SI3345607T1 - Postopki spreminjanja rasti kosti z dajanjem antagonista ali agonista SOST ali WISE - Google Patents
Postopki spreminjanja rasti kosti z dajanjem antagonista ali agonista SOST ali WISEInfo
- Publication number
- SI3345607T1 SI3345607T1 SI200732194T SI200732194T SI3345607T1 SI 3345607 T1 SI3345607 T1 SI 3345607T1 SI 200732194 T SI200732194 T SI 200732194T SI 200732194 T SI200732194 T SI 200732194T SI 3345607 T1 SI3345607 T1 SI 3345607T1
- Authority
- SI
- Slovenia
- Prior art keywords
- sost
- agonist
- administration
- methods
- bone growth
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A61L2300/256—Antibodies, e.g. immunoglobulins, vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/432—Inhibitors, antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Marine Sciences & Fisheries (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88264206P | 2006-12-29 | 2006-12-29 | |
EP18157578.8A EP3345607B1 (en) | 2006-12-29 | 2007-12-21 | Methods of altering bone growth by administration of sost or wise antagonist or agonist |
Publications (1)
Publication Number | Publication Date |
---|---|
SI3345607T1 true SI3345607T1 (sl) | 2023-03-31 |
Family
ID=39584303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200732194T SI3345607T1 (sl) | 2006-12-29 | 2007-12-21 | Postopki spreminjanja rasti kosti z dajanjem antagonista ali agonista SOST ali WISE |
Country Status (12)
Country | Link |
---|---|
US (8) | US8178099B2 (sl) |
EP (3) | EP4176884A1 (sl) |
JP (4) | JP2010528002A (sl) |
DK (1) | DK3345607T3 (sl) |
ES (2) | ES2930183T3 (sl) |
FI (1) | FI3345607T3 (sl) |
HU (1) | HUE060822T2 (sl) |
LT (1) | LT3345607T (sl) |
PL (1) | PL3345607T3 (sl) |
PT (1) | PT3345607T (sl) |
SI (1) | SI3345607T1 (sl) |
WO (1) | WO2009131553A2 (sl) |
Families Citing this family (37)
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ES2350454T3 (es) | 1998-11-27 | 2011-01-24 | Ucb Pharma S.A. | Composiciones y métodos para incrementar la mineralización de la sustancia ósea. |
US7585501B2 (en) | 2002-06-14 | 2009-09-08 | Stowers Institute For Medical Research | Compositions and methods for treating kidney disease |
US7893218B2 (en) | 2003-06-16 | 2011-02-22 | Stowers Institute For Medical Research | Antibodies that specifically bind SOST peptides |
AU2003276430A1 (en) | 2002-06-14 | 2003-12-31 | Stowers Institute For Medical Research | Wise/sost nucleic acid sequences and amino acid sequences |
AU2004262640B2 (en) | 2003-06-16 | 2010-12-23 | Ucb Manufacturing, Inc. | Antibodies specific for sclerostin and methods for increasing bone mineralization |
US8461155B2 (en) * | 2003-09-22 | 2013-06-11 | University Of Connecticut | Sclerostin and the inhibition of WNT signaling and bone formation |
WO2006026731A1 (en) | 2004-08-30 | 2006-03-09 | Spineovations, Inc. | Method of treating spinal internal disk derangement |
US7592429B2 (en) | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
SI3345607T1 (sl) * | 2006-12-29 | 2023-03-31 | Ossifi-Mab Llc | Postopki spreminjanja rasti kosti z dajanjem antagonista ali agonista SOST ali WISE |
CL2008002775A1 (es) | 2007-09-17 | 2008-11-07 | Amgen Inc | Uso de un agente de unión a esclerostina para inhibir la resorción ósea. |
