SI3057962T1 - Oblika hidrokloridne soli za ezh2 inhibicijo - Google Patents
Oblika hidrokloridne soli za ezh2 inhibicijoInfo
- Publication number
- SI3057962T1 SI3057962T1 SI201432051T SI201432051T SI3057962T1 SI 3057962 T1 SI3057962 T1 SI 3057962T1 SI 201432051 T SI201432051 T SI 201432051T SI 201432051 T SI201432051 T SI 201432051T SI 3057962 T1 SI3057962 T1 SI 3057962T1
- Authority
- SI
- Slovenia
- Prior art keywords
- salt form
- hydrochloride salt
- ezh2 inhibition
- ezh2
- inhibition
- Prior art date
Links
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical group N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 title 1
- 101150090105 Ezh2 gene Proteins 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361891786P | 2013-10-16 | 2013-10-16 | |
| PCT/US2014/060724 WO2015057859A1 (en) | 2013-10-16 | 2014-10-15 | Hydrochloride salt form for ezh2 inhibition |
| EP14854272.3A EP3057962B1 (en) | 2013-10-16 | 2014-10-15 | Hydrochloride salt form for ezh2 inhibition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3057962T1 true SI3057962T1 (sl) | 2024-01-31 |
Family
ID=52828660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201432051T SI3057962T1 (sl) | 2013-10-16 | 2014-10-15 | Oblika hidrokloridne soli za ezh2 inhibicijo |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US10040782B2 (sl) |
| EP (2) | EP4324525A3 (sl) |
| JP (2) | JP6608812B2 (sl) |
| KR (1) | KR102142177B1 (sl) |
| CN (1) | CN105829302B (sl) |
| AU (2) | AU2014337300B2 (sl) |
| CA (1) | CA2925889C (sl) |
| CL (1) | CL2016000866A1 (sl) |
| DK (1) | DK3057962T3 (sl) |
| EA (1) | EA038869B1 (sl) |
| ES (1) | ES2960953T3 (sl) |
| FI (1) | FI3057962T3 (sl) |
| HU (1) | HUE063984T2 (sl) |
| IL (1) | IL244787B (sl) |
| LT (1) | LT3057962T (sl) |
| MA (1) | MA38949A1 (sl) |
| MX (1) | MX2016004703A (sl) |
| MY (1) | MY179802A (sl) |
| PE (1) | PE20161273A1 (sl) |
| PL (1) | PL3057962T3 (sl) |
| PT (1) | PT3057962T (sl) |
| SG (2) | SG11201602269QA (sl) |
| SI (1) | SI3057962T1 (sl) |
| WO (1) | WO2015057859A1 (sl) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3438B1 (ar) | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
| CN104603130B (zh) | 2012-04-13 | 2018-04-27 | Epizyme股份有限公司 | 人类组蛋白甲基转移酶ezh2抑制剂的盐形式 |
| LT2908823T (lt) | 2012-10-15 | 2019-10-25 | Epizyme Inc | Vėžio gydymo būdai |
| SG11201602269QA (en) | 2013-10-16 | 2016-04-28 | Epizyme Inc | Hydrochloride salt form for ezh2 inhibition |
| BR112016012713A2 (pt) | 2013-12-06 | 2017-08-08 | Epizyme Inc | Método para tratamento de câncer em um paciente necessitado, e, método de selecionar um paciente para um método de tratamento |
| CN106999498B (zh) | 2014-06-17 | 2021-06-08 | Epizyme股份有限公司 | 用于治疗淋巴瘤的ezh2抑制剂 |
| JP2017532338A (ja) | 2014-10-16 | 2017-11-02 | エピザイム，インコーポレイティド | 癌を治療する方法 |
| HUE062159T2 (hu) * | 2014-11-17 | 2023-10-28 | Epizyme Inc | Módszer a rák kezelésére N-((4,6-dimetil-2-oxo-l,2-dihidropiridin-3-il)metil)-5-(etil(tetrahidro-2H -pirán-4-il)amino)-4-metil-4'-(morfolinmetil)-[1,1'-bifenil]-3-karboxamiddal |
| EA201792304A1 (ru) | 2015-04-20 | 2018-03-30 | Эпизайм, Инк. | Комбинированная терапия для лечения рака |
| WO2016201328A1 (en) | 2015-06-10 | 2016-12-15 | Epizyme, Inc. | Ezh2 inhibitors for treating lymphoma |
| CN108025191A (zh) | 2015-08-24 | 2018-05-11 | Epizyme股份有限公司 | 治疗癌症的方法 |
