패치.
  6. 제1항 내지 제5항에 있어서, 저장기는 0.3 내지 10.0중량%의 니트로글리세린을 함유하는 것을 특징으로 하는 활성 물질-함유 패치.
  7. 제1항 내지 제6항에 있어서, 니트로글리세린은 니트로글리세린-락토오스-제제에서 미리 혼합된 수지들과 혼합되는 것을 특징으로 하는 활성 물질-함유 패치.
  8. 제1항 내지 제7항에 있어서, 저장기는 0.1 내지 5중량%의 가소제를 함유하는 것을 특징으로 하는 활성 물질-함유 패치.
  9. 제1항 내지 제8항에 있어서, 저장기는 0.1 내지 2중량%의 항-노화 제제들을포함하는 것을 특징으로 하는 활성 물질-함유 패치.
  10. 제1항 내지 제9항에 있어서, 저장기는 0.3 내지 0.4mm의 두께를 갖는 것을 특징으로 하는 활성 물질-함유 패치.
  11. 제1항 내지 제10항에 있어서, 저장기가 여러 층으로 구성되는 것을 특징으로 하는 활성 물질-함유 패치.
  12. 제1항 내지 제11항에 있어서, 만일 피부로의 충분한 자율 점착을 보여주지 않는다면 저장기는 압력 민감접착 층과 함께 제공되는 것을 특징으로 하는 활성 물질-함유 패치.
  13. 제1항 내지 제12항에 있어서, 만일 피부로의 충분한 자율 점착을 보여주지 않는다면 저장기는 압력 민감접착 테두리와 함께 제공되는 것을 특징으로 하는 활성 물질-함유 패치.
  14. 저장기가 60℃보다 낮은 온도에서 용융물로부터 적용되는 것을 특징으로 하는 니트로글리세린-함유 패치의 제조 방법.
  15. 인간과 수의학에서 치료 목적을 위해 사용되는 제1항 내지 제13항의 니트로글리세린-함유 패치의 사용 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950703007A 1993-01-23 1994-01-10 니트로글리세린-함유 패치, 그것의 제조 방법 및 사용 방법(nitroglycerine-containing plaster, process for producing the same and its use) Abandoned KR960700049A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP4301781.9 1993-01-23
DE4301781A DE4301781C2 (de) 1993-01-23 1993-01-23 Nitroglycerinhaltiges Pflaster, Verfahren zu seiner Herstellung und Verwendung
PCT/EP1994/000053 WO1994016691A1 (de) 1993-01-23 1994-01-10 Nitroglycerinhaltiges pflaster, verfahren zu seiner herstellung und verwendung

Publications (1)

Publication Number Publication Date
KR960700049A true KR960700049A (ko) 1996-01-19

Family

ID=6478779

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950703007A Abandoned KR960700049A (ko) 1993-01-23 1994-01-10 니트로글리세린-함유 패치, 그것의 제조 방법 및 사용 방법(nitroglycerine-containing plaster, process for producing the same and its use)

Country Status (26)

Country Link
US (1) US5670164A (ko)
EP (1) EP0680319B1 (ko)
JP (1) JPH08505631A (ko)
KR (1) KR960700049A (ko)
AT (1) ATE149829T1 (ko)
AU (1) AU687775B2 (ko)
CA (1) CA2153571A1 (ko)
CZ (1) CZ284899B6 (ko)
DE (2) DE4301781C2 (ko)
DK (1) DK0680319T3 (ko)
ES (1) ES2102199T3 (ko)
FI (1) FI953532A0 (ko)
GR (1) GR3023505T3 (ko)
HR (1) HRP940030B1 (ko)
HU (1) HU220768B1 (ko)
IL (1) IL108233A (ko)
MY (1) MY110391A (ko)
NO (1) NO952908D0 (ko)
NZ (1) NZ259710A (ko)
PH (1) PH31559A (ko)
PL (1) PL174806B1 (ko)
SI (1) SI9400029A (ko)
SK (1) SK279839B6 (ko)
WO (1) WO1994016691A1 (ko)
YU (1) YU48663B (ko)
ZA (1) ZA94415B (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19814084B4 (de) * 1998-03-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung
ATE302598T1 (de) * 1999-04-01 2005-09-15 Alza Corp Transdermale vorrichtung zur arzneistoffverabreichung mit einem polyurethanwirkstoffreservoir
DE10041478A1 (de) 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
EP3406249A1 (en) 2001-02-19 2018-11-28 Novartis AG Treatment of breast tumors with a rapamycin derivative in combination with an aromatase inhibitor
US8246979B2 (en) 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system for the administration of rotigotine
DE10234673B4 (de) * 2002-07-30 2007-08-16 Schwarz Pharma Ag Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren
US8246980B2 (en) * 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system
US8211462B2 (en) * 2002-07-30 2012-07-03 Ucb Pharma Gmbh Hot-melt TTS for administering rotigotine
ES2239196T3 (es) * 2002-12-02 2005-09-16 Schwarz Pharma Ag Suministro iontoforetico de rotigotina para el tratamiento de la enfermedad de parkinson.
DE10261696A1 (de) * 2002-12-30 2004-07-15 Schwarz Pharma Ag Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base
EP2921184A1 (de) 2014-03-19 2015-09-23 LTS LOHMANN Therapie-Systeme AG Überpflaster mit verbesserter Verträglichkeit und einer langen Haftungsdauer und Verfahren zu seiner Herstellung