AR068767A1 (es) | 2007-10-12 | 2009-12-02 | Novartis Ag | Anticuerpos contra esclerostina, composiciones y metodos de uso de estos anticuerpos para tratar un trastorno patologico mediado por esclerostina |
MX2010005656A (es) * | 2007-11-21 | 2010-11-12 | Amgen Inc | Anticuerpos y epitopos de enlace wise. |
US8469961B2 (en) * | 2008-03-05 | 2013-06-25 | Neville Alleyne | Methods and compositions for minimally invasive capsular augmentation of canine coxofemoral joints |
WO2010115932A1 (en) * | 2009-04-08 | 2010-10-14 | Novartis Ag | Combination for the treatment of bone loss |
TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
JP2013525294A (ja) * | 2010-04-16 | 2013-06-20 | ノバルティス アーゲー | インプラント骨結合を改善するための方法および組成物 |
SMT202000095T1 (it) | 2010-05-14 | 2020-03-13 | Amgen Inc | Formulazioni di anticorpi anti-sclerostina ad alta concentrazione |
WO2012028683A1 (en) | 2010-09-02 | 2012-03-08 | Novartis Ag | Antibody gel system for sustained drug delivery |
WO2012118903A2 (en) | 2011-03-01 | 2012-09-07 | Amgen Inc. | Bispecific binding agents |
MX338078B (es) | 2011-03-25 | 2016-04-01 | Amgen Inc | Cristales de anticuerpos anti-esclerostina y formulaciones de los mismos. |
PL2739311T3 (pl) | 2011-08-04 | 2018-08-31 | Amgen Inc. | Metoda leczenia szczelinowych uszkodzeń kości |
WO2013101451A1 (en) | 2011-12-28 | 2013-07-04 | Amgen Inc. | Method of treating alvelor bone loss through the use of anti-sclerostin antibodies |
WO2014006100A1 (en) | 2012-07-05 | 2014-01-09 | Ucb Pharma S.A. | Treatment for bone diseases |
UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
US9770415B2 (en) * | 2012-11-27 | 2017-09-26 | Southwest Research Institute | Delivery substrates from aligned polymer biomaterials for tissue repair |
WO2014121196A1 (en) | 2013-02-04 | 2014-08-07 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a wnt pathway inhibitor |
MA41142A (fr) | 2014-12-12 | 2017-10-17 | Amgen Inc | Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement |
ES2693579T3 (es) | 2015-01-16 | 2018-12-12 | Spineovations, Inc. | Método de tratamiento del disco intervertebral |
GB201604124D0 (en) | 2016-03-10 | 2016-04-27 | Ucb Biopharma Sprl | Pharmaceutical formulation |
CN106202901A (zh) * | 2016-07-04 | 2016-12-07 | 奥美之路(北京)健康科技股份有限公司 | 骨龄远程在线判读系统 |
WO2018115879A1 (en) | 2016-12-21 | 2018-06-28 | Mereo Biopharma 3 Limited | Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta |
CN111712573B (zh) * | 2018-02-12 | 2023-10-20 | 安沛治疗有限公司 | 针对骨硬化蛋白的适体及其用途 |
JP7405764B2 (ja) | 2018-03-30 | 2023-12-26 | アムジエン・インコーポレーテツド | C末端抗体改変体 |
WO2020163290A1 (en) * | 2019-02-04 | 2020-08-13 | Emory University | Sclerostin inhibitors that promote bone morphogenetic protein expression |
US20220259298A1 (en) * | 2019-07-12 | 2022-08-18 | Kyoto University | Neutralizing Antibody for Tooth Regeneration Treatment Targeting USAG-1 Molecule |
CN111658821A (zh) * | 2020-06-03 | 2020-09-15 | 深圳市百吉因生物科技有限公司 | 负载小干扰rna的胶原基骨修复材料及制备方法及在制备治疗骨质疏松骨折材料中的应用 |
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2007
- 2007-12-21 SI SI200732194T patent/SI3345607T1/sl unknown
- 2007-12-21 PT PT181575788T patent/PT3345607T/pt unknown