| AU2017211331A1 (en) | 2016-01-29 | 2018-06-07 | Epizyme, Inc. | Combination therapy for treating cancer |
| WO2017210395A1 (en) | 2016-06-01 | 2017-12-07 | Epizyme, Inc. | Use of ezh2 inhibitors for treating cancer |
| EP3471830A4 (en) | 2016-06-17 | 2020-02-26 | Epizyme Inc | EZH2 INHIBITORS TO TREAT CANCER |
| TW201831181A (zh) | 2017-01-19 | 2018-09-01 | 日商第一三共股份有限公司 | 用以用於治療ｈｔｌｖ－１相關脊髓病之醫藥組成物 |
| WO2018183885A1 (en) | 2017-03-31 | 2018-10-04 | Epizyme, Inc. | Combination therapy for treating cancer |
| EP3630080A4 (en) | 2017-06-02 | 2021-03-10 | Epizyme, Inc. | USE OF EZH2 INHIBITORS TO TREAT CANCER |
| US11452727B2 (en) | 2017-09-05 | 2022-09-27 | Epizyme, Inc. | Combination therapy for treating cancer |
| CA3104209A1 (en) | 2018-07-09 | 2020-01-16 | Fondation Asile Des Aveugles | Inhibition of prc2 subunits to treat eye disorders |
| EP4017527A1 (en) | 2019-08-22 | 2022-06-29 | Juno Therapeutics, Inc. | Combination therapy of a t cell therapy and an enhancer of zeste homolog 2 (ezh2) inhibitor and related methods |
| WO2023209591A1 (en) | 2022-04-27 | 2023-11-02 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate with ezh1 and/or ezh2 inhibitor |
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| SG11201602269QA (en) | 2013-10-16 | 2016-04-28 | Epizyme Inc | Hydrochloride salt form for ezh2 inhibition |
-
2014
- 2014-10-15 SG SG11201602269QA patent/SG11201602269QA/en unknown
- 2014-10-15 CA CA2925889A patent/CA2925889C/en active Active
- 2014-10-15 MA MA38949A patent/MA38949A1/fr unknown
- 2014-10-15 EP EP23203529.5A patent/EP4324525A3/en active Pending
- 2014-10-15 US US15/029,848 patent/US10040782B2/en active Active
- 2014-10-15 EP EP14854272.3A patent/EP3057962B1/en active Active
- 2014-10-15 PE PE2016000506A patent/PE20161273A1/es unknown
- 2014-10-15 LT LTEPPCT/US2014/060724T patent/LT3057962T/lt unknown
- 2014-10-15 DK DK14854272.3T patent/DK3057962T3/da active
- 2014-10-15 PT PT148542723T patent/PT3057962T/pt unknown
- 2014-10-15 ES ES14854272T patent/ES2960953T3/es active Active
- 2014-10-15 SG SG10201901977XA patent/SG10201901977XA/en unknown
- 2014-10-15 JP JP2016519378A patent/JP6608812B2/ja active Active
- 2014-10-15 FI FIEP14854272.3T patent/FI3057962T3/fi active
- 2014-10-15 KR KR1020167011534A patent/KR102142177B1/ko active Active
- 2014-10-15 MY MYPI2016000542A patent/MY179802A/en unknown
- 2014-10-15 HU HUE14854272A patent/HUE063984T2/hu unknown
- 2014-10-15 AU AU2014337300A patent/AU2014337300B2/en active Active
- 2014-10-15 MX MX2016004703A patent/MX2016004703A/es active IP Right Grant
- 2014-10-15 PL PL14854272.3T patent/PL3057962T3/pl unknown
- 2014-10-15 WO PCT/US2014/060724 patent/WO2015057859A1/en active Application Filing
- 2014-10-15 EA EA201690650A patent/EA038869B1/ru unknown
- 2014-10-15 CN CN201480056428.6A patent/CN105829302B/zh active Active
- 2014-10-15 SI SI201432051T patent/SI3057962T1/sl unknown
-
2016
- 2016-03-28 IL IL244787A patent/IL244787B/en unknown
- 2016-04-13 CL CL2016000866A patent/CL2016000866A1/es unknown
-
2018
- 2018-06-05 US US16/000,539 patent/US10710987B2/en active Active
- 2018-12-11 JP JP2018231817A patent/JP2019052181A/ja active Pending
-
2019
- 2019-04-02 AU AU2019202246A patent/AU2019202246A1/en not_active Abandoned
-
2020
- 2020-06-03 US US16/891,427 patent/US20210017163A1/en not_active Abandoned
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