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3742951A (en) * 1971-08-09 1973-07-03 Alza Corp Bandage for controlled release of vasodilators
FR2435950A1 (fr) * 1978-06-05 1980-04-11 Riker Laboratories Inc Pansement medical comprenant une composition a base de nitroglycerine, sa fabrication et son application
US4725272A (en) * 1981-06-29 1988-02-16 Alza Corporation Novel bandage for administering beneficial drug
DE3315272C2 (de) * 1983-04-27 1986-03-27 Lohmann Gmbh & Co Kg, 5450 Neuwied Pharmazeutisches Produkt und Verfahren zu seiner Herstellung
DE3315245A1 (de) * 1983-04-27 1984-10-31 Lohmann Gmbh & Co Kg, 5450 Neuwied Pharmazeutisches produkt
US4701509A (en) * 1984-09-17 1987-10-20 Johnson & Johnson Products, Inc. N-vinyl caprolactam-containing hot melt adhesives
EP0204968B1 (de) * 1985-05-24 1989-09-27 Beiersdorf Aktiengesellschaft Nitro-Pflaster
US4666441A (en) * 1985-12-17 1987-05-19 Ciba-Geigy Corporation Multicompartmentalized transdermal patches
DE3786199T2 (de) * 1986-04-03 1993-09-23 Hercon Lab Artikel fuer die verabreichung pharmakologisch aktiver substanzen.
CH672888A5 (ko) * 1986-11-07 1990-01-15 Mepha Ag
US5306502A (en) * 1987-09-01 1994-04-26 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Apparatus for delivering nitroglycerin to the skin, processes for the production thereof and the use thereof
US5273757A (en) * 1987-09-01 1993-12-28 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Apparatus for the delivery of substances, processes for the production thereof and use thereof
DE3743946A1 (de) * 1987-09-01 1989-03-09 Lohmann Gmbh & Co Kg Vorrichtung zur abgabe von nitroglycerin an die haut, verfahren zu ihrer herstellung sowie ihre verwendung
DE3743945A1 (de) * 1987-09-01 1989-03-09 Lohmann Gmbh & Co Kg Vorrichtung zur abgabe von stoffen, verfahren zu ihrer herstellung sowie ihre verwendung
DE3905051A1 (de) * 1989-02-18 1990-08-30 Lohmann Therapie Syst Lts Therapeutisches system zur verzoegerten und gesteuerten transdermalen oder transmucosalen verabreichung von wirkstoffen (i)

Also Published As

Publication number Publication date
ATE149829T1 (de) 1997-03-15
YU48663B (sh) 1999-06-15
SI9400029A (en) 1994-09-30
PL174806B1 (pl) 1998-09-30
DK0680319T3 (da) 1997-09-01
IL108233A0 (en) 1994-04-12
CZ184195A3 (en) 1996-03-13
CA2153571A1 (en) 1994-08-04
EP0680319B1 (de) 1997-03-12
DE4301781C2 (de) 1995-07-20
AU5860694A (en) 1994-08-15
HU9501966D0 (en) 1995-09-28
HUT72983A (en) 1996-06-28
US5670164A (en) 1997-09-23
NO952908L (no) 1995-07-21
EP0680319A1 (de) 1995-11-08
HRP940030B1 (en) 1999-10-31
PL309602A1 (en) 1995-10-30
AU687775B2 (en) 1998-03-05
SK279839B6 (sk) 1999-04-13
FI953532L (fi) 1995-07-21
CZ284899B6 (cs) 1999-04-14
GR3023505T3 (en) 1997-08-29
NZ259710A (en) 1996-06-25
YU2594A (sh) 1996-10-18
PH31559A (en) 1998-11-03
WO1994016691A1 (de) 1994-08-04
NO952908D0 (no) 1995-07-21
SK89195A3 (en) 1996-06-05
JPH08505631A (ja) 1996-06-18
ES2102199T3 (es) 1997-07-16
HU220768B1 (hu) 2002-05-28
MY110391A (en) 1998-04-30
HRP940030A2 (en) 1996-06-30
DE59402070D1 (de) 1997-04-17
IL108233A (en) 1997-08-14
DE4301781A1 (de) 1994-07-28
FI953532A0 (fi) 1995-07-21
ZA94415B (en) 1994-08-31

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