- 2007-12-21 LT LTEP18157578.8T patent/LT3345607T/lt unknown
- 2007-12-21 ES ES18157578T patent/ES2930183T3/es active Active
- 2007-12-21 HU HUE18157578A patent/HUE060822T2/hu unknown
- 2007-12-21 EP EP22200370.9A patent/EP4176884A1/en active Pending
- 2007-12-21 JP JP2010509325A patent/JP2010528002A/ja not_active Withdrawn
- 2007-12-21 EP EP18157578.8A patent/EP3345607B1/en active Active
- 2007-12-21 DK DK18157578.8T patent/DK3345607T3/da active
- 2007-12-21 FI FIEP18157578.8T patent/FI3345607T3/fi active
- 2007-12-21 US US11/962,522 patent/US8178099B2/en active Active
- 2007-12-21 WO PCT/US2007/088542 patent/WO2009131553A2/en active Application Filing
- 2007-12-21 PL PL18157578.8T patent/PL3345607T3/pl unknown
- 2007-12-21 ES ES07875255.7T patent/ES2666650T3/es active Active
- 2007-12-21 EP EP07875255.7A patent/EP2144613B1/en not_active Revoked
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2012
- 2012-03-15 US US13/420,846 patent/US20120201815A1/en not_active Abandoned
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2013
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- 2013-12-11 JP JP2013255627A patent/JP2014074046A/ja not_active Withdrawn
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2014
- 2014-10-02 US US14/504,544 patent/US20150086571A1/en not_active Abandoned
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2016
- 2016-08-22 JP JP2016161654A patent/JP2017014263A/ja not_active Withdrawn
- 2016-09-19 US US15/269,022 patent/US11608373B2/en active Active
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2018
- 2018-09-26 JP JP2018179643A patent/JP2018199725A/ja active Pending
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2023
- 2023-03-20 US US18/123,569 patent/US11807681B2/en active Active
- 2023-06-21 US US18/339,147 patent/US11891438B2/en active Active
- 2023-12-29 US US18/401,117 patent/US20240360207A1/en active Pending
Also Published As
Publication number | Publication date |
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EP3345607B1 (en) | 2022-10-26 |
EP3345607A1 (en) | 2018-07-11 |
US20240360207A1 (en) | 2024-10-31 |
PT3345607T (pt) | 2022-11-21 |
US8877196B2 (en) | 2014-11-04 |
JP2010528002A (ja) | 2010-08-19 |
JP2018199725A (ja) | 2018-12-20 |
ES2930183T3 (es) | 2022-12-07 |
LT3345607T (lt) | 2023-01-10 |
JP2017014263A (ja) | 2017-01-19 |
US20130195856A1 (en) | 2013-08-01 |
PL3345607T3 (pl) | 2023-01-09 |
US20080160060A1 (en) | 2008-07-03 |
JP2014074046A (ja) | 2014-04-24 |
US20230357377A1 (en) | 2023-11-09 |
EP2144613A2 (en) | 2010-01-20 |
DK3345607T3 (da) | 2022-11-21 |
ES2666650T3 (es) | 2018-05-07 |
US20170044248A1 (en) | 2017-02-16 |
US20150086571A1 (en) | 2015-03-26 |
US11891438B2 (en) | 2024-02-06 |
US8178099B2 (en) | 2012-05-15 |
WO2009131553A2 (en) | 2009-10-29 |
EP4176884A1 (en) | 2023-05-10 |
US11807681B2 (en) | 2023-11-07 |
US11608373B2 (en) | 2023-03-21 |
US20230226086A1 (en) | 2023-07-20 |
US20120201815A1 (en) | 2012-08-09 |
WO2009131553A3 (en) | 2010-04-29 |
FI3345607T3 (fi) | 2022-11-30 |
EP2144613B1 (en) | 2018-03-21 |
HUE060822T2 (hu) | 2023-04-28 |